It was another day of bullhorn diplomacy by Iran's top nuclear officials, who appear to be struggling to halt momentum for a new round of international sanctions. The head of Iran's atomic energy agency, Ali Akbar Salehi, began the day by calling IAEA chief Yukiya Amano "biased."
Salehi added that Iran hopes that Amano will change his approach.
The remarks coincide with a meeting of the IAEA board in Vienna, which began Monday, in which Amano complained that Tehran "has not provided the agency with the necessary cooperation," and that he could "not confirm that all nuclear material in Iran is [being used] in peaceful activities."
Amano's report to the IAEA board also stressed that Tehran may be working to develop a nuclear warhead, and its recent decision to enrich uranium to the 20-percent level could, in theory, give it the material needed to produce an atomic bomb.
Iran has repeatedly insisted that its nuclear program is intended for peaceful civilian purposes, but the West suspects it is covertly working to produce nuclear weapons.
Iran's Ambassador to the IAEA, Ali Asgar Soltaniyah, added his voice to the diplomatic debate Tuesday, insisting Iran has been cooperating in good faith with the IAEA.
"We have fully cooperated in the context of the comprehensive safeguards," he said. "Mr. Amano not only in his opening statement today but also in the press conference he also confirmed that there has been full cooperation by Iran, and the [IAEA] has been able to continue its verification activities in Iran for the declared nuclear material as we said, but [you should not] expect us to go beyond our legal obligations."
Soltaniyah said Tehran does not consider U.N. Security Council resolutions over its nuclear program to be "legitimate," and that it would not conform to them.
Iran missed an international deadline at the end of January to accept a U.N. draft nuclear deal to exchange close to 70% of it stockpile of low-grade uranium for more highly enriched uranium from France and Russia. It has been making contradictory statements about the deal for weeks.
Royal Military College of Canada political science teacher Houchang Hassan-yari says Iranian officials are trying to create confusion in order to buy time:
"Salehi, sometimes Soltaniyeh, Larijani, Ahmadinejad, Muttaqi and others say they are ready to negotiate, they are ready to transfer their enriched uranium to Russia and then they refuse to do it," he noted. "So, I think the Iranian regime uses different personalities inside the system, using different language for the same purpose. The purpose is buying time not to fulfill their responsibility by answering very clearly the resolutions passed by the IAEA board of governors, but also by the U.N. Security Council. So, they were successful to this point. Nobody is talking about the resolutions passed by the U.N. Security Council and they are forgotten. So, the Iranians are very, very good in creating a new quasi-crisis in order to force the other side to forget the previous step."
Hassan-yari notes the only point at which he thinks the Iranian regime will conform to the demands of the United Nations is when it feels its existence is threatened.


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Teddy Bear Puppies For Sale In Wayland Iowa
Teddy bear puppies for sale in iowa.
Teddy bear puppies for sale in wayland iowa. This page displays 10 zuchon dog classified listings in wayland, iowa, usa. Breeders might not be regularly. Page 1 contains zuchon puppies for sale listings in wayland, iowa, usa.
Hello, if you are searching for teddy bear puppies in the state of iowa then you are the right place. He loves toys and playing games. Her sire and dam are pictured here.
Storm is a cute male bichon frise. Expected may 15th, 2021, this litter of f1 mini bernedoodles for sale will be ready to go home july 10th, 2021! Current vaccines and worming, health guarantee male $1300.00 female $1500.00.
Is your family ready to buy a zuchon dog in wayland, iowa, usa? Some of the iowa, ia cities that we plan to include puppies for sale and rescue organizations are listed below. We are also a member of the iowa pet breeders association and the pet professionals of southeast iowa.
I am a licensed, professional dog breeder with decades of experience in raising quality puppies for qualified families. He is going to be a bigger sheltie at. Small breeder of shichon shihpoo.
You will find a comprehensive list of all the breeder that are located in your state. Looking for a dog breeder in iowa? If you are located in this state and would like to be listed in our breeder and rescue directory please contact me.
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domain: pet


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Two more persons were tested COVID-19 positive in Guwahati on May 16.
Assam Health Minister Himanta Biswa Sarma informed that the two new cases were related to the Fancy Bazaar cases which led to a spike in number of cases in Guwahati in the last few days.
“2 more persons, related to Aloo Godam case, test #COVID19 positive in Guwahati,” the minister tweeted.
Sixteen cases have already been detected from the Fancy Bazaar area in the last few days, with the Kamrup Metro district administration declaring many areas as containment zone.
With this, the number of positive cases in the state went up to 91, of which 41 people recovered, and 46 are active cases. Assam reported two COVID-19 related deaths while two cases migrated to other states.

domain: topicality


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Webteam: March 2017
Tuesday March 14th. Isaiah 53. 3-7
He was despised and rejected by men, a man of sorrows, and familiar with suffering. Like one from whom men hide their faces he was despised, and we esteemed him not. Surely he took up our infirmities and carried our sorrows, yet we considered him stricken by God, smitten by him and afflicted. But he was pierced for our transgressions, he was crushed for our iniquities; the punishment that brought us peace was upon him, and by his wounds we are healed. We all, like sheep, have gone astray, each of us has turned to his own way, and the Lord has laid on him the iniquity of us all. He was oppressed and afflicted, ye he did not open his mouth; he was led like a lamb to the slaughter, and as a sheep before her shearers is silent, so he did not open his mouth
Well known words, and it's hard not to start singing, (Handel had a lot to answer for!). But we know that crucifixion was a horrible and cruel death. Artists of the crucifixion often show a Jesus either looking very serene, or even smiling. Can't think that's how it really was. Rather a human body tortured and abused beyond recognition. Isaiah understands that the one to come, the Messiah was not going to have an easy time, but the reason for the suffering was not because of HIS wrongdoing, but the wrong doing of humankind. And by bearing the pain, the abuse, silently, HE could take on all the sin of the world, and by doing that it enabled a fallen humanity to be reconciled with a perfect creator God.
Lord God, thank you that in the kingdom of Heaven there is enough love to enable us to be a part of it, in the past, in the now and in the future. Thank you that Jesus made it possible.
Heather Garbutt Allhallowgate, Ripon
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domain: christianity


Telangana used an algorithm to build 360-degree profiles of citizens and decide whether they were eligible for state's welfare. The profiles were faulty. As a result, subsidised food was denied to thousands of poor. The state government knew of the blunder, but did not fix it. The Collective’s member Tapasya travelled to the state to understand how states are using artificial intelligence in an unintelligent way, at the cost of citizens. They report along with Kumar Sambhav and Divij Joshi. The story was produced with support from the Pulitzer Center’s AI Accountability Network.


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Mail purchase brides will be the excellent alternative for those, who have in search of real love in international lands nevertheless do not have time or perhaps money to get married at this time there. For them, thinking about finding a life partner outside their own country can be exhilarating. When trying to find your life partner internationally, you should know one or two things. This will help you avoid the heartbreak and frustration that may arise if you choose an unacceptable mail buy brides.
First of all, you should know that many of these ship order wedding brides come from Vietnam, a country that is affected with dangerous terrorists and also other criminal elements. Therefore , it usually is wise to shell out some money and time in selection the prospects published here to make certain that you will be marrying a trustworthy person. There are many Japanese women who have been successfully committed to international men via Vietnam. So , it is possible, even though unlikely, that might be the type of female who would always be acceptable for you as a life-long mate.
Second, the success rate for these marriages with international men by Vietnam is not very superior. The reasons because of this are similar to those that account for the failure of all marriage alliances. Many men out of this country might lack esteem for the ladies they marry, they may be under pressure from their native country to wed a Western man, or they could want to escape from an unsatisfied marriage. Also if you successfully discover some Japanese girls that are interested in getting married to foreign men, you can find still an excellent chance that things do not ever work out. Therefore it’s very crucial to spend several quality time researching the lifestyle of Vietnam before considering a marriage with one of its mail order birdes-to-be.
Third, even if you do get deliver order birdes-to-be from Vietnam, you still should be aware of the dangers associated with this kind of marriage. Before getting married to a foreign girl, you should spend plenty of time observing her and the country. You need to know both her native dialect and the traditions she was raised in. You must spend time on it’s own together every day so that you can develop a rapport prior to introducing the foreign bride-to-be into your home. In case you fail to produce a good impression on her, you might risk her rejecting you when you make an effort to introduce her to your family and friends.
It is also vital that you remember that the ladies from Korea are often fewer conservative compared to the women supply by china manufacturer. In addition , most of the foreign birdes-to-be from Korea come from countries with cultures similar to our personal. In fact , a large number of foreign men whom choose to get -mail order birdes-to-be from Korea are actually out of Philippines. A few Filipina girls will be honest about needing to marry a foreign man who may have an excellent work and a superb income. Although other Philippine girls may be looking for the enjoyment of achieving a man right from a different way of life at least for a short period of time.
Something else to think about when it comes to becoming all mail order brides to be is the possibility of operating outside of the usa. There are persons from foreign countries such as Latin America, India, and Mexico who are looking for American men to marry. There are even several companies who will support foreign brides to be in picking prospective husbands from throughout the Atlantic area. Some all mail order brides to be will even visit these countries to meet all their future partners. Of course , you really sure that you can obtain along with any husbands you do discover!
One of the risks associated with marrying a foreign star of the wedding is that she may not have all of the basic domestic requirements that would let you fully trust her. This can include such things as health insurance and access to a great abroad hospital. The moment dealing with any kind of mail buy brides from foreign countries, it is critical that you just thoroughly check out their backdrops before signing at the bottom line. It will be very helpful to with regional law enforcement companies or the consular departments belonging to the American Légation in the country in which the -mail order wedding brides wish to marry. They can provide valuable info regarding the home-based laws of this country when the foreign star of the event may be residing.
While the previously discussed risks are risks that one must consider when considering becoming all mail order brides to be, the benefits also are many. For instance , many people have found absolutely adore and joy after they betrothed a foreign bride. Some people experience even achieve success for making a living by simply setting up their businesses in the new nation in which they live. Therefore , while there a few risks to the type of marital relationship, there are also a large number of rewards. Therefore , if you are taking into consideration the possibility of getting married to a foreign national, consider your options cautiously and consider the likely rewards that you could experience.

domain: relationship


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Radio observations from astronomical sources like supernovae became one the most important sources of information about the physical properties of those objects. However, such radio observations are affected by various types of noise such as those from sky, background, receiver, and the system itself. Therefore, it is essential to eliminate or reduce these undesired noise from the signals in order to ensure accurate measurements and analysis of radio observations. One of the most commonly used methods for reducing the noise is to use a noise calibrator. In this study, the 3-m Baghdad University Radio Telescope (BURT) has been used to observe crab nebula with and without using a calibration unit in order to investigate its impact on the signal. Radio observations of crab nebula have been carried out for different periods in 2022. Several parameters of the telescope have been calculated and analyzed using statistical measurements with and without using the noise calibration unit. Those parameters are receiver gain, system temperature, antenna temperature, and degree per flux unit. The results of this research revealed that the fluctuation sensitivity of BURT improved by about an order of magnitude, when the noise calibration unit is used. The root mean square error and the radiometer equation of the antenna temperature decreased to less than 33% and 10%, respectively in comparison to their initial values. In conclusion, the noise calibration unit plays a crucial role to improve the sensitivity of a radio telescope drastically.
Jallod, Uday E.; Ali, Lana T.; Mahdi, Hareth S.; and Abood, Kamal M.
"Improving the BURT’s Sensitivity using Noise Calibration Unit via Crab Nebula Observations,"
Karbala International Journal of Modern Science: Vol. 9
, Article 9.
Available at: https://doi.org/10.33640/2405-609X.3306
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

domain: astronomy


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5 Tips about twin projects You Can Use TodayMildew and condensation issues come about when the relative humidity is simply too significant. Relative humidity is the
In architecture, functionalism is definitely the theory that structures should be built based only over the intent and performance of your creating.
How functional house designs can Save You Time, Stress, and Money.
Within the mid-1930s, functionalism began to be reviewed being an aesthetic technique as an alternative to a make any difference of structure integrity (use). The thought of functionalism was conflated with insufficient ornamentation, that is a unique issue.
If upgrading the insulation within an existing residence, an awesome location to start may be the attic place. Attics tend to be exactly where a great deal of heat is staying misplaced, so upgrading the attic insulation can frequently create a massive big difference in the Power expenses, especially in the colder seasons.
The 2-Minute Rule for projects of energy-efficient houses
The intent is to lessen property Electrical power use as Price-correctly as feasible, and afterwards fulfill the diminished needs with on-web page renewable Strength methods. To find out more about the details of creating and developing an extremely-successful house, go to Making The united states Assets for Electrical power-Productive Properties.
In its Simatic output facility in Amberg , Germany, Siemens is already applying an extensive documentation and evaluation program and has attained an especially small error charge in output.
twin projects Things To Know Before You Buy
A number of the typical features are flat roofing, stuccoed partitions, architectural glazing and effectively-lit rooms, an industrial expression and nautical impressed specifics, together with spherical Home windows.[three] The global inventory market place crisis and economic meltdown in 1929, instigated the must use cost-effective materials, including brick and concrete, and to construct immediately and proficiently. These demands turned One more signature of the Nordic version of functionalist architecture, in particular in buildings from your 1930s, and carried in excess of into modernist architecture when industrial serial creation grew to become a lot more commonplace just after Environment War II.
Start out! Use this Device to check out how your home's Strength use steps up when compared to similar properties
The first Norwegian zero-energy houses constructed from ecological components in Hurdal in close proximity to Oslo. The houses are already created from building and finishing products that have ecolabels and its photo voltaic panels produce as much electric power as the inhabitants of its apartments consume.
That is a game changer to the countless displaced folks throughout the world and also in Pakistan, with above twenty million homeless persons.
New Step by Step Map For twin projects
Electronic Twin platforms are getting to be a significant technologies to capital undertaking delivery and supply Improved predictability and efficiency all over the asset lifecycle, from venture progress, execution and functions.
We’re back again! It’s been quite a while considering that we’ve manufactured twin lens reflex cameras, but we’re happy to introduce you to the most recent version towards the Rolleiflex Digital camera family members.
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It is gentleman and read more machine”.four Systems such as Digital Twin platforms, AI, discipline automation and predictive analytics and cloud-dependent collaborative venture progress platforms will adjust how we operate And just how leadership helps make selections. "Initial movers" in Engineering and Design will establish new profits streams, establish shopper intimacy and travel standardization and process efficiencies, even though cutting down the total put in expense of offering projects and operating People belongings on these platforms.

domain: design


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Catalogue Number: KTP3004-ABK
Fig. Western blot of specific proteins fraction using Abbkine ExKine™ Total Membrane Protein Extraction Kit. Sample: 293T cells lysate. H: hydrophilic phase extraction was analyzed using Na+/K+-ATPase Antibody. M: Membrane protein extraction was analyzed using Na+/K+-ATPase Antibody.
|Type:||Protein Extraction Kit|
|Shipping Condition:||Blue Ice|
|Unit(s):||200 T, 50 T|
Description: The preparation of an extract from membrane is often the first step in studying membrane proteins and their interactions. The resulting preparation can be used directly in Western blotting, Dot blot, Immunoprecipitation, or as a starting point for the purification of specific proteins.
Abbkine ExKine™ Total Membrane Protein Extraction Kit provides a simple, rapid and reproducible method to extract total membrane proteins.

domain: chemistry


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Dr. Amjad Safvi has spent more than 15 years in the medical field focusing on vascular issues, particularly varicose and spider veins. He now oversees Advanced Vein Treatment & Cosmetic Center, where he and his caring staff treat patients to complimentary consultations before administering laser, radio-frequency, and sclerotherapy vein treatments along with a host of other aesthetic treatments. The facility’s laser collection, the high-tech cherry on its med-spa sundae, allows the staff to showcase hair-removal, anti-aging, and facial-rejuvenation treatments that round out a crowded roster that includes SkinMedica chemical peels, Botox injections, and fillers that can last up to five years.
Once clients are comfortably ensconced in the dentist's chair, the oral exam begins. The resident toothsperts will check each individual incisor, cuspid, bicuspid, and molar for chips, cracks, staining, and loitering Minnesota Twins, ensuring that enamel bones are sound for biting, and gums and soft tissues will be inspected for any signs of periodontal disease. The x-ray battery exposes the roots and inner sanctums of oral stalagmites to reveal any soft spots, problem areas, or cavities. When your mouth checks out as mammalian and your teeth are cleared for takeoff, the professional teeth cleaning begins. An expert cleaning removes all the buildup and surface staining that regular brushing and flossing can't—hardened tartar, hard-to-reach plaque, and bacterial graffiti along the gum line.
With hundreds of locations across the country, Right Dental Group represents a collection of oral-healthcare professionals who deliver a variety of quality dental services. The collective places an emphasis on relationship building—meaning patients can confess their most egregious toffee-apple trespasses while receiving a teeth scrubbing delivered with precision and understanding. Each of the dentists is prescreened for a consistent record of excellence and the ability to efficiently locate a cavity in a toothstack. A skilled doctor and staff will skillfully probe forgotten mouth corners, eradicating tartar and expunging plaque from bacterial lairs. The included x-rays will help uncover any oral problem areas that cannot be seen with the shamelessly naked eye. After treatment, clients will be privy to tips that explain the proper brushing and flossing techniques to ward off gum disease and tooth loss, ensuring tongue-stoppers remain firmly rooted to the rest of the skeletal system.
Before Dr. Gibson became a devout dentist and was on the advisory board for the American Academy of Cosmetic Dentistry (AACD), she was crowned Mrs. USA for 2005–2006, named a Miss Hawaiian Tropic world finalist (1997), and awarded a slew of other impressive accolades. Dr. Arnold is on the Advisory Board for the Academy of Comprehensive Esthetics (ACE). Let Dr. Gibson or Dr. Arnold and their skilled staff of tooth-buffers, who always put patients' needs first, brighten your smile an average of eight shades with a quick, safe Zoom! whitening procedure. Your chompers will be glazed with Zoom!'s proprietary whitening gel before the low-heat Zoom! light activates the gel's stain-busting powers, breaking apart age-old coffee, cigarette, or coffee and cigarette stains. When the treatment is finished (up to four sessions for a total of 60–75 minutes), your teeth will look youthful and naturally clean.
The offices of Grand Dental Group dazzle smiles with cosmetic and general dentistry performed by an experienced and upbeat staff that includes Dr. Mark Kaschube, who practices at the Channahon office and moonlights as a professional magician, and music-loving Dr. Steve Napier. During the comprehensive dental exam, a tooth technician inspects enamel and gums, deftly maneuvering sterile instruments to detect signs of cavities, gum disease, and molar mutiny. A technician then captures candid snapshots of canoodling incisors and bicuspids with bitewing x-rays, which help the skilled staff pinpoint subsurface decay and root out deep-seated signs of gum disease. Enamel illuminates after a dental detailer scours chompers with a comprehensive cleaning to purge plaque.

domain: health


Lab-Grown diamonds are chemically, optically and physically identical to earth-mined diamonds.
Lab-Grown diamonds are priced up to 40%-60% less
Lab-Grown diamonds are free of any environmental or humanitarian concerns.
Explore our in-stock Lab Grown Diamond Collection
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Lab-Grown diamonds (also called lab created, man made, or cultured diamonds) are chemically, optically and physically identical to earth mined diamonds, but are more ethical, beautiful and affordable than any diamond we will ever get out of the earth. We're replicating the earth's natural process by crystallizing carbon in a modern-day lab environment into brilliant diamonds that are priced up to 40% less, and are free of any environmental or humanitarian concerns.
Are lab created diamonds real?
Yes! Lab created diamonds are real diamonds, identical in every way (but the price!) to mined diamonds. Not to be confused with cubic zirconia, moissanite, or a "look-a-like" diamond, lab grown diamonds are 100% pure crystallized carbon. Think of it as making ice in your modern-day freezer versus getting it from a glacier; both are frozen H2O regardless of the origin. Labs crystalizing carbon into stunning rough diamonds that are then cut, polished and graded just like earth mined diamonds. Lab created carry the same optical, physical and chemical properties. They have the same refractive index, dispersion, and hardness, and are graded to the same standards as mined diamonds by leading independent gemological institutes
How much are lab created diamonds?
On average, Diamond Shoal Jewelers lab-grown diamonds are priced 30-50% less than an equivalent quality earth mined diamond. However, just like with mined diamonds, prices will vary based on the diamond’s 4C’s – cut, clarity, color, and carat.
The difference in price is because our supply chain is so much shorter. Earth mined diamonds can travel to 5 countries and touch 20 hands before it reaches the end consumer, but our lab created diamonds go from lab, to our casting house, to you.
To give you an example of pricing, a 1.0 ct Round Cut Laboratory Grown Diamond, H/VS1 is approximately $2,500 versus an equivalent mined diamond priced at approximately $5,000 or higher. Now you can get engaged, plus pay for your wedding and go on a honeymoon without starting your life together in debt. That’s the way it should be!


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“On the Spot” backs members of Culture on the Edge into a corner to talk about their backgrounds, their ongoing work, and what might be gained by an alternative understanding of how identity works.
1. When people ask what you study, what do you tell them?
I tell them that I study religious people. I say this instead of “religion” because I want to emphasize that there is no religion without people behind the enterprise. That may seem a truism, to some, but since our field still engages so readily with talking about all sorts of disembodied religious traditions — i.e., differentiating between “Christianity” and the “Christians” who practice it — I think this is a really important distinction that places the emphasis back on human behavior. This explanation also helps with the task of clarifying that I’m not involved in some sort of ministry or theological pursuit, which is a presumption that most of us get when asked this question.
2. How do questions of identity manifest in your research?
My research up to this point in time has dealt largely with how various American conservative Christian entities re-negotiate their identities within a religious framework in order to secure certain social outcomes. More specifically, I’ve been looking at how evangelicals use religious ideas for particular ends within the American political system. I think the most important takeaway from this research has been that the identities and other types of portrayals that evangelicals make for themselves and others shift substantially as the political winds dictate, all while claiming no such shifting at all (in the name of eternality or god’s will). Instead of calling this hypocrisy or some sort of failure to live out “authentic values,” as is often the rhetoric from those on the left, I just see this as the normal mechanics of a social group. Everyone does it, in other words, because social groups are always looking to secure their own legitimacy, and when the social conditions change dramatically, so will, at times, their own identities. Continue reading “On the Spot with Leslie Dorrough Smith”
Is prayer always a form of supplication, intercession, or thanksgiving? Or can it serve other functions?
Screenshot from YouTube
From the Pennsylvania Capital Star:
“A first-year member of the Pennsylvania House on Monday offered a prayer laden with political and Christian imagery shortly before the swearing in of the chamber’s first Muslim woman. Rep. Stephanie Borowicz, R-Clinton, said “Jesus” 13 times, “God” six times, and “Lord” four times, as Raging Chicken Press writer Sean Kitchen first noted on Twitter. She also expressed thanks to God that President Donald Trump “stands besides Israel” in a rambling, nearly two minute prayer. “Jesus, you are our only hope,” Borowicz said during the prayer. Borowicz delivered the prayer shortly before Movita Johnson-Harrell — the first Muslim woman elected to the General Assembly — was sworn in.”
See the full video here.
During the Super Bowl, RAM Trucks debuted a controversial truck commercial splicing images of Americana with a sermon excerpt from slain Civil Rights leader, Dr. Martin Luther King, Jr.
After outrage gave way to discourse, cultural critics were quick to point to the irony of Dodge’s signification. In the originating sermon, “The Drum Major’s Instinct,” King critiques self-interested pursuits that hinder people’s ability to see the value in others. He literally calls out Americans who ride in expensive “Chrysler” vehicles for the ego trip. NB: FiatChrysler Automobiles is the parent company of RAM.
To make the point, the left-leaning magazine Current Affairs re-edited the commercial with an audio excerpt from the same sermon that they believe to be more indicative of King’s message. Continue reading “On Kings and Trump Cards”
With a conference in Baltimore followed immediately by a national Fall harvest festival where many of our members live (American Thanksgiving, that is), well, we figured that a brief hiatus is necessary while some of us eat, catch-up on email, and reshuffle the alphabet for more posts from the Edge in the future. Continue reading “We’ll Be Right Back…”
With all-American Fourth of July festivities like fireworks, frankfurters, and hamburgers, we continually construct our identification with an imagined community, as Benedict Anderson emphasized thirty years ago. Like the nation, the values that we associate with the United States, (e.g., democracy, equality, and liberty) are imagined constructs whose conceptions shift over time.
The United States is a nation of immigrants with the Statue of Liberty welcoming the “huddled masses” one of those frequently invoked traits. Beyond questions over the place of Native Americans in the nation of immigrants and contemporary debates over “immigration reform” and “border security,” the recent court case involving a yoga program in the Encinitas, California, public schools (which I have discussed previously here and here) illustrates the imagined nature of this national trait in a surprising way. Continue reading “All-American Fireworks, Hamburgers, Frankfurters and Yoga”

domain: philosophy


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Mevalonate kinase deficiency
|Mevalonate kinase deficiency|
|Other names||Mevalonic aciduria and Hyper immunoglobin D syndrome (HIDS)|
|A patient with mevalonate kinase deficiency at the age of 21 months, displaying characteristic craniofacial features.|
|Specialty||Hematology, neurology, immunology, medical genetics, endocrinology|
It is characterized by an elevated level of immunoglobin D in the blood.
The enzyme is involved in biosynthesis of cholesterols and isoprenoids. The enzyme is necessary for the conversion of mevalonate to mevalonate-5-phosphate in the presence of Mg2+ [Harper's biochemistry manual]. Mevalonate kinase deficiency causes the accumulation of mevalonate in urine and hence the activity of the enzyme is again reduced Mevalonate kinase deficiency. It was first described as HIDS in 1984.
Mevalonate kinase deficiency is inherited in an autosomal recessive manner, meaning that a child must inherit a defective copy of the gene from both parents to be affected. It is an example of a loss-of-function mutation. The gene which codes for mevalonate kinase consists of 10 exons at locus 12q14. About 63 pathological sequence variations in the gene have been characterized. The most common of these are V377I, I268T, H20P/N and P167L, present in 70% of affected individuals.
Immunoglobulin D (IgD) is a protein produced by a certain type of white blood cells. There are five classes of Immunoglobin like IgG, IgA and IgM, IgE and IgD. They play an important role in the immune system. The function of IgD is still unclear.
There is a relationship between MKD and the interleukin 1beta (IL-Iβ). There is an increased IL-1β secretion and mevalonate kinase deficiency in MKD is most likely mediated by defective protein prenylation (Prenylation refers to addition of hydrophobic residues to proteins) ] and non-sterol isoprenoids, such as farnesyl pyrophosphate (FPP) or geranylgeranyl pyrophosphate (GGPP) are coupled to a target protein, which affects the activity and the cellular location. In a human monocytic MKD model it was found that the deficiency of GGPP leads to overproduction of IL-1β and defective prenylation of RhoA. This causes an increased level of Rac1 and PKB which was affecting the GTPases and B7-Glycoproteins. It was earlier found that Rac1/PI3K/PKB pathway had been linked to the pathogenesis of MKD. The inactivation of RhoA acts an inducer of IL-1β mRNA transcription independent of NLRP3- or caspase-1 activity. Due to defective RhoA there is a formation of defective mitochondria (elongated and instable) in the cell. If a defective mitochondria it is cleared in the cell by the mechanism of autophagia. But, in MKD the clearance of defective mitochondria from the cytosol is disrupted. As a result, the mitochondrial DNA starts accumulating in the cytosol which binds and activates NLRP3 which is responsible for the production of IL-1β. The activation can be direct or indirect. It can also be activated by reactive oxygen species (ROS). It is known that monocytes and macrophages also produce higher levels of tumor necrosis factor alpha (TNF-α), interleukin 6(IL-6) other than IL-Iβ  During the febrile (fever) attacks and during the attacks the C - reactive protein (CRP) also increases. The CRP is released by liver which causes inflammation.
Hyperimmunoglobulinemia D with recurrent fever is a periodic fever syndrome originally described in 1984 by the internist Jos van der Meer, then at Leiden University Medical Centre. No more than 300 cases have been described worldwide. It is now recognised as an allelic variant of MKD.
Signs and symptoms
HIDS is one of a number of periodic fever syndromes. It is characterised by attacks of fever, arthralgia, skin lesions including cyclical mouth ulcers, and diarrhea. Laboratory features include an acute phase response (elevated CRP and ESR) and markedly elevated IgD (and often IgA), although cases with normal IgD have been described.
Virtually all people with the syndrome have mutations in the gene for mevalonate kinase, which is part of the HMG-CoA reductase pathway, an important cellular metabolic pathway. Indeed, similar fever attacks (but normal IgD) have been described in patients with mevalonic aciduria – an inborn error of metabolism now seen as a severe form of HIDS.
It is not known how mevalonate kinase mutations cause the febrile episodes, although it is presumed that other products of the cholesterol biosynthesis pathway, the prenylation chains (geranylgeraniol and farnesol) might play a role.
Mevalonate kinase deficiency causes an accumulation of mevalonic acid in the urine, resulting from insufficient activity of the enzyme mevalonate kinase (ATP:mevalonate 5-phosphotransferase; EC 220.127.116.11).
The disorder was first described in 1985.
Classified as an inborn error of metabolism, mevalonate kinase deficiency usually results in developmental delay, hypotonia, anemia, hepatosplenomegaly, various dysmorphic features, mental retardation, an overall failure to thrive and several other features.
There is no treatment for MKD. But, the inflammation and the other effects can be reduced to a certain extent.
- IL-1 targeting drugs can be used to reduce the effects of the disorder. Anakinra is antagonist to IL-1 receptors. Anakinra binds the IL-1 receptor, preventing the actions of both IL-1α and IL-1β, and it has been proved to reduce the clinical and biochemical inflammation in MKD. It can effectively decreases the frequency as well as the severity of inflammatory attacks when used on a daily basis. Disadvantages with the usage of this drug are occurrence of painful injection site reaction and as the drug is discontinued in the near future the febrile attacks start. (Examined in a 12-year-old patient).
- Canakinumab is a long acting monoclonal antibody which is directed against IL-1β has shown to be effective in reducing both frequency and severity in patients suffering from mild and severe MKD in case reports and observational case series. It reduces the physiological effects but the biochemical parameter still remain elevated (Galeotti et al. demonstrated that it is more effective than anakinra –considered 6 patients suffering from MKD).
- Anti-TNF therapy might be effective in MKD, but the effect is mostly partial and therapy failure and clinical deterioration have been described frequently in patients on infliximab or etanercept. A beneficial effect of human monoclonal anti-TNFα antibody adalimumab was seen in a small number of MKD patients.
- Most MKD patients are benefited by anti-IL-1 therapy. However, anti-IL-1-resistant disease may also occur. Example. tocilizumab (a humanized monoclonal antibody against the interleukin-6 (IL-6) receptor). This drug is used when the patients are unresponsive towards Anakinra. (Shendi et al. treated a young woman in whom anakinra was ineffective with tocilizumab). It was found that it was effective in reducing the biochemical and clinical inflammation .Stoffels et al. observed reduction of frequency and severity of the inflammatory attacks, although after several months of treatment one of these two patients persistently showed mild inflammatory symptoms in the absence of biochemical inflammatory markers.
- A beneficial effect of hematopoietic stem cell transplantation can be used in severe mevalonate kinase deficiency conditions (Improvement of cerebral myelinisation on MRI after allogenic stem cell transplantation was observed in one girl). But, liver transplantation did not influence febrile attacks in this patient.
Treatment for HIDS
Canakinumab has been approved for treatment of HIDS and has shown to be effective. The immunosuppressant drugs etanercept and anakinra have also shown to be effective. Statin drugs might decrease the level of mevalonate and are presently being investigated. A recent single case report highlighted bisphosphonates as a potential therapeutic option.
In the world less than 1 in 1.00.000 have HIDS . 200 individuals throughout the world do suffer from MVK.
- Online Mendelian Inheritance in Man (OMIM) 251170
- "Mevalonate kinase deficiency".
- Mancini J, Philip N, Chabrol B, Divry P, Rolland MO, Pinsard N (May–Jun 1993). "Mevalonic aciduria in 3 siblings: a new recognizable metabolic encephalopathy". Pediatr. Neurol. 9 (3): 243–246. doi:10.1016/0887-8994(93)90095-T. PMID 8352861.
- Background information, HIDS.net, retrieved 28 August 2016
- "Mevalonate Kinase Deficiency".
- Mulders-Manders, CM; Simon, A (2015). "Hyper-IgD syndrome/mevalonate kinase deficiency: what is new?". Semin Immunopathol. 37 (4): 371–6. doi:10.1007/s00281-015-0492-6. PMC 4491100. PMID 25990874.
- van der Meer JW, Vossen JM, Radl J, et al. (May 1984). "Hyperimmunoglobulinaemia D and periodic fever: a new syndrome". Lancet. 1 (8386): 1087–90. doi:10.1016/S0140-6736(84)92505-4. PMID 6144826.
- "OMIM Entry - * 251170 - MEVALONATE KINASE; MVK". omim.org.
- Drenth JP, van der Meer JW (December 2001). "Hereditary periodic fever". N. Engl. J. Med. 345 (24): 1748–57. doi:10.1056/NEJMra010200. PMID 11742050.
- Drenth JP, Cuisset L, Grateau G, et al. (June 1999). "Mutations in the gene encoding mevalonate kinase cause hyper-IgD and periodic fever syndrome. International Hyper-IgD Study Group". Nat. Genet. 22 (2): 178–81. doi:10.1038/9696. PMID 10369262.
- Houten SM, Kuis W, Duran M, et al. (June 1999). "Mutations in MVK, encoding mevalonate kinase, cause hyperimmunoglobulinaemia D and periodic fever syndrome". Nat. Genet. 22 (2): 175–7. doi:10.1038/9691. PMID 10369261.
- Bretón Martínez JR, Cánovas Martínez A, Casaña Pérez S, Escribá Alepuz J, Giménez Vázquez F (Oct 2007). "Mevalonic aciduria: report of two cases". J. Inherit. Metab. Dis. 30 (5): 829. doi:10.1007/s10545-007-0618-7. PMID 17578678.
- Berger R, Smit GP, Schierbeek H, Bijsterveld K, le Coultre R (Oct 1985). "Mevalonic aciduria: an inborn error of cholesterol biosynthesis?". Clin. Chim. Acta. 152 (1–2): 219–222. doi:10.1016/0009-8981(85)90195-0. PMID 4053401.
- Aróstegui, JI; Anton, J.; Calvo, I.; Robles, A.; Speziale, A.; Joubert, Y.; Junge, G.; Yagüe, J. (2015-01-01). "Long-term efficacy and safety of Canakinumab in active Hyper-IgD syndrome (HIDS): results from an open-label study". Pediatric Rheumatology. 13 (1): O58. doi:10.1186/1546-0096-13-S1-O58. ISSN 1546-0096. PMC 4596954.
- Kozlova, A.; Mamzerova, E.; Maschan, A.; Shcherbina, A. (2014-06-01). "AB0918 Efficacy and Safety of Treatment of Children with Traps and Hids with IL1 Blocker (CANAKINUMAB)". Annals of the Rheumatic Diseases. 73 (Suppl 2): 1103–1104. doi:10.1136/annrheumdis-2014-eular.3697. ISSN 0003-4967.
- Takada, Kazuki; Aksentijevich, Ivona; Mahadevan, Vijayabhanu; Dean, Jane A.; Kelley, Richard I.; Kastner, Daniel L. (2003-09-01). "Favorable preliminary experience with etanercept in two patients with the hyperimmunoglobulinemia D and periodic fever syndrome". Arthritis and Rheumatism. 48 (9): 2645–2651. doi:10.1002/art.11218. ISSN 0004-3591. PMID 13130485.
- Rigante D, Ansuini V, Bertoni B, et al. (November 2006). "Treatment with anakinra in the hyperimmunoglobulinemia D/periodic fever syndrome". Rheumatol. Int. 27 (1): 97–100. doi:10.1007/s00296-006-0164-x. PMID 16871408.
- Cantarini, L; Vitale, A; Magnotti, F; Lucherini, O. M.; Caso, F; Frediani, B; Galeazzi, M; Rigante, D (2013). "Weekly oral alendronate in mevalonate kinase deficiency". Orphanet Journal of Rare Diseases. 8: 196. doi:10.1186/1750-1172-8-196. PMC 3880037. PMID 24360083.

domain: biology


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Cost of living in Vec-Liepaja, Latvia compared to Allahabad, India
WARNING! This comparison is based on only a few data points. At this point it is only a guess. It is based on 108 prices entered by 6 different people.
These prices were last updated on June 22, 2017. Exchange rate: 72.075 INR / EUR
Do you live in Allahabad? We need your help!
What do you think about this comparison?
Cost of living in Vec-Liepaja (Latvia) is 11% more expensive than in Allahabad (India)
For example, you would need at least ₨78,475 (€1,089) in Vec-Liepaja to maintain the same standard of living that you can have with ₨71,000 in Allahabad.
Recent Prices Added
- Monthly rent - 900 sqft furnished accommodation in expensive area in Omaha, Nebraska costs $1,017 (6 minutes ago)
- Public transport in Singapore costs SGD $77 (about 1 hour ago)
- Monthly rent - 900 sqft furnished accommodation in expensive area in Delhi costs ₨30,495 (about 2 hours ago)
- Internet connection 300 mbps, 1 month in Shanghai costs 元150 (about 2 hours ago)
- Public transport in Hyderabad costs ₨32 (about 2 hours ago)
- Monthly rent - 85 m2 furnished accommodation in expensive area in Heidelberg costs €1,818 (about 2 hours ago)

domain: travel


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In 1960, Mr. Robert Huck ran and operated the Blennerhassett Hotel. One of our most famous guests to have stayed at the hotel, at this time period was a young senator from Massachusetts, Senator John F. Kennedy. While running for the presidency in 1960, it was crucial to win West Virginia’s electoral vote. Kennedy toured through West Virginia in the spring of 1960, coming through Parkersburg on two different occasions in May of 1960.
Both times that he was in Parkersburg, Kennedy stayed at the Blennerhassett Hotel. On one of his trips to Parkersburg, his brothers Ted and Bobby stayed at The Blennerhassett, as well. A banquet luncheon was also held here at the Blennerhassett Hotel in his honor. Senator Kennedy stayed in suite 216 at the Blennerhassett Hotel, which at the time in 1960 was our largest guest suite, and was located on the second floor, on the fourth street side of the building.
Discover More History! Click one of the links below to explore more about the history at The Blennerhassett Hotel & Spa!
Click below for hotel photos and newspaper clippings over the decades! If you have any additional images or clippings not listed here, we’d love to have a copy! Please email email@example.com.


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Diabetes Gettysburg Address..(thought about it when I read this.)
Four score and four years ago, our Canadian brethren brought forth, on this continent, a new medication, conceived in ingenuity, and dedicated to the novel idea that billions should not die.
Now, we are engaged in a great global war of chronic disease- testing whether, a group of diabetics, we can long endure. (With toes and teeth intact) We are met on a battlefield of that war- the field of research. We have come to dedicate a portion of ourselves, to eradication of that dread disease, that sucked the last breath from their dying lips. It is altogether proper that we should do this.
But, in a larger sense, we cannot dedicate-we cannot consecrate- we cannot ever do enough. The brave individuals, living and dead, who have struggled (and continue to struggle) consecrate it far beyond our poor power to add or detract. Rather, it is for us, the living, to be dedicated to this last remaining task- that from these pitied dead we take increased devotion toward ending diabetes- that we here resolve that these dead shall not have died in vain, that this planet shall have a new birth of freedom, and that this disease, of, for, and by the people- shall rapidly perish from this earth.
Have a great 4th, everyone. We enjoy so many freedoms, and the "life" (in the life,liberty, and the pursuit of happiness) part is a biggie(one that PWD's, prior to insulin, did not have).


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In the latest episode Frameline, Barbara Goslawski and I tsat down with filmmaker Ngardy Conteh George to discuss her latest documentary Mr. Jane and Finch. Over the course of our conversation George explains what makes activist Winston LaRose such a fascinating individual, an unconventional election and much more. We also take a few minutes to discuss the five documentaries in the Best Documentary Feature category at this year’s Academy Awards.
If you missed the episode when it aired live, you can find the recording on iTunes, Google Play, Soundcloud or listen to it on the Frameline website via the link below:
Frameline: Ngardy Conteh George on Mr. Jane and Finch
Published by Courtney Small
The founder of Cinema Axis, Courtney is a Rotten Tomatoes approved critic who can frequently be heard discussing film as co-host of Frameline on Radio Regent. Courtney has contributed to several publications including Leonard Maltin, That Shelf, POV Magazine, In the Seats, Black Girl Nerds, and Comix Asylum. He has appeared on ET Canada and Hollywood Suite's Cinema A to Z. Courtney celebrates diversity in cinema as host of the Changing Reels podcast and is a member of the Toronto Film Critics Association, the Online Film Critics Society, and the African American Film Critics Association.
View all posts by Courtney Small

domain: movie


What is 4G?
4G is short for '4th Generation', the latest evolution of mobile technology. It's about giving you faster download speeds and a better overall mobile internet experience
With 4G, you’ll be able to:
- Experience amazing picture quality when watching HD movies and YouTube clips on–the-go, with less buffering.
- Stream your favourite music and share files, more quickly.
- Make video calls that feel more realistic.
- Enjoy better real-time gaming.
4G won't replace the existing 3G network - it will enhance it. If you've got a 4G compatible device, you'll be able to access our entire 3G network and 4G network.
PHONES AND MODEMS
See our coverage map to check coverage in your area.
4G MOBILE BROADBAND MODEMS


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Benign Tumors Of The Cervix
Endocervical polyps are the most common benign neoplasms of the cervix. Please note that the word neoplasm refers to a cancerous growth. They are focal hyperplastic (abnormal cell growth) protrusions of the endocervical folds, including the epithelium and substantia propria. They are most common in the fourth to sixth decades of life and usually are asymptomatic but may cause profuse leukorrhea or postcoital spotting. (blood after orgasm)
Grossly, they appear as typical polypoid structures protruding from the cervical os. At times, endometrial polyps protrude through the cervical os. They cannot be distinguished from endocervical polyps by gross appearance. Microscopically, a variety of histologic patterns are observed, including (1) typical endocervical mucosal (2) inflammatory (granulation tissue) (3) fibrous (4) vascular (5) pseudodecidual (6) mixed endocervical and endometrial (7) pseudosarcomatous.
Treatment is removal, which can usually be accomplished by twisting the polyp with a dressing forceps if the pedicle is slender. Smaller polyps may be removed with punch biopsy forceps. Polyps with a thick stalk may require surgical removal.
Microglandular hyperplasia Microglandular hyperplasia refers to a clinically polypoid growth measuring 1-2 cm. It occurs most often in women who are on oral contraceptive therapy or Depo-Provera and in pregnant or postpartum women. It reflects the influence of progesterone. Microscopically, it consists of tightly packed glandular or tubular units, which vary in size, lined by a flattened-to-cuboidal epithelium with eosinophilic granular cytoplasm containing small quantities of mucin. Nuclei are uniform, and mitotic figures are rare. Squamous metaplasia and reserve cell hyperplasia are common. An atypical form of hyperplasia can be mistaken for clear cell carcinoma. Unlike clear cell carcinoma, it lacks stromal invasion, has scant mitotic activity, and lacks intracellular glycogen
Squamous papilloma Squamous papilloma is a benign solid tumor typically located on the ectocervix. It arises most commonly as a result of inflammation or trauma. Grossly, the tumors are usually small, measuring 2-5 mm in diameter. Microscopically, the surface epithelium may show acanthosis, parakeratosis, and hyperkeratosis. The stroma has increased vascularity and a chronic inflammatory infiltrate. Treatment is removal. The squamous papilloma resembles a typical condyloma acuminatum but lacks the koilocytes microscopically.
Smooth muscle tumors (leiomyomas) These benign neoplasms may originate in the cervix and account for approximately 8% of all uterine smooth muscle tumors. They are similar to tumors in the fundus. When located in the cervix, they usually are small, ie, 5-10 mm in diameter. Symptoms depend on size and location. Microscopically, leiomyomas resemble the typical smooth muscle tumor found in the uterine corpus. Treatment is required only for those patients who are symptomatic. The cervical leiomyoma is usually part of the spectrum of uterine smooth muscle tumors.
Mesonephric duct remnants When present, mesonephric duct remnants are typically located at the 3-o'clock and the 9-o'clock positions, deep within the cervical stroma. They usually are incidental findings and are present in approximately 15-20% of serially sectioned cervices. As the name implies, mesonephric duct remnants are vestiges of the mesonephric or Wolffian duct. Usually, they are only a few millimeters in diameter and seldom are grossly visible. Microscopically, they consist of a proliferation of small round tubules lined by epithelium that is cuboidal to low columnar. The tubules tend to cluster around a central duct. The cells lining the tubules contain no glycogen or mucin, but the center of the tubule may contain a pink material that contains glycogen or mucin.
Endometriosis When present in the cervix, endometriosis is usually an incidental finding. Grossly, it may appear as a bluish-red or bluish-black lesion, typically 1-3 mm in diameter. Microscopically, the implants are typical endometriosis, consisting of endometrial glands, endometrial stroma, and hemosiderin-laden macrophages. The implants usually gain access to the cervix during childbirth or previous surgery.
Papillary adenofibroma This neoplasm is uncommon. Grossly, it appears as a polypoid structure. Microscopically, the neoplasm contains branching clefts and papillary excrescences lined by mucinous epithelium with foci of squamous metaplasia. A compact, cellular, fibrous tissue composed of spindle-shaped and stellate fibroblasts supports the epithelium. The stroma is devoid of smooth muscle, and mitoses are rare. Similar growths occur in the endometrium and the fallopian tubes.
Heterologous tissue Heterologous tissue includes cartilage, glia, and skin with appendages. This type of tumor rarely occurs in the cervix. While they may arise de novo, these tumors probably represent implants of fetal tissue from a previous aborted pregnancy. Hemangiomas Hemangiomas in the cervix are rare in occurence and are similar to those found elsewhere in the body.
Gregory Mburu us a medical professional and a part time marketr. He post information about breast cancer and other gynaecological neoplastic disorders at http://breast-cancer-information.blogspot.com/
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What is Going On With Pharmacies in Canada
There is a large amount of talk lately in regard to Canadian pharmacies, and why not? pharmacies in Canada provide the same identical perscription drugs you would find at the local pharmacy, deliver to your front door, and most importantly, save you some cash. But not all pharmacies are the same.
Toenail Fungus: Treatment and Prevention
A thick, yellowish nail with splotchy white areas is a classic presentation for a fungal toenail. In the early stages the toenail is only slightly discolored, or slightly thickened.
Naturopathic Medicine is an holistic approach that relies on natural remedies. Sunlight, air, and water are thought of as natural healers; this, along with nutritional supplements and massage therapies are all part of naturopathic medicine.
Ativan Side Effects Lawyer
The drug Lorazepan is marketed under the names Alzapam, Ativan, Loraz, Lorazepam, Intensol. Ativan is the safest form of this type of drug because it has less of an effect on the liver than other benzodiazepines, which means that a patient can take it in conjunction with other liver affecting medications like birth control pills, anti-abuse drugs, propranolol, and ulcer medications.
Medical Billing PDA: 21st Century Convenience for Medical Practices
Medical Billing PDAOne of the first things I notice about a medical office, whether it be with my dentist, my family doctor, or my optometrist, is the walls full of color-coded files containing medical histories, billing information, and tracking information for prescriptions check ups and various other things. As a patient, it is fun to trace the colored tags across the files and wonder what they mean.
Curing Lou Gehrigs Disease
ALS is the disease that took the life of the famed baseball player. The disease benched Lou Gehrig from the game that he loved and later took his life.
Stevens Johnson Syndrome (SJS) is a severe and deadly allergic reaction to certain drugs, some proscription and some over the counter, which causes the severe burning of skin and mucosal membranes from the inside out. 15% of people who develop Stevens Johnson Syndrome will die as a direct result.
Dr. Will Horsley, M.D.
Dr. Horsley is Cornea fellowship trained and Lasik board certified by the American Board of Eye Surgeons, (http://www.
I Hurt All Over... How to Ease Away the Pain of Fibromyalgia!
At one moment, a life of activity consumed with enjoyable activities like biking, golfing, going to the movies, out to dinner. Then one day, it's gone.
The Cox-2 Prescription Painkillers Are Back?
This past week, the FDA held a meeting in order to decide what should be done about Merck's Vioxx and Pfizer's Bextra and Celebrex. The Food and Drug Administration originally intended to ban these pain medications.
How You Can Erase Low Back Pain Using the Latest Medical Techniques!
"If you're one the nine out of ten adults in the United States who suffers from low back pain, I have good news for you!" states Dr. Nathan Wei, a board-certified rheumatologist and Clinical Director of the Arthritis and Osteoporosis Center of Maryland.
Bextra Recall: Lawyer Says Help Is On The Way
By now, you have probably heard of the prescription drug Bextra. You may not know, however, why that a recall is in order.
Powerful Arthritis Pain Relief For All Of Us
When you ask what arthritis is, professinals will tell you it's inflammation of one or more joints. But you know it better as pain, swelling, stiffness, deformity, and/or a diminished range of motion of those joints! It's estimated that over 50 million Americans suffer from osteoarthritis, rheumatoid arthritis and other related conditions.
Irritable Bowel Syndrome: Simple Self-Help Tips
If you have been diagnosed with irritable bowel syndrome (IBS), you will know how difficult it is to treat. Doctors can be dismissive of IBS symptoms such as diarrhea, constipation and bloating, and when treatment is offered it may only help for a short while before the distressing symptoms return.
Over The Counter Pain Medication: How To Choose The Right Drugs
With the recent front-page news about the possible hazards of pain medications, you may be taking a look at your over-the-counter (or OTC) pain medications with a wary eye. While all drugs, including those you don't need a prescription for, can be dangerous, some basic knowledge can help you avoid the pitfalls for the pain relief you need.
The Highway to Health - Bumped Heads
I recently had a reader send me this comment:"As a full-time dad I have to deal with just about every minor illness my two children pickup, everything from a bump on the head to chicken pox. I found the Highway to Health ebook very useful and it's one of the first things I reach for when something goes wrong!"Mr John Bradbury United KingdomIt got me thinking - although the Highway to Health does cover headaches, perhaps going into a little more detail about 'bumps on the head' would be useful.
Increase Your Risk of Heart Disease With Lipitor and Pravachol
Results of a new study comparing the effectiveness of Pfizer Inc.,'s Lipitor with Pravachol, made by Bristol-Myers Squibb, was recently published in the New York Times.
"It's a chemical imbalance." I've heard those words so many times in the last decade, it's becoming routine for Doctors to blame everything on it.
Clinton on South Beach Diet
Clinton's recent quadruple bypass surgery has been largely debated. Being on the South Beach Diet made everybody wonder how the former president's illness advanced so much as to need to be surgically corrected.
The P Value And Its Significance
When diversifying an investment portfolio, one needs to consider investing in the healthcare industries. Pharmaceutical companies that have strong pipelines of investigation drugs have strong growth speculations.
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Gender, Leadership, and Crisis: A Framing Analysis of Sally Mason's Presidency of the University of Iowa
Texas State University, Center for Diversity and Gender Studies
This textual analysis of a gendered media framing process addresses news coverage of Sally Mason, who was inaugurated as president of the University of Iowa in 2007. The coverage analyzed here focuses on two crises which Mason faced shortly after taking office: The alleged multiple sexual assault in 2007 of a female student-athlete by two male student-athletes and the flooding of the Iowa campus in 2008. In examining the related news texts of the city's principal newspaper, the Press-Citizen, the authors have engaged in a critical inquiry into the ways in which reportorial routines reproduce the cultural-historical themes of patriarchy. Their analysis of the divergent directions of these two frames assigned to Mason and her leadership style– one negative in the sexual assault case and one positive in the later flood– are explained based on Reese's (2008) framing process model of reification, transmission, and naturalization.
gender, leadership, Mason, Sally, higher education, University of Iowa
Barnes, E., & Durham, F. (2011). Gender, leadership, and crisis: A framing analysis of Sally Mason's presidency of the University of Iowa. <i>Journal of Research on Women and Gender, 2</i>(1), pp. 83-110.

domain: sociology


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The Exo Terra Moss Ball helps provide crystal clear water and reduce odours.
Designed to resemble its natural counterpart, the Exo Terra Moss Ball contains a special absorption resin that helps reduce many of the compounds that encourage unsightly organic matter accumulation.
By absorbing and trapping phosphate, nitrite and nitrate within its core, the Exo Terra Moss Ball helps to create ideal conditions for animals and plants.
Key Features :
- Traps phosphate, nitrite and nitrate
- Easy and effective deodorizer
- Reduces organic matter accumulation
- Effective for up to 2 months
- Treats 30-60 litre enclosures


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It’s a hard job and can be quite confusing. It’s a really important choice. How can you know you made the ideal choice until it is too late?
Here’s a manual for you to search for the ideal toronto wedding photographer wedding photographer to the wedding day. This is something which you will need to do early on your listing.
1. Decide what your budget is to this most significant part your wedding day. You do not need to break the bank to receive a good photographer, but you really do need to have some concept of just how much you’ll spend with it. You do not wish to leave the job of capturing your memories of the day to a amateur. It’s probably among the biggest regrets you’ll have if it isn’t done correctly.
2. Is it important to the wedding photographer for you to the capitol building and shoot images, or would you like a photo on a dock overlooking the lake, or are you going to need a photo shoot Olbrich Gardens? It’s crucial to ask your photographer whenever they could accommodate these images which you’ve dreamed of getting on your wedding album.
3. Look on the sites of the Madison wedding photographers which you like to restrict your search. Examine the galleries of previous pictures to determine if you enjoy what they’ve done. Learn as much info as possible on their site.
4. What are their costs? What will they comprise for this cost? Can you receive the rights to the pictures or are you going to want to pay individually for each picture? Looking at their website may provide you many replies, but could also lead one to ask better questions.
5. Produce a brief list. This is a time consuming, however, crucial step.
6. Call those in your list and establish a time to meet up together. Remember that this will most likely have to get performed on a week because their weekends are often filled taking photos of different weddings. Insist on meeting together where you are able to see what type of equipment they’ll use as well as some other pictures. Do not just sit in a coffee shop and allow them to spoon feed you exactly what they would like you to understand. A lot of people are able to let you know exactly what you would like to this, but the evidence is in the images.
7. Have a look at the equipment they’ll be using to take your wedding photographs. Ask them to let you know about it. In the event the gear resembles something you may see a news photographer or anything on the sidelines of a Badger football game, you then realize they have the equipment is necessary to find quality pictures.
8. Watch what they have done along with different weddings and also what other couples do which could be like the things which you wish to do. Do they have some creative suggestions that will improve your experience? This dialog will provide you a fantastic idea about how they will work together with you in your wedding day. Are you familiar with them? Can they have some decent ideas? Most Madison wedding photographers may take the conventional images, but will they catch the emotion of the day along with the shots you did not expect. Go over the time they’ll have to do the presented shots. Would you take the photos before or after the service together with all the relatives as well as the posed shots in the church? Is it significant for the groom to not see you ahead of the service or is it even more important your guest do not wait too long prior to the reception? You’ll have to organize your reception and occasions to present your photographer sufficient time to acquire the fantastic wedding photos you desire.
9. Ensure that you are clear on what their providers comprise. You don’t wish to be amazed that they’re not about to catch the reception since you didn’t know the “bundle” that you pick.
10. Be ready to put the deposit down. Your Madison wedding photographer will devote that day to you in their calendar and will ask you to just put down a portion of this fee beforehand. This ought to come alongside a contract which outlines the arrangement you have made.
For an global award winning professional photographer with more than 14 decades of experience, have a look at this site for the very best Wedding Photography www.avangardphoto.com/images/video.mpg

domain: photo


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As of this morning, the crypto market cap has skyrocketed to a brand new all-time high, topping $3 Million!
The overall crypto market value increased by 3.1% in this morning’s Asian trading session due to the positive market momentum, where the market cap topped $3 million at the time of publication.
During the past week, the overall market cap has climbed by 8.4%, and during the last month, it has risen by 25.5%. The market value was $775 billion on the 1st of January of 2021, and now it has surged by a staggering 284%.
Crypto Market Cap: $3 Trillion
— CoinGecko (@coingecko) November 8, 2021
Data from CompaniesMarketCap suggest that Microsoft, the world’s biggest company with a market cap of $2.5 trillion is now in the rearview mirror of cryptocurrency markets, having already surpassed it. Nonetheless, there are still milestones to be reached seeing as the current market cap value is merely a fourth of the $11.5 trillion market capitalization of Gold.
Bitcoin (BTC) has a market capitalization of $1.12 trillion and a market share of 41.3 %, having incurred an increase of 6.9%. These stats amount to the same as Tesla more or less, but still below the Silver market cap which stands at $ 1.36 million.
Ethereum (ETH) is also quite successful having passed JPMorgan Chase’s $496 billion market cap and topping $560 billion.
At present, Binance Coin (BNB) has a market capitalization of $107 billion, making it the 3rd largest cryptocurrency.
The 24-hour trading volume has amounted to a phenomenal $138 billion, the total of the March 2019 market capitalization of the crypto market.
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Also read: Ripple CTO, David Schwartz, is bullish on the future of NFTs

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At Settings > Client Portal > Domain URL there is an option to optionally configure a separate client portal domain. But unfortunately there is nothing in the documentation about this option.
- How do I need to enter the domain?
- What DNS settings are needed? I guess an A-Record to the IP address of the INv5 server. Or is a CNAME record needed?
- Does this require settings to the NGINX configuration?
Any help is much appreciated.


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i started playing this game in 2008 when i was 9 years old & i've gone through various accounts over those years, now i'm 21, still using this account & still play this game from time to time.
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Fierce Dragon in Training
A few weeks ago, Katherine asked me if I wanted to go the the butterfly pavilion with her. Since I love that place, I agreed. This weekend was the first weekend that we both had time to go together. Since I wasn't going there with someone who wasn't into photography, I wasn't expecting to take very many shots, but I got in more than I thought I was going to. I ended up taking about 150 photos during our 1.5 hour trip.


In 1892, John H. Froehlich, Froehlich, IA, Mounted A Gasoline Fueled Internal Combustion Engine On A Traction Geared Frame And Used It To Power A Threshing Machine. A Change In Power Source Had Begun On North American Farms. In 1892, The Case Co., Racine, Wi, Built An Experimental Gas Traction Engine. In 1898 A Patent Was Issued To The Van Duzen Co. Cincinnati, OH, For A Gasoline Traction Engine. Huber Mnfg., Marion, Oh, Bought This Patent In 1898 And Produced 30 Prototype Units. In 1902, Hart-Parr, Founded By Charles W. Hart And Charles H.
Society: ASABEMain Category: Agricultural & BiologicalSub Category: VehiclesEra: 1890-1899DateCreated: 1892Floyd County MuseumCharles CityState: IAZip: 50616Country: USAWebsite: https://www.asabe.org/awards-landmarks/asabe-historic-landmarks/internal-combustion-tractor-35.aspxCreator: Froehlich, John H.
YearAdded:Image Credit: Courtesy WikiCommons/RifeIdeas (CC BY-SA 3.0)
Society: ASMEMain Category: Mechanical, RoadSub Category: Road TransportationEra: 1910-1919DateCreated: 1910Lumberman's MuseumPattenState: MEZip: 04765Country: USAWebsite: http://www.asme.org/about-asme/history/landmarks/topics-m-z/road-and-off-road-transportation/-79-lombard-steam-log-hauler-%281910%29Creator: Lombard, Alvin
This steam crawler-tractor emancipated horses from the killing work of hauling trains of sleds over iced roads in the winter woods of the United States and Canada. Designed, patented (1901), and built by Alvin C. Lombard (1856-1937) of Waterville, Maine, eighty-three "Lombards" were the first practical examples of the often-tried lag or crawler tread that would become the mark of the internal combustion engine-driven agricultural and construction equipment and military tank in current use.
YearAdded:Image Credit: Courtesy Flickr/cliff1066,Era_date_from: 1910
Society: ASMEMain Category: MechanicalSub Category: Water TransportationEra: 1900-1909DateCreated: 1909Outboard Marine CorpMilwaukeeState: WIZip: 53218Country: USAWebsite: http://www.asme.org/about-asme/history/landmarks/topics-m-z/water-transportation/-65-evinrude-outboard-motor-%281909%29Creator: Evinrude, Ole
This outboard motor, designed and built by Ole Evinrude (1877-1934) at the Evinrude Motor Company in Milwaukee, Wisconsin, was quickly accepted by the boating public of the United States. Bess Evinrude called the prototype a "coffee grinder," but it moved a boat through water better than the huge steam- or foot-driven motors available in 1907. She encouraged him to build and sell ten, then twenty, soon resulting in the redirection of their automotive equipment business to outboard motors.
YearAdded:Image Credit: Courtesy Flickr/Mr. T in DC (CC BY-ND 2.0)Era_date_from: 1909


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Due to its geological framework, Rukwa Region is endowed with abundant mineral deposits of different kinds including precious metals, base metals, other metals, gemstones, industrial minerals, and building materials. Table 11 shows the types of minerals and the locations where they may be found:
Table 11 Minerals of Rukwa and their locations
Although sulphur is not being mentioned, there are indications of the mineral being available in Sumbawanga Municipal area.
Hard rocks and sand are plentiful for building materials..
Except for the quantity of coal which is estimated to be 18 million metric tons, there are is no information on approximate quantities of the other various minerals in the region.
The mineral exploration and prospecting activities that have been done in the region is very minimal. Large numbers of the mineral occurrences are still unevaluated.
There are about 90 Prospecting Licences (PLs) held by different companies in the region but only 4 PLs are being worked actively. There are 30 valid Primary Prospecting Licenses (PPLs) for prospecting various kinds of minerals in the region. These small scale mineral prospectors help a lot to discover new occurrences of minerals and sometimes result into a mineral rush.
Rukwa Region has only one large scale mineral right. This Mining Licence is for gold located at Singililwa southeast of Mpanda. The licence number is ML 43/99 property of Kapufi Gold Mining limited. The company stopped production since 2002 due to technical reasons related to economic mining.
There are 205 valid Primary Mining Licenses for small scale miners in Rukwa Region. The licenses are for different types of minerals which are gold, lead, gemstones, coal and building materials. Sumbawanga District has 93 PMLs, Mpanda District 92 PMLs and Nkasi District 20 PMLs. A large number of these licenses are not active due to lack of capital for operating them.
Large scale coal mining has started in Sumbawanga rural district. A company named Upendo Group Ltd operating from Sumbawanga ventured in coal mining from 2004. It is currently extracting and supplying to consumers about 500 tons of coal per month. The firm has identified possible markets for a total of 6,000 tons per month but has not been able to supply the same due to i) inadequate operating equipment, and ii) poor road conditions making transportation of the coal to the markets very expensive.
Upendo Group is in the process of securing a bank loan for investing in the coal mining and its plans include producing coal of different qualities for industrial and domestic use.
Presence of favorable policies/acts and regulations (The Mineral Policy (1997), Mining act (1998) and Mining Regulations (1999)
Lack of Capital
Lack of Technology
Lack of Environmental Management Knowledge
Lack of knowledge about HIV/AIDS
Lack of Information about Minerals
Natural forests reserves totaling 20 in number occupy 43% of the region much of them being in Mpanda district. Table 7 shows the areas covered by forests in every district.
Table 7 Area covered by Forests by District
A number of forest products are harvested from the Miombo Woodlands, which are predominant in Mpanda and part of Nkasi districts and where commercially valuable timbers such as Mninga (Pterocarpus angolensis) are found. Forest products include timber, fuel wood and charcoal, honey and beeswax. The timber finds its market locally in the region's towns but the bulk is exported to other regions such as Tabora, Manza, Dodoma , Morogoro and Dar es Salaam .
Of the 1.5 million hectares o the plateau, over 700,000 hectares of land are completely deforested resulting in great shortage of wood for both construction and fuel. This forces women to travel long distance searching for fuel supplies.
Efforts are being made to set aside specific areas and hills for regeneration, protect water sources and encourage Local Authorities to buy black wattle seeds for distribution and planting in the villages.
Honey and beeswax have for a long time been produced by traditional beekeepers especially in Mpanda District. Reliable production data is hard to obtain in virtually all districts in the region. However the Table 8 below provides information available on total production and value for the period of five years between 1997 to 2001.
Table 8 Honey and Beeswax Production (1997 2001)
Tanzania honey has proved to be among the best and could comfortably compete with honey coming from Australia , China , Mexico and Saudi Arabia if its potential could be fully taped. The current production of honey country wide is only about 3.5% of the production potential . Given the good demand and market for these products, this sub-sector should be developed and improved through the introduction of modern honey/wax production gear such as modern beehives ad protective gear.
Has the quality of honey in Mpanda been affected by the fertilizers being used for tobacco production?
|Copyright © 2008 -Rukwa Regional Commissioner's Office, SUMBAWANGA, TEL: 025 - 2802137/2802138, FAX: 025-2802217/2802144|


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Lam Dong is a province located upstream of the Dong Nai river system. Although not as complicated as the downstream provinces affected by natural disasters related to sea level rise, Lam Dong suffers from typical disasters such as droughts and floods. This study focused on assessing the impact of precipitation on flow changes by Mike NAM model. Under the impact of climate change, the results of river basin flow calculations according to climate change scenarios show that the flow of river basins has a marked change in stages, and in particular , under the influence of climate change, the trend tends to increase. Annual flow, in the period 2016- 2035, the Dong Nai river basin increases by 1.75% on average, the Krong No river basin increases by 1.63%, the La Nga river basin increases by 1.79% and the Luy river area Cai Phan Thiet river increased by 2.2%. Research results can serve as a basis for local reference in water resource planning and socio-economic development.
Cite this paper
Nguyen Thi Hang, Nguyen Ky Phung (2019),
1. Andersen, H.E., Kronvang, B., Larsen, S.E., Hoffmann, C.C., Jensen, T.S., Rasmussen, E.K., 2006. Climate change impacts on hydrology and nutrients in a Danish lowland river basin. Science of the Total Environment, 365: 223 – 237.
2. Bonacci, O., Tadic, Z., Trninic, D., 1992. Effects of dams and reservoirs on the hydrological characteristics of the lower Drava River. Regul. Rivers Res. Manag, 7 (4): 349–357.
3. Climate Institute, Ocean & Sea Level Rise, April, 2010.
4. Kalvova, J., Nemesova, I., 1997. Projections of climate change for the Czech Republic. Climate Change, 36: 41 - 64.
5. Michal Jenicek, 2007. Rainfall-runoff modelling in small and middle-large catchments – an overview.
6. Ministry of Natural Resources and Environment (MONRE), 2016. - Climate change scenarios, sea level rise for Vietnam, Hanoi.
7. Nemec, J., Schaake, J., 1982. Sensitivity of water resources systems to climate variation. Hydrological Sciences Journal, 2: 327- 43.
8. Nguyen, H. K., 2009. Statistics in hydrology, Hanoi National University.
9. Vu, T.H., Nguyen, K.P., 2011. Influence and change of water volume from upstream to downstream due to climate change. Meteorology and Hydrology.
10. http:// www.vn. undp.org/ content/dam/ vietnam/docs/Article/32332_Global_HDR_laun ch_Presentation_MP_1_July-vn.pdf.


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