Please assess the completion status of the following clinical trial:

Trial Title: Temozolomide for Second-Line Treatment of Neuroendocrine Carcinomas

Study Design Characteristics:
- Allocation: None
- Intervention Model: SINGLE_GROUP
- Observational Model: None
- Primary Purpose: TREATMENT
- Time Perspective: None
- Masking: NONE
- Phase: PHASE2
- Number of Arms: 1.0

Eligibility Criteria:
Inclusion Criteria:~* Signed informed consent prior to initiation of any study-specific procedures or treatment, as confirmation of the patient's awareness and willingness to comply with the study requirements.~* Patients ≥18 years of age.~* Histologically confirmed Metastatic Neuroendocrine Carcinoma (Ki67\>20% Ki67 must be quantified in percentage) with documented progression of disease per investigator assessment following or during first-line platinum-based treatment.~* Eastern Cooperative Oncology Group (ECOG) performance status (PS) of 0-2.~* At least 28 days since prior radiation therapy or surgery and recovery from treatment.~* Patients must have measurable disease which must be evaluable per RECIST v1.1.~* Estimated life expectancy of ≥12 weeks.~Exclusion Criteria:~* - Patients \< 18 years of age~* Diagnosis of well differentiated G1/G2 NEN~* Psychiatric or addictive disorders or other conditions that, in the opinion of the investigator, would prevent the patient from meeting the study requirements.~* Serious active infection requiring i.v. antibiotics and/or hospitalization at study entry.~* Patients who are treated with any medicinal product that contraindicates the use of the study drug, may interfere with the planned treatment, affects patient compliance or puts the patient at high risk for treatment-related complications.~* Pregnant or lactating females. Serum pregnancy test to be assessed within 7 days prior to study treatment start, or within 14 days with a confirmatory urine pregnancy test within 7 days prior to study treatment start. Women of childbearing potential (defined as \<2 years after last menstruation and not surgically sterile) not using effective, non-hormonal means of contraception (intrauterine contraceptive device, barrier method of contraception in conjunction with spermicidal jelly). Perimenopausal women must be amenorrheic for at least 12 months to be considered of non-childbearing potential~* Patients with meningeal carcinomatosis~* Patients with organ allografts requiring immunosuppression~* Patients with known positive HIV status~* Patients with a hypersensitivity to Temozolomide or Dacarbazine~* Any laboratory values at baseline as follows:~Hematology:~1. Absolute Neutrophil Count (ANC) \<1.5x109/L or 1500/mm3~2. Platelet count \<100x109/L~3. Hemoglobin \<8 g/dL (Note: hemoglobin levels may be supported by transfusion or erythropoietin or other approved hematopoietic growth factors).~Coagulation:~1. International Normalized Ratio (INR) \>1.5 except for patients on stable anticoagulant therapy~2. Activated Partial Thromboplastin Time (aPTT) ≥1.5 times upper limit of normal (ULN) or greater than the lower limit of the therapeutic range Note: The use of full-dose oral or parenteral anticoagulants is permitted as long as the INR or aPTT is within therapeutic limits (according to the medical standard in the institution) and the patient has been on a stable dose of anticoagulants for at least two weeks at the time of Day 1, Cycle 1.~Serum chemistry:~1. Total bilirubin \>1.5 times ULN~2. Aspartate Aminotransferase (AST) or Alanine Aminotransferase (ALT) \>2 times ULN (\>5 times ULN for patients with known liver involvement)~3. Alkaline Phosphatase (ALP) \>2 times ULN (\>5 times ULN for patients with known liver involvement and \>7 times ULN for patients with known bone involvement).

- Gender: ALL
- Minimum Age: 18 Years
- Maximum Age: None
- Healthy Volunteers: f

Study Arms:
- Temozolomide (Type: EXPERIMENTAL): Temozolomide 75mg/m2 metronomic schedule: one week on/one week off in a cycle of 28 days

Based on this trial design, predict the completion outcome and termination type (if applicable).