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Free Spin Bonus deals: What You Need to Know
One of the biggest reasons gambling establishment enthusiast decide to associated with move over to on the net casinos is for the particular promotions and bonus deals that are it?s offered by land-based establishment. Naturally , this refers to a sizable variety of bonuses, which include welcome offers, refill bonuses, VIP offers, loyalty schemes and even more.
All these online casino bonuses reveals their own terms and conditions and enormous variety of benefits to provide you with edge for signing up for casino. The bonus deals on offer have a great deal to do with the programmers available at the gambling establishment as the payout prices, game types in addition to special developer bonus deals play a major role in what bonus deals are accessible. Many casinos feature very much bigger match bonus deals while others tend to concentrate on smaller values that include easier terms and conditions.
The same characteristics apply to a free rewrite casino bonus in most cases, you will find added terms and conditions as these offers serve as a dual bonus. Not only you get the free spins that will allow you play the newest and most popular video games, but you also get the winnings that seem as bonus cash in your account you can use to play more video games.
Free of charge spin bonuses have not been available because the beginning of on the net casinos in the middle 90?s, but since we were holding introduced, these have come to be one of the preferred and a lot popular form of gambling establishment bonuses for gamers around the world. They provide an excellent variety of benefits in order to accompany any gambling desires while concentrating on gaming from the extremely start.
The terms and conditions of any free spin added bonus would be a bit puzzling for a first-time participant as there are conditions for the free spins itself plus the winnings you initialize with those rotates. Furthermore, there are also several variations of free rewrite bonuses, some giving a bonus before you make down payment, others giving you a better free spin benefit and even some apply it as a reward if new games available.
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What are Free of charge Spin Bonuses?
A free of charge spin bonus is often a casino offer which gives you the opportunity to play childish games for free as if you had been playing for real cash and win added bonus cash. Many will confuse this gambling establishment bonus with an in-game ui feature where the overall game gives you free spins, which often this is not. Instead, together with casino free spins, you will get to play some of the standard slot using a set betting benefit and it?s attainable to activate each of the bonuses and the in-game ui free spin function while playing gambling establishment free spins.
These bonuses are becoming amazingly popular because they offer excellent rewards with most internet casinos, including a large variety of online game choices, low betting requirements, enhanced wagering values and much more. There is no doubt about it, a free of charge spin bonus is good for anyone seeking a campaign that really adds to the slot machine game gaming experience because it offers 2 bonus deals in 1 .
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At the same time, there are so many varieties of free spin bonus deals that have been adjusted with the casinos that function them, which develop a unique offer to profit players in the casino?s unique way.
Varieties of No Deposit Bonuses
Due to the fact online casinos include started adjusting free of charge spin bonuses, we now have seen a large selection of promotions that presents exclusive benefits for each gambling establishment. Some would basically offer a free rewrite bonus when you join and accept down payment bonus while others elect to add free spins if you register without setting up a deposit or increase the free spin earnings by increasing the particular bet value of each and every spin.
The fact is, these free rounds are always evolving like casinos find innovative ways to enhance winnings in addition to attract players with a really good bonuses under the sunlight. Here are some of the most well-known forms of casinos bonus deals currently available:
No Deposit Free of charge Spin Bonuses
A free free spin added bonus is one of the most popular slot machine game bonuses are available in the particular casino industry. This specific bonus would give you up to 50 free rounds before you even produce a deposit, which allows that you play some of the most well-known games and succeed bonus money.
The great thing about a new no deposit free rewrite bonus is that it offers you the opportunity to play the very best games at the gambling establishment with a fixed wagering value and handle other games and bet as you?d you should once the bonus earnings from the spins can be found in your account.
Since this is a offer, you can expect strict stipulations with the bonus plus the wagering requirements are generally around doubt compared to of a normal free of charge spin bonus on the casino. The stipulations would also just provide around seven days to use the added bonus or it?s taken out of the account.
Also be on the lookout for the games you may play with the added bonus, which is available in the particular terms and conditions. With no put in free spins, most internet casinos only allow you to enjoy 1 or 2 games while using actual spins although also limiting the particular games available with the particular bonus funds how the free spins reward.
Put in Free Spins Bonuses
Deposit free of charge spin bonuses will be by far the best with regards to value as internet casinos would offer a very much bigger amount of free rounds and present cheaper terms and conditions for the earnings you activate through the spins.
Some casinos may possibly only include a number of free spins with a put in bonus while others equal to 200 as part of the added bonus. However , when you obtain a large amount of free spins, you are likely to find a division within the terms and conditions that express 20 free spins for 10 days or anything similar. This does not put you at a drawback, but simply means you can play all the free rounds in one day. Naturally , there are also some internet casinos that let you perform as you?d you should by giving you the complete amount from the start.
Deposit free of charge spin bonuses are likely to include unique stipulations apart from the bonus money you?ll receive included in the bonus. This pertains to wagering requirements, how much time you can play the particular free spins, what the added bonus value is limited in order to and the games on the market to play free spins plus the games that can make contributions towards wagering.
Customer loyalty and VIP Free rounds
Customer loyalty and VIP ideas commonly include free rounds as an additional repay to provide members with an increase of opportunities to play the most up-to-date games and gain more cash. With customer loyalty plans, free spins will be available at internet casinos that allow you to choose between funds and free spins. Naturally , there are also casinos which include stores where you can utilize your points to invest in free spins, special absolutely free spin promotions plus more.
VIP free spins on the other hand, normally include more chances as some casinos gives you a free ” spin ” bonus when you enhanced to a new levels and introduce fresh games with a absolutely free spin offer. Consequently , as a higher-ranking VIP player, you can expect to acquire regular free ” spin ” bonuses to play the most up-to-date games first.
The conditions for these types of absolutely free spin bonuses are typically a lot better than those wanted to new players. Consequently , you might find it whole lot easier to wager typically the bonus, have access to a much greater selection of games and perhaps receive the winnings throughout cold hard cash immediately after the bonus (very high VIP levels).
Increased Bet Free rounds
Enhanced free spin additional bonuses are scares, although well worth accepting for many who desire big bonus offer opportunities. Casinos give these types of bonuses having welcome offers, VIP benefits and certain promotional rewards of which boost winnings.
Basically, these kinds of bonuses are precisely the same as a regular absolutely free spin offer, but rather of minimum solution per round, they give a higher bet, which in turn increases the winnings you will receive from blends, bonus games and yes it would also aid to activate features.
The conditions for these bonuses act like the bonuses previously mentioned, which all depends to the reasoning as to why typically the bonus was paid in the first place. If it was basically for a VIP person, the terms and conditions can be lower than that of a new player who received typically the bonus with a everyone should be open offer. However , products or services casino promotion, typically the terms and conditions will provide all the info you need to choose a bonus offer that suits your needs.
How Do Free rounds Bonuses Work?
In the casino?s point of view, there are plenty of things to consider with a absolutely free spin bonus, such as type of slots along with the payout rates, that includes a lot to do with precisely how high the gambling requirements, the bets value per ” spin ” and the games authorized in the bonus.
However , for any player, those details rarely really matter when the terms and conditions provide all the info you need. All you need to give some thought to is the bonus on its own and what it provides.
When it comes to how a bonus works for any player, it really is simply. The modern casino rewards these free rounds to be played over a certain selection of game titles (stated in the words and conditions) for either minimum solution or with an increased betting value. In the free spin give, you cannot change the bets values, but you will still have access to be able to specific game capabilities such as audio and video adjustments.
Typically the free spins are precisely the same as it would be in the event that you where playing the game having real money, meaning every one of the bonus features, repay opportunities, free ” spin ” bonuses and exact payout percentages really are identical to the normal game while using the absolutely free spin bonus.
Once you encourage a combination or bonus offer feature during the bonus offer, the casino gathers the funds and even adds it towards your bonus account, which can be exactly the same as processing a regular match bonus offer from the casino.
The profits from the free spins really are subject to wagering demands, meaning you?ll simply know how much typically the wagering requirements really are once the bonus is normally complete. The gambling value would continue to be the same, but since an individual wouldn?t know what the overall bonus amount is normally beforehand, it?s improbable to know how much it is advisable to wager. Therefore , typically the casino doesn?t add the free spin gambling information before every one of the free spins are played out.
Free Spin Conditions
Typically the terms and conditions of a absolutely free spin bonus are incredibly important as it can determine what games an individual play as well as wht is the possibilities are having bonus cash developed by the free spins. Nearly all online casinos include things like unique requirements which has a free spin bonus offer, which relates to typically the games they provide, the amount of free spins are bundled, the type of free ” spin ” bonus and much more.
The conditions for a free ” spin ” bonus would include things like two sections. The initial, would provide information about how one can use the free spins and just how much time you have. This will be significant as casinos almost never inform you about the game titles allowed after bonus offer has been accepted. Naturally , you can go back and even check or call the support crew, but you might turn yourself into for disappointment whether it only allows pai gow poker that you?re certainly not interested. The time reduce also plays a serious role as some internet casinos would only continue free spin additional bonuses active for 24 hours.
As mentioned above, typically the wagering requirements simply apply to the profits you activate for free spins. In some cases, these kinds of requirements would be the identical to that of a suit bonus, but it is valued at reading through the conditions as free spins perhaps have their own wagering demands. The casino presents this information in a url on the promotion site or with the additional information about the bonus.
Casinos typically include betting restrictions to the winnings of your free spin bonus offer, which stops through betting high figures on games when wagering. You would must also look at game limits and contributions like a games (tables, online video poker and some slots) might not contribute 100 percent of the betting price as seen while using the majority of slots.
Free ” spin ” bonuses that repay cash as a VIP program wouldn?t include things like wagering requirements, nevertheless it would still provide you with information regarding the length of time the free spins continue to be valid and what game titles the bonus is accessible on.
How to Use a no cost Spin Bonus
There are plenty of factors that come straight into play with a free ” spin ” casino bonus, which in turn firstly depends on the sort of offer they provide. Yet , there are a few tips and tricks you could apply to most varieties of this bonus to offer you an edge when it comes to earning. If the bonus is restricted to 1 game honestly, that is not paying out effectively at the time you first try it out, don?t feel that you will need to play all the free rounds right away. Simply escape the game and next later to see precisely how it is then.
If the bonus offer allows multiple game titles, apply the same secret and jump involving games to find the kinds that payout effectively and offer great bonus offer winnings.
Once you?ve played out all the spins, occurs bonus funds properly and set limits of which force you to abandon the game once you get to them. Also remember to enhance your limits having big wins, which in turn ensures you never suffer a loss of too much with a video game, but also have the opportunity to maintain great rewards.
Would it be Worth Accepting some sort of No Deposit Bonus?
Free ” spin ” casino bonuses are among the most popular for gamers as it offers a twice bonus. Sure, this suggests more terms and conditions, nevertheless the actual free spins rarely add that much for the requirements and it has well worth accepting these people as they allow you to have fun with even more games.
Of course , absolutely free spin bonuses which has a higher VIP levels or those that provide you with higher betting figures are great, but by so doing, it all comes down to typically the terms and conditions and the gambling requirements it includes.
These additional bonuses are great for players who seem to enjoy slots mainly because, especially with a modern casino that let?s you decide on the slots you would like to play with typically the free spins while in addition including various chances with the bonus funds winnings without making use of strict limits in terms of how long you can get the cash and how significantly you can withdraw. Look at also our critical reviews of most trusted absolutely free pokies.
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Bob Behnken and Doug Hurley—the astronauts aboard SpaceX’s Dragon Endeavour capsule—executed the world’s highest cannonball yesterday. They splashed down in the Gulf of Mexico off the coast of Florida after spending the last two-ish months aboard the International Space Station.
It’s a big deal, because rockets, SpaceX, Elon Musk, etc. But it’s also historic: This is the first time in 45 years that astronauts from any nation have returned to Earth via splashdown.
While any homecoming from space is complicated, SpaceX and NASA had to contend with the additional challenge presented by Tropical Storm Isaias, which was lashing Florida’s east coast around the same time the craft landed.
Zoom out: The astronauts’ safe return was the final step in certifying Musk’s SpaceX to begin routine, operational spaceflights to the ISS. He had this to say about it:
Elon Musk's Twitter feed
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Caesar reportedly practised “illeism”
By guest blogger David Robson
Socrates famously declared that “the unexamined life is not worth living” and that “knowing thyself” was the path to true wisdom. But is there a right and a wrong way to go about such self-reflection?
Simple rumination – the process of churning your concerns around in your head – isn’t the answer. It’s likely to cause you to become stuck in the rut of your own thoughts and immersed in the emotions that might be leading you astray. Certainly, research has shown that people who are prone to rumination also often suffer from impaired decision-making under pressure and are at substantially increased risk of depression.
Instead, the scientific research suggests that you should adopt an ancient rhetorical method favoured by the likes of Julius Caesar and known as “illeism” – or speaking about yourself in the third person (the term was coined by Samuel Taylor Coleridge from the Latin ille meaning “he, that”). If I was considering an argument that I’d had with a friend, for instance, I may start by silently thinking to myself “David felt frustrated that…” The idea is that this small change in perspective can clear your emotional fog, allowing you to see past your biases.
A bulk of research has already shown that this kind of third-person thinking can temporarily improve decision making. Now a preprint at PsyArxiv finds that it can also bring long-term benefits to thinking and emotional regulation. It is, according to the authors, “the first evidence that wisdom-related cognitive and affective processes can be trained in daily life and of how to do so.”
The findings are the brainchild of Igor Grossmann at the University of Waterloo, whose work on the psychology of wisdom was one of the inspirations for my recent book on intelligence and how we can make wiser decisions.
Grossmann’s aim is to build a strong experimental footing for the study of wisdom, which had long been considered too nebulous for scientific inquiry. In one his earlier experiments, he established that it’s possible to measure wise reasoning and that, as with IQ, people’s scores matter. He did this by asking participants to discuss out-loud a personal or political dilemma, which he then scored on various elements of thinking long-considered crucial to wisdom, including: intellectual humility; taking the perspective of others; recognising uncertainty; and having the capacity to search for a compromise. Grossmann found that these wise-reasoning scores were far better than intelligence tests at predicting emotional well-being, and relationship satisfaction – supporting the idea that wisdom, as defined by these qualities, constitutes a unique construct that determines how we navigate life challenges.
Working with Ethan Kross at the University of Michigan, Grossmann has also looked for ways to improve these scores – with some striking experiments demonstrating the power of illeism. In a series of laboratory experiments, they found that people tend to be humbler, and readier to consider other perspectives, when they are asked to describe problems in the third person.
Imagine, for instance, that you are arguing with your partner. Adopting a third-person perspective might help you to recognise their point of view or to accept the limits of your understanding of the problem at hand. Or imagine you are considering moving jobs. Taking the distanced perspective could help you to weigh up the benefits and the risks of the move more dispassionately.
This previous research only involved short-term interventions, however – meaning it was far from clear whether wiser reasoning would become a long-term habit with regular practice at illeism.
To find out, Grossmann’s team first asked nearly 300 participants to describe a challenging social situation,while two independent psychologists scored them on the different aspects of wise reasoning (intellectual humility etc). The participants then had to fill out a daily diary for four weeks. Each day they had to describe a situation they’d just experienced, such as a disagreement with a colleague or some bad news. Half were prompted to do so in the first-person, while the others were encouraged to describe their trials from a third-person perspective. At the end of the study all participants repeated the wise-reasoning test.
Grossmann’s results were exactly as he hoped. While the control participants showed no overall change in their wise reasoning scores, those using illeism improved in their intellectual humility, perspective-taking and capacity to find a compromise.
A further stage of the study suggested that this newfound wisdom also translated into greater emotional regulation and stability. After they had finished the four-week diary intervention, participants had to predict how their feelings of trust, frustration or anger about a close family member or friend might change over the next month – then, after that month was up, they reported back on how things had actually gone…

domain: psychology


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domain: gamble


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Sol-Gel Technologies Reports First Quarter 2020 Financial Results and Corporate Update
- New Drug Applications for Epsolay® and Twyneo® remain on track for the second quarter and second half 2020, respectively
- Completed a $23 million underwritten public offering in February with an additional $5 million investment from Sol-Gel’s controlling shareholder in April, providing cash runway into mid-2021 and funds pre-commercialization efforts for Epsolay and Twyneo
- Top-line generic product revenue of $3.4 million in first quarter 2020
NESS ZIONA, Israel, May 14, 2020 (GLOBE NEWSWIRE) -- Sol-Gel Technologies, Ltd. (NASDAQ: SLGL), a clinical-stage dermatology company focused on identifying, developing and commercializing branded and generic topical drug products for the treatment of skin diseases, today announced financial results for the first quarter ended March 31, 2020 and provided an update on its clinical development programs.
“In the first quarter of 2020, we strengthened our balance sheet through a $23 million underwritten public offering in February and a subsequent $5 million private placement that closed just after the end of the first quarter. This capital from new and existing shareholders, including our controlling shareholder, M. Arkin Dermatology Ltd., extends our cash runway to mid-2021, and funds our pre-commercialization efforts for Epsolay and Twyneo,” commented Dr. Alon Seri-Levy, Chief Executive Officer of Sol-Gel. “We remain on track to file our New Drug Application (NDA) for Epsolay with the FDA in the second quarter of this year and our NDA for Twyneo in the second half this year, both exciting milestones for the company.”
“I also want to acknowledge the efforts of our employees and the whole healthcare system in working to keep our community safe during the ongoing COVID-19 pandemic,” continued Dr. Seri-Levy. “At Sol-Gel, we have been fortunate to have seen only minimal impact to our operations to date, largely due to the advanced clinical status of our two lead programs, Epsolay and Twyneo.”
Corporate Highlights and Recent Developments
- Strengthened balance sheet with $28.0 million in gross proceeds from the February underwritten public offering of $23.0 million and from the $5.0 million that Sol-Gel’s controlling shareholder, M. Arkin Dermatology Ltd., invested in April. Despite market conditions, the April purchase of ordinary shares and warrants was at the same terms as the February underwritten public offering, $11.00 per ordinary share and an accompanying warrant to purchase 0.80 of an ordinary share. The warrants have an initial exercise price of $14.00 per share, subject to certain adjustments, and will expire on February 19, 2023.
- In the first quarter of 2020, Sol-Gel generated revenue of $3.4 million from its collaboration agreement with Perrigo.
- In response to COVID-19, Sol-Gel immediately implemented policies and procedures to protect the health, safety and welfare of employees and their families and to help mitigate the spread of the coronavirus including mandatory work-from-home and frequent on-site sterilization.
Clinical Program Updates
- Sol-Gel expects to file an NDA for Epsolay (encapsulated benzoyl peroxide, 5%, cream) in the second quarter of 2020. If approved, Epsolay has the potential to be the first FDA-approved single-agent BPO prescription drug product and to redefine the standard of care for the treatment of inflammatory lesions associated with rosacea.
- Sol-Gel expects to file an NDA for Twyneo (encapsulated benzoyl peroxide, 3%, and encapsulated tretinoin, 0.1%, cream) in the second half of 2020. If approved, Twyneo has the potential to become a preferred treatment for acne.
- In January, Sol-Gel announced positive topline results from an open-label long-term safety study of Epsolay. Of the 209 patients (57.6%) that completed 52 weeks of treatment with Epsolay, 153 (73.2%) reached “clear” or “almost clear”, 46 (22%) reached “mild” rosacea, only 10 (4.8%) had “moderate” rosacea, and none had “severe” rosacea on a Global Assessment (IGA) 5-point scale. Additionally, at the end of the study, more than 90% of these patients had “none” or “mild” cutaneous signs or symptoms (burning or stinging, itching, dryness and scaling) and no “severe” scores were recorded.
- A proof of concept clinical study of SGT-210, erlotinib gel, a topical epidermal growth factor receptor inhibitor, for the potential treatment of punctuate palmoplantar keratoderma type 1 initiated in January 2020. This clinical study was recently expanded to include other types of palmoplantar keratoderma. Patient enrollment is expected to be renewed subject to Israel Ministry of Health guidelines for COVID-19. Data is expected in 2021.
- In early 2020, Sol-Gel added to its pre-clinical pipeline tapinarof, an aryl hydrocarbon receptor agonist, and roflumilast, a PDE4 inhibitor, each to be developed for potential treatment of psoriasis, as mono or combination therapies and other dermatological indications. Sol-Gel continues to work to advance these assets into the clinic.
Financial Results for the Three Months ended March 31, 2020
Revenue in the first quarter 2020 was $3.5 million. The revenue was mainly due to sales of a generic product from the collaboration arrangement with Perrigo. The decrease in revenue from the previous quarter follows from continued generic competition.
Research and development expenses were $7.9 million in the first quarter of 2020 compared to $10.8 million during the same period in 2019. The decrease of $2.9 million was mainly attributed to a decrease of $2.6 million in clinical trial expenses, mainly related to clinical trials of Epsolay and a decrease of $0.5 million in manufacturing expenses of Epsolay and Twyneo, partially offset by an increase of $0.2 million in regulatory expenses, mainly related to preparing for the NDA submissions for Epsolay and Twyneo.
General and administrative expenses were $2.8 million in the first quarter of 2020 compared to $1.7 million during the same period in 2019. The increase of $1.1 million was mainly attributed to an increase of $1.0 million in commercialization expenses and an increase of $0.1 million in other expenses.
Sol-Gel reported a loss of $7.1 million for the first quarter of 2020 compared to loss of $5.7 million for the same period in 2019.
As of March 31, 2020, Sol-Gel had $20.4 million in cash, cash equivalents and deposits and $45.8 million in marketable securities for a total balance of $66.2 million, excluding the additional $5.0 million investment by Sol-Gel’s controlling shareholder which closed in April. Based on current assumptions, Sol-Gel expects its existing cash resources will enable funding of operational and capital expenditure requirements into mid-2021. As previously disclosed, Sol-Gel does not plan to raise additional dilutive capital to fund pre-commercialization activities for Epsolay and Twyneo.
About Sol-Gel Technologies
Sol-Gel is a clinical-stage dermatology company focused on identifying, developing and commercializing branded and generic topical drug products for the treatment of skin diseases. Sol-Gel leverages its proprietary microencapsulation technology platform for Twyneo, for the treatment of acne vulgaris, and Epsolay, for the treatment of papulopustular rosacea. The Company’s pipeline also includes SGT-210, an early-stage topical epidermal growth factor receptor inhibitor, erlotinib, for the treatment of punctate palmoplantar keratoderma, and preclinical assets tapinarof and roflumilast. For additional information, please visit www.sol-gel.com.
Epsolay® is an investigational topical cream containing encapsulated benzoyl peroxide, 5%, for the treatment of papulopustular rosacea. Epsolay utilizes a patented technology process to encapsulate benzoyl peroxide within silica microcapsules to create a barrier between the medication and the skin. The slow migration of medication from the microcapsules delivers treatment doses onto the skin, while the barrier reduces the ability of benzoyl peroxide to induce the strong oxidation process that can result in significant skin irritation, such as erythema, burning and stinging. Silica is chemically inert, photochemically and physically stable, and is safely used in topical products. If approved, Epsolay has the potential to be the first FDA-approved single-active benzoyl peroxide prescription drug product.
About Papulopustular Rosacea
Papulopustular rosacea is a chronic and recurrent inflammatory skin disorder that affects nearly 5 million Americans. The condition is common, especially in fair-skinned people of Celtic and northern European heritage. Onset is usually after age 30 and typically begins as flushing and subtle redness on the cheeks, nose, chin or forehead. If left untreated, rosacea can slowly worsen over time. As the condition progresses the redness becomes more persistent, blood vessels become visible and pimples often appear. Other symptoms may include burning, stinging, dry skin, plaques and skin thickening.
Twyneo is an investigational, antibiotic-free, fixed-dose combination of encapsulated benzoyl peroxide, 3%, and encapsulated tretinoin, 0.1%, cream for the treatment of acne vulgaris. If approved, it will be the first acne treatment that contains a fixed-dose combination of benzoyl peroxide and tretinoin, which are separately encapsulated in silica using Sol-Gel proprietary microencapsulation technology. Tretinoin and benzoyl peroxide are widely believed to be highly effective as a combination treatment for acne; however, benzoyl peroxide causes degradation of the tretinoin molecule, thereby reducing its effectiveness. The silica microcapsule protects tretinoin from oxidative decomposition by benzoyl peroxide, thereby enhancing the stability of the active drug ingredients. The silica shell also allows for an extended drug delivery time and creates a barrier between the drug substances and the skin, which may reduce the irritation typically associated with topical application of benzoyl peroxide and tretinoin on acne-affected skin.
About Acne Vulgaris
Acne vulgaris is a common multifactorial skin disease that according to the American Academy of Dermatology affects approximately 40 to 50 million people in the United States. The disease occurs most frequently during childhood and adolescence (affecting 80% to 85% of all adolescents) but it may also appear in adults. Acne patients suffer from the appearance of lesions on areas of the body with a large concentration of oil glands, such as the face, chest, neck and back. These lesions can be inflamed (papules, pustules, nodules) or non-inflamed (comedones). Acne can have a profound effect on the quality of life of those suffering from the disease. In addition to carrying a substantial risk of permanent facial scarring, the appearance of lesions may cause psychological strain, social withdrawal and lowered self-esteem.
This press release contains “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995. All statements contained in this press release that do not relate to matters of historical fact should be considered forward-looking statements, including, but not limited to, statements regarding the progress of our product candidates, the timing of the submission of an NDA for Epsolay and an NDA for Twyneo, and the Company’s expectations regarding its liquidity and ability to fund operational and capital expenditure requirements. These forward-looking statements include information about possible or assumed future results of our business, financial condition, results of operations, liquidity, plans and objectives. In some cases, you can identify forward-looking statements by terminology such as “believe,” “may,” “estimate,” “continue,” “anticipate,” “intend,” “should,” “plan,” “expect,” “predict,” “potential,” or the negative of these terms or other similar expressions. Forward-looking statements are based on information we have when those statements are made or our management’s current expectation and are subject to risks and uncertainties that could cause actual performance or results to differ materially from those expressed in or suggested by the forward-looking statements. Important factors that could cause such differences include, but are not limited to, risks relating to the effects of COVID-19 (coronavirus), the timing of a launch of a branded tapinarof product and the launch of a branded topical roflumilast in the U.S., risks related to the timing of the submission of an NDA for Epsolay and an NDA for Twyneo as well as the following factors: (i) the adequacy of our financial and other resources, particularly in light of our history of recurring losses and the uncertainty regarding the adequacy of our liquidity to pursue our complete business objectives; (ii) our ability to complete the development of our product candidates; (iii) our ability to find suitable co-development partners; (iv) our ability to obtain and maintain regulatory approvals for our product candidates in our target markets and the possibility of adverse regulatory or legal actions relating to our product candidates even if regulatory approval is obtained; (v) our ability to commercialize our pharmaceutical product candidates; (vi) our ability to obtain and maintain adequate protection of our intellectual property; (vii) our ability to manufacture our product candidates in commercial quantities, at an adequate quality or at an acceptable cost; (viii) our ability to establish adequate sales, marketing and distribution channels; (ix) acceptance of our product candidates by healthcare professionals and patients; (x) the possibility that we may face third-party claims of intellectual property infringement; (xi) the timing and results of clinical trials that we may conduct or that our competitors and others may conduct relating to our or their products; (xii) intense competition in our industry, with competitors having substantially greater financial, technological, research and development, regulatory and clinical, manufacturing, marketing and sales, distribution and personnel resources than we do; (xiii) potential product liability claims; (xiv) potential adverse federal, state and local government regulation in the United States, Europe or Israel; and (xv) loss or retirement of key executives and research scientists. These and other important factors discussed in the Company's Annual Report on Form 20-F filed with the Securities and Exchange Commission (“SEC”) on March 24 , 2020 and our other reports filed with the SEC could cause actual results to differ materially from those indicated by the forward-looking statements made in this press release. Any such forward-looking statements represent management’s estimates as of the date of this press release. Except as required by law, we undertake no obligation to update publicly any forward-looking statements after the date of this press release to conform these statements.
SOL-GEL TECHNOLOGIES LTD.
CONSOLIDATED BALANCE SHEETS
(U.S. dollars in thousands, except share and per share data)
|December 31,||March 31,|
|A s s e t s|
|Cash and cash equivalents||$||9,412||$||2,199|
|Receivables from collaborative arrangements||4,120||3,594|
|Prepaid expenses and other current assets||1,293||863|
|TOTAL CURRENT ASSETS||55,791||70,618|
|Restricted long-term deposits||472||1,268|
|Property and equipment, net||2,314||2,363|
|Operating lease right-of-use assets||2,040||1,904|
|Funds in respect of employee rights upon retirement||684||663|
|TOTAL NON-CURRENT ASSETS||5,510||6,198|
|Liabilities and shareholders' equity|
|Other accounts payable||4,123||4,972|
|Current maturities of operating leases||672||525|
|TOTAL CURRENT LIABILITIES||6,505||7,423|
|LONG-TERM LIABILITIES -|
|Operating leases liabilities||1,373||1,315|
|Liability for employee rights upon retirement||958||946|
|TOTAL LONG-TERM LIABILITIES||2,331||2,261|
|Ordinary Shares, NIS 0.1 par value – authorized: 50,000,000 as of December 31, 2019 and March 31, 2020; issued and outstanding: 20,402,800 and 22,514,488 as of December 31, 2019 and March 31, 2020, respectively.||561||622|
|Additional paid-in capital||203,977||225,693|
|TOTAL SHAREHOLDERS' EQUITY||52,465||67,132|
|TOTAL LIABILITIES AND SHAREHOLDERS' EQUITY||$||61,303||$||76,816|
SOL-GEL TECHNOLOGIES LTD.
CONSOLIDATED STATEMENTS OF OPERATIONS
(U.S. dollars in thousands, except share and per share data)
|Three months ended|
|Research and Development||10,793||7,930|
|General and Administrative||1,694||2,761|
|TOTAL OPERATING LOSS||$||6,129||$||7,226|
|FINANCIAL INCOME, net||(401||)||(116||)|
|LOSS BEFORE INCOME TAXES||$||5,728||$||7,110|
|LOSS FOR THE PERIOD||$||5,728||$||7,110|
|BASIC AND DILUTED LOSS PER ORDINARY SHARE||$||0.30||$||0.33|
|WEIGHTED AVERAGE NUMBER OF SHARES OUTSTANDING USED IN COMPUTATION OF BASIC AND DILUTED LOSS PER SHARE||18,949,968||21,361,514|
For further information, please contact:
Chief Financial Officer
Source: Sol-Gel Technologies Ltd.

domain: economics


text:
Re: (OT) Storage (8*IDE HDs) any experiences? - diodes
> > > at these extremes... the diodes wont help....and the dioes will simply
> > > burn up due to the current it has to pass to get to that "voltage"
> > > one side being a diode drop ( 0.7v ) across itself..
> > > - a power mosfet is better suited ...
> hmm, mosfet doesn't make sense to me - IIRC they only work like switches
> I think you should use "Shotkey-diods" the largest one i know could pass
> 200 ampere - and they've less than ~0.4V voltage drop
Mosfets are a kind of transistors with less loss of energy than a bipoar
type. I agree that the only thing you could use is a shottky diode, the drop
is about 0.1-0.2 Volts, I think; therefore it won't produce so much heat and
maybe you won't even need any heatsinks for them. But I think it is
generally not a good thing to reduce the supply voltage by 0.2 Volts this
way, because computers are very sensitive to voltage changes... If there
will be a high load for only a short time, the voltage maybe drops down the
specs and your components are down.

domain: physics


FEMA Disaster Recovery Center opens in Jefferson City
JEFFERSON CITY - FEMA opened the doors of a new Disaster Recovery Center in Cole County over the weekend.
Victims of tornado and flooding damaged in counties declared damaged by FEMA are eligible to apply for federal aid.
People will have the chance to meet face to face with FEMA employees to see if they're eligible for aid, check the status of applications, and meet with other organizations that can provide aid.
Representatives from the U.S. Small Business Administration are also on site to give details on low-interest loans it can provide in addition to insurance benefits and FEMA aid.
FEMA Media Relations Specialist Nikki Gaskins said the purpose isn't to get victims houses back to their pre-damage conditions, rather supplement their costs to get people back into livable homes.
"It really is a team effort here," Gaskins said. "We're just one piece of the puzzle working with the state, and other municipalities within the state to get people on the road to recovery."
Gaskins said FEMA has provided about $2.5 million in grant money directly to providers impacted by tornados and flooding to date.
According to a press release, FEMA-declared counties include: Andrew, Atchison, Boone, Buchanan, Carroll, Chariton, Cole, Greene, Holt, Jackson, Jasper, Lafayette, Lincoln, Livingston, Miller, Mississippi, New Madrid, Osage, Pemiscot, Perry, Pike, Platte, Pulaski, Ray, St. Charles, and St. Genevieve.
The center is open 8 a.m. to 7 p.m. daily at the Cole County/Jefferson City Office of Emergency Management, 1736 Southridge Drive.


text:
World Mental Health Day is celebrated around the globe every year on October 10. It is a day for mental health education, awareness and advocacy against social stigma.
Those who have been going through depression or other mental health illnesses know this is a winding road with lots of ups and downs. Often this is a solo journey with a lack of support as those who suffer are silent.
Mental health issues do not discriminate; They can impact anyone no matter age, skin colour, income or social status and this is why a Watford businessman has decided to speak out about suicide following his brother's death. Amandip Sidhu's brother was a doctor who committed suicide in 2018.
Amandip Sidhu's brother, Jagdip, was a doctor who committed suicide in 2018. Talking about his brother, Amandip said: “Jagdip outwardly had everything one would aspire to but was slowly crushed by the demands of the workplace.
“He didn’t tell anyone because he was afraid of letting his patients and colleagues down. The system he worked so hard and cared for didn’t look after him.
“You would think health professionals would be less vulnerable because of their training but they are among the worst affected professions by suicide.”
Following his brother death, Amandip Sidhu has decided to raise awareness and help others. Amandip set up Doctors in Distress whose goals include campaigning for greater awareness of the pressures facing doctors and encouraging more compassionate and supportive workplaces.
If doctors look after patients, then who is looking after the doctors? It is a question Amandip Sidhu turned over in his mind following the suicide of his brother.
Amandip first realised something was wrong when, without warning, Jagdip announced that his workplace had signed him off work with stress. He thinks his brother may have misinterpreted this as a punitive measure threatening a 25-year career in which he had never took a day off sick.
Amandip added: “I went to see him that weekend and he was a different person from the calm dependable brother I knew. His hands were shaking, he was close to tears and looked completely drained. It never crossed my mind that he would do anything to harm himself.
“He couldn’t get any perspective on what had happened or see that he wasn’t to blame. We’re all human at the end of the day but doctors seem to think they have to be more than that.”
Amandip received an email several days later from Jagdip asking that his younger brother help his wife put his affairs in order. Jagdip’s body was found later the same day.
“I couldn’t believe it," Amandip said. "I went home on autopilot and woke crying in the middle of the night. I had to break the news to my mum the next day which was the hardest thing to do.
“One thing we agreed on was to be open about what happened. It can happen to anyone and we wanted to ensure others learnt from this and prevent future tragedies. There is still a lot of stigma around suicide when what we need is to talk about it more.”
Don't suffer in silence
You don't have to suffer in silence if you're struggling with your mental health. Here are some groups you can contact when you need help.
Samaritans: Phone 116 123, 24 hours a day, or email firstname.lastname@example.org, in confidence
Childline: Phone 0800 1111. Calls are free and won't show up on your bill
PAPYRUS: A voluntary organisation supporting suicidal teens and young adults. Phone 0800 068 4141
Depression Alliance: A charity for people with depression. No helpline but offers useful resources and links to other information
Students Against Depression: A website for students who are depressed, have low mood, or are suicidal. Click here to visit
Bullying UK: A website for both children and adults affected by bullying. Click here
Campaign Against Living Miserably (CALM): For young men who are feeling unhappy. There is a helpline: 0800 58 58 58 or visit the website
Amandip was determined no-one else was put in a similar position and made contact with Dame Clare Gerada, an advocate for doctors’ health, who ran a support group for bereaved medics’ families who had died suddenly or by suicide. He invited Clare to help steer Doctors in Distress and she subsequently became Chair of the trustees’ board.
The response to the charity’s work has been overwhelmingly positive and Amandip recently attended a memorial tree planting ceremony at Ealing Hospital in memory of all health professionals who have died by suicide. It was a poignant event for Amandip whose brother started his career at Ealing.
He added: “It was a step in the right direction but a lot remains to be done because this is a systemic problem. We need a properly resourced and staffed health service along with genuine support and compassionate leadership for doctors who feel they are struggling to cope.”
For more information, see doctors-in-distress.org.uk.


New Delhi [India], June 1 (ANI): The Supreme Court on Wednesday quashed the proceedings before National Green Tribunal (NGT) which halted the construction work at Rushikonda Hills in Visakhapatnam, Andhra Pradesh.
A bench of Justices BR Gavai and Hima Kohli said that orders of the High Court would prevail over NGT in case of contradicting orders passed by the High Court and the green tribunal.
“The contradicting orders of the High Court and the National Green Tribunal would leave to an anomalous situation, as authorities wouldn’t know which order to follow. In such a case, orders of the Constitutional Court would prevail over orders of the Tribunal,” the bench said.
The apex court was hearing a plea of the State of Andhra Pradesh against orders of the NGT which halted the construction works at Rushikonda Hills in Visakhapatnam as part of a tourism project.
It observed that it wasn’t appropriate on part of NGT to continue proceedings before it specifically when it was pointed out that the High court was seized of the matter and had passed orders.
The top court said that the continuation of proceedings before NGT when the High Court is seized of the same issue will not be in the interest of justice, hence it directed the parties to approach the High Court for appropriate orders.
The bench also observed that though development is necessary for the economic development of the nation, it is equally necessary to safeguard the environment to preserve a pollution-free environment for future generations.
It directed that until the High Court takes a fresh call on the issue of construction, the construction will be permitted only in the flat areas, the area where construction existed earlier and was later demolished. It clarified that until the High Court considers the issue, no construction will be carried out on an area excavated from the hills.
The NGT had passed the order on a letter written to it by MP K Raghu Ramakrishna Raju, alleging violation of CRZ norms by the project.
The NGT’s order came even as Andhra Pradesh High Court in December allowed the work to go on as the State claimed to have received all statutory clearances. (ANI)


text:
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