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Chronic kidney disease occurs commonly in middle-aged and older pets, but may also affect younger pets born with congenital problems. Kidney injuries can also occur in pets with serious infections, inflammatory conditions, or when blood flow becomes compromised, such as during anesthesia. The Groves Veterinary Clinic team believes early detection and dietary management are key to successful kidney disease treatment, so we’re sharing our knowledge about kidney disease and how diet and other treatments can affect your pet’s health.
Pet kidney functions
Dogs and cats have two kidneys located inside their abdomen that serve several important body functions, including:
- Filtering metabolic waste products from the blood
- Regulating water balance and hydration
- Regulating electrolyte, mineral, and protein levels
- Maintaining normal blood pressure
- Stimulating red blood cell production
Pet kidney disease signs
Pets with kidney disease usually do not show any signs until more than two-thirds of their kidney function is lost, and the body can no longer compensate. Pets do not feel well at this stage, because a cascade of events is occurring inside their bodies. Early stages may have milder signs than later, more severe stages. Kidney disease signs in dogs and cats may include:
- Weight loss
- Increased thirst and urination, causing dilute urine
- Decreased appetite
- Nausea and vomiting
- Foul breath
These signs occur because the kidneys can no longer filter the blood or conserve water properly. Pets who lose too much fluid and protein in their urine become dehydrated and lose weight, while waste products build up, and they feel sick. Also, their calcium and phosphorus balance is disrupted and their metabolism altered, and they may develop high blood pressure, anemia, and urinary tract infections or stones. Presence of kidney disease signs combined with blood work, urinalysis, and urine culture can diagnose kidney disease and associated complications.
Pet kidney disease causes
When older pets develop kidney disease, the cause is often unknown and attributed to aging. In younger pets, some kidney diseases, such as polycystic kidney disease, are inherited. Chronic kidney failure may also result after a sudden kidney insult, called acute kidney injury. Potential kidney disease causes include:
- Autoimmune disease
- Tick-borne disease
- Vascular events (i.e., blood clots, stroke)
- Congenital or genetic diseases
- Decreased blood flow during anesthesia
How diet impacts kidney function in pets
Reducing the amount of certain dietary substances can also reduce the kidneys’ workload and improve or normalize mineral balance. Studies show that pets who consume renal diets live longer, have lower blood toxin levels, and often maintain weight better than pets who eat a regular diet. Because pets with kidney disease usually feel nauseous, most prescription veterinary diets are formulated in many extra-tasty options, so finding the one your pet likes best should not be difficult. A veterinary nutritionist-formulated diet is another good choice for pets who feel too sick or don’t like the commercial foods. In any case, proper nutrient balance is key to preserving remaining kidney function and helping your pet feel better. Key renal diet components include:
- Reduced protein — Moderately restricted protein reduces blood waste products and urinary protein loss, and helps prevent further kidney damage.
- Reduced phosphorus — High phosphorus levels from kidney disease lead to decreased blood calcium levels through hormonal dysregulation. Blood calcium has important electrolyte effects, and can affect bone health and heart rhythm. Many studies have proved that reducing dietary phosphorus significantly improves survival times.
- Increased omega-3 fatty acids — EPA and DHA fatty acids reduce inflammation and slow further kidney damage.
- Increased potassium — Potassium deficiency that occurs in kidney disease can result in serious heart problems, but can be offset by increased dietary levels. Some dogs have the opposite problem and may need a special, home-cooked diet instead of a commercial option.
If you choose a renal diet, you must commit to ensuring your pet is not fed any table scraps or treats that are not specially formulated. Renal diets are researched thoroughly and carefully balanced, and adding anything to your pet’s food can upset nutrient balance, render the diet ineffective, and reduce your pet’s disease control. Ensure you obtain veterinarian approval before adding food, treats, or supplements to your pet’s diet.
Other pet kidney disease treatments
Renal diets are only one facet of kidney disease treatment, and work best when combined with other strategies. Additional kidney disease treatments may include:
- Supplements to maintain mineral balance
- Hormone injections to counteract anemia
- Medications to treat high blood pressure and reduce protein loss
- Medications to reduce nausea and vomiting, and stimulate appetite
- At-home fluids given under the skin
- Enhanced water or water fountains to encourage fluid intake
- Hospitalization with IV fluids and medications for pets with acute illness
Pet kidney disease outlook
Pets with chronic kidney disease who are managed closely with diet and other treatments often live many months or years beyond their diagnosis. However, these pets must visit the veterinarian every few months for blood and urine tests, blood pressure monitoring, and weight monitoring, so therapy adjustments can be made, if necessary. They may experience acute illness bouts, which can be treated with a few days’ stay in the veterinary hospital. Some pets will eventually die from kidney disease, while others live many years and die from unrelated causes. The best way to help your pet with kidney disease is to follow your veterinarian’s nutritional and medical management recommendations.
Annual veterinary visits with wellness blood and urine testing can help our Groves Veterinary Clinic team detect kidney disease in the early stages and recommend an appropriate renal diet to prevent further damage. Contact us to schedule a wellness visit, or if you are concerned that your pet is showing kidney or other disease signs.

domain: medical


After seeing this series of tweets about responsive images and picturefill.js, I started wondering if there was another approach web developers should take for serving up images. The following relates to inline or content images, not background or decorative images. For example, large images in the middle of a long article on a news site.
Imagine loading pages without inline images even present by default. Pages would load blazingly fast, because there are fewer HTTP requests overall and images aren’t taking up bandwidth on initial page load. The user could tap or click an image placeholder to request the image.
I think it would be great to see this user tested on content-heavy sites, such as blogs or news sites.


text: Excellent research, well documented. My one complaint is that some of the sources of the outrageous criticisms of citizen's right are from known crackpots. I would have enjoyed more seeing some of the more neutral comments from liberals who are merely badly informed or quoting incorrect 'studies.' Most of what is refuted is from sources that are known to be low-riders with not much credibility. But, the book is packed with real-life examples of how guns have helped citizens, how guns lower rather than raise crime rates,and the whys and wherefores of America's historical use of guns for defense.

domain: library


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With the summer holidays now in full swing, you’re probably looking for fresh ideas for having fun with the little ones.
A little educational fun is always best, which is why we are so excited to check out the exciting schedule of events planned in the National Library of Ireland, this month.
If your kids are looking to do something a little different, there is a wide range of activities for them to enjoy – and we can guarantee you that they will learn something new.
So, without further ado, here is the complete list of child and family events taking place this month:
Each Tuesday, from July 4 to 25 inclusive, the library will be hosting an afternoon of trails with stories and drawings. Your little ones will have loads of fun, and it’s totally free – now that’s what we call a win-win situation!
Drop-in Tuesdays will run from 2:15 to 3:30pm.
Thursday afternoon workshops
There will be a fun and exciting workshop on each Thursday of the month, between 2:30 and 4pm. Here’s what’s coming up for the rest of the month:
July 20 – ‘Catchy Captions: Capturing Newspapers at the National Library’
This is the ideal workshop for the child who just loves sharing the news! Here, little ones will get to discover the lost world of Newspapers at the National Library of Ireland – and even become an illustrator, creating their own catchy caption and cartoon!
July 27 – ‘Miss Battersby’s Birds – Flapping good fun’
This is one workshop that your little scribbler won’t want to miss. Miss Battersby’s sketchbooks, house in the library, are packed with stunning watercolours of exotic birds. Inspired by these works of art, the children will be invited to create their own.
For more information, check out www.nli.ie.


Life and Material Sciences
Broadband, High-Brightness Light in Materials Science & Life Science Applications
High Performance Analytical Spectroscopy is widely used in the materials and life sciences to analyze the molecular composition of complex materials. To achieve the most precise analysis, wavelengths that cover the range from the deepest ultraviolet through visible and into the near infrared. Traditionally, combinations of deuterium lamps and tungsten halogen lamps have been used. These lamps suffer from short operating life, low brightness and limited spectral range. Energetiq’s EQ-99X and EQ-77 Laser-Driven Light Sources offer much higher brightness across the whole spectrum, from 170nm to 2100nm (UV-Vis_NIR) and an order of magnitude longer life, enabling a new class of instruments capable of analyzing much smaller samples, with high precision and throughput.
Surface Science techniques in the materials sciences, such as Photoemission Electron Microscopy (PEEM), can take advantage of the high brightness and deep ultraviolet output of LDLS sources such as the EQ-77. In PEEM applications, the high photon energy, i.e. short wavelength, light must be focused to a small spot on the sample, perhaps 100µm in diameter. Usually, this must be accomplished at a significant working distance and through a vacuum window in the PEEM instrument. Traditionally used Xe and Hg arc sources have little output in the 200nm wavelength range, and their large plasma size, in the millimeter range, makes imaging the source on the sample an inefficient process. By contrast, the ~150um diameter high-brightness plasma in the EQ-1500 allows straightforward and efficient re-imaging of the source onto the sample, even with a long working distance. The high output of short wavelengths, usually selected from the broadband LDLS spectrum by narrow bandpass filters, has been demonstrated to produce PEEM images with significant intensity and contrast.
Biological Imaging - The ability to see the structure of living organisms and to analyze the relationship between form and function is key to biological studies. However, living organisms are dynamic structures, and biological processes that occur over time such as protein changes, cell division, embryo development, or neural activity necessitate the visualization of structures in multi-dimensions. With the development of advanced biological imaging technology it is now possible to observe molecular and cellular interactions that underlie essential functions within living cells and tissues as they take place. The Energetiq EQ-99X and EQ-77 Laser-Driven Light Source are ideal tools to use for these particular studies due to the high resolution, power, and brightness of the light generated. By utilizing DUV light as the light source, the nanostructure of living cells and tissues can be directly observed with extremely high resolution, without the extreme purchasing and operating costs associated with the use of conventional lasers.
Request More Information
Are you looking for more information on this product family? Fill out the form to request a quote, demo, or additional technical information.
Soft X-Ray Light in Life Sciences Applications
Soft X-Ray Microscopy and Soft X-Ray Microbeams - Soft x-ray light for microbeam studies and microscopy can readily be found in national lab synchrotron facilities. However, this limits the availability of soft x-rays to those researchers who are able to obtain beam time and who are able to bring their experiments to the synchrotrons. With its novel plasma approach, Energetiq’s compact EQ-10SXR Soft X-Ray Light Source enables soft x-ray microbeam and microscope experiments to be carried out in any typical biological research laboratory.
Microbeam studies of the effects of ionizing radiation on biological cells have long been performed using particle accelerators. The limitations of charged particle beams such as alpha particles include difficulty in focusing the beam to below one micrometer in diameter. Soft x-rays provide similar ionizing radiation effects on biological samples, but are readily focused to very small spot size using Fresnel zone-plate lenses. In principle, beams significantly less than 100nm in diameter can be produced using such optics. This allows the targeting of sub-cellular structures within cells with a controlled soft x-ray beam, to evaluate the response of such structures to ionizing radiation. Applications include the effects of environmental radiation, and the mechanisms of radiotherapy for cancer and the like.
In soft x-ray microscopy, images produced with soft (low energy) x-ray beams have 10 times the resolution of images obtained with the best visible light microscopes. In addition, studies can be done on living cells without destroying them. Soft x-ray microscopy can make a major contribution to the understanding of cell function and structure. The Energetiq EQ-10SXR light source has been shown to produce sufficient 2.88nm light to allow production of high resolution images in a practical time.


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Used KLA / TENCOR / ICOS T830 #9188785 for sale
KLA / TENCOR / ICOS T830 is a wafer testing and metrology equipment designed for semiconductor manufacturing. This tool combines test, double-sided scanning, and in-line dimensional metrology in a fully integrated platform. The system utilizes both optical and electrical wafer testing functions for a variety of device types, giving users reliable and precise results. KLA T830 utilizes an enclosed single-stage vacuum scanning unit for processing two wafers at a time. It allows users to quickly transition between wafer sizes, providing enhanced throughput. The machine also offers single-sided and short wafer inspection capability. Along with its dedicated double-sided scanning capabilities, ICOS T830 offers a comprehensive set of front and backside optical, electrical, and dimensional measurements. Using its specialized optical design, T830 can obtain high-resolution images of wafers up to 24" in diameter with a 5x reduction optical tool. At this size, even the smallest features such as pits or cracks can be seen in high detail. The asset also utilizes in-plane imaging for defect coverage over entire die surfaces, which helps ensure that defects are not missed when testing and inspecting large substrates. TENCOR T830 offers a variety of electrical test options, including four-point contact, contactless, open-short-load test, current testing, and a variety of other electrical parameter measurements. It has multiple measurement mechanisms that can be combined with specialized instruments for device isolation and stress detection. With its integrated dimensional metrology, it can measure die sizes, thicknesses, and topology, as well as the offsets of the same two points between different wafers. In addition to its testing and measurement function, KLA / TENCOR / ICOS T830 integrates data management and reporting capabilities. All systems data recorded by the tool is stored in a secure database which can be accessed by authorized personnel. Reports can be generated and exported in various formats, allowing the user to review and analyze results. Overall, KLA T830 is an advanced wafer testing and metrology model designed to provide reliable results while reducing the cost and complexity of semiconductor manufacturing. Its advanced features and capabilities make it a valuable tool for the industry.
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domain: physics


1. What is the name of the group that has calcium carbonate spicules?
- Basic sponges
- Calcareous sponges
- Sessile sponges
1 of 18
Other questions in this quiz
2. How many species of sponges are there?
3. Water enters the sponge through
- Small pores
- The water canal
4. Some sponges show radial symmetry but most show no symmetry
5. Two of the groups have spicules made of
- Calcium carbonate


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The Gospel Coalition and Fiel Ministries desire to strengthen thousands of congregations by helping to equip the pastors and elders called to shepherd them. TGC International Outreach is engaged in a combat against the Theological Famine of today's Global Church by partnering with translators, publishers, and missions networks to provide new access to biblical resources in digital and physical formats. Fiel's Executive Director, James Richard Denham III, is on the advisory board of TGC International and desires to bring these resources to the Portuguese-speaking world.
One of TGC International's Relief Projects was in partnership with Fiel Ministries (then Editora Fiel). This Relief Project funded 500 pastor's courses for seminaries, Bible schools, and churches in Portuguese-speaking Africa.
TGC's Packing Hope Project provided 5,000 Portuguese copies of Don Carson's book, "The God Who is There", for distribution at conferences and other outreaches among Portuguese-speaking communities.
If you would like to know more about Packing Hope and TGC Relief Projects, please click here.

domain: christianity


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Where to and how do you wear a mask
Do you know the correct way to wear a mask to ensure it protects you, your friends and family?
For example, if you touch the front of the mask while you’re wearing it, then you may pick up the very germs that the mask has protected you from. It is important to only touch the elastic when wearing or removing your mask. But if you do touch the mask, then wash or sanitise your hands immediately.
The Victorian Government has recently mandated wearing masks in public in metropolitan Melbourne or the Mitchell Shire. Outside of these areas the Federal health advice remains, that if you are well then face masks are not required where there is low community transmission of COVID-19 and you can maintain safe social distancing.
You may choose to voluntarily wear a mask if you are in a situation where physical distancing is difficult, such as on public transport or in busy areas like shopping centres.
The main reason to wear a mask is to protect other people, because if you are unknowingly infected, wearing a mask will reduce the chance that you will pass the virus on to others.
Wearing a mask
If you choose to wear a mask, it is important to:
- Wash your hands before putting on the mask.
- Make sure it covers your nose and mouth and fits snugly under your chin, over the bridge of your nose and against the sides of your face.
- Do not touch the front of the mask while wearing it or when removing it. If you do touch the mask, wash or sanitise your hands immediately. Do not allow the mask to hang around your neck.
- Wash or sanitise your hands after removing the mask.
Single-use masks should not be re-used and should be discarded immediately after use. Wash and dry reusable masks after use and store in a clean dry place.
People with chronic respiratory conditions should seek medical advice before using a mask.
Make you own cloth mask
There are a number of tutorials or downloadable instructions for making your own face masks.
The Australian Government Department of Health has developed an instructional guide.
Don’t forget that your reusable cloth mask needs to be clean and dry to be most effective. Reusable cloth masks should be washed at least daily. Depending on the fabric, they can be washed in the washing machine with other clothes, on the warmest water setting for the fabric. If possible, dry your cloth mask in direct sunlight.
Melbournians, however, must wear a mask when leaving home. There are a few exceptions, such as if you cannot wear a mask for medical, practical or professional reasons. For more information visit Health and Human Services. And the Victorian Government has advised that residents must only leave home for four reasons: shopping for food and supplies, caregiving, exercise or work, if you cannot work from home.
Stay to update
It is best to stay informed with your local authority as responses to the coronavirus vary with each state or Territory government:

domain: health


text: A galaxy is a huge group of stars, gas, and dust that are held together by gravity. They are so big that it is hard to even imagine how big they are! There are many different types of galaxies, and they come in all sorts of shapes and sizes. Some galaxies are small and have just a few hundred stars, while others are so big that they have trillions of stars. Our own galaxy, the Milky Way, is a medium-sized galaxy and is shaped like a spiral. It is made up of a central bulge, a flat disk, and a halo. The stars in a galaxy are held together by the force of gravity, and they orbit around the center of the galaxy just like planets orbit around the Sun.

domain: astronomy


Home >>Saboo Cement Mill Design
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If you have any problems about our product and service,please feel free to give your inquiry in the form below. We will reply you within 24 hours as soon as possible.Thank you!
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Letting go of someone is a scary feat to tackle. I’ve spent much time observing why people stay in relationships or handle break ups so terribly. It’s unfortunate I have to admit that I’ve seen many more unhappy and ill-fitting relationships than I have otherwise. This is why I can’t imagine the soul-freeing break up to be so devastating.
In reality, humans are emotional creatures. This statement includes men, no matter how emotionally deficient they appear to be. We all fall for the wrong one at least once in our lives and when the levee breaks, we let it consume us.
There are many reasons why even couples who clearly shouldn’t have been together, can suffer from the break up. It’s possible that the two weren’t on the same level of understanding or commitment. There are plenty of ways to interpret the meaning of a relationship and unless it’s communicated properly, one of you will most likely be horribly blind-sighted later on.
It could be the unsettling and selfish fear of them finding someone better. I know a handful of girls, and even some guys, who have stayed in a relationship because they don’t want their significant other finding someone else. It’s not because they want to keep their significant other under lock and key because they feel as if they’ve struck gold. It’s because they don’t want to feel like failures while their significant other goes out and possibly succeeds in the dating world. That makes us question ourselves, “Well, why didn’t it work with me?” Unless you’re ready to seriously ponder that question as an adult, do not dwell on it.
What I find to be the most common is that now you’re back to square one, you’re alone. You don’t have that safety blanket; nobody to call when you’re bored or sad. They aren’t there to accompany you in uncomfortable situations or to be your date for special occasions. Now you have to re-learn how to live as a human being without the extra limb. You have to learn how to be comfortable in your own skin and you have to do it by yourself.
You’re also put back into the single world. Although it is a beautiful and majestic place, straight out of a relationship it can be the equivalent to the Department of Motor Vehicles: pushy people, frustration and long waiting periods. Depending on how long you’ve been out of the game, this could be a nightmare. I have that problem now after recently splitting with my boyfriend of almost three years and I seem only to appeal to creeps. If anyone else has this problem, you are not alone and stay strong.
It is important to accept one of two truths, if not both when letting go of someone whether it’s a boyfriend, girlfriend or just a friend. Let’s be honest, break-ups between friends can be much more catastrophic than intimate relationships.
One is that you are confident that you gave the relationship your all. You exercised all efforts in giving this person every fiber of your being, so even in the event of a break up, you aren’t left feeling regretful. There is no second guessing if you could have done something more to salvage the union and beating yourself up over it. Sometimes things just don’t work or weren’t meant to be and it doesn’t have to be anyone’s fault. Take what you can out of the experience and appreciate the memories.
The second truth is that the other person didn’t want to give any more of their all. That stings and I know it does, but it hurts less than possibly being treated like dirt later on. In my opinion, the only thing that feels worse than being cheated on is being dated out of pity. Thus meaning your significant other was too much of a chicken sh*t to let you know they’ve mentally checked out of dating you and is sparing themselves, and not you, the theatrics.
You can’t change anyone who doesn’t want to change and you can’t make someone do something unwillingly. Even if they did want to change, it isn’t your job or your responsibility to do it for them. If this is the case, count your lucky stars for the break up and be thankful you got out when you did. Nobody deserves anyone who doesn’t at least wholeheartedly care about them. Not me, not you and not even the dumbass that you were dating.
It takes a lot of energy and time to break the routine of a relationship as well as the overall attachment you have to that person; that attachment is perfectly warranted and most of the time inevitable. Life can seem unbearable during this period because “everything” we knew is now gone. In reality, this isn’t everything you’ve ever known so you need to take a step back from the ledge and tone down the dramatics.
You lived before you loved and you’ll live after you’ve loved. Believe it or not, you’ll move on and love again. This doesn’t mean you have to stop loving them either, but you do need to move on so someone more deserving of your love can come along and seize the opportunity that is you.
I’m a firm believer in fairness because girls can destroy boys just as easily as boys can destroy girls. My ex-boyfriend calls me a truck driver because I ran over his heart with an 18-wheeler. Is it a clever label? Absolutely. Am I proud of it? Most certainly not. But, we let each other go as a potential romantic interest and we’ve been the best of friends ever since.
I’m not encouraging anyone to go out right this moment and find a life partner, but if you’re actively pursuing a relationship with someone, you need to give enough of a sh*t to make it work. Don’t half ass it because you’re wasting everyone’s time.
If life hasn’t taught us anything else, it has taught us that time is precious. So even if you end up spending a lot of that time alone, do whatever it takes to enjoy it.
Photo Courtesy: Tumblr

domain: psychology


text:
This is our Favorite family restaurant in Edmonton.
It is even a great lunch place for meetings with friends and colleges.
Excellent salads, and the mushroom soup is good too.
The food (mostly pastas) is excellent - very tasty - without being over the top in any way. The portions are good, without stuffing you. The atmosphere is warm and inviting - not pretentious. The prices are quite reasonable given what you get and how good it is. They even take reservations.
If you are looking for a great 'family' or casual dining restaurant in Edmonton, give this one a try - you will Not be disappointed.
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domain: food


Many coastal areas in the South Pacific Ocean can provide significant marine energy resources in the near future. The installation of marine hydrokinetic (MHK) devices in these regions will require new approaches to understand physical and environmental processes that are relevant for the installation of turbine arrays, which are also specific of each site. The coastal morphology of the Chacao channel in southern Chile, which separates the Chiloé island from the main continent (41º47'S, 73º31'W) stands out as an important energy resource that can potentially contribute a significant power capacity. This coastal area not only sustains delicate ecosystems with limited anthropic intervention, but it is characterized by a complex bathymetry that can have important effects on the performance of MHK devices and their local impacts. To understand the interactions of the local bathymetry and ambient turbulence with turbine arrays, we carry out a series of numerical simulations with a coherent-structure resolving turbulence model using the actuator disk parameterization. The main objective of this study is to further our understanding on the physical processes associated with the installation of the turbine arrays. We perform simulations with different geometries and inlet boundary conditions, from simple cases in a rectangular channel, to more complex cases that include the high-resolution bathymetry of an extensive area of the Chacao channel. The results show how the interactions between the MHK devices, the local flow, and the bed can affect the energy flux and potential generation in specific sites. The results also provide new insights of local impacts of MHK devices and they can also help to optimize turbine arrays in natural environments. This work has been supported by Fondecyt project 1130940, and the Marine Energy Research & Innovation Center (MERIC) financed by Corfo and based in Santiago, Chile.


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Nowadays, the hot button topic for manufacturers, distributors, and retailers alike, the current tariff wars are driving many organizations to rethink the way they align and maximize their global supply chains.
Joseph Brusuelas, chief economist at RSM, said that rising inflation, a lack of available workers and more are contributing to some concerns for the economy and the stock market and that trade and tariff wars are a wild-card that is more likely to hurt the economy than help it.
REALLY? Read on . . .
We live in uncertain times. President Donald Trump’s ‘America First’ economic policy, while boosting the US economy has caused controversy overseas.
Trade tariffs impact industry sectors in different ways. For example, the Trump administration’s duty hikes on steel and aluminum imports will have a positive impact on US-domiciled metal producers. However, for metal consumers further down the production line, the tariffs might not be as positive because prices and credit risks could potentially go up.
For US-domiciled insurance companies, the impact of the trade tariff war will be felt through sector allocations in their portfolios. Certain sectors, such as agriculture or retail, are likely to feel the effects of trade uncertainty more keenly, which could lead to a rebalancing of insurance portfolios in those areas.
Tariff Wars – The BIG Question
“A big question for many industries, including insurance, is whether trade uncertainty will stunt economic growth. Every job created and household formed brings with it a number of risks that have to be insured. The insurance business is strong when the economy is strong, but if trade concerns drag down potential growth, that could result in lost interest for insurers,” said Richard Sega, global chief investment strategist at Conning.
There has been some concern about potential economic inflation as a result of increased tariffs and their impact on costs throughout the global supply chain. Sega agrees there may be some general inflation in the US, but attributes it to increased monetary velocity as a result of US tax reforms rather than a direct effect of Trump’s trade policies. Regardless of its cause, economic inflation will have an impact on insurance firms.
“Certain kinds of fixed-benefit coverages, like life insurance or disability insurance policies, are relatively unaffected by inflation on the liability side. The impact on their asset portfolio is more concerning, especially if inflation affects the valuation of their equities and interest rates on bonds and so on,” Sega told Insurance Business.
“Property and casualty (P&C) writers face a different kind of problem,” he added. “Economic inflation tends to lead to an increase in the severity and frequency of claims, with more surpassing the attachment point or deductible level. That’s an un-hedge-able risk from an insurance company’s portfolio standpoint. It has to be handled through pricing, which is a real challenge for P&C insurance firms when they’re faced with an inflationary period.”
Trade protectionism and market volitivity also present opportunities for fundamental investors, like Conning, to upgrade the portfolios and credit strength of high-quality companies, Sega explained. Picking at opportunities through times of trouble sets companies in a good position to take on risk once issues are resolved.
During these uncertain times, Conning has turned to diversification when investing, looking at asset classes beyond corporate credit, which is most popular with the insurance industry. The firm is eyeing investment opportunities in a structured product, commercial mortgage loans, and asset-backed securities, all of which bring some yield but don’t threaten corporate credit exposure.
“If the worst-case scenario plays out and there’s an all-out spiral of retaliatory tariffs, there’s no putting a happy face on it,” Sega added. “Emerging markets with export-based economies would probably get hurt the most, as opposed to the US where domestic policies of late have been very positive. Even with a trade drag, I believe the US economy will still do fairly well – just not nearly as well as it could do without all of these trade frictions.
“I believe President Trump wants to put a trade deal together that he can point to as a success, and, in order to do that, people on the other side have to be able to point to successes too. My expectation is that we will get a negotiated solution to the trade uncertainties out there, and when that happens, it could be very positive for the markets.”
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If You’re Our Client
FYI small business insurance Murrieta CA 92563-92562
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domain: economics


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A day before Honda Aircraft formally announced that the HondaJet will use the GE-Honda HF120 engine, Spectrum Aeronautical announced that its new all-composite midsize Freedom S-40 jet will be powered by the HF120, at a thrust rating of more than 2,000 pounds. The stand-up-cabin Freedom will cruise at up to 435 knots, and fly 2,200 nm at up to 45,000 feet. Certification and entry-into-service is set for 2010.
In The Works: Spectrum Aeronautical Freedom S-40
- December 7, 2006, 10:25 AM

domain: aerospace


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Charged nanoparticles delivery to the eye using hydrogel iontophoresis.
ABSTRACT Ocular iontophoresis has been investigated for many years as a non-invasive technique for enhancing ionized drug penetration through ocular tissues. In this study we assessed the penetration of charged fluorescent nanoparticles into rabbit eyes using hydrogel iontophoresis. Particle distribution into ocular tissues and penetration efficiency of negative nanoparticles compared with positive nanoparticles was also evaluated. Cathodal and anodal iontophoretic administrations were performed using polyacrylic hydrogels loaded with charged nanoparticle suspension (20-45 nm), applying a current intensity of 1.5 mA for 5 min onto the cornea and sclera. At pre-set time points post treatment, eyes were dissected and tissues were evaluated for fluorescence intensity. Strong fluorescence evidence was observed at anterior and posterior ocular tissues. Negative particle distribution profile revealed fast uptake into the outer ocular tissues, within 30 min post treatment, followed by particle migration into the inner tissues up to 12 h post treatment. The positively charged particles demonstrated better penetration abilities into inner ocular tissues compared to the negatively charge particles. This work provides an opening for the development of a new ocular therapeutic pathway using iontophoresis of extended release drug-loaded charged nanoparticles.
- Journal of controlled release : official journal of the Controlled Release Society. 05/2014;
- [Show abstract] [Hide abstract]
ABSTRACT: The basic concepts, major mechanisms, technological developments and advantages of the topical application of lipid-based systems (microemulsions, nanoemulsions, liposomes and solid lipid nanoparticles), polymeric systems (hydrogels, contact lenses, polymeric nanoparticles and dendrimers) and physical methods (iontophoresis and sonophoresis) will be reviewed. Although very convenient for patients, topical administration of conventional drug formulations for the treatment of eye diseases requires high drug doses, frequent administration and rarely provides high drug bioavailability. Thus, strategies to improve the efficacy of topical treatments have been extensively investigated. In general, the majority of the successful delivery systems are present on the ocular surface over an extended period of time, and these systems typically improve drug bioavailability in the anterior chamber whereas the physical methods facilitate drug penetration over a very short period of time through ocular barriers, such as the cornea and sclera. Although in the early stages, the combination of these delivery systems with physical methods would appear to be a promising tool to decrease the dose and frequency of administration; thereby, patient compliance and treatment efficacy will be improved.The Journal of pharmacy and pharmacology. 04/2014; 66(4):507-30.
Article: Ocular delivery of macromolecules.[Show abstract] [Hide abstract]
ABSTRACT: Biopharmaceuticals are making increasing impact on medicine, including treatment of indications in the eye. Macromolecular drugs are typically given by physician---administered invasive delivery methods, because non---invasive ocular delivery methods, such as eye drops, and systemic delivery, have low bioavailability and/or poor ocular targeting. There is a need to improve delivery of biopharmaceuticals to enable less---invasive delivery routes, less---frequent dosing through controlled--- release drug delivery and improved drug targeting within the eye to increase efficacy and reduce side effects. This review discusses the barriers to drug delivery via various ophthalmic routes of administration in the context of macromolecule delivery and discusses efforts to develop controlled--- release systems for delivery of biopharmaceuticals to the eye. The growing number of macromolecular therapies in the eye needs improved drug delivery methods that increase drug efficacy, safety and patient compliance.Journal of controlled release : official journal of the Controlled Release Society. 07/2014;

domain: chemistry


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My child is 4 and has been diagnosed with autism spectrum disorder. He’ll eat most anything that I puree. But he refuses to eat even small pieces of solid food except for soft cheese puffs, and he can’t drink from a straw. How can I teach him to chew real food?
Autism Speaks is pleased to spotlight the publication of Solving Sleep Problems in Children with Autism Spectrum Disorders: A Guide for Frazzled Families.
What is it about autism and trains? We know it’s not just our son because we keep meeting other children – and adults – on the spectrum who are so fascinated by them.
“My adult autistic son has been spitting up. It seems to be triggered by anxiety, will last a day and then stop as quickly as it started. He’s on medication for gastric reflux and had endoscopies to open up a narrow esophagus. He also takes medication for seizures and has a hiatal hernia. Any suggestions?”
“Our child, severely affected by autism, refuses to eat anything but sweets. How can I direct her diet in healthier directions?”
“When I physically discipline my 6-year-old son [who has autism], he starts to hit himself. Should I use physical discipline? Do I just let him hit himself?”
By developmental-behavioral pediatrician Paul Wang, Autism Speaks’ senior vice president for medical research.


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The Unbinding of Mary Reade by Miriam McNamara
There’s no place for a girl in Mary’s world. Not in the home of her mum, desperately drunk and poor. Not in the household of her wealthy granny, where no girl can be named an heir. And certainly not in the arms of Nat, her childhood love who never knew her for who she was. As a sailor aboard a Caribbean merchant ship, Mary’s livelihood—and her safety—depends on her ability to disguise her gender.
At least, that’s what she thinks is true. But then pirates attack the ship, and in the midst of the gang of cutthroats, Mary spots something… Read more.
Trigger & Content Warnings
- Ableism & ableist language
- Attempted rape & sexual assault
- Child abuse
- Domestic violence
- Death of a friend
- Gun violence
- Hunting mentioned

domain: literature


Can you believe it, after only six and a half years on the job, the mayor finally has some good news out of Albany? Here's the NY Post story on the deal for the Gansevoort recycling center: " Mayor Bloomberg broke his Albany losing streak yesterday by winning state approval to build a trash-transfer station on the Hudson River near Gansevoort Street - the last hurdle to his sweeping overhaul of the city's garbage system."
We guess that Bloomgerg finally gets it: you have to really negotiate with Shelly Silver and you can't simply bogart him as you do some others we can think of. But what really has the mayor gained from this deal? According to his court historian, quit a lot it seems: "The victory allows Bloomberg to complete his massive revision of the city's Solid Waste Management Plan.
The plan represented Bloomberg's answer to the looming trash crisis he inherited after then-Mayor Rudy Giuliani closed the massive Fresh Kills Landfill on Staten Island. "This is a legacy project for the mayor," Deputy Mayor for Operations Edward Skyler told The Post. "We're fundamentally handling the way the city handles its garbage, to deal with it an environmentally friendly way and not pit communities against each other."
A legacy project? We'll let the real historians be the judge of that; but let's just say that as far as garbage removal is concerned-there's not much there there. The mayor still hasn't figured out any significant way to actually reduce the amount of garbage exported, and the administration's cluelessness on organic waste is right up there as one reason why this Gansevoort deal ain't no great shakes.
Some tinkering with how you transport the waste you're exporting is no substitute for a plan that would radically reduce the amounts sent out to area landfills. As we've said in the past, if this is, as the mayor has described it, a "groundbreaking" plan, than the man must be digging with a plastic spoon.


Samsung’s Galaxy Xcover 3 is all about being rugged. Its main claim to fame is the Xcover 3 is fully IP67 and MIL-STD-810G certified, so be it water, dust, salt, humidity, vibration, solar radiation and thermal shock, the Xcover 3 has them covered. The display is a 4.5” 480 x 800 PLS TFT LCD, which generates a PPI of ~207 and the primary camera capture images at 5MP. Powering the Xcover 3 is a Marvel Armada PXA1908 SoC, comprising of a quad-core 1.2GHz CPU, a Vivante GC7000 GPU and 1.5GB of RAM. Internal storage sits at 8GB, which can be expanded upon by way of microSD. Members are free to browse the various topics available for the Samsung Galaxy Xcover 3.


HBO has just unveiled the official trailer for its latest drama series, “True Detective: Night Country.” This gripping new installment stars the talented Jodie Foster and Kali Reis, who take on the roles of Detectives Liz Danvers and Evangeline Navarro, respectively. Their task? To unravel the mysterious disappearance of eight men from the Tsalal Arctic Research Station in Ennis, Alaska.
The trailer, revealed at Warner Bros. Discovery’s CCXP Panel in São Paulo, Brazil, teases a story set against the backdrop of a harsh, endless winter night in Alaska. This setting serves as more than just a backdrop; it’s a character in its own right, shaping the narrative and adding to the show’s eerie atmosphere.
Jodie Foster and Kali Reis lead a cast that includes notable names like Fiona Shaw, Finn Bennett, Christopher Eccleston, and John Hawkes. Each actor brings their unique flair to the series, promising a rich and engaging viewing experience. Guest stars like Anna Lambe, Aka Niviâna, and Joel D. Montgrand add depth to the already impressive roster.
The responsibility of steering this ship lies with Issa López, who not only serves as the showrunner but also writes and directs all the episodes. It’s a hefty task, but López’s vision seems to shine through in the gripping narrative and intense character studies presented in the trailer.
Executive producers for the series include big names like Barry Jenkins, Matthew McConaughey, Woody Harrelson, and Cary Joji Fukunaga. Their involvement hints at the quality and depth we can expect from this series.
“True Detective: Night Country” isn’t just a detective story; it’s a journey into the heart of darkness, both literal and metaphorical. As Foster’s and Reis’ characters delve into the case, they also confront their personal demons. The series promises to be more than just a crime drama; it’s a deep dive into the human psyche set against the haunting backdrop of Alaska’s frozen landscape.
With such a talented cast and crew, “True Detective: Night Country” is gearing up to be a must-watch. It’s a series that promises to keep us on the edge of our seats, eagerly waiting for each new episode.
Have something to add? Let us know in the comments below!


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MCTC has introduced its vast range of catering services to TORM crew members including its full catering management programme, which is delivered with a complimentary training package to enhance the skillset of crew members.
The company’s full Catering Competence Development Programme will be delivered to crews, alongside full management of all the vessels’ catering needs, including budget management, recipe planning and ordering of provisions. Crew members will also have access to expert advice on health and nutrition, fitness, wellbeing and mental health.
TORM’s priority was to implement a high level of training standards to its cooks and ensure they were all being armed with the right skills to be able to run their kitchens efficiently, plan nutritious menus, budget plan, order provisions, and cook healthy and balanced meals for crew members.
Vice President, Head of Procurement, Purchase and Logistics at TORM, Tony Giner, said: “We have been in talks with MCTC for the last few years, but having worked with other providers we decided to make the switch to MCTC about six months ago. We officially launched around a month ago with our crew members and I have to say we are extremely happy to have found such a fantastic partner in MCTC.
“Bearing in mind the supply chain challenges we are all facing at the moment and the fact that TORM has recently completely revolutionised its own supply chain, this really was the perfect storm for failure, but with MCTC’s complete professionalism they have executed this transition flawlessly.”
TORM crew members working in the galley will now a receive a standardised approach to their training, where they will have their current skillset assessed and an individual training plan will be created for them.
Catering Manager at TORM, Jogvan Trondesen Andreasen, added: “The move to MCTC’s services has been really welcomed by our crew members. They can see that we have invested in their training and they are all very positive as they can see how their careers can progress and develop.”
MCTC will deliver its services to galley crews on all 75 of TORM’S vessels who cater for around 3,500 seafarers working on the vessels.
CEO of MCTC, Christian Ioannou said: “We are delighted to partner with TORM who share our desire to provide cooks with the very best training to give them the skillset needed to run their kitchens effectively and provide healthy and nutritious meals to all seafarers onboard. Mealtimes are so important for crew members and is the glue that connects them all at the end of a hardworking day.”

domain: news


Environmental/ Tree Planting at Cuckoo Nest Farm Addingham
Sat 13th December 2014 at 10.00 am - 1.00 pm
For the 4th year in succession Blaize members and friends planted 500 trees. This year the planting was at Cuckoo Nest Farm in Addingham. We were guided again by Ian Butterfield a representative from the Forest of Bradford.
This year's planting consisted of Oak, Silver Birch and other broad leafed trees. As the area had a population of wild deer the trees had to be protected by much stouter stakes and tree sheaths to stop them being eaten.


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Day 1 in Kanazawa
Welcome to Kanazawa! Upon arrival at the airport, you will go through customs and immigration. Should you opt to purchase a transfer to your hotel; a representative will be waiting for you as you exit immigration. Arrive at your hotel, check in and do not give in to jet lag! There is so much for you to see and do!
We recommend you get acquainted with the city, take a walk around the heart of the city and explore the beautiful verdant landscapes of the Kanazawa Castle Park. Stroll through the tree-lined paths and take in the surroundings and fresh air, there are paths leading up to the old castle ruins.
Just outside the park is the 21st Century Museum of Contemporary Art. Take some time to explore the museum, taking in the art exhibits from acclaimed contemporary Japanese artists and others from around the world. Some of the iconic pieces on display include Leandro Erlich`s `Swimming Pool`, and James Turrell`s `Blue Planet Sky`.
Make your way over to the famous Omicho Market, which has been operating for over 280 years. Also known as `Kanazawa`s Kitchen` the market is packed with over 185 stalls offering some of the freshest fish and seafood in the country. Enjoy some lunch in the market and sample all kinds of delicious food, there are tons of restaurants located inside the market serving up sushi and other cuisines.
After lunch, take a leisurely stroll through the mesmerizing Kenroku-en Garden (Garden of Six Attributes) the most famous sight in the city. The vibrant gardens spread throughout 29 acres in the heart of Kanazawa, ranked by the Japanese as one of the top 3 gardens in the country. Discover the perfect landscaping, trickling streams, perfect ponds, and quaint traditional teahouses found throughout the park. The Seisonkaku Villa is on the grounds built by a Maeda lord for his mother, the parts that remain showcase daimyo palace architecture, with bright blues and reds featured on the upper floor.
Kanazawa is part of the UNESCO Creative Cities Network featuring over 30 local arts and crafts made in the city. One of the famed items produced in the city is the gold leaf, which is used to decorate cakes and other food and add a sparkle to some sake. Wander around the shops found along the streets of Kakinokibatake, a popular shopping district in the city selling gold leaf, lacquerware, and other interesting trinkets. The Hakuza Gold Leaf shop is located in the city of Kanazawa, which is responsible for 99% of Japan`s gold leaf production. This shop is housed in a traditional warehouse decorated entirely in gold!
Visit one of the traditional Japanese teahouses dotted around the city. Shima Teahouse is almost 200 years old, housed in a well-preserved building which is also a museum. Travel back in time and take in the traditional atmosphere, enjoy a cup of matcha and relax.
As evening time approaches, make your way to the Higashi Chaya-gai district, found across the Asano River, the most famous Geisha area in the city. Take in the serene setting of the ancient labyrinth of winding streets charmingly decorated with tall narrow buildings covered in twinkling lights. Chaya means teahouses and this vibrant preserved district is filled with places where you can enjoy being entertained by real Geisha`s with traditional song and dance. The Shima Teahouse is open to all and is well worth visiting for a refined experience in an elegant setting.
Higashi Chaya is the main entertainment district in Kanazawa where you will find a wide selection of restaurants offering delicious local cuisine including sushi and sashimi, which is some of the best around with fresh fish and seafood straight from the Sea of Japan. Stop in and enjoy some dinner, then take an evening stroll through the picturesque streets.
Day 2 in Kanazawa
Start your day off with some breakfast in one of the many cafes found in the heart of the city serving fresh tea, coffee, and freshly baked sweets and pastries. Take a stroll around the Kanazawa Castle Park and see all the locals getting in their daily exercise including tai chi and yoga.
Head to the Kanazawa Castle is the large, partially restored castle located in the city of Kanazawa, sitting opposite the Kenroku-en Garden it was the seat of power for the local Maeda clan for 14 generations during the Sengoku period. The castle burnt down on several occasions, the Ishikawa Gate and the Sanjikken Nagaya (samurai warehouse) are the original construction, the gate dates from 1788 facing the gardens.
Check out some of the fantastic museums in the city, Ishikawa Prefectural Museum of Art features a wide assortment of original Japanese creations including displays of pottery, contemporary paintings, lacquer, and porcelain. The museum is located close to the famous Kenrokuen Gardens. Ishikawa Prefectural History Museum is housed in a red brick building that was once a weapons warehouse for the Japanese Army. The museum features various types of material related to history and culture exhibited in 3D and other forms from primitive to present times.
For lunch, head back over to the famous Omoicho Market and try some `Kaiseidon` a heaping portion of raw fish over a bowl of hot rice, its delicious and a specialty in Kanazawa. Be sure to sample some `jizake` or local sake, made from Kanazawa`s exceptionally clean water from the melted snow on the nearby mountains which produces the finest rice in Japan.
Make your way to Myoryu-ji also known as the Ninja Temple, a Buddhist temple featuring secret passageways, trap doors, and hidden rooms. The building features unique Japanese architecture and fascinating history, making it a popular attraction in the city.
Next up is Nagamachi, which was once the residence for Kanazawa`s Samurai. The area boasts beautifully preserved historical buildings such as the Nomura Samurai House and Garden, Kanazawa Shinise Memorial Hall, and the Kyu-Kaga Hanshi Takada Family House. Visit the Nagamachi Yuzen Kan to try some silk dying, visit the museum here and the sweet candy shop!
Visit the D. T. Suzuki Museum, a simple and elegant museum displaying works from the Japanese philosopher D. T. Suzuki, he was a major 20th Century Zen philosopher and the writer responsible for introducing Zen Buddhism to the West, born in the city of Kanazawa. Check out the interactive displays and memorabilia on his work and life, the museum invites you to empty your mind from distraction and visit the contemplative space outside at the water `garden`.
Head up the Bokodai Observatory located at the base of Mt. Utatsuyama with views over the streets of Kanazawa. The buildings elevation soars to 462 feet and overlooks the Kanazawa Castle and views that stretch as far as the Sea of Japan and the peaks of Mt. Haku mountain ranges.
Do some shopping in Kakinokibatake, which is also a well-known gourmet district packed with restaurants serving both local cuisine and international fare. Enjoy dinner here and try Kanazawa`s famous beef, Noto-gyu, a premium grilled steak that melts in your mouth accompanied by delicious local vegetables. After dinner, take a romantic evening stroll and enjoy an ice cream coated in gold leaf.
Head to Hotel Kanazawa to the 16th floor where the `Raspberry` Bar is located, the perfect spot in the city for a late-night drink with spectacular night views of the sparkling city. The bar features a piano bar and an extensive cocktail menu.
Additional Days in Kanazawa
If you are able to spend additional days in Kanazawa take some side trips and visit the surrounding areas including Shirakawa-go and Gokayama, two spectacular scenic and secluded mountain village destinations famous for their traditional architecture. Both locations are UNESCO World Heritage Site and can be reached via a bus ride or car journey from Kanazawa.
Takayama city is a popular sightseeing location to visit and can be reached via train, bus or car from Kanazawa. The city is known for its beautifully preserved wooden buildings, temples, and museums and is also the host to the vibrant Takayama Festival taking place twice a year in the spring and autumn months. Takayama is also a popular skiing destination in the surrounding mountains.
There are plenty of festivals to enjoy in the city of Kanazawa including the Asanogawa Riverside Garden Party held on the second Saturday and Sunday in April. The party takes place along the Asano River banks which are decorated by beautiful blooming cherry blossoms. There are traditional songs, dance and shows put on by local geisha and maiko at the elevated stage by the river.
The Hyakuman-goku Festival takes place the first weekend in June, a huge Ishikawa festival celebrating the entry of Lord Maeda Toshiie who was the founder of the Kaga Domain into Kanazawa Castle in 1583. The festival lasts for three days including a parade on Saturday, a citywide folk dancing competition on Saturday night, public tea ceremony and children`s lantern parade on Friday night. The opening ceremony is performed at the Kanazawa Station.
Your Last Day in Kanazawa
Depart from your hotel to the airport for your return flight home. We recommend that you purchase a private transfer to the airport if so the representative will meet you at your hotel with plenty of time to get you to the airport for your flight out.

domain: artistic


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It could be because geeks are making significant impact in a world that is becoming increasingly reliant on information technology.
Harry Potter is my geeky passion of choice because, like millions of others, I’ve been a fan since I was a kid.
Read Also: 8 Tell-Tale Signs You’re A Geek Nonetheless, all is not lost because we have here 20 good reasons why you should consider giving geeks a chance since they are…
To be a geek, you have to be obsessed with something to qualify.
Regardless of what geeks are obsessed with, you can’t deny that their level of loyalty exceeds beyond the extraordinary. Geeks love to solve problems; it gives them an adrenaline rush when they’re beating the final boss in their favorite video games or troubleshooting their operating system. And to add to point #1, when they get into it, they can obsess over a bug in the system that they spend hours on it without stopping for a break.
A tech gadget, an operating system, comic book superheroes, a sci-fi fantasy realm, a gaming portal, you name it, geeks eat, sleep and breathed it. It’s not a healthy way to approach a problem, but it sure gives you the results you want, especially when it comes to tech support.
Match has been around for more than two decades, making it the most established dating site in the industry.

domain: hobby


Foam Concrete has some compelling advantage over traditional construction. If you are looking to build or renovate your home within the next few years, give your building a closer look. Foam Pouring Concrete is generally made by extremely fluid cement slurry. It is also called light weight concrete which has the potential to stay in place during the curing process.
Foam concrete is an exclusive item for construction which has the strength of cement, lightweight, sand and other material. Its durability is remarkable especially in the construction of the home or any other commercial project. When it sets or solidifies it doesn’t collapse or shrink.
Foam Pouring Concrete is unique product having high strength of the cement and widely utilized in the construction industry. Its durability is amazing and it is best environmental friendly green product.Here, Maple Concrete Pumping Company offer complete construction services in Toronto. With five successful years, Maple has built a reputation among all companies. Maple employees have ample experience in their work and have a great thought in mind. We offer you the most consistent and reliable services at reasonably priced.
Maple’s Foam Pouring Concrete method is designed for variety of strength and densities of the product and easily available for different uses. Light-Weight foam is famous for its features like Eco-friendly, durable, Earthquake resistant, lower water absorption and much more. It’s also a designer-friendly in nature that helps workers to give you an enhanced appeal.
We at Maple also expertise in other construction services like ICF Concrete Filling, Small Concrete Pump, Commercial Concrete Pump and much more. We never compromise with the safety factor of our clients as well as staffs. We provide advanced machines & well services at the reasonable charge.


Ask The Experts: Is this BLM demand legitimate?
November 2016 by Chris Ralph
Q: The Arizona BLM state office has started sending out registered letters to association placer claim holders...
Need some help putting together a BLM proposal.
Frogs' extinction from fungus
The Bawl Mill • Our Readers Say • Legislative and Regulatory Update • Detecting: Small Creek Yields Good Gold • The Challenge of Winter Dredging • What Have You Got to Lose? • MMAC Update • How to Upgrade Your Pocket Plunger • Glaciers and Placer Gold Deposits • What's In A Name? • Oregon Miners Still Fighting • Greenhorn Finds Gold in Colorado • Mining Stock Quotes and Mineral & Metal Prices • Melman on Gold & Silver


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XB-ART-30733Can J Biochem 1982 Mar 01;603:243-51. doi: 10.1139/o82-029.
Show Gene links Show Anatomy links
Vitellogenin mRNA in locust fat body: identification, isolation, and quantitative changes induced by juvenile hormone.
Change in RNA during the juvenile hormone (JH) stimulated synthesis of vitellogenin (Vg) in the fat body of adult female Locusta migratoria have been studied. Total RNA from mature females, but not that from males or prereproductive females, shows a 6300 nucleotide component, which has been isolated by binding to oligo(dT)-cellulose and sucrose gradient centrifugation, and identified as Vg mRNA by translation in Xenopus oocytes. It has been assayed quantitatively by photometric scanning after electrophoresis. During a gonotrophic cycle, Vg mRNA increased rapidly from 0 up to about 1% of the total fat body RNA, or more than 10(6) copies per cell. After destruction of the corpora allata (the source of JH) by treatment with ethoxyprecocene, Vg synthesis was stimulated by injection of 150 micrograms of the JH analog, methoprene. In primary stimulation, Vg mRNA was first detected at 24 h and showed a marked lag in accumulation; in secondary stimulation by methoprene after decay of the primary effect, Vg mRNA was detected after only 12 h and accumulation was much more rapid. Both in the natural cycle and in experimental stimulation, Vg mRNA did not disappear in correlation with declining Vg synthesis, which suggests conservation of mRNA in untranslated form. Total (chiefly ribosomal) RNA showed a different pattern, accumulating markedly during primary and only slightly during secondary stimulation. The data indicate that JH acts selectively (though not necessarily directly) on transcription of the Vg genes.
PubMed ID: 6177387
Article link: Can J Biochem


text: Find the best prices for Paraiso - Airport car hire Tabasco. Search for rental car deals in Paraiso at hundreds of travel sites. Cheap Car Hire Paraiso. You can rent a car car for daily, weekly, monthly and yearly car rentals at the cheapest prices. With advantageous prices starting from 15 Euro per day, take advantage of Tabasco Paraiso rent a car and Paraiso bus station car rental, Paraiso airport cheap car rental, Paraiso center rent a car.

domain: travel


text:
Exploration and the Colonial Era People, Terms & Concepts
first European to establish a trade route to Asia
settler out to get goods. Got lost found North America (New World)
Who America is named after
The trade between Columbus and the natives.
areas that are settled by immigrants
the first English attempt to settlement.
The second English settlement
ruled by the king. sent colonies out in search of land.
Made the king obey the law
House of Burgesses
the first of self government in English colonies
A farmer who found the crop tobacco and became rich off of it.
group of Christians that didnt agree with the king to worship God in their own way.
meant to increase nations wealth
Balance of Trade
concerns how much stuff you sent out of your country.
Force people to sell anything of value.
trade between America, Europe, and Africa
slaves were token from their home land to America were many were killed.
people were already settled had slaves and crops.

domain: history


Years after he spoke out about the criticism he received from some people in the church community, J. Drew Sheard II — the musician and son of gospel music legend Karen Clark Sheard — is playing the drums in gospel star Erica Campbell’s church.
Campbell, the solo gospel music artist who got her start in the duo Mary Mary, is now the first lady of the California Worship Center headed by her music producer-husband Warryn Campbell.
Erica recently took to Twitter to reveal that they had a guest drummer at their place of worship, none other than Sheard, 26.
“Thanks @jdrewsheard_jds for helping us out on the drums at @caliworship @warryncampbell,” she wrote. “Super cool having @jdrewsheard_JDS on the drums @CaliWorship today!!”
The news comes months after Kierra Sheard, another gospel singer who happens to be J Drew II’s sister, revealed that her brother has felt judgment from the Christian community in the past.
“There are people out there like my brother, who are probably just tired of church people and the judgment and the negativity … ” Sheard told The Huffington Post earlier this year.
CLICK HERE to read story


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On sale, I bought a medium width and they fit good for everyday wear. I would need a narrow to actually play on the court.
They start out pretty stiff, it takes a couple of weeks of regular wear to soften them up a bit.
This shoe has a good sole and is light in weight. I like how it shapes to my foot when I am playing tennis. This shoe also goes with some of my outfits.
Great shoe - well fitted. Perfect on the courts.
My second pair of these now. I also Like how they wear evenly on the courts, they have some longevity to them. The interior is very cushy and soft, comfortable to wear all day!
I've always liked K-Swiss and this shoe did not let me down. Playing tennis and love how this shoe performs. Would definitely recommend!!
Read All 10 Reviews...

domain: fashion


text:
In a bold move toward building Alberta’s quantum landscape, the University of Calgary has entered a partnership with PASQAL, a global leader in neutral atoms quantum computing. This collaboration marks a significant milestone in the pursuit of quantum innovation, exemplifying UCalgary’s commitment to fostering technological advancement within the province.
At the heart of this partnership lies a multifaceted approach to fostering comprehensive growth in Alberta’s quantum landscape. Together, Quantum City, the University of Calgary’s new quantum innovation hub, and PASQAL are poised to establish an experimental data centre, providing a robust platform for cutting-edge research and development initiatives and promoting bilateral exchanges between France, Quebec, and Alberta’s quantum ecosystems.†
Additionally, a suite of educational programs, workshops, and industry exposure opportunities will be curated to equip students and researchers with the skills and insights necessary to thrive in the next quantum era.†
Rob Thompson, associate vice-president (research) and executive director, Research Services at the University of Calgary, emphasizes the importance of the partnership. "This collaboration highlights UCalgary’s dedication to cultivating a vibrant quantum ecosystem in Alberta." He elaborated on the university’s vision, highlighting three pillars foundational at Quantum City: talent generation, quantum commercialization, and quantum infrastructure.
"This partnership is instrumental in advancing each of these pillars," explains Dr. Thompson, PhD. "By working together, we’re not only nurturing the next generation of quantum talent but also accelerating the commercialization and applications of quantum technologies while ensuring the development of sustainable quantum infrastructure."†
PASQAL’s contributions include funding research programs and aiding faculty recruitment, leveraging its global network to attract top-tier quantum talent, thus maintaining Alberta’s leadership in quantum innovation. Meanwhile, the University of Calgary will provide access to its planned Quantum City qHub and qLab facilities, facilitating interdisciplinary collaboration and quantum technology commercialization.†
"We are proud to partner with a distinguished institution that shares our vision for advancing quantum technologies," says RaphaŽl de Thoury, CEO of PASQAL-Canada.†
"This partnership not only enhances our research capabilities but also positions us to contribute significantly to the global quantum community. Together, we are set to unlock new quantum innovations that address real-world challenges."†
The collaboration between PASQAL and UCalgary’s Quantum City will foster international co-operation and further enhance Alberta’s prominence on the global quantum stage.
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Covid-19 Financial Support
Examine Federal, State, local and private sector resources that may benefit businesses financially.
Visit this site to stay informed of what the city is doing to ensure continuity of services, learn of any changes or delays to services, and to read updates from the Mayor’s office.
Kiva Microloans in Tacoma
In an effort to help underserved entrepreneurs and small business owners gain access to much-needed capital, Spaceworks joins forces with Kiva and the City of Tacoma to offer 0% interest microloans to Tacoma small business owners. These crowdfunded loans fill a critical lending gap for businesses that are too young, too small, or too innovative to receive loans from traditional lenders. Loans range from $1,000 to $15,000 with terms of 1-5 years to pay them back. The process requires no credit score, collateral pledges, or U.S. citizenship documentation.
Tacoma Partners with Pierce County to Expand Rental Assistance Program-Applications (opened March 8, 2021)
There are documents and information you can start collecting now to prepare for submission. Additional information may need to be collected by the provider upon intake to determine eligibility, but before you start the application you should have:
· Household information, including birthdays, for all household members
· Income verification for all household members for each income source including 2020 tax return for entire household OR household W-2’s, Unemployment statements, Alimony, child support, disability, retirement or VA benefits, Current or past pay stubs
· COVID impact documentation including Proof of unemployment, Loss of wages, Loss of job, Unexpected increase in costs of childcare, etc.
· Landlord name, email and phone number
· Copy of lease or rental agreement
· Statement from landlord with past due balance
· If you’re requesting utility assistance, provide copies of past due utility bills
Utilities paid directly to your landlord will need to be included in the rent past due amount and a payment will be made to the landlord directly.
In keeping with the City’s Welcoming Cities Policy, we will not be tracking or providing information to Immigration and Customs Enforcement about immigration or citizenship status.
Contact Information for the Rental Assistance Program
Visit piercecountywa.gov/housinghelp for more information about the program, eligibility and how to apply.
Foreclosure Prevention and Mortgage Assistance Program.
In partnership with Pierce County and Habitat for Humanity, the City’s new program provides foreclosure prevention counseling and up to four months of mortgage assistance – with a $6,000 cap – paid directly to the loan servicer, bank, or mortgage company of households who live in the city limits of Tacoma, have experienced loss of employment or reduction in wages due to COVID-19, and have an income at or below 80 percent Area Median Income for Pierce County.
Applications for the City’s Foreclosure Prevention Counseling and Mortgage Assistance Program can be submitted online. They will be accepted on a rolling basis with applicants being reviewed on a first come, first served basis until all funds have been awarded.
Requests for general information, information in alternate formats, or for technical assistance with the online application, can be directed to Habitat for Humanity Director of Homeowner Services Deena Giesen at (253) 627-5626 ext. 106, Monday through Friday, from 9 AM to 4 PM or firstname.lastname@example.org.
To Access the Minority Business Development Agency (MBDA) Tacoma Business Center PPE Grants and One-On One Technical Assistance to Support Your Business with the COVID-19 Business Recovery Efforts.
To request PPE and or technical assistance for your business continuity and or business assessment; please apply here https://mbda-tacoma.com/mbda-tacoma-launches-cares-act-program/ or contact
MBDA-Tacoma Business Center
T: (253) 591-5240
- Guidance on Federal Disaster Loans for Small Businesses and Private Nonprofits
Current state requirements for employers and individuals are posted on the Governor’s website
COVID-19 Resources and Information for Housing Providers and Renters.
Washington State Department of Commerce Economic Resiliency Team (ERT) Business Response Center
The team is currently able to answer questions as quickly as they are received. If you’re a business owner or operator with a question, Ask Your Question Here.
Department of Commerce Small Business Flex Fund
Borrow up to $150,000 at 3-4.5% for 60 – 72 months if you are a Washington headquartered small business.
Eligible businesses will have fewer than 50 employees, annual revenues of less than $3 million and prove a direct negative financial impact from Covid-19. Businesses must have their headquarters or main office in Washington State. Collateral is not required however there are other security requirements. Payday loan stores, fortune tellers, adult bookstores, strip clubs and track wagering facilities, regardless of headquarters location, are not eligible. You can apply even if you received other Covid-19 assistance.
Eligible uses include: payroll; utilities and rent; marketing and advertising; building improvements or repairs and; other business expenses.
To access information on this non-forgiveable loan fund, please visit: https://smallbusinessflexfund.org/
Startup Washington Small Business Resiliency Assistance
Technical assistance for small business owners from culturally and historically disadvantaged communities.
Technical assistance can include:
- Finding and help applying for assistance to help your business right now, whether you are open or closed
- Translation assistance
- Navigating local, state and federal resources
- Business coaching
Impact Washington is providing no-cost guidance to manufacturers to
- review existing procedures
- conduct an assessment, and
- advise on how to implement controls to protect workers.
Manufacturers may request assistance by calling (425) 438-1146 or e-mailing email@example.com. The information provided in the files below may be useful to other businesses in addition to manufacturers.
Aerospace Manufacturers Jobs Protection Program opens 3rd and Final Round for funding
November 8, 2021
Contact the Economic Development Board of Tacoma-Pierce County for more information or assistance. Maddie Merton, 253-317-1903
PPP Loan Forgiveness
On July 28, 2021, the SBA launched a streamlined application portal to allow borrowers with Paycheck Protection Program loans of $150,000 or less through participating lenders to apply for forgiveness directly through the SBA.
EIDL Loans program updates
- Increasing the COVID EIDL Cap. The SBA will lift the COVID EIDL cap from $500,000 to $2 million. Loan funds can be used for any normal operating expenses and working capital, including payroll, purchasing equipment, and paying debt.
- Implementation of a Deferred Payment Period. The SBA will ensure small business owners will not have to begin COVID EIDL repayment until two years after loan origination so that they can get through the pandemic without having to worry about making ends meet.
- Establishment of a 30-Day Exclusivity Window. To ensure main street businesses have additional time to access these funds, the SBA will implement a 30-day exclusivity window of approving and disbursing funds for loans of $500,000 or less. Approval and disbursement of loans over $500,000 will begin after the 30-day period.
- Expansion of Eligible Use of Funds. COVID EIDL funds will now be eligible to prepay commercial debt and make payments on federal business debt.
- Simplification of affiliation requirements. To ease the COVID EIDL application process for small businesses, the SBA has established more simplified affiliation requirements to model those of the Restaurant Revitalization Fund.
To learn about eligibility and application requirements and how to apply, visit sba.gov/eidl. The last day that applications may be received is December 31, 2021. All eligible applicants should file their applications as soon as possible.
Thanks to vaccines, small businesses across America have opened back up. Keep the momentum going by getting vaccinated. Find a vaccine provider near you. Learn how businesses can get tax credits for allowing employees to get vaccinated.
Do you own a small business in the construction or service industry? There’s a good chance you’ll need a surety bond for public contracts. SBA guarantees bid, performance and payment surety bonds issued by certain surety companies. Watch this short video to learn more about the SBA Surety Bond Guarantee Program.Thinking about government contracting opportunities for your small business? Register for the ChallengeHER webinar on September 23, 2021 for information and resources to help you get started.
- Click here to view a summary of the new federal stimulus package
- From the SBA: Coronavirus Recovery Information in Other Languages (sba.gov)
- SBA Lender Match helps you find lenders – Small Business
- U.S. Small Business Administration announced that the deadline to apply for the Economic Injury Disaster Loan (EIDL) program for the COVID-19 Pandemic disaster declaration is extended to Dec. 31, 2021.
- Employee Retention Tax Credit
- SBA Express Bridge Loan Pilot Program
- National Council of Nonprofits
- Visit this site for guidance on the CARES Act specific to charitable nonprofit organizations. Resources include a CARES Act Loan Options matrix and webinar titled: Federal Coronavirus Relief Bills: What Do They Mean for Nonprofits?
- Export/Import Bank of the United States
- EXIM is offering the relief measures outlined on their fact sheet
- Northwest Trade Adjustment Assistance Center
United States Government
Comprehensive Official verified and updated Information of all aspects of the Federal Covid-19 Response.
Government Response to Coronavirus, COVID-19. Learn about international travel restrictions, how you can prepare for coronavirus, and what the U.S. government is doing in response to the virus.
Comcast RISE program in Washington.
In addition to continuing to offer media, marketing, and technology upgrades, Comcast RISE will provide one million dollars in grants to small businesses owned by people of color in King and Pierce counties (where the highest concentration of small businesses owned by people of color in Washington are located). One hundred businesses will each receive $10,000. The application window is October 1-14 and eligible small business will be able to apply online at www.comcastrise.com. Winners will be notified on November 23, 2021.
- Directory of Youth Resources & Programs
- Transportation Support for Food & Essential Workers
- Small Business Owners & Entrepreneurs Emergency Funding Application Help


The 2014 Safety Fair will be held on May 17th from 10:00 AM to 2:00 PM. The location and additional information will be posted soon.
The Safety Fair is presented by the Estes Park Police Department in conjunction with other state, county and government agencies. Usually held in the spring of each year, (check the website calendar for exact dates). The goal of this event is to create a fun and active learning environment to educate the youth of Northern Colorado on the topics of alcohol and drug awareness, bicycle safety, fire safety, career opportunities and emergency services technology.
The event usually features plenty of fire trucks, police cars and vehicles for the kids to climb on and in, a bike rodeo and other fun, interactive events. It is an event that grows every year. Each youth that attends will receive a free gift and lunch while supplies last.


Researchers at UC Davis will soon have a new and very special tool to examine the structure and composition of materials at an atomic scale. The new Focused Ion Beam microscope, or dual-beam FIB, now being installed in the College of Engineering’s Center for Nano-Micromanufacturing (NCM2) is one of the first three instruments of its advanced type in the world — and currently the only one of its kind in the U.S..
“It will be transformative for materials science here,” said Klaus van Benthem, associate professor in the Department of Chemical Engineering and Materials Science. “We’ve never had images of this brilliance before.”
Materials scientists try to understand the structure and properties of both new and existing materials. Breakthroughs in technology from electronics to solar panels to industrial catalysts often depend on new discoveries about materials.
The microscope was manufactured by FEI, Inc.
of Hillsborough, Ore. and has a list price of $1.75 million. Purchase of the instrument was mostly supported by a grant from the U.S. Office of Naval Research.
The dual-beam FIB instrument includes both a scanning electron microscope and a focused beam of gallium ions that can be tuned across a wide energy range, van Benthem said. The gallium beam can be used for imaging, or more significantly it can be used to remove layers of material on a scale of two to five nanometers. Researchers can use it to generate three-dimensional images of the structure of new materials, or to prepare exquisitely thin samples for transmission electron microscopy.
It’s like an archaeologist using a brush, rather than a shovel, to carefully remove layers of dirt and expose fragile remains.
“The name of the game is to remove material atom by atom, without damaging the surface underneath,” van Benthem said.
The FIB will also be combined with other instruments at UC Davis to measure the chemical composition of materials on the atomic scale, or to study how individual crystals are oriented. It can also be used to “write” tiny electronic circuits on to surfaces.
Work on setting up the machine is already underway, and graduate students will play a key role in running the instrument and training new users.
“Students can learn a great deal from working with a cutting-edge instrument like this,” van Benthem said.
The microscope was manufactured in the Czech Republic and is the first to be shipped to the U.S.. So far, two others have been installed worldwide, in Japan and in Germany, van Benthem said.
The Center for Nano-Micromanufacturing provides facilities to campus researchers and off-campus users for work on nanomaterials and microfabrication, including a class 100 clean room facility. The FIB microscope will be available to both campus and off-campus users in early April, and van Benthem said he’s already getting requests from potential users around the world.
“It’s really going to put us on the map,” he said.