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The first stage of the MUSA Project has been a success. In the morning (9:23 a.m. local time, 2:23 a.m. in Costa Rica) the rocket with the research device made entirely in Costa Rica took off from the spaceport of Esrange, Sweden. It is only the second time in the country’s history that a device manufactured on national soil and by Costa Rican hands has reached space. The MUSA Project cube traveled aboard the Swedish Space Corporation (SSC) SubOrbital Express 3 mission rocket to an altitude of 260 kilometers and remained in microgravity for 6 minutes.
In charge of the project is the startup Orbital Space Technologies (OST), in collaboration with the Space Systems Laboratory (SETEC-Lab) and the Center for Research in Biotechnology (CIB) of the Technological of Costa Rica (TEC), the Central American Association of Aeronautics and Space (ACAE) and Swedish Space Corporation (SSC). The flight is being financed through a fundraising campaign and with the help of private sponsors such as ArrozImperio, Liberty Empresas, NassarAbogadosCentroamérica, Honor, GrupoAproveco and Sisters LA. “For us, more than fulfilling the dream of carrying out our first space mission, it is a motivation to continue working on what we like the most. It has been a process of years with which we finally achieved the first step and it gives us great satisfaction to know that it was our work that reached space”, commented Valeria DittelTortós, CEO of Orbital Space Technologies.
The MUSA Project seeks a treatment against the disease that destroys banana plantations, also called Panama disease. What started as a student dream three years ago is coming true today. With this launch, the Costa Rican company manages to test the necessary technology for the development of new experiments on board spacecraft, such as the International Space Station (ISS) or private space stations. Last Wednesday, November 23rd, several members of the Orbital team were in Esrange, Sweden, where they recovered the rocket payload, including the cube with the MUSA experiment.
In this first stage, the aim was to validate the critical systems in a short period of microgravity, to subsequently improve the design and send it to the International Space Station, where it will be exposed for approximately 2 weeks to microgravity conditions. What follows is to evaluate the information. At the end of January 2023, an activity will be carried out to present the results. «For OST this suborbital flight means a firm step as a space company in an emerging country like Costa Rica, projecting our mission of being a connection between Latin America and space, by generating technologies for experimentation in microgravity. These technologies align with our vision of being able to help generate innovative solutions to problems on Earth”,Dittel concluded.
Dr. Johan CarvajalGodínez, coordinator of the TEC’s Space Systems Laboratory commented that “this successful launch of the MUSA experiment aboard the Swedish Space Corporation rocket is a great satisfaction. This shows that the Costa Rican space industry has the capacity to implement space projects of great scientific value, and accelerate the technological development of Costa Rica. This collaboration between SETEC-Lab and OST will continue to bear fruit in the publication of the results of the experiment and future phases of the project”.
For his part, the president of ACAE, Dr. Julio Calvo Alvarado, appreciated the importance of adding young faces to the country’s scientific development: “With this suborbital flight, our country achieves the second space mission after the Irazú Project. The newest thing on this occasion is that the leadership is university students, with a high participation of women. This fills us with pride and joy, because they are proof of the paradigm shift that higher education in our nations so much requires. Here we see students of scientific and technological careers, from public and private universities, working together and inspired to face great challenges with the innovation and entrepreneurship of their own company”.
In 2020, just after congress approved the project for the creation of the Costa Rican Space Agency (AEC), the Swedish Space Corporation (SSC) told TEC researchers the availability of space on one of its suborbital flights. The members of SETEC-Lab, who had coordinated the Irazú Project to launch the first satellite of Costa Rica and Central America into space, decided to bet on facilitating space for a private company to develop in the aerospace area, according to Carvajal.
This is how the connection between the Swedish corporation and Orbital Space Technologies began to take place, always with the advice of the Technological and the accompaniment of ACAE. “Working with Orbital Space Technologies is right in line with the goal of making our ability to send rockets into space at the service of science, and expanding it to other nations by having the possibility to work not only at the level of Sweden or Europe, but the whole world. There are a lot of organizations that have brilliant ideas for things they can do in space, but they can’t fund a full launch. So we offer to do a carpool, which allows us to support start-up companies, as well as universities, at what we consider to be a very good price. What SCC gets in return is the ability to travel more often”, explained Gunnar Florin, SSC’s director of business development.
The Swedish Space Corporation emerged in 1972 and in its 50-year history it has expanded its powers, as well as the number of subsidiaries around the world. As Florin explained, they already have constant suborbital launch capabilities and terrestrial connection to satellites from all over the globe, with stations in Europe, Chile and Australia, among others. “Our goal is to be a global provider of advanced space services”, said the representative of the SSC.


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update resort 2019 - recent from the catwalks
Philosophy di Lorenzo Serafini
These are my favourite looks from my choice of best resort 2019 collections presented these last days. Are they not adorable? xoxo
All images from www.vogue.com. Please click on image of your choice for a closer look.

domain: fashion


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We have the best brands for high performance
Check out our extensive inventory of race parts to keep you going from A to B fast!
Check out our best sellers.
What do our customers say?
Easily the best customer service you will ever get. Rick is very knowledgeable and goes out of his way to assist you with whatever you need.
Alway goes out of there way to help get you where you need to get
Very knowledgeable and helpful. His over 20 years of racing experience helps you pick the right parts at the best prices.
If you can get it from them I would they have GREAT customer service and very nice to work with!
Brenda J Hurt
Simply the best. Unparalleled knowledge and always goes the extra mile great customer service
Tim R Riker
I have ordered from Rick a couple times. Great prices and fast shipping. Also, great customer service!

domain: automotive


To speed iterative prototyping and fixture creation for some assemblies and housings, IAR has brought reliable and low-cost FDM prototyping in-house. Common items we print include speaker baffle adapters, customer housing mockups for probe microphone measurements, or other fixtures to support device assembly or measurements. Maximum print size on this device is approximately 9 x 8 x 8 inches. High-resolution SLA and smaller assemblies will continue to be sourced from a handful of Indianapolis-based prototyping shops.
Many far-field voice devices employ beamforming microphone arrays to improve speech recognition and communication performance. However, often the simulation of the acoustic wave during DSP design only includes phase differences due to array spacing and neglects more complex geometry such as element porting, enclosures, tables or walls. These objects cause diffraction and reflections of the incoming acoustic wave around the sensor can lead to errors in beamforming and direction-of-arrival algorithms. IAR can use Comsol Multiphysics or Lumped Element Simulation (depending upon the complexity of geometry, frequency range of interest and available time) to provide simulated complex acoustic pressure “vectors” to DSP designers to improve the performance of the array including geometric features, prior to any prototype production or PCB fabrication.


Scotland’s Gardens scheme announces record number of gardens to open for charity in 2014
Dunblane Community Gardens, Stirlingshire
Dunblane Community Gardens which boasts one of the world’s longest hosta borders including a hosta named after Andy Murray, is one of over 60 gardens to be opening for the Scotland’s Gardens charity for the first time. It is not the only community project to be newly involved. Watch Us Grow, an organic fruit and vegetable garden in Glasgow will feature as will a horticultural therapy project, Gardening Leave near Ayr which helps army veterans with mental health issues. In total around 600 gardens will be opening their gates to visitors this year.
“We’re so pleased to have more gardens opening than ever before which means there really is a garden for every sort of taste, “said Paddy Scott, Chief Executive Officer of Scotland’s Gardens, adding, ”A theme for 2014 is definitely community gardening. An increasing number of amateur gardeners are clubbing together and creating wonderful green spaces for the public to enjoy which is so lovely to see and we hope will encourage even more people to get the gardening bug.”
Other interesting new city gardens to visit include Kincarrathie House in Perth, originally the home of the whisky baron and philanthropist A K Bell; Newbold House Garden in Forres planted to attract wildlife including a butterfly garden; and Dalkeith Polytunnel in Kirkwall.
Scotland’s Gardens raises money for charity by facilitating the opening of privately owned gardens usually inaccessible to the public. Visitors can plan their days out to participating gardens by clicking on to www.scotlandsgardens.org


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Goat Milk Bubble Bath
A great addition to the bath for a relaxing and skin nourishing treat. Our Goat milk bubble bath starts to dissolve/fizz once added to the bath water releasing the skin loving ingredients into the bath. It will leave your skin naturally moisturized. Your skin will feel nourished and silky smooth!
To Use: Simply add desired amount to a warm bathtub, let fizz, soak yourself and enjoy! If you would like, you can also use the bubble bath for a foot or hand soak!
Ingredients: Sodium Bicarb, Citric Acid, Coco Butter, Goat Milk, Almond Oil, Epsom Salt, SLSA, Potassium bitartrate, Fragrance, may contain mica
Net Weight: 16oz
SLSa is derived from coconut and palm oils. SLSa is a safe, skin friendly cleanser that offers rich lather without the irritation potential of some of the other good foamers. Because the molecular size of this surfactant is large it doesn’t penetrate the skin or the mucuos membranes, so it does not cause the skin irritation as other sulfates, making it an excellent choice for soaks and facial cleansers and any other gentle cleansing products

domain: chemistry


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The Economy “Doesn't Need You Anymore”
Are we in an "awful" in-between phase of our planet's productivity curve and that technology is rapidly reducing the number of workers and resources that are required to make what the planet needs?
In an essay by Hank Williams, the tech entrepreneur argues that we are in an “awful” in-between phase of our planet's productivity curve. He says that technology has vastly reduced the number of workers and resources that are required to make what the planet needs. Williams says:
When you read in the press the oft-quoted concept that “those jobs aren’t coming back” this “reduction of need” is what underlies all of it. Technology has reduced the need for labor. And the labor that *is* needed can’t be done in more developed nations because there are people elsewhere who will happily provide that labor less expensively.

domain: philosophy


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Payment Methods: We accept cash, checks and most credit cards at the yoga studio, and credit cards online.
3 Month Class Packages:
Punch-cards allow you to come to classes around your schedule, start anytime, come different days or times if desired, and save money. Punch-cards are available in our online store and at the studio. They can be used for any regular yoga or meditation classes over a 3 month period, and make wonderful gifts.
AUGUST SPECIAL: All punchcards purchased in the month of August will get the senior/student pricing.
6 Classes for $75 (senior 65+/ full time students with ID $70)
10 Classes for $108 (senior 65+/ full time students with ID $100)
Punchcards offer our classes at a discounted rate, and are valid for 3 months.
Meditation Classes are by cash donation or punchcard. $5-$12 suggested.
Single YOGA Classes: $15 each. ($12 senior age 65+ or full-time college student with valid id)
GIFT CERTIFICATES are available in our online store in any amount from $12 to $200. Can be used on any of our classes, events, and products for sale. Good for 1 year.
Monthly unlimited card for $90. Take as many classes as you like for $90 per month.
For private yoga lessons, or to arrange corporate workshops and classes, please email us.
Visit our online store to purchase a punch-card or pay for a single class. Payment also accepted at the door.
Punch cards are non-refundable.
*Please arrive about 10 minutes early for all classes. Classes start on time and Door is locked at the beginning of classes.

domain: hobby


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Readers’ Rigs: Bob’s Tommasini Sintesi
Readers’ Rig: Carbon and alloy can be made into a fine bike frame, but Bob Shaver’s Tommasini Sintesi is a steel work of art. Obviously being Italian, the bike is built up with Campagnolo and a special Selle Italia/Ferrari saddle. A show bike, one of a kind.
Name: Bob Shaver
Location: Denver, CO
Bike: 1992 Tommasini Sintesi
Groupset: Campagnolo Super Record Ergo Power/Exa Drive
Wheels: Campagnolo Lambda Strada 32
Pedals: Campagnolo Super Record Clipless
Saddle: Selle Italia Novus/Ferrari Engineering with Carbon Rails
Other: Special paint mix: “Magenta Brillante”
Weight: 21 lbs.
When did you buy it?
It was ordered January 1992; arriving in late summer 1992.
What made you choose this bike?
Love at first sight! In January, 1992 while exhibiting at a bike industry show, I stopped by the Tommasini booth to chat with my friend who was the U.S. distributor. When I saw their show bike I knew I had to have one in my size. But Sr. Tommasini said, “No. It is our show bike, one of a kind.” However I was persistent and ultimately Sr. Tommasini said he would make an exception. My friend told me later that only two others were produced like the show bike; mine and one for a Tommasini dealer in the U.K. I have no written documentation but I have never seen one like it anywhere or on the Internet and have no reason to doubt what was told to me.
Have you done any modifications/additions to it?
No, just regular drive train upgrades and countless wax jobs!
How many miles/kilometers do you do a year?
I have not ridden this bike since September of 2017, where it has been hanging in my office since. I have probably ridden this bike 25,000 – 30,000 miles. Now on average, I ride 4,000 – 5,000 miles per year.
What do you love about this bike?
The flawless brazing of the lug work and the brilliant magenta color combined with the chrome. Also, I like the fact that the paint scheme is less complicated or extravagant and multi-colored than many of the Tommasinis.
Favorite riding area?
Recreational rides where the bike always receives positive comments.
First mountain ride, Fall 1992 “Tour of the San Juan’s” in Southern CO. Durango, Ouray, Telluride, Cortez, Durango
Favorite riding experience on your bike?
Being shot at while riding with my friend Wayne-the-Train, on our Tommasinis in 1994 and… not being hit or killed! This event occurred on Squaw Pass (we refer to it as Squawk Pass), a favorite 18-mile alpine climb near Denver. It was a wonderful summer day, mid-week, with no traffic. Wayne had dropped me and was 100 meters ahead. A long hard honk shocked me out of my suffering; which also got Wayne’s attention. I looked back to see inches away from my wheel, a huge pickup driven by a red-faced driver. He pulled alongside me, flipped me off and then sped up right behind Wayne. I thought he was going to hit him. The driver honked again as before but this time he slowly pulled around, going about our speed. Wayne had slowed down, so we were now together. Then, the driver slid the small back window open and fired two shots: POP! POP! He sped off laughing and honking.
Of course, this was before the days of cell phones, with the nearest pay phone five miles uphill at Echo Lake. So we ended up not reporting him. All this happened on one of the few long stretches on Squawk, with lots of visibility where cars can easily pass. So this guy was literally, “Loaded for Bear.” (Or cyclists!).
It’s funny what you notice in the span of a few seconds on a bike. The truck was a new,1994 dark green Dodge with paper “Dealer” plates. The back gate was down so I could see a cooler in the back, a folded chair and a fishing pole. So this guy, in his brand new truck was probably headed to Echo Lake or Summit Lake on the road to Mt. Evans, for a relaxing day of solitude and fishing. If anyone was ever in need of a bike ride, it was this guy.
By the way, Wayne, at 6’3” with a steady, strong pedal stroke, who always takes more than his fare share at the front, is a favorite wheel to sit on. His moniker was given by former Colorado Governor, Bill Ritter. One day as we were passing a group with Wayne at the front, Bill called out, “Hop on Wayne the Train for a free ride!”
Something magical happens when you hop on a bike. You keenly experience your surroundings, your senses become more acute and when riding with others a unique bond is created. To me, the bike is the one thing that does not discriminate; it is there for anyone who makes the effort to take that first pedal stroke and keep right on pedaling. And ultimately, it gives back more than the effort you put into it. It’s the most beautiful sport in the world in all its many iterations of use. And most of all, you will meet the nicest people while riding it! Please ride safely!
Last Ride, “Ride for Black Rhinos.” September 2017, Denver, CO: I helped organize the ride to raise funds for one of Paul Sherwen’s favorite charities. I took the opportunity to surprise him wearing the jersey of the Paris team we both raced on although not in the same year; Paul in 1977 and I in 1976. Sadly, Paul died in 2018
Thanks to Bob for sharing his ride with us. Got a bike that you walk into the room just to stare at? Well how about sharing it with fellow PEZ fans and getting it featured in Readers’ Rigs so we can all stare at it! Contact [email protected] and your bike could be featured in all its glory here on the pages of PEZ.


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Today (March 30), the Minnesota Senate Agriculture & Rural Development Committee is finalizing its proposed budget — and its proposal falls short.
While the Governor and the Minnesota House Climate Action Caucus have put out exciting proposals to build a resilient, regenerative farm and food system, the Senate is failing to include meaningful investments in the countryside. Would you take just a few moments to e-mail the Senate Agriculture & Rural Development Committee?
With an historic budget surplus, there’s no excuse to fail to deliver for our independent small and mid-sized farmers, food system, and rural communities this legislative session. You can read the Land Stewardship Project’s recent letter to the Senate Agriculture & Rural Development Finance & Policy Committee here.
We need to push the Senate to restore the Governor’s proposal, at minimum, and ask them to strengthen it further by:
- Creating a Certification Navigator Position within the Minnesota Department of Agriculture with $150,000 to help processors develop HAACP and Sanitation Standard Operating Procedures (SSOP) plans for their operations and navigate certification and inspection processes.
- Including $100,000 for reimbursing small meat processors for food safety and business planning.
- Establishing statewide soil-healthy farming goals and creating a statewide soil health action plan.
- Doubling the funding for the farm-to-school grant program to match demand for the program and allow early care centers to participate.

domain: agronomy


Turn you cell phone into a portable scanner
According to NYT, researchers at Xerox Research Center Europe (located in Grenoble, France) are working on the means to transform the diminutive camera in your cellphone into a portable document scanner.
"When we give it to test users, they appreciate it easily," said Christopher Dance, senior scientist and image processing manager for Xerox Research Center Europe. "Even the simplest of applications, just sharing the documents and storing the documents you have captured. You could even handwrite a message and send it to someone's phone." (...) Xerox researchers believe the technology will be useful for just about anyone with a job that requires research in the field. The theory is that someone attending a trade show or conference, for example, could capture and store pertinent documents in their cellphone.
What is even more interesting is:
Xerox researchers are also working on complementary technology for cataloging these and other digital images. Although it's part of a different research project that hasn't come to fruition, the technology will sort through and group images using histograms, which chart the pixels associated with a particular part of a digital photograph. In some instances, text descriptions will be tied to these histograms.


High Temp Tube Furnaces
Our high temp tube furnaces are all built to order exactly to customer specification. With a maximum temperature of 1800°C our high temp tube furnaces provide excellent uniformity and temperature control. We fit a mesh heat shield as standard to all our tube furnaces to minimise risk and keep operators safe.
Ultra ‘high grade’ insulation materials are used to ensure our furnaces are as energy efficient as possible.
With an industrially durable design and long lasting powder coated finish our high temperature tube furnaces are robust and will stand the test of time.
Independent over-temperature protection is available as an option, using a digital alarm working from a separate thermocouple, safeguarding both the furnace or any furnace contents from over-heat damage at any temperature.
All our high temp tube furnaces are compatible with our gas tight ends, this allows inert gasses to be introduced and contained within the chamber.Our high temp tube furnace range is supported by a wide range of equipment and extras such as RS 232, RS 485 comms, stainless steel gas tight ends, ceramic work tubes, multiple heated zones and furnace tables, for more information click here.We design and build in house so if you have a bespoke requirement please do not hesitate to contact us.
Our in-house experts and CAD design team are on hand to assist you and will complete your project through consultancy, design, manufacture, installation and ongoing support.
Full training and ongoing support is offered as standard and we promise the best possible service.
Available in the UK, USA and Worldwide directly from Vecstar or through our approved distributors.


The Monster Factory offers unique expertise in the field of voice-acting destined for many types of virtual monsters and creatures. Our talent has partaken in creating and designing voices for over more than twenty video game titles, films and TV productions.
In a world where companies engaged in the video game and film industry are looking to reach unparalleled levels of realism, the quality of sounds produced by our artists is unmatched. Our talent pool, which consists of women and men, offers diverse sonorities and voice textures for all of your projects.
Metal genre singers have the unique ability to produce unreal sonorities and vocal textures.
Organic sounds without having to resort to computer modification for all of your projects.
Our expertise adapts to different kinds of projects, ranging from AAA games to more modest releases.
If you would like to hire any of our voice artists for your project or you would like to know more about our work? Do not hesitate and send us an email:
To learn more about us Click here
Dead by Daylight
Rainbow Six Siege


Important: For orders with add on name embroidery, please specify the name under remarks in the following format "Name (font type, thread colour)". Ideally not more than 10 letters. To avoid delay in the embroidery process, please ensure the desired font type and thread colour is specified in the format mentioned earlier.
Bashful Cream Bunny’s gorgeous long ears look like two big dollops of clotted cream. Mmmm! Time for scones and a hippity-hop on the grass! With a bunny pal as soft as butter icing, summer days are so inviting!
SAFETY & CARE
- Tested to and passes the European Safety Standard for toys: EN71 parts 1, 2 & 3 for all ages.
- Suitable from birth. Huge and Large sizes - please do not leave in a cot/ crib.
- Made from 100% polyester.
- Hand wash only; do not tumble dry, dry clean or iron. Not recommended to clean in a washing machine.


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Best Life Insurance for Whiteville, NC
Compare multiple Whiteville, NC life insurance quotes in order to find the most affordable and best-quality coverage. Enter your Zip above and you will be able to choose from the best options available in Columbus county. Life insurance comparison is the best way to save money on your coverage and ensure you are not overpaying.If you want to buy Whiteville, North Carolina life insurance you need to make sure you purchase the best policy for the best rate. Insurance can be expensive depending on the type of policy and the policy amount.
Know How Much Insurance You Need
First, you need to determine how much insurance you need. This will differ depending on your life's situation. If you're single, you'll need a different policy than someone who is married which children. A retired senior and a young college student may need a different life insurance policy.
Life insurance may be used to pay for your burial expenses and help to ease the financial burden your family may experience due to your passing. That means the more impact your death will have on your loved one, the higher your insurance policy coverage amount should be.
Get Online Price Quotes
Go online and get life insurance quotes. The amount of the quote will be determined by many factors including your age, health conditions, and the coverage amount. If you choose term insurance it will cost less than whole life insurance. You should get quotes from several insurance companies.
When you go online, you can find Whiteville, NC life insurance quotes from insurance companies and brokers. The insurance company would be the issuing company. They will generally give you a quote for their policies. Insurance brokers and agents can provide you with a number of quotes, depending on the companies they work with.
Contact an Insurance Agent
If you already have life insurance, you can contact your insurance agent. The insurance agent will be able to tell you if your policy coverage amount can be increased. They can also help you determine if you need a new policy and the best type of policy for you to choose.
If you work with an independent insurance agent, they would be able to help you determine the best company to choose for any additional life insurance you may need. If the insurance agent works for a company, then they can give you advice on that company's products.
Compare Insurance PoliciesWhen you have several quotes, you should start looking into the different policies. If you're comparing several different policies, you can look at the terms of each in order to determine whether or not they are the same. If the policy terms are different, then you should consider whether or not the differences would have an impact on your decision to buy.
When comparing policies make sure to look at the benefits and disadvantages of each type of policy. If you do not understand the terms of the policy, then you should talk to an insurance agent or broker. Allow them to explain the terms of the policies so that you can understand what you're paying for.
Compare Insurance Quotes
After you choose a specific type of policy, you should start looking at the quotes. If the quotes are similar, then you should look closely at the companies themselves. You should select a company has a good reputation.
More North Carolina Cities Nearby:
Lifestyle insurance is a single of these factors that most folks do not especially appear ahead to dealing with. Soon after all, matters working with one's eventual death are things that most folks are generally not comfy with. Even so, daily life insurance policy is really critical in that it offers defense and makes certain the ongoing welfare of a person's dependents in scenario the worst occurs. This article's guidelines regarding existence insurance coverage can make it an simpler process.
When taking into consideration lifestyle insurance coverage, be positive to undertake a healthful lifestyle, as this will greatly effect your prices. Give up cigarette smoking and lose weight. Be certain to be forthcoming with this details, as properly as any other healthful activities that you can identify. Your fee is often time negotiable.
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Life insurance coverage is an crucial item to have in location, specially if you have a family members that will want to be provided for after you have died. Do not leave this essential issue until it is as well late. Examine a daily life insurance policies plan as soon as you are ready and make sure that it is backed up with a existing will.
Analysis your life insurance plan thoroughly before you sign on the dotted line. Make certain that you are informed of the exclusions, inclusions, discount rates, no payment for dying caused by a pre-current illness clauses and other conditions of your existence insurance policy plan ahead of committing to it. With out understanding exactly what your policy handles, when you die you could inadvertently leave loved ones customers left powering in a difficult situation.
Purchase existence insurance coverage as early as you can manage to. The more mature you get, the larger your rates rise. Insurance policies organizations foundation their charges on the likelihood of the insured contracting an ailment or other condition. Moreover, you run the risk of becoming turned down for protection if you happen to turn into unwell before you use for existence insurance.
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If you intend on obtaining life insurance policy in the potential, commence arranging for it, now. Get measures to enhance your overall health, such as, quitting using tobacco. You can start a health and fitness program and try to reach your optimal fat. Have all the suggested well being screening assessments for someone of your age and gender. Function on acquiring your cholesterol and blood strain to appropriate amounts. Not only will you search and come to feel far better, you may help save a bundle on your existence insurance coverage.
If you happen to be a smoker who was addicted and cigarette smoking cigarettes at the time of your daily life insurance plan, you can really stop smoking and conserve money. Most organizations will permit you reapply for a policy as a non-smoker right after a specific quantity of time has handed. So there is certainly some incentive in it if you can give up.
From knowing how to save funds on daily life insurance policies to figuring out which kind of strategy you must go with, this article has described some of the finer factors of the insurance policies market, so that you can uncover the ideal deal feasible on a good quality insurance coverage program. Act prior to it's way too late. Choose up that strategy.

domain: finance


Is there any non-digital (naturally existing) mechanism to compare two or more waves in such a way: ...
I am having a problem with reflection on an acrylic surface, in the IR part of the spectrum. This reflection is interfering with an algorithm that looks at objects, as it makes two show up when only ...
What are the reasons that optical fibers have to be thin (small radius of the fiber)? Is there a good picture which explains this in detail?
Some explanations of the device base it on a simple echo of light: "The camera transmits invisible near-infrared light and measures its “time of flight” after it reflects off the objects. ...


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FIVE THINGS You Need to Know for Thursday, September 23
FIVE THINGS YOU NEED TO KNOW
1. Creeping Death unleashed their 'Humanity Transcends' visualizer - watch it here.
2. Have you listened to 'Cloaked,' the new single from Rolo Tomassi? If not, listen here.
3. "An interesting chorus, some killer verse riffs, a ripping solo, and a really super chunky breakdown" that's what Metal Injection said about the new Enterprise Earth video for 'Where Dreams Are Broken' - watch it here. Did you see the Deluxe edition of their new album 'The Chosen' yet? Pre-order here.
4. "A rousing blend of savage power that’s ready for the mosh pit as it is for your next clandestine ritual in the woods," said Decibel about 'Leave Me The Ashes Of The Earth' from Mastiff - out now!
QUOTE OF THE WEEK: "It's always good to see that rock and roll is healthy and thriving. It may not be the focal point that at times in history it takes over, but it's always out there," says Jerry Cantrell of Alice In Chains.
SONG OF THE WEEK: 'Survivor' by Pop Evil - listen below.
VINYL OF THE WEEK: Just over two weeks 'til the new Creeping Death EP 'The Edge of Existence' comes out - pre-order it here.
TOP 5 TRACKS OF THE WEEK: great tunes from SeeYouSpaceCowboy, Trap Them, Underoath, Pig Destroyer, and Fireball Ministry - listen below.
VIDEO OF THE WEEK: Check out the Creeping Death 'Humanity Transcends' visualizer!

domain: entertainment


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The Long Beach Museum of Art is celebrating mid-century oil painter Alice Taylor Gafford, often referred to as the “the dean of black artists in Los Angeles.” Gafford is recognized not only for her art but her influential role in founding and developing a number of pioneering art groups in Southern California including the Val Verde Art and Hobby Show that now bears her name (the Alice Gafford Art and Hobby Show).
Using Gafford’s painting, “The Tea Party,” as an example, the museum invites anyone to participate in their artist workshop to recreate the celebrated painting using oil pastels provided by the museum. “The Tea Party” is a permanent fixture in the museum’s collection and is now on view as part of their latest exhibition, “Decade by Decade: Women Artists of California” showcasing a collection of paintings, photographs, sculptures, prints, drawings and other art pieces made by female artists over the past 70 years.
Adult Workshop: Still Life with Oil Pastels is from 5 p.m. to 7 p.m. at the Long Beach Museum of Art (2300 E. Ocean Blvd.) Tickets range from $5 to $15. For more information and to purchase your tickets, click here.

domain: painting


Unlike many of our competitors that are content to simply package a property for sale, we take an active role in ongoing property management and development—using our industry knowledge and passion to maximize production performance. Texas Energy Holding has also established three subsidiary companies that work together to control costs and maximize production on certain company-managed properties.
Since our inception, Texas Energy Holdings has more than doubled our oil and gas portfolio each year. We’ve participated in or managed the drilling of hundreds of wells in Texas, Oklahoma, New Mexico, Louisiana, Illinois, and Indiana; however, our current portfolio is focused solely on Texas and Oklahoma.
Our scope of operations includes:
We focus on acquiring properties that offer immediate cash flow potential from existing wells. Then, we seek to enhance the value of these properties by applying proven, cost-conscious geological and mechanical rework and recompletion strategies. Strategies include simple mechanical upgrades and maintenance, secondary recovery, and tertiary recovery methods; and accessing behind-the-pipe reserves from existing wellbores.
Our developmental drilling projects are concentrated solely in fields that have proven, documented histories of oil and gas production. The majority of our prospects directly offset known producing wells. These targeted activities are designed to open up new areas of opportunity and often work to counter natural production declines in existing properties under management.


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MARSHALL - When John Allen retired after 39 years teaching language arts at Marshall Middle School, he returned to what he knew best growing up.
Allen left his family's farm north of Franklin more than 40 years ago to go to college. During his years at the University of Minnesota in Morris he worked weekends, fall harvests, and drove a pea combine for Green Giant in the early 1970s.
After Allen accepted the retirement incentive offered by Marshall Public Schools last May he couldn't stay idle, and volunteered twice a week in his wife Julie's first-grade class at Park Side Elementary School.
Photo by Steve Browne
Retired Marshall Middle School teacher John Allen now works with his brother-in-law bringing in the harvest.
"I'd never taught any lower than sixth grade," Allen said. "It's quite an experience, those kids just worship you."
Then word got around Allen was at loose ends. Allen's brother-in-law Mike Sullivan and his three sons own and lease a total of 6,000 acres near Redwood Falls.
"When my brother-in-law heard I was retiring he told me, 'I've got a tractor with your name on it for fall harvest.' I thought he was kidding, but this time of year they're really busy," Allen said.
Now Allen is again driving a tractor, but it's not quite like it was 40 years ago.
"We didn't have tractors with cabs," Allen said. "Now we've got air conditioning, CD players and a radio to communicate with everybody on the crew. The machines are so much stronger and can do so much more. It's a little bouncy at times, but overall, pretty darn comfortable."
According to Allen, better lights on tractors and combines which make it possible to work well after dark and the GPS steering systems have changed how people work, enabling them to work longer hours without as much fatigue.
"Another change is lunch," Allen said. "It used to be everybody would stop and get off the tractors and eat together. Now you have lunch in the cab and keep going."
Farm practices have changed as well, as farmers have learned more about caring for the soil.
"Look there," Allen said, "farmers used to plow the corn stalks as deep as they could so nothing but dirt showed on top. Now we try for an even mix to prevent erosion."
Technology changed the rhythms of harvest, but this year also has a different rhythm, Allen said. Because of the long dry spell that followed rain and hail, the corn yields are lower, but the moisture content is low enough the corn doesn't need drying. And because the air is so dry the harvest doesn't have to wait until the sun burns off the morning dew.
As for what the future holds after his return to farming, Allen said it will probably be purely seasonal for him, working the spring planting and the fall harvest. But he'll definitely stay with it now.
"There is such a link to nature," Allen said. "When you see the moon come up over the fields, it's wonderful."
So, for the rest of harvest, Allen's wife will have to do without her husband's help in her classroom and the dinner he'd been fixing her every evening. It doesn't seem to bother her though.
"I think it's awesome," Julie Allen said. "He's having a great time. He loved teaching but he's thoroughly enjoying farming."


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The perfect shade of red ! This is by far my favorite red polish ever ! Classic red. I pair this with both base and top coat from Essie, and it lasts a long time. It looks so classy I love it so much !
Eye Makeup Remover -Nivea - Express Eye Makeup Remover
iheartmakeup01 1/31/2013 8:46:00 PM
I HATE this eye makeup remover ! Seriously, I never had my eyes irritated after removing my eye makeup with any other eye makeup remover, but this one made my eyes so red ! It burned my eyes like crazy. It was impossible to apply any cream or makeup on because of the burning sensation. Sure it removes makeup well, but it is by far the WORST eye makeup remover I've ever try! Never again.
Foundations -Cover Girl - Outlast Stay Fabulous 3 in 1 Foundation
iheartmakeup01 1/31/2013 11:12:00 AM
This foundation is simply amazing ! (I wear the shade Ivory, it matches my skin perfectly) I usually don't wear and don't like liquid foundation, cause it feels too heavy on my skin. I also have very oily skin, which is sensitive and prone to break outs. My pores are easily clogged too. But, this is by far the best liquid foundation I've ever tried!! It evens my skin tone perfectly, doesn't set into pores at all (I think it minimize them instead) and it lasts all day ! Liquid foundations usually don't last on me, and I always have to set it with a powder, and blot a few times. But, this foundation stay fabulous all the day, as it claims to do! The only con is that it may accentuate the dry patches. Be sure you moisturize your skin before. I tried to put this on with my fingers, but it wasn't natural and felt heavy. So, I used a damp beauty blender instead, and I can tell it was way better !! I would repurchase anytime.
Moisturizers -Live Clean - Soothing Daily Moisturizer
iheartmakeup01 12/18/2012 7:10:00 PM
I absolutely love this product ! Since I have very acne-prone skin and I break out easily with any product, this one had never broke me out !! It's a very good moisturizer, simple and without all the chemicals ! Seriously, this can be a bit pricey, but it contains much product, so it's ok!:) Give it a try, you won't be disappointed !
I thought I did a review on this, but it seems like I didn't. So...what to say about this curler...I LOVE it so much ! Seriously, I was sceptical about it since every lash curler seems to be the same...but hell NO! This one is the best one ever ! I use this every morning before apply my mascara and it holds the curl very well. I know it's kinda pricey (around 20 $) but definitively worth it!
Merci Montagne Jeunesse !! :) First, I tried many different masks of this brand. Some I LOVE, but some I hate... Si I tried Strawberry & cream gel mask, dead sea tonic (cloth) mask (it burns at first :(), peach kernel and walnut scrub, blemish mud, dead sea mud pac masque, moisture miracle hair masque, aloes tonic (cloth) mask (burns!), cucumber peel-off mask, sauna fudge mask, the tea tree and spearmint one! It didn't like the consistency of the first one. It was too runny. Plus, I didn't feel it did something to my skin overall. So, my faves are the Peach kernel & walnut scrub (I LOVE THIS SO MUCH !!! the best scrub ever ! gentle, smells good and with one package, you could do up to 5 scrubs !), the dead sea mud pac masque (which I really LOVE! it cleans so well and make my skin incredibly soft! I just bought the tottle of this). I loved the fudge sauna too! (the best warming mask I think. Smells so delicious that I could eat it !! Leaves pores clean). And the last but not least, THE MOISTURE MIRACLE hair masque ! ( Which is soooooo moisturizing and leaves my hair sooo soft and smell good ! This is my new must-have) I can't believe I haven't use MJ products before...
I LOVE this primer !!! I tried the Dior one...and it was a big fail for me. But this one...it is the best by far ! It lenghtens and volumize my lashes and make them so beautiful after I apply any other mascara (drugstore). I very like how it works. I know it is VERY pricey (35 $) but it is worth it and lasts me a long time (4-6 months or more). Try it !
Mascara -Christian Dior - DiorShow Maximizer Lash Plumping Serum
iheartmakeup01 12/18/2012 2:18:00 PM
Didn't like this primer. I used to apply my Lancôme Cils booster, but I ran out so I decided to try this one instead. Unfortunately, I hate it ! It makes my lashes so clumpy after I apply any mascara on this! Definitively not worth the price...
Liquid -Bourjois - Healthy Mix Serum Gel Foundation
iheartmakeup01 9/2/2012 12:03:00 PM
I LOVE this foundation! I'm glad I've found this !(Thanks MUA!) After reading great reviews on it, I bought it at my local Shoppers drug mart, for $27 CAD. Yet expensive, but worth it! I usually don't put foundation on because it always melt on my face and I find this to heavy on my skin since I feel it melting on. I've got really oily skin and acne-prone skin and this foundation isn't that oily (I put my Maybelline matte pressed powder on and it's perfect to control oil) This foundation doesn't break me out (yet, I'll update if it does), and THAT was surprised me since I break out with everything ! It leaves a dewy (without greasy) look and it's not heavy on my skin. I also like the packaging that comes with a pump. I would repurchase for sure and recommend this !(: EDIT : No longer use this foundation. I've very acne-prone skin and almost every product make me break out! So, this foundation have clogged my pores and I got some whiteheads and bumps after the first time of using this. Fortunately, I returned it and got my money back! I'm so disappointed because I wanted so much to love this! I took off two lippies...
OHHHH GOSH !! This is by far the BEST soap ever !! I don't know if it's this papaya soap or my sulfur soap I used before, but THIS is a MIRACLE as it cleared my cystic acne! I've used this for like 5 days, and now my skin is clear (I've got some acne scars that are noticeable, but I think they slowly fade away!), my skin is sooooooo smooth that I couldn't believe it when I touched it and looked in the mirror! Seriously, THANK YOU Likas for making such a miracle on earth (: I would repurchase anytime, and I hope it will never be discontinued.
THE BEST EVER !!! A lifesaver...a miracle on earth!! OK, no, seriously, I used it only one time and gosh!!! my skin's so smooth and clean! I can't believe how fresh it looks! I LOOOOOOOVE this mask alot! I ordered online because they don't sell it where I live (Quebec, Canada). I was really cheap, shipping and handling fees were more expensive than the mask itself, LOL! That's the only CON. I also bought the tube with 33% more, bonus edition. It's kinda big deal! Anyway, this is my best purchase ever, so happy I found this! Thanks "Queen Helene" !! (:
I LOOOOOVEEE this mascara !!!! It works great on my lashes. First, it doesn't clump. I apply my cil booster XL by Lancôme before, and this mascara after with two coats. It thickens my lashes and give them more length. I love the false lashes effect that it provides me. More volume, more length and more DRAMA ! (I got it in Black drama with the curved brush) It's my fave mascara now!
At first, I was so excited to try this because of all the good reviews on this. I bought plain greek yogurt (1.99 $ CAD). I applied it on my skin and let it on for about 45 min. I rinsed it off with lukewarm water. I was disappointed with the result. Sure, my skin was noticeably smoother but it dried out my skin like crazy. Also, my skin was red and my acne scars were very noticeable. I didn't notice any effect on my pores. Seriously, I'm glad it works for other reviewers, but for me, it was a mess. Maybe I'll give a second try because I very want to love it ! It's cheap and I love that it smoothes my skin tho.
Misc Beauty Tools -E.L.F. - Mechanical Eyelash Curler
iheartmakeup01 7/19/2012 9:38:00 PM
Worst lash curler ever !! three words : loss of lashes. I won't buy it again.
AWESOME !!! I just bought one tube after reading the good reviews on it, and I can't believe how well it works ! I get that big volume after one coat, but if I want that dramatic look, I add two more coats ! It doesn't clump. I uploaded a picture to show how nice this mascara works (6th picture). I apply my Cil Booster XL by Lancôme before I curl my lashes with a lash curler, and I apply two or three coats of this mascara. It wonderful!! I got it on sale for only 2,67 $ CAD...still can't believe it! Go get one, you won't be disappointed!

domain: beauty


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by John Aubin | Thu, Jun 13th 11:50am EDT
Joe Biagini allowed two earned runs on one hit and two walks while striking out none across one-third of an inning Wednesday against the Orioles.
Biagini was named the temporary closer for the Blue Jays while Ken Giles is on the 10-day. He did not make a good impression in his first appearance as he could not get out of the eight inning. Unless your desperate for saves its better to leave Biagini on the waiver wire.

domain: sports


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Fri, 23 November 2012 at 10:50 am
Eve Hewson Stuns in 'Flaunt' Magazine!
The film is about a retired rock star living off his royalties in Dublin, who returns to New York City to find the man responsible for a humiliation suffered by his recently deceased father during WWII.
For more on Eve, visit Flaunt.com!
Like Just Jared on Facebook

domain: movie


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What to Drink to Lose Belly Fat in 2 Weeks?
You may be wondering what to drink to lose belly fat in two weeks. The answer is a combination of vegetables, fruit, and herbal teas. Here are the top four. Also, incorporate chi seeds, jeera, and pineapple juice into your diet. These are all great sources of fibre and help reduce fat. Also, keep in mind that eating fibre-rich foods is a better option than limiting them.
Jeera or Cumin water
There are two ways to consume jeera for weight loss. One method involves adding a teaspoon of cumin seeds to a glass of water overnight. The next day, strain the mixture and drink the liquid three times a day. Alternatively, you can add some organic honey to the mix and drink it. Both ways are effective in accelerating weight loss. The only difference is that you must include the seeds in your daily routine to maximize benefit.
Studies have shown that jeera water can help people lose weight. The jeera plant releases essential nutrients into the water, causing it to turn an earthy yellow. Drinking jeera water daily can help you lose weight and improve your metabolism. You can combine this with a healthy diet and exercise routine to see visible results. For the most effective results, you must be patient and continue your regimen.
One teaspoon of jeera can be soaked overnight in water. In the morning, strain the mixture and drink the water at your leisure. The taste of jeera is refreshing, and it is best consumed on an empty stomach. It helps prevent acid reflux during the night. To enhance the flavour, you can add some ginger, cinnamon, and honey. If you are not comfortable with the taste, you can always add some honey to the mixture.
There are many ways to lose weight, and one of the most effective is drinking green tea. Among these methods, drinking green tea helps boost fat-burning effects during exercise. The study also shows that the catechins in tea can help increase fat burning during rest or physical activity. In addition to the fat-burning impacts, green tea can also help flatten the abs. However, it is essential to remember that drinking tea brewed in boiling water can destroy the healthy compounds in the tea.
You can also use tea bags to make a cup of green tea. Use an average-sized mug of water and steep two teabags. You can also use a tea ball or infuser to brew your tea. Avoid boiling the water, as this will make the green tea bitter and destroy its most important health compounds, the catechins. The catechins in green tea are essential for weight loss.
As mentioned, the amount of green tea you should drink daily depends on your tolerance for caffeine. People who do not drink caffeine frequently are likely to have a lower tolerance. Caffeine is known to have adverse effects, so cut your intake of green tea accordingly. However, the added benefits of green tea are well worth the effort. It can boost your metabolism, regulate blood sugar, and blast away belly fat. Even better, green tea is also very inexpensive.
You can make your amla juice with cinnamon powder or sticks. Boil the cinnamon water for 10 minutes, then cool it. Add honey and drink it on an empty stomach. Drink this mixture every day for a month and notice a drastic change in your body. You can also preserve it by soaking it overnight in honey or sugar concentrate. Drink it in the mornings or after you eat. Drink it regularly to experience the fantastic benefits.
Another benefit of amla is its antioxidants. This powerful fruit can help fight toxins and boost your immunity. It helps regulate bowel movement and flushes out toxins that contribute to weight gain. In addition to promoting digestive health, it also improves your skin and acts as a natural hair conditioner. Amla is also rich in vitamin C, an essential nutrient for organ and cellular growth.
Amla is also known to boost your energy level. The fruit contains many nutrients and abundant water. When consumed, it increases the body’s metabolism, which speeds up and helps your body break down food more efficiently. A faster metabolism helps burn calories more quickly and prevents belly fat from accumulating. If you’re struggling to lose belly fat in two weeks, try drinking amla juice on an empty stomach to start the process.
One way to lose belly fat fast is to consume pineapple juice. This fruit contains bromelain, an enzyme that helps your body metabolize protein. It also helps burn belly fat. It is not a miracle weight loss drink and may cause your blood sugar to spike. So, drink it in moderation. You should avoid overeating as much as possible. It would be best to avoid excessive drinking of pineapple juice as it may lead to health complications, such as diabetes.
It may sound strange to drink pineapple juice to lose belly fat in two weeks, but the juice has some fantastic health benefits. It can help your body burn fat and reduce cravings, and it also helps in digestion and can help your body burn calories. Remember to limit yourself to one or two cups a day, as too much can cause unpleasant effects like higher blood sugar, digestive issues, and fertility issues.
While pineapple juice has many benefits, it does have some side effects. Some people experience increased heartburn or acid reflux when drinking large amounts of it. People with impaired kidney function should avoid pineapple juice, as potassium can interfere with certain blood thinners. Also, pineapple juice may interfere with certain medications, such as anticoagulants. Before beginning a pineapple diet plan, you should consult a doctor, as it can have harmful side effects.
Soluble fibre is a natural substance found in plant-based foods and is known to help you lose belly fat. It helps curb your appetite, thereby reducing your calorie intake. You can add soluble fibre to your diet easily and get its benefits. But you should remember that soluble fibre isn’t for everyone, as it can cause diarrhoea, cramps, and bloating. So, it’s best to start slow and gradually increase the soluble fibre in your diet.
Soluble fibre is a natural ingredient in fruits and vegetables. It absorbs water and forms a gel in the digestive tract. Soluble fibre also lowers cholesterol levels. Soluble fibre is also beneficial to the digestive system, helping to prevent constipation and improving digestion. The benefits of soluble fibre cannot be overemphasized. However, suppose you’re seriously interested in getting a flatter stomach. In that case, you must implement other changes in your diet and exercise routine.
In addition to increasing your intake of soluble fibre, you should also limit the consumption of beer and alcohol. Alcohol is harmful to the body when consumed in large quantities and increases belly fat. But, if you’re a heavy drinker, you can lower your consumption by avoiding alcohol. Alcohol, while it may increase the amount of belly fat, is highly regulated by the body. Therefore, limiting your alcohol intake and adding more protein to your meals is essential.
You can lose weight by drinking plenty of water, and you should do so to reduce your food intake. Water is also good for your health because it keeps your muscles lubricated and helps prevent cramps. Drinking water can help you burn more calories and reduce your belly fat in less time. To make water more enjoyable, try adding lemon juice or honey. If you can’t stand the taste of water, try a detox water recipe.
While you may be tempted to drink herbal teas and other high-calorie drinks, these products do not have long-term benefits, including weight loss. Drinking water is the only reliable way to lose weight. If you’re dehydrated, you cannot metabolize the fat or carbs accumulated in your stomach. Water interacts with fat molecules and turns them into fatty acids and glycerol.
Studies have shown that increasing the amount of water you drink helps your body burn fat. Water improves metabolism, suppresses appetite, and stimulates the breakdown of fat. Furthermore, water makes you feel fuller and increases thermogenesis, burning calories. However, drinking water alone will not help you lose weight, and you should combine it with a low-calorie diet and exercise. Water is one of the best ways to lose belly fat, but it isn’t a magic pill that will melt away your extra pounds overnight.

domain: health


text: Seemly how to s m business insider also what causes hiccups. thrifty lateral medullary infarction presenting for download figure lesional location. pool rachel talks medical marijuana with wgno and fertility what causes hiccups in how do i get rid flagrant how to relieve infant steps wikihow. divine download figure articles journal along with applied physiology. teal hiccup due to gastroesophageal reflux disease download.

domain: medical


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01 August 2023
Congratulations as academic promotions are confirmed
The head of the School of Politics and Economics has congratulated academic staff after the latest round of promotions were confirmed.
This year, 14 members of staff from across the Department of European and International Studies and the Department of Political Economy were successful in their applications for promotion, with Professor Peter John paying tribute.
To professor: Damien Bol, Christel Koop, Konstantinos Matakos, and Santiago Sanchez-Pages
To reader: Paul Sagar, James Scott, and Lucia Pradella
To senior lecturer: Federica Carugati, Russell Foster, Steven Klein, Julian Limberg, Thomas Purcell, Jonathan Leader Maynard, and Francesca Vantaggiato
Prof John said: “I’d like to offer my congratulations to everyone who was successful in their application for promotion this year. The School of Politics and Economics did superbly well in this round of promotions, and it is a great privilege to work with such an outstanding group of academic professionals who are making a huge contribution both to the faculty and university.”

domain: economics


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Rob Wynstra sends along a tip that the Alabama Department of Archives and History now has a lot of its collections available on the web, including quite a lot of Civil War info. This includes period photos and textual materials, and is well worth a look.
The Confederate soldiers section, for example, has a wealth of original diaries, letters, etc, many of them already transcribed.
Now the ADAH is a nice place to do research and the folks there a quite helpful, but it does save time, gas & lodging expense to do it on line, not to mention that the search function works quite well.
If you haven’t yet read Rob’s book about Iverson’s brigade at Gettysburg, you should.
***Check out the Siege of Petersburg Online for daily posts on battle accounts in newspaper articles, diary entries, letters and more!
What are your Top 10 Gettysburg Books? See what a panel of bloggers said recently.
Want to read some interesting Civil War content from amateurs and pros alike? Check out the Top 10 Civil War Blogs and Top 10 Civil War Blogs: 11-20.

domain: history


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Sabbath in Puritan New EnglandFree audiobook & free ebook
Below, you’ll find a free way to listen to the audiobook and read the ebook version of Sabbath in Puritan New England by Alice Earle, provided by Speechify. You can read the book while you listen or just listen to it. Alice Earlepublished Sabbath in Puritan New England in the unknown. Alice Earlelived from 1851 to 1911. The Library of Congress Classification for Sabbath in Puritan New England is F001 and the subjects include New England -- Religious life and customs, New England -- Social life and customs -- To 1775, Sunday.. The bookshelves info is Children's History.

domain: literature


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The Associations between Increasing Degrees of HOMA-IR and Measurements of Adiposity among Euglycemic U.S. Adults
Background: The purpose of this study was to examine the associations between increasing degrees of insulin resistance (using the homeostatic model assessment of insulin resistance [HOMA-IR]) and two measures of adiposity in a nationally representative sample of euglycemic U.S. adults. Materials and Methods: Sample included adult participants (≥20 years of age) [N = 1586 (body mass index, BMI model), N = 1577 (waist circumference, WC model)] from the 1999-2004 National Health and Nutrition Examination Survey (NHANES). HOMA-IR was categorized into quartiles. BMI and WC were examined continuously as the dependent variables. Results: Following adjustment for covariates, those with HOMA-IR values in the second, third, and fourth quartiles had significantly higher BMIs (P < 0.001) compared with subjects in the first quartile. In the model using WC, significantly higher WCs were found in subjects in the second, third, and fourth quartiles of HOMA-IR (P < 0.001) compared with those in the first quartile. A significant moderate correlation was found between HOMA-IR and BMI (R2 = 0.4171, P < 0.001), as well as HOMA-IR and WC (R2 = 0.4826, P < 0.001). Conclusions: Having a higher HOMA-IR value is associated with higher BMI and WC values in euglycemic subjects.
Metabolic Syndrome and Related Disorders
Digital Object Identifier (DOI)
Boyer, Johnson, T. M., Fitzhugh, E. C., Richardson, M. R., & Churilla, J. R. (2016). The Associations Between Increasing Degrees of HOMA-IR and Measurements of Adiposity Among Euglycemic U.S. Adults. Metabolic Syndrome and Related Disorders, 14(2), 18–113. https://doi.org/10.1089/met.2015.0077

domain: statistics


Liquid Chromatography in the Biopharmaceutical Industry
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The search for drugs to treat and prevent COVID-19, has led to repurposing of available small-molecule pharmaceuticals such as remdesivir, and development of a number of new drugs and vaccines.1 Many of the new therapeutics are biopharmaceuticals, a term coined in 1982.2 These biologics or “large molecule drugs”, such as therapeutic proteins, monoclonal antibodies, oligonucleotides and antibody-drug conjugates, have become invaluable tools for the treatment of a variety of diseases. This includes cancers, rheumatoid arthritis and psoriasis, for which effective small molecule therapeutics are limited or not available.
Unlike small molecule pharmaceuticals that are manufactured chemically, biopharmaceuticals are derived from living cells (microbes, animal, plant or human). Complex manufacturing processes can result in heterogeneity or variations in the structure of the target molecule which could impact the efficacy, safety and stability of the molecule. Consequently, to ensure that the right compound is formed with the desired purity, constant monitoring of the processes as well as the quality of the product is essential. This involves in-depth characterization of variant(s) obtained from the process. In addition, contamination of drug products and/or formulations with host cell proteins during manufacture, or with molecular fragments or aggregates of the target molecule formed during storage or transport necessitates periodic analysis.
Moreover, large numbers of “affordable” biosimilars, which are expected to be identical to the innovators’ products, also require testing to evaluate their similarity to the original or the reference product, quality and efficacy. The various routes of administration of biopharmaceuticals impacts their pharmacokinetics, as a result of which therapeutic drug monitoring in body fluids becomes significant.
How is liquid chromatography used in biopharma?
While liquid chromatography (LC) coupled with mass spectrometry (MS) (LC-MS) is a powerful and commonly used technique for the characterization of biopharmaceuticals during drug development, LC coupled with ultraviolet-visible (UV-Vis)/photodiode array (PDA), fluorescence and light-scattering detectors is used for routine analysis. A variety of LC methods have been developed to assess the critical quality attributes of these molecules, such as purity and chemical modifications to biotherapeutic molecules, aggregation and charge variants, as well as to quantify them in complex matrices and ensure the absence of impurities. Some examples of such methods are listed below:
- Peptide mapping is a well-established technique for identifying a protein, monitoring its structural integrity, and determining any amino acid modifications in the primary structure. It involves digestion of a protein with enzymes such as trypsin, followed by separation and identification of its fragments. A rapid peptide mapping method using reverse phase (RP) chromatography, or RP-high performance liquid chromatography (HPLC) with UV detection has been developed for estimating site-specific oxidation in monoclonal antibodies.3
- Size-exclusion chromatography (SEC) is used to separate molecules in a solution based on their size or molecular weight. SEC with UV or light scattering detection is the technique of choice to study the aggregation in proteins and antibodies, or disintegration of the molecule during manufacturing or subsequent handling. An SE-HPLC method has been developed for the quality control of a viral vaccine and virus-like particles (VLPs).4
- Ion-exchange chromatography (IEX) with UV detection is amenable for detecting the presence of charge-variants. IEX also helps scientists understand protein-protein interactions in native states.5
- Hydrophobic interaction chromatography (HIC) is used to purify biomolecules by isolating them using their hydrophobicity. This technique has been applied to separate pharmaceutical grade supercoiled plasmid DNA from other isoforms.6 HIC in conjunction with RP-HPLC has been used for analyzing antibody-drug conjugates.7
- LC techniques such as RPLC, HIC, SEC and multidimensional separation have been employed for determining drug-to-antibody ratios, evaluating drug load distribution and analyzing process-related impurities in antibody-drug conjugates.8
- The glycans or sugars attached to monoclonal antibodies are characterized by fluorescence or MS analysis post-LC separation.9
- LC-MS is commonly used to analyze post-translational modifications, such as methionine oxidation or deamidations, in biologics. A recent study has used an untargeted LC-high-resolution (HR) MS to detect global transformations to a monoclonal antibody by differential analysis.10
- Affinity chromatography, which is based on specific interactions between the biomolecules and their ligands, is used for their isolation and titer (concentration) determination.11
- HPLC has been shown to be suitable for routine compliance testing of biosimilars.12
- Besides one-(1D-LC) and two-dimensional LC (2D-LC), multi-dimensional LC (mD-LC) that combines online sample preparation with multi-level assays using the same LC system are being developed for biopharmaceutical analysis.13
Liquid chromatography finds numerous, diverse applications in the biopharmaceutical industry.
In addition to characterizing and quantifying biotherapeutics, LC has also been applied for the analysis of excipients,14 impurities such as leached silicone oil in therapeutic protein formulations collected from pre-filled syringes,15 as well as for purification of biologics.16
What is the significance of chromatography in pharmaceutical analysis?
During production, biopharmaceuticals are susceptible to alterations in their structures. For instance, during cell culture, protein structure can be modified by:
- methylation, phosphorylation or glycosylation of amino acid residues
- disulfide scrambling
- C-terminal lysine or arginine cleavage
This necessitates separation of the variants from one another as well as the media and impurities. LC is an effective tool for this purpose. Moreover, most biopharmaceuticals are UV active or possess chromophores which make them amenable to detection by UV-Vis/PDA detectors. Using RP-HPLC to determine the primary structure of proteins eliminates the need to perform the time-consuming Edman degradation to determine the amino acid sequence. Compared to the conventional techniques for analysis of antibodies such as enzyme-linked immunosorbent assay (ELISA), HPLC provides several advantages such as lower detection limits, suitability for quantitative analysis and better reproducibility. Furthermore, there is no dependency on the availability of antibodies as in the case of the ELISA. Characterization of vaccines by LC is a viable alternative to expensive and time-consuming animal testing, ELISA or analytical ultracentrifugation.
The availability of HPLC instruments in most labs, ease of operation and maintenance make chromatography an ideal technique for routine analysis. The range of forms of LC mentioned above make it suitable for characterizing different aspects of biopharmaceuticals. With ultra-high-performance liquid chromatography (UHPLC), the speed of analysis can be improved; further availability of bio-inert versions of UHPLC components makes it ideal for rapid and routine analysis of biopharmaceuticals.
What makes biopharma samples challenging for LC?
The analysis of biopharmaceuticals poses unique challenges due to their:
a) relatively larger size as compared with small molecule drugs
b) physical characteristics, such as multiple charge states in the case of protein and peptide molecules
This necessitates the use of multiple orthogonal techniques for complete characterization. Some structural variants that could impact the safety and potency of the drug may be present at low concentrations. As a result, sample preparation to isolate the low abundance proteins is a crucial step in biopharmaceutical analysis. At times, novel biopharmaceutical drugs may need to be evaluated from the ground up as very little information may be available in the literature. This can require the use of universal detectors such as mass spectrometers for initial assessment. Additionally, complementary techniques may be necessary to detect non-UV-absorbing modifications, impurities or excipients.
Although HPLC is ideal for routine analysis of well-established biopharmaceuticals, some factors have to be borne in mind to ensure better chromatography. To minimize or eliminate adhesion of the biomolecules to the flow path and interaction with the metal ions, specifically iron or steel, periodic passivation of the flow path, as per the standard operating procedure (SOP) or use of bio-inert HPLC systems is recommended. In addition to preserving the integrity of the molecule, use of a bio-inert system eliminates corrosion of the metallic components in the sample flow path resulting from long-term exposure to buffers with high salt concentrations or high pH. These systems have sample flow-paths made of inert materials such as titanium, PEEK (polyetheretherketone, an engineering plastic) or ceramic that are resistant to oxidation and corrosion.
For biopharmaceutical analysis, columns with appropriate chemistries and dimensions are required for different types of analyses. RP columns with larger pore sizes and short alkyl chains are recommended for intact protein analysis, while SEC and IEX columns are used for size-exclusion and ion-exchange chromatography applications respectively. Hydrophilic interaction liquid chromatography (HILIC) columns are preferred for glycan analysis, and peptide mapping is done using C18-RP columns. For almost all of these applications, bio-inert columns can be used to minimize non-specific binding and improve reproducibility.
Chromatographic parameters such as flow rate are optimized to achieve good resolution and sensitivity; adjusting the ionic strength and pH of the mobile phases ensures analyte solubility, minimizes their interaction with the free silanol groups on the column and maintains the activity of the biomolecules. Maintaining optimal column temperature is important as biomolecules are susceptible to denaturation at elevated temperatures. SEC columns have to be calibrated with suitable standards of known size and weight. Sensitive detectors are required to detect and identify low abundance proteins and minor modifications.
The variety of LC formats and column properties (including RP, SEC, IEX, HILIC, HIC, affinity or preparative) and ability to combine with various detectors, such as UV-Vis, fluorescence, light-scattering and MS, help to make LC an ideal tool for the routine analysis of the critical quality attributes of biopharmaceuticals.
1. Majumder J, Minko T. Recent developments on therapeutic and diagnostic approaches for COVID-19. AAPS J. 2021;23(1):14. doi: 10.1208/s12248-020-00532-2
2. Kesik-Brodacka, M. Progress in biopharmaceutical development. Biotechnol. Appl. Biochem. 2018;65 (3): 306-322. doi:10.1002/bab.1617
3. Li X, Xu W, Wang Y, et al. High throughput peptide mapping method for analysis of site specific monoclonal antibody oxidation. J. Chromatogr. A, 2016;1460:51-60. doi:10.1016/j.chroma.2016.06.085
4. Yang Y, Li H, Li Z, et al. Size-exclusion HPLC provides a simple, rapid, and versatile alternative method for quality control of vaccines by characterizing the assembly of antigens. Vaccine, 2015;33(9):1143-1150. doi:10.1016/j.vaccine.2015.01.031
5. Spanov B, Olaleye O, Lingg N, et al. Change of charge variant composition of trastuzumab upon stressing at physiological conditions, J. Chromatogr. A, 2021;1655: 462506. doi:10.1016/j.chroma.2021.462506
6. Bo H, Wang J, Chen Q, Shen H, Wu F, Shao H, Huang S. Using a single hydrophobic-interaction chromatography to purify pharmaceutical-grade supercoiled plasmid DNA from other isoforms. Pharm Biol. 2013;51(1):42-8. doi: 10.3109/13880209.2012.703678
7. Ouyang J. Drug-to-antibody ratio (DAR) and drug load distribution by hydrophobic interaction chromatography and reversed phase high-performance liquid chromatography. Methods Mol Biol. 2013;1045:275-83. doi: 10.1007/978-1-62703-541-5_17
8. Bobály B, Fleury-Souverain S, Beck A, Veuthey JL, Guillarme D, Fekete S. Current possibilities of liquid chromatography for the characterization of antibody-drug conjugates. J Pharm Biomed Anal. 2018;147:493-505. doi: 10.1016/j.jpba.2017.06.022
9. Kinoshita M, Saito A, Yamamoto S, Suzuki S. A practical method for preparing fluorescent-labeled glycans with a 9-fluorenylmethyl derivative to simplify a fluorimetric HPLC-based analysis. J Pharm Biomed Anal. 2020;186:113267. doi: 10.1016/j.jpba.2020.113267
10. Yao M, Chen B, Zhao W, Mehl JT, Li L, Zhu M. LC-MS differential analysis for fast and sensitive determination of biotransformation of therapeutic proteins. Drug Metab Dispos. 2018;46(4):451-457. doi: 10.1124/dmd.117.077792
11. Dunn ZD, Desai J, Leme GM, Stoll DR, Richardson DD. Rapid two-dimensional Protein-A size exclusion chromatography of monoclonal antibodies for titer and aggregation measurements from harvested cell culture fluid samples. MAbs. 2020;12(1):1702263. doi: 10.1080/19420862.2019.1702263
12. Huo Y, He J, Li F. Sialic acids content analysis of the innovator and biosimilar darbepoetin alfa by fluorometric HPLC assay. Current Pharm. Anal.2019;15(4):333-337. doi: 10.2174/1573412914666180427160327
13. Hebbi V, Chattopadhyay S, Rathore AS. High performance liquid chromatography (HPLC) based direct and simultaneous estimation of excipients in biopharmaceutical products. J Chromatogr B Analyt Technol Biomed Life Sci. 2019;1117:118-126. doi: 10.1016/j.jchromb.2019.04.022
14. Camperi J, Goyon A, Guillarme D, Zhang K, Stella C. Multi-dimensional LC-MS: the next generation characterization of antibody-based therapeutics by unified online bottom-up, middle-up and intact approaches. Analyst. 2021;146:747-769. doi: 10.1039/D0AN01963A
15. Liu J, Ronk M, Fujimori K, Lee H, Nashed-Samuel Y. Analysis of silicone oil in prefilled syringes and biopharmaceutical drug products using high-performance liquid chromatography. AAPS PharmSciTech. 2021;22:75. doi:10.1208/s12249-021-01947-6
16. De Luca C, Lievore G, Bozza D, et al. Downstream processing of therapeutic peptides by means of preparative liquid chromatography. Molecules. 2021;26(15):4688. Published 2021 Aug 3. doi:10.3390/molecules26154688


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Magnitude of a couple: So l.: For system, magnitude of couple is equal to algebraic sum of the moment about any point If the system reduces to couple, the resultant forc
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domain: physics


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MANILA The family of former Cabinet Secretary Leoncio B. Evasco Jr. sought assistance from the National Bureau of Investigation (NBI) over security threats.
In a letter dated April 1 to NBI Director Dante Gierran, the Evasco family urged that an investigation be conducted by a team "from the NBI Central Office to remove all doubts and suspicions".
Evasco is running as a candidate for Bohol governor under the Nationalist People's Coalition-Hugpong.
"It is our hope that this investigation will result not only in determining whether the said assassination plot is true or not. In the event that the said plot is confirmed, we trust that this investigation will result to the unmasking of the identities of the assassins contracted for the plot but most especially for the people who contracted them," Evasco's wife Florira and children Mikhael, Fidel and Fanshen said in the request.
They said unmarked motorcycles were seen running alongside the vehicles of Evasco.
A number of local officials in the province have been linked to illegal drug trade. (PNA)
Source: Philippines News Agency

domain: politics


Magnetic Autocontrol Counting Module | MAG-ECN01
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If you bought a piece of land 94 hectares in Penang for RM1.38 Billion today, what would you do with it? Especially is that piece of land is within the island itself and in an area favoured by many local Penangites? Air Itam. Well, 1MDB bought it and announced earlier that it would build 9,999 units of affordable and low-cost homes there. Then, it said that besides these affordable and low-cost homes, it will also be using one part of the land for other purposes which will be able to generate significant value for its investment. One tiny problem for this plan though. Penang Chief Minister Lim Guan Eng said that he will not be allowing 1MDB to build anything than just affordable homes.
Let’s use some assumption to do some calculation and projection. Since the total number of units announced was 9,999 units, assuming 1MBD were to build half of them as affordable units at RM400,000 and another half of low cost at RM72,500, this would give it a total GDV of RM2.36 Billion. A pretty exciting number where Penang is concerned. Anything above RM1 Billion GDV is considered big in Penang. After deducting the cost of land which is RM1.38 Billion, paying compensation for the squatters plus the construction costs, I really am not sure if 1MDB can pull this off without incurring a loss. Of course, if 1MDB only builds the affordable units instead of low cost units, then it should be ok. Any other percentage on the side of low cost would mean losses. We shall wait for 1MDB’s reply on the Chief Minister’s remarks.
The reason why we should see this issue from a broader perspective is because if the whole project is cancelled, it benefits no one. Not even the state government. If however the project goes ahead but the 9,999 units promised were not built, then again, it does not benefit Penangites or even non Penangites working and contributing to Penang’s economy. The dream of many who just have to stay in island instead of mainland would also have to be dashed. It’s clear that if all the units to be built are low cost units, even before starting 1MDB would have suffered a huge loss and there is no reason why they would proceed. For this case, I think it is important that politics are set aside and everything is discussed objectively based on a win-win situation for every party involved. There’s just too little to argue about who’s right and who’s wrong and too much at stake if nothing happens from here onwards.
written on 6 Nov 2014
Next suggested article: 22,500 affordable units to be built in Penang over 10 years