Please assess the completion status of the following clinical trial:

Trial Title: Study of Anti-HB-EGF Antibody KHK2866 in Subjects With Advanced Solid Tumors and Ovarian Cancer

Study Design Characteristics:
- Allocation: NON_RANDOMIZED
- Intervention Model: PARALLEL
- Observational Model: None
- Primary Purpose: TREATMENT
- Time Perspective: None
- Masking: NONE
- Phase: PHASE1
- Number of Arms: 4.0

Eligibility Criteria:
Inclusion Criteria:~* Histologically or cytologically documented, measurable or non-measurable, advanced primary or recurrent solid tumor (Phase 1a only) which is unresponsive to standard therapy or for which there is no standard therapy available.~* Histologically or cytologically documented ovarian, primary peritoneal, or fallopian tube cancer.~* The subject has objective radiographic disease progression and either unmeasurable or measurable disease during or following the last treatment regimen, or serum cancer antigen-125 (CA-125) greater than 2X the upper limit of normal (\[ULN\] \>70 U/mL~* Life expectancy \>3 months.~* Performance status \< 3 at study entry.~* Age \> 18 years.~* Normal left ventricular ejection fraction.~* Recovered from the effects of recent surgery, radiotherapy, chemotherapy, hormonal therapy, or other therapies for cancer~* Preserved hepatic, renal, and hematopoetic organ function.~* Male and female subjects must use medically accepted contraception.~Exclusion Criteria:~* Ovarian malignancy of low malignant potential.~* Received anti-cancer chemotherapy, hormonal therapy, radiotherapy, immunotherapy, or investigational agents within 4 weeks prior to the first dose of KHK2866 (6 weeks for nitrosourea or mitomycin chemotherapy).~* received Mabs or had major surgery within 4 weeks of the first dose of KHK2866.~* Requires administration of a prohibited medication or treatment including: prophylactic use of erythroid and/or granulocyte colony stimulating factors; concurrent anti-cancer treatment; biologic response modifiers for any condition~* Brain metastases, leptomeningeal or primary brain neoplasm, even if treated.~* Previously untreated or uncontrolled epidural metastasis~* Cerebrovascular accident, Transient ischemic attack; symptomatic head trauma, or seizures or any kind within 6 months~* Dementia, or other disorders of mentation or difficulty speaking or difficulty with comprehension.~* Suspected impending bowel obstruction~* The subject is pregnant,or is lactating.~* Significant uncontrolled intercurrent illness~* Known HIV infection or AIDS-related illness.~* Known active hepatitis B or C or other active liver disease.~* Psychiatric illness, disability or social situation that would compromise the subject's safety, ability to provide consent, or limit his/her compliance with study requirements.~* Experienced a unmanageable hypersensitivity reactions to Mabs or other therapeutic proteins.~* History of second primary cancer, with the exception of: a) curatively resected non-melanomatous skin cancer; b) curatively treated cervical carcinoma in-situ; or c) other primary solid tumor treated with curative intent and no known active disease present and no treatment administered during the last 2 years.~* Additional exclusion criteria for subjects proposed for enrollment into the Phase 1b portion:~  * History of hypersensitivity or infusion reaction to any of the proposed chemotherapy arm's agents that could not be controlled with pre-medication and/or infusion rate adjustment;~ * Prior treatment with KHK2866;~ * History of Grade ≥ 3 non-hematologic or Grade 4 hematologic toxicity attributable to any of the proposed chemotherapy arm's agents~ * For subjects proposed to receive treatment with KHK2866 plus PLD: prior total cumulative exposure to doxorubicin must be ≤ 240 mg/m2.~* Subjects with a known history of interstitial lung disease or pulmonary fibrosis. Subjects must have pulse oximetry \>88% on room air at rest, and a DLco of \>49% if there is no evidence of lung metastasis.

- Gender: ALL
- Minimum Age: 18 Years
- Maximum Age: None
- Healthy Volunteers: f

Study Arms:
- KHK2866 as monotherapy (Type: EXPERIMENTAL): Groups of subjects will receive a weekly infusions of KHK2866 as treatment for advanced cancer. If there no severe side effects, the dose will be increased for future subjects. A total of four groups are anticipated. Once an acceptable dose is determined an additional seven subjects will be treated at that dose.
- KHK2866, gemcitabine+carboplatin (Type: EXPERIMENTAL): Open to subjects with ovarian, fallopian tube, or primary peritoneal cancer only.~One group of subjects will receive one dose below the maximum tolerated dose of KHK2866 identified in Phase 1a along with gemcitabine and carboplatin. The dose of KHK2866 will be increased to the MTD for the next group if no severe side effects are noted. Once an acceptable dose is determined an additional seven subjects will be treated at that dose.
- KHK2866, weekly paclitaxel (Type: EXPERIMENTAL): Open to subjects with ovarian, fallopian tube, or primary peritoneal cancer only.~One group of subjects will receive one dose below the maximum tolerated dose of KHK2866 identified in Phase 1a along with weekly paclitaxel (80 mg/m2). The dose of KHK2866 will be increased to the MTD for the next group if no severe side effects are noted. Once an acceptable dose is determined an additional seven subjects will be treated at that dose.
- KHK2866, pegylated liposomal doxorubicin (Type: EXPERIMENTAL): Open to subjects with ovarian, fallopian tube, or primary peritoneal cancer only.~One group of subjects will receive one dose below the maximum tolerated dose of KHK2866 identified in Phase 1a along with monthly PLD (40 mg/m2). The dose of KHK2866 will be increased to the MTD for the next group if no severe side effects are noted. Once an acceptable dose is determined an additional seven subjects will be treated at that dose.

Based on this trial design, predict the completion outcome and termination type (if applicable).