Please assess the completion status of the following clinical trial:

Trial Title: Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of IONIS ANGPTL3-LRx in Healthy Volunteers With Elevated Triglycerides and Participants With Familial Hypercholesterolemia

Study Design Characteristics:
- Allocation: RANDOMIZED
- Intervention Model: PARALLEL
- Observational Model: None
- Primary Purpose: OTHER
- Time Perspective: None
- Masking: DOUBLE
- Phase: PHASE1
- Number of Arms: 11.0

Eligibility Criteria:
Inclusion Criteria for All Cohorts:~* Must have given written informed consent and be able to comply with all study requirements~* Males or females 18 to 65 years, inclusive, at the time of informed consent~* Body Mass Index (BMI) ≤ 35.0 kg/m2~* Females must be non-pregnant and non-lactating, and either surgically sterile or postmenopausal.~* Males must be surgically sterile, abstinent or using an acceptable contraceptive method~Inclusion criteria for Cohorts, A, D, and AA to DD only:~* Fasting triglycerides (TG) ≥ 150 mg/dL at Screening~* Fasting low density lipoprotein cholesterol (LDL-C) \> 70 mg/dL at Screening~Inclusion criteria for Cohorts B and C only:~* Fasting TG 90 - 150 mg/dL at Screening~* Fasting LDL-C \> 70 mg/dL at Screening~Inclusion Criteria for Cohort EE Only:~* Homozygous FH diagnosis and fasting LDL-C ≥ 190 mg/dL (4.9 mmol/L)~Inclusion Criteria for Cohort FF Only:~* Heterozygous FH diagnosis and fasting LDL-C ≥ 160 mg/dL (4.1 mmol/L)~Inclusion Criteria for Cohorts EE and FF Only:~* Maximally tolerated stable LDL-C lowering agents (stable for at least 12 weeks)~* On stable low-fat diet~* Stable weight (± 4 kg) for ≥ 6 weeks prior to screening~Exclusion Criteria for All Cohorts:~* Known history or positive test for Human Immunodeficiency Virus (HIV), Hepatitis C (HCV), or Hepatitis B (HBV)~* Treatment with another Study Drug, biological agent, or device within one-month or 5-half-lives of screening~* Regular use of alcohol within 6 months of screening~* Use of concomitant drugs unless authorized by the Sponsor Medical Monitor~* Known contraindication and/or allergy to heparin~* Smoking \> 10 cigarettes a day~* Considered unsuitable for inclusion by the Principal Investigator~Exclusion Criteria for Cohorts EE and FF:~* Myocardial infarction, percutaneous transluminal coronary intervention, or coronary artery bypass graft surgery within 12 weeks prior to screening, or cerebrovascular accident within 24 weeks prior to screening. Participants with adequately treated stable angina, per Investigator assessment, may be included~* Congestive heart failure defined by NYHA Classes III or IV~* Type 2 diabetes mellitus (T2DM) with HbA1c \> 8.0%~* Prior treatment with gene therapy~* Currently receiving apheresis treatments or last apheresis treatment was within 8 weeks of screening

- Gender: ALL
- Minimum Age: 18 Years
- Maximum Age: 65 Years
- Healthy Volunteers: t

Study Arms:
- Cohorts A, D: Placebo (Type: PLACEBO_COMPARATOR): Participants received a single-dose of IONIS ANGPTL3-LRx-matching placebo subcutaneously on Day 1.
- Cohorts A, D: IONIS ANGPTL3-LRx 20 mg (Type: EXPERIMENTAL): Participants received a single-dose of IONIS ANGPTL3-LRx 20 milligrams (mg) subcutaneously on Day 1.
- Cohorts A, D: IONIS ANGPTL3-LRx 120 mg (Type: EXPERIMENTAL): Participants received a single-dose of IONIS ANGPTL3-LRx 120 mg subcutaneously on Day 1.
- Cohorts B, C: Placebo (Type: PLACEBO_COMPARATOR): Participants received a single-dose of IONIS ANGPTL3-LRx-matching placebo subcutaneously on Day 1.
- Cohorts B, C: IONIS ANGPTL3-LRx 40 mg (Type: EXPERIMENTAL): Participants received a single-dose of IONIS ANGPTL3-LRx 40 mg subcutaneously on Day 1.
- Cohorts B, C: IONIS ANGPTL3-LRx 80 mg (Type: EXPERIMENTAL): Participants received a single-dose of IONIS ANGPTL3-LRx 80 mg subcutaneously on Day 1.
- Cohorts AA-DD: Placebo (Type: PLACEBO_COMPARATOR): Participants received IONIS ANGPTL3-LRx-matching placebo subcutaneously once per week for 6 weeks.
- Cohorts AA-DD: IONIS ANGPTL3-LRx 10 mg (Type: EXPERIMENTAL): Participants received IONIS ANGPTL3-LRx 10 mg subcutaneously once per week for 6 weeks.
- Cohorts AA-DD: IONIS ANGPTL3-LRx 20 mg (Type: EXPERIMENTAL): Participants received IONIS ANGPTL3-LRx 20 mg subcutaneously once per week for 6 weeks.
- Cohorts AA-DD: IONIS ANGPTL3-LRx 40 mg (Type: EXPERIMENTAL): Participants received IONIS ANGPTL3-LRx 40 mg subcutaneously once per week for 6 weeks.
- Cohorts AA-DD: IONIS ANGPTL3-LRx 60 mg (Type: EXPERIMENTAL): Participants received IONIS ANGPTL3-LRx 60 mg subcutaneously once per week for 6 weeks.

Based on this trial design, predict the completion outcome and termination type (if applicable).