Please assess the completion status of the following clinical trial:

Trial Title: Pemetrexed Disodium or Erlotinib Hydrochloride as Second-Line Therapy in Treating Patients With Advanced Non-small Cell Lung Cancer

Study Design Characteristics:
- Allocation: RANDOMIZED
- Intervention Model: PARALLEL
- Observational Model: None
- Primary Purpose: TREATMENT
- Time Perspective: None
- Masking: NONE
- Phase: PHASE3
- Number of Arms: 2.0

Eligibility Criteria:
Inclusion Criteria:~* Documented recurrence or disease progression of NSCLC~  * NSCLC must be confirmed by pathologic examination, either on initial diagnosis or disease recurrence/progression; mixed histology allowed if all components consistent with NSCLC~* Measurable disease, defined as at least one lesion whose longest diameter can be accurately measured as \>= 2.0 cm by conventional techniques or as \>= 1.0 cm by spiral computed tomography (CT); if spiral CT is used, it must be used for both pre- and post- treatment tumor assessments~* Prior radiation therapy is permitted as long as:~  * Recovered from the toxic effects of radiation treatment before study entry, except for alopecia~ * =\< 25% of bone marrow radiated~ * Presence of measurable disease whether in-field disease progression/recurrence or disease outside the treatment fields of radiation port~* Absolute neutrophil count (ANC) \>= 1,500 uL~* Platelet (PLT) \>= 100,000 uL~* Hemoglobin (Hgb) \>= 10 g/dL~* Total bilirubin: within normal institutional limits (WNL) OR direct bilirubin =\< upper limit of normal (ULN)~* Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =\< 2.5 x ULN~* International normalized ratio (INR) =\< 1.5~* Calculated creatinine clearance \>= 45 mL/min using the Cockcroft-Gault formula~* Eastern Cooperative Oncology Group (ECOG) performance status (PS) 0, 1, or 2~* Negative pregnancy test done =\< 7 days prior to pre-registration, for women of childbearing potential only~* Ability to provide informed consent~* Life expectancy \>= 12 weeks~* Tissue available and willing to submit tissue for central pathology review and EGFR evaluation; performed on original diagnostic/recurrent tissue (preferably paraffin-embedded tissue blocks); if institution unable to release tissue blocks, willing to submit 25 unstained slides (15 sections cut at 5 microns mounted on charged slides and 10 sections cut at 10 microns mounted on uncharged slides)~* Must be previously treated for advanced disease with only 1 chemotherapy regimen which must contain cytotoxic agent(s); adjuvant/neoadjuvant treatment with cytotoxic agent(s) administered \< 12 months (from date chemotherapy was started) prior to pre-registration will be considered as one prior treatment; NOTE: adjuvant/neoadjuvant treatment administered \>= 12 months, use of targeted agents such as monoclonal antibodies prior to pre-registration will NOT be counted as one prior treatment; patient could have had adjuvant/neoadjuvant chemotherapy \>= 12 months and 1 systemic chemotherapy regimen for metastatic or recurrent disease~* Able to take folic acid, vitamin B12 supplementation, and dexamethasone~* Able to permanently discontinue aspirin dose of \>= 1.3 grams/day \>= 10 days before and after pemetrexed treatment~* Fertile patients must use effective contraception~* Able to take folic acid, vitamin B_12 supplementation, and dexamethasone~* Stable brain metastasis that have been treated with either whole brain radiation therapy or gamma knife surgery and are off steroid treatment for \> 14 days prior to pre-registration, if applicable~* Willingness to return to enrolling institution for treatment and follow-up~Exclusion Criteria:~* Any of the following:~  * Pregnant women~ * Nursing women~ * Men or women of childbearing potential who are unwilling to employ adequate contraception~* Any clinically significant infection, at the treating physician's discretion~* Known human immunodeficiency virus (HIV) positive patients~* Impairment of gastrointestinal (GI) function, inability to swallow pills in the absence of a feeding tube, or GI disease that may significantly alter absorption of oral medications (e.g. ulcerative disease, uncontrolled nausea and vomiting, malabsorption syndromes, bowel obstruction, etc)~* Serious condition that, in the opinion of the investigator, would compromise the patient's ability to complete the study or increase the risk for serious adverse events~* Any of the following prior therapies:~  * Prior radiation to \> 25% of bone marrow~ * EGFR tyrosine kinase inhibitors~ * Pemetrexed~ * Chemotherapy =\< 3 weeks prior to pre-registration~ * Mitomycin C/nitrosoureas =\< 6 weeks prior to pre-registration~ * Immunotherapy =\< 2 weeks prior to pre-registration~ * Biologic therapy =\< 2 weeks prior to pre-registration~ * Gene therapy =\< 2 weeks prior to pre-registration~ * Full field radiation therapy =\< 4 weeks prior to pre-registration~ * Limited field radiation therapy =\< 2 weeks prior to pre-registration~ * Major surgery (i.e., laparotomy), open biopsy, or significant traumatic injury =\< 4 weeks prior to pre-registration or anticipation of need for major surgical procedure during the course of the study; minor surgery =\< 2 weeks prior to pre-registration; insertion of a vascular access device is not considered major or minor surgery in this regard~* Other chemotherapy, immunotherapy, hormonal therapy, radiotherapy, or any ancillary therapy considered investigational (utilized for a non-Food and Drug Administration \[FDA\]-approved indication and in the context of a research investigation) =\< 4 weeks prior to pre-registration~* Steroid therapy for brain metastasis =\< 14 days prior to pre-registration~* Symptomatic serosal effusion (\>= Common Terminology Criteria for Adverse Events \[CTCAE\] v3.0 grade 2 dyspnea) that is not amenable to drainage prior to pre-registration~* Other invasive solid or hematologic malignancy; exceptions: prior malignancy was diagnosed and definitively treated \>= 5 years previously with no subsequent evidence of recurrence; patients with a history of low-grade (Gleason score =\< 6) localized prostate cancer will be eligible even if diagnosed \< 3 years prior to pre-registration; these patients may continue on medications concomitantly to maintain their disease remission as necessary; patients with carcinoma in situ, regardless of organ involvement, or non-melanoma cutaneous carcinomas are eligible if these were definitively treated \>= 3 years previously with no subsequent evidence of recurrence; Note: patients with breast cancer that was definitively treated \> 5 years earlier but continue to receive aromatase inhibitors are NOT eligible~* Only non-measurable disease, defined as all other lesions, including small lesions whose longest diameter measures \< 2 cm with conventional techniques or \< 1.0 cm with spiral CT, and truly non-measurable lesions, which include the following as per Response Evaluation Criteria In Solid Tumors (RECIST) criteria dated June 1999:~  * Bone lesions~ * Leptomeningeal disease~ * Ascites~ * Pleural/pericardial effusion~ * Inflammatory breast disease~ * Lymphangitis cutis/pulmonis~ * Abdominal masses that are not confirmed and followed by imaging techniques~ * Cystic lesions~ * Single disease site in prior radiation field~* Any of the following concurrent severe and/or uncontrolled medical conditions:~  * Angina pectoris~ * History of congestive heart failure =\< 3 months prior to pre-registration, unless ejection fraction \> 40%~ * Myocardial infarction =\< 6 months prior to pre-registration~ * Cardiac arrhythmia~ * Diabetes mellitus~ * Hypertension~ * Any other severe underlying diseases which are, in the judgment of the investigator, inappropriate for entry into this study~* Respiratory symptoms \> CTCAE grade 1

- Gender: ALL
- Minimum Age: 18 Years
- Maximum Age: None
- Healthy Volunteers: f

Study Arms:
- Arm I (erlotinib hydrochloride) (Type: EXPERIMENTAL): Patients receive erlotinib hydrochloride PO QD on days 1-21. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.
- Arm II (pemetrexed disodium) (Type: EXPERIMENTAL): Patients receive pemetrexed disodium IV over 10 minutes on day 1. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.

Based on this trial design, predict the completion outcome and termination type (if applicable).