While the focus for the heaviest and most impactful snow looks to be focused over the Pennines, a broader yellow warning for snow covers north Wales, northern and central England, Northern Ireland and southern Scotland.
Disruption is possible across large parts of the country on Thursday and Friday. Met Office chief meteorologist Matthew Lehnert said: “Snow will have settled quite widely in central parts of the UK as we move into Thursday morning leaving tricky conditions for the morning travel period. It will be another very cold night, especially under clear skies in Scotland where temperatures could get down to -15°C again tonight.
“An amber warning for snow has been issued for the high ground running north in the centre of northern England as snow redevelops through the course of Thursday and persist until early Friday. Here we could see up to 40cm of snow accompanied by strong winds causing blizzard conditions.”
What is the latest weather forecast?
Here is the latest UK forecast from the Met Office:
Cold, cloudy, windy and unsettled for many today. Spells of rain will affect southern UK. Further north, spells of snow will affect parts of Wales, the Midlands, northern England, Northern Ireland and southern Scotland. Northern Scotland brighter with snow showers.
Further snow across parts of Wales, the Midlands, northern England, Northern Ireland and southern Scotland, heaviest snow northern England. Rain at times in the far south. Windy.
Early rain and snow across England and Wales clearing southwards, sunshine following with snow showers in the east. Sunny spells Scotland and Northern Ireland, but snow showers too. Cold.
Saturday to Monday
After a cold start to Saturday, turning milder but unsettled for most with rain and strong winds. Remaining colder in the far north, with some further snowfall.
The Met Office said: “Another area of low pressure arrives into the west through Saturday making uncertain progress east. This will be accompanied by a band of rain, which will turn occasionally to sleet and snow.
“The focus of snow is most likely to be mainly high ground across northern England initially, later pushing into Scotland.
“Further organised bands of snow showers are likely to continue to affect northern Scotland with some reasonable totals building up over the western Highlands and Grampians especially where these features combine. It is likely weather warnings will be issued once the detail of potential impacts becomes clearer.”
How long will it snow for?
The Met Office expects the current band of rain, sleet and snow to clear for most areas on Monday, other than northern Scotland.
However, those hoping this will signal a turn to warmer and drier weather will be disappointed.
As the week goes on widespread heavy rain is expected to move across much of the country from the south-west, with more snow possible in high ground areas of Northern Ireland and northern England.
Temperatures will be milder in the south, but colder in the north. For the rest of the period up to 22 March, low pressure and unsettled conditions will probably bring wetter conditions for most, particularly in the west.
Milder conditions are likely for many, whilst colder conditions are likely in the far north, with further snow and ice at times, the Met Office says. There will be strong winds and coastal gales mainly in western areas.
For the period from 23 March to 6 April, the Met Office says: “Confidence remains fairly low during this period, with a lot of uncertainty. However, in general it’s likely to be drier further north, apart from occasional wintry showers, while rain and strong winds are more likely to be more of a feature in the south, with a low risk of snow at times, mainly on the boundary between these two regimes.
“Milder conditions may extend north periodically. Temperatures overall mainly around average, with milder spells in the south and colder spells in the north.”


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A masterpiece from France's Chef of the Century, L'Atelier de Joel Robuchon is the culinary workshop of the gourmet mastermind. Featuring unique ... More
L'Atelier Joel Robuchon - MGM Grand Hotel & Casino - MGM Res
A masterpiece from France's Chef of the Century, L'Atelier de Joel Robuchon is the culinary workshop of the gourmet mastermind. Featuring unique counter service where your dinner is prepared right before your eyes. Enjoy tapas, a tasting menu, and wines from around the world in a friendly and interactive atmosphere.
The Carriage House is a non gaming hotel tucked away between the MGM Grand and the Aladdin Hotel, just one
block of the Las Vegas *Strip*. McCarran International airport is 3 miles away and our location affords easy access ...
Welcome to Motel 6 Las Vegas Tropicana in Las Vegas, NevadaThis is the largest Motel 6 and is located across
the street from the MGM Grand. Many casinos are within walking distance. Downtowns Fremont Street Experience is a short ...
CHEAPEST RATES At the AAE Wild West Las Vegas:** Free deluxe breakfast including eggs, bacon, omelets, oatmeal, pancakes and more!**
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*Terms & Conditions: Savings calculation is based on Flight + Hotel vacation package bookings for a 3 month period for 2 adults with a 2+ night length of stay compared to price of the same components if booked separately during same period. Savings will vary based on origin/destination, length of trip, travel dates and selected travel supplier(s). Savings not available on all packages.

domain: travel


Japan Admits 3 Nuclear Meltdowns, More Radiation Leaked into Sea; U.S. Nuclear Waste Poses Deadly Risks, Democracy Now, June 10, 2011:
[...] AMY GOODMAN: And you say Japan is equal to or worse than Chernobyl, the Fukushima Daiichi plant?
ROBERT ALVAREZ [former senior policy adviser to the U.S. Secretary of Energy]: That’s correct, because if—the Soviet Union and Russia basically have claimed that about 50 million curies of radioactivity were released to the environment—this is roughly comparable to what the Japanese government has currently admitted—and that this site continues to release significant amount of radiation in the atmosphere, nowhere near as large as it did during the first week or two, but it’s still quite significant. [...]
Published: June 11th, 2011 at 8:48 pm ET


PADI Divemaster #173399
I have been a high school and college educator for 30 years and in Virginia almost 10 years. I currently teach chemistry at Western Albemarle High School and marine biology courses at Piedmont Virginia Community College.
I have always had a passion for nature study and outdoor activities and I have been lucky to include this passion in my teaching. I directed backpacking / ecology courses for high school students for 10 years before an overwhelming interest in marine biology caused me to change my emphasis to marine ecosystems.
I have been a diver for 20 years. I am a divemaster. For me diving is a tool to observe and study the biodiversity of the oceans and to pass my passion on to others.
Teaching is also a lifelong passion. In the last 2 years eighty high school students and adults have received college credit for my marine biology courses. I have many varied interests, many related to water sports: backpacking and hiking, kayaking and sailing, biking, scuba and snorkeling, and my favorite indoor sport-racquetball.
For more information on my college credit biology program for are high schools students and other interested folks please click on Youth Scuba and follow the links. Thank You.


6 hours ago
Clouds will gradually increase in Philadelphia today, but any precipitation in the form of showers or drizzle should hold off until after midnight. Temperatures will reach the upper 40s this afternoon, then fall into the lower 40s this evening. The winds will be out of the southwest in the 5 to 10 mph range.
15 hours ago
- 1844 S. 12th St., Philadelphia, 19148-2106 Comment
- 2039 S. Darien St., Philadelphia, 19122-1300 Comment
- 1538 S. 10th St., Philadelphia, 19147-6330 Comment
- 1916 S. Warnock St., Philadelphia, 19148-2333 Comment
- 922 Cross St., Philadelphia, 19147-6312 Comment
- Page 1 of 2
27 hours ago
High temperatures today through Tuesday will average 10 to 15 degrees above normal, generally in the 40s and 50s! The next chance of rain will be Sunday night into Monday, mainly across New Jersey and Pennsylvania. Some light freezing rain or freezing drizzle is possible across the southern Poconos Sunday night and Monday morning. More widespread rain is likely Monday night through Tuesday, from New Jersey and Pennsylvania southward into Delmarva. The latest forecast for your area is available at weather.gov/phi by entering your location in the upper left hand corner.


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Davidson Galleries, Seattle Print Arts, and Pratt Fine Arts Center are very pleased to welcome Australian artist and master printer Michael Kempson to Seattle. For over thirty years he has taught printmaking in Australia and taken part in visiting professor programs internationally. Since 2004 he has been the Senior Lecturer, Convenor of Printmaking Studies at University of New South Wales Art & Design in Sydney.
Michael Kempson is also the founder and director of Cicada Press which on average has produced over 150 editions a year for the past 14 years through collaboration with established and emerging artists from around the world
During his time in Seattle, Michael Kempson will be opening his solo exhibition Child’ Play at Davidson Galleries in Pioneer Square. This exhibition features 50 beautifully produced etchings of seemingly benign, yet strangely unsettling stuffed creatures who represent in their placement and orientation the darker sides of contemporary international power-play and cold conflict.
February 2 - 24th at Davidson Galleries
First Thursday Opening Reception February 1st 6 to 8

domain: artistic


So I need to develop a login application where you'd have;
My question is; how can I put text adjacent to the JTextField? Would I use a JLabel?
What layout manager should I use? (Baring in mind I've looked at documentation and can't make my mind up).
Thank you in advance.
Maybe you should consider using JavaFx if it is available. The reason why is because there is something called SceneBuilder that lets you drag and drop different items onto the pane that you are creating.
If you wanted to use swing your best bet would be to use a JLabel, and then the JTextField next to the said JLabel. Honestly, I think javafx is much easier to use, and if you are considering using it I would watch these tutorials: https://www.youtube.com/watch?v=FLkOX4Eez6o Best of luck! :)


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Cash & Commitments offers a snapshot of how your business is tracking financially by providing an overview of cash on hand, cash that you have deposited into a designated account, committed expenses and Tax/VAT.
2. Balance Sheet
3. This Tile has no date picker which means it is a snapshot overview so you will need to select All Dates to get your most recent balance sheet report then click on Run report
Once your Balance Sheet is loaded up you will see Cash on Hand is shown under your fixed assets displayed by your Bank or the name of your account for depositing cash. If you happen to have other accounts such as credit cards connected, be aware that money can also be deposited as displayed in the above example, Cash On Hand is made up from the total bank accounts and credit cards or by other means of depositing cash
Invoices Receiveable is the Total Debtors
Bills Payable is Total Trade Creditors
Sales Tax payable is Total Current Liabilities
Your Total Cash Position displayed at the top of the Tile is calculated by Cash on Hand + Invoices Receivable - Bills Payable + Sales Tax Payable

domain: finance


Electro-Harmonix Bass Big Muff Pi gives you a Big Muff fuzz/distortion sound designed for bass. Keep the low frequencies intact. You also have the ability to mix in the dry signal when your sound stays clear regardless of heavy distortion.
Volume: Sets output volume level.
Tone: Controls the tone of the pedal. At 7 o'clock the sound is at its darkest, at 5 o'clock you will get the most high frequencies.
Sustain: Sets the amount of distortion and sustain.
Switch: With a small switch in the middle of the pedal you can choose between three different sounds. Bass Boost position activates a bass boost. In Norm position you will get the classic Big Muff Pi sound. In Dry position the dry signal is mixed in with distortion. Dry signal volume level stays the same while you can adjust the mix by adjusting the distortion with the pedal's other controls.
- Power Requirements: 2.1 mm 9V DC centre negative power supply or 9V battery. 7 mA
- True Bypass
- Made in USA


text:
Humanity has visited Uranus only once, and that was 30 years ago. NASA's Voyager 2 spacecraft got its closest look at the mysterious, distant, gaseous planet on Jan. 24, 1986.
Part of a joint European-Russian mission to search for signs of life on Mars may be delayed due to cash flow problems, the European Space Agency said Friday.
Two astronauts aborted their spacewalk Friday and hurried back into the International Space Station after water leaked into one of the men's helmets in a scary repeat of a near-drowning 2½ years ago.
NASA's Juno mission to Jupiter has broken the record to become humanity's most distant solar-powered emissary. The milestone occurred at 11 a.m. PST (2 p.m. EST, 19:00 UTC) on Wednesday, Jan. 13, when Juno was about 493 million ...
Scientists initiated Friday a last-chance manoeuvre to contact a long-silent robot-lab dropped more than a year ago onto the surface of a comet hurtling through our solar system.
Gaze up into the sky and you'll see something rare. And, no, it won't be Santa. He and his reindeers will have already zoomed across the horizon.
NASA announced on Tuesday it has suspended the March 2016 launch of its InSight mission to Mars because of problems with a key scientific component.
Two American astronauts helped move a stalled rail car back into place outside the International Space Station on Monday, quickly finishing the primary job of an unplanned spacewalk before moving on to other housekeeping ...
Two solid whacks to a stuck brake handle was all it took for a spacewalking American astronaut to fix a stalled rail car outside the International Space Station, NASA said Monday.

domain: aerospace


text:
Brican Flight Systems & TIER 1 UAV Solutions Partnership Announcement
October 26, 2016
TIER 1 UAV Solutions has been selected by Brican Flight Systems (BFS) to be their first operational launch customer for the TD100E UAS.
TIER 1 UAV Solutions will be providing consultation, SFOC support, training, research flights, and distribution of the TD100E.
Company Founder and President John Saunders will be travelling to the Unmanned Systems Canada Conference in Edmonton at the beginning of November as part of the Brican team and will be available at the Brican booth.


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Do not want to defend myself against debt that is long-term? This is what you must know about bad credit payday advances.
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Many finance majors additionally work at utilities and industrial and retail corporations as monetary officers. Finance graduates who enter into investments generally work for investment banking companies, mutual funds, or insurance corporations in areas similar to portfolio administration Finance, security evaluation, pension fund investment or stock brokerage. You’ll learn how to use data and expertise as tools to gauge and make the best financial choices.
- Reports on budgeting and information forecasting are utilized by stockholders to determine the proper time to purchase and promote.
- The Division of Business and Finance provides stewardship of the college’s human, financial, and physical resources, all of which enhance the college’s capacity to achieve its mission.
Top to bottom, Business Finance Group makes SBA 504 lending easy on the bank and a price add for our clients. This journal supports Mendeley Data, enabling you to deposit any analysis knowledge related along with your manuscript in a free-to-use, open access repository. During the submission process, after uploading your manuscript, you’ll have the chance to upload your related datasets directly to Mendeley Data. The datasets will be listed and directly accessible to readers next to your revealed article on-line. Our online submission system guides you stepwise via the process of coming into your article particulars and uploading your information. The system converts your article files to a single PDF file used in the peer-review process. Editable information (e.g., Word, LaTeX) are required to typeset your article for final publication.
About Business & Finance
The financial analysis happens whereas acquiring and tracking an actual property. That property is proposed to be an apartment constructing, since a residential funding is the most probably that small buyers can acquire. The class continues to look at real property financial modeling, but with the use of Argus.
This recommendation does not apply to college students pursuing associate diploma completion before transfer. A finance diploma locations a higher emphasis on math to organize college students for a job that entails financial evaluation. Learn tips on how to guide organizations in making financial decisions and monitor, analyze and handle market tendencies with a level in finance. As a Gies finance student, you ought to have access to teaching by world-leading academics and industry professionals. Your classroom studying is supplemented by hands-on motion studying alternatives, exposure to state-of-the-art technological tools, and exceptional technical and organizational resources such as the Margolis Market Information Lab. In the extremely competitive field of finance, a level from Gies will set you aside. Businesses can put money into the stocks, or equity securities, of other companies.
Be Part Of The College Of Business
A bachelor’s diploma in finance, accounting, business, math or economics could be helpful for private financial advisors, although requirements range relying on the employer. Specific coaching in taxes, property planning and investments is normally a requirement as nicely.
Our best skilled advice on tips on how to grow your corporation — from attracting new prospects to maintaining current clients happy and having the capital to do it. Grow Our greatest skilled advice on the way to grow your small business — from attracting new prospects to maintaining current clients pleased and having the capital to do it. Depending on the college you attend- you’ll be able to log on and search the catalog of courses and will even get to look at the exact syllabus previous to becoming a member of. When you associate Business with Community Business Finance, our expertise, effectivity and lending relationships will allow you to create a hit story for your corporation. You could withdraw your consent to cookies at any time once you have entered the internet site through a link within the privateness policy, which yow will discover at the backside of every web page on the internet site. Therefore, it won’t damage to perform a little research into the different sorts available. This will assist you to select the source of funding that fits greatest along with your scenario and firm stage.
The Hoffmann International Institute For Business And Society
Ray’s Financial Trading Room replicates a real-world buying and selling environment and capabilities as each a classroom and a laboratory. Students have exclusive entry to the same instruments and software program that are used on Wall Street. The room is supplied with a ticker board which displays market information for a big selection of stocks, indices, bonds, currencies and commodities. The relevant know-how, gadgets and software allow college students to be locked into real life simulations—making trades and performing research in real-time on firms and markets from around the world. The “bench layout” design of the room also mimics that of an actual Wall Street buying and selling desk and could be rearranged to permit for a collaborative seating setting to foster face to face interaction between students and faculty. The Business and Financial Modeling on-line program will characteristic a Capstone project that permits members to apply their knowledge to the actual world. Theoretical and empirical work in finance has tended to ignore how the dimensions of a agency may influence its monetary characteristics and monetary behavior.
Whether they work as controllers, credit managers, treasurers, or risk managers, financial managers are responsible for preserving an organization’s financial affairs wholesome. These positions include Business & Finance quite a lot of accountability as professionals oversee the long-term monetary objectives of their firms.

domain: economics


Water meter gasket Du 40 55x44x2mm Ru16
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The Alveomesh is a technical fabric made out exclusively of recycled polyester. It brings breathability, flexibility and lightness to the shoe.
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After a hard day at work or with the kids, sometimes you just want an easy and fun dinner. Chicken Quesadillas!
I’ve ordered these out in restaurants many times, but none are like the ones I make. I put chunks of chicken, sauteed strips of green bell pepper & sliced onions, and gooey Monterey Jack cheese melted everywhere. Yum.
Just saute some peppers and onions (or anything you want in your Quesadilla), cut a boneless chicken breast into long strips and cook in a skillet until lightly browned (they cook very quickly). Then your ready to assemble your Quesadilla. Fold over and cook until tortilla is lightly browned. Cut into wedges and serve with sour cream and salsa.
Chicken QuesadillasPrint Recipe
- 1 whole boneless, skinless chicken breast, halved
- 1 large green pepper, thinly sliced
- 1 large red pepper, thinly sliced
- 1/2 very large yellow onion, thinly sliced
- 1/2 c. (more or less) Mexican or Monterey Jack shredded cheese
- 2 -4 10 inch tortillas
Saute sliced peppers and onions in a 12″ skillet with a little oil on medium high until cooked and slightly browned.
In a separate pan, put a little oil in pan and saute chicken breasts on medium until browned and cooked all the way through. Slice into thin slices on the diagonal.
Clean out the same pan that cooked the pepper mixture with a paper towel. Spray with cooking spray. Take one tortilla and lay flat in pan. Fill one half with pepper mixture, sliced chicken and cheese. Fold the empty side of tortilla over the filled side. Cook on medium until lightly browned; flip and cook on the other side. Remove to a cutting board and cut into wedges with a large knife.
Repeat with remaining tortillas and ingredients. Serve with salsa and sour cream.

domain: food


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It is quite simple to sign up for a international wife absolutely free dating web page and find your better match. But we have a downside to cost-free dating sites. They sometimes are filled with untrue profiles, plus they can be filled up by spammers and people. So always be very careful at the time you join any kind of free online dating site.
If you are searching the Internet just for singles which you have chosen, you will very easily get thousands of strikes. The problem with this is that you have no idea which in turn of these websites really works. To be able to weed out the fake information and the useless websites, it is vital to join a worldwide dating service. This way, you get to choose and choose which in turn website satisfies your needs one of the most.
To start with, joining any dating service online is a lot easier than going out over a date with a random new person. There are a lot of users globally and only just a few thousand people essentially take the time to join an international dating site. For that reason, it is extremely impossible that you would definitely bump in someone wearing an American or an Australian bikini although browsing the world wide web at night. A forum with regards to international internet dating sites on the other hand is a chance to fulfill someone with similar passions as yourself. You might actually find ideal partner! Naturally , not all foreign dating sites give international online dating services so if you are searching for a genuine foreign dating service, you should do a bit of research.
The first thing it is advisable to check out when looking for a foreign dating site is whether it allows you to upload photographs of your self. If it would not allow you to publish pictures, you really should join a different site. Plenty of international dating forums will allow you to upload pictures, but some do not. Only 10% on the foreign seeing site websites allow individuals to upload pictures. If you are serious about finding a long-term partner, you need to be you need to can trust the website you join. Do not simply register with the 1st website you see – rather, take the time to look around a little more before you make your decision.
Another important component you will want to consider when joining any kind of free online dating site is if they have any kind of national users. The majority of no cost dating sites enable singles from any country in the world to join up and get involved. Unfortunately, there is merely one known dating service which catches the interest of virtually every nation in the world – MySpace. When you are serious about finding a long-term spouse, you will excel to join a fashionable dating service containing thousands of subscribers.
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After getting made your decision to sign on with a well-liked online dating site, be ready to put some effort and time into the research for a perfect long term partner. Although free international dating sites tend to have a large number of individuals, this does not imply that everyone you meet will probably be compatible with you. A foreign going out with experience could be rewarding, but you need to know tips on how to be effective at buying prospective long-term spouse.
Many Asian girls prefer to particular date men who also are interested in them as individuals. However , there are a few exceptions, therefore don’t be amazed if you run across a handful of men exactly who seem genuinely interested in internet dating an Hard anodized cookware woman to be a fling. Typically, however , Cookware females opt to date bright white men. It could not as challenging as you might think to find the right person – the key is to stick with quality over number!

domain: relationship


text:
Heeding my own advice, on my recent holiday, I only took my Fuji X100S and left the big, heavy stuff at home. These photos are what came from a wander round Venice late...Read More
Home » Posts made in August, 2014
Buy My Books
Kindle Edition 99p!
Kindle Edition £1!

domain: photo


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BACKGROUND AND AIM The circulating peptide leptin produced by fat cells acts on central receptors to control food intake and body weight homeostasis. Contrary to initial reports, leptin expression has also been detected in the human placenta, muscles, and recently, in rat gastric chief cells. Here we investigate the possible presence of leptin and leptin receptor in the human stomach.
METHODS Leptin and leptin receptor expression were assessed by immunohistochemistry, reverse transcriptase-polymerase chain reaction (RT-PCR), and western blot analysis on biopsy samples from 24 normal individuals. Fourteen (10 healthy volunteers and four patients with non-ulcer dyspepsia and normal gastric mucosa histology) were analysed for gastric secretions. Plasma and fundic mucosa leptin content was determined by radioimmunoassay.
RESULTS In fundic biopsies from normal individuals, immunoreactive leptin cells were found in the lower half of the fundic glands. mRNA encoding ob protein was detected in the corpus of the human stomach. The amount of fundic leptin was 10.4 (3.7) ng leptin/g mucosa, as determined by radioimmunoassay. Intravenous infusions of pentagastrin or secretin caused an increase in circulating leptin levels and leptin release into the gastric juice. The leptin receptor was present in the basolateral membranes of fundic and antral gastric cells. mRNA encoding Ob-RL was detected in both the corpus and antrum, consistent with a protein of ∼120 kDa detected by immunoblotting.
CONCLUSION These data provide the first evidence of the presence of leptin and leptin receptor proteins in the human stomach and suggest that gastric epithelial cells may be direct targets for leptin. Therefore, we conclude that leptin may have a physiological role in the human stomach, although much work is required to establish this.
- leptin receptor
- human stomach
Abbreviations used in this paper
- reverse transcription-polymerase chain reaction
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Leptin, the product of the obgene,1 is an adipocyte hormone which regulates energy homeostasis by informing the brain about fatty tissue mass.2-4 Injection of exogenous leptin intoob/ob mice inhibits food intake and reduces body weight via activation of specific brain receptors.5 ,6 Conversely, leptin deficiency in mice and humans causes obesity and may also cause diabetes syndromes, including hyperinsulinaemia.7 ,8 Recent reports have shown that leptin inhibits insulin secretion9 ,10 and stimulates glucose transport and turnover in hepatocytes.11 ,12Contrary to initial reports, leptin is not restricted to adipocytes. It has also been detected in the human placenta,13muscles,14 and rat gastric chief cells.15Detection of leptin in rat gastric epithelium prompted us to investigate the possible presence and role of leptin and its receptors in the human stomach.
Materials and methods
For immunocytochemical studies, 24 individuals were randomly selected from the files of our gastroenterology department (Bichat Hospital, Paris, France), these cases having been reported elsewhere.16 ,17 They included 15 healthy volunteers and nine patients with non-ulcer dyspepsia (n=24) who gave informed consent for upper endoscopy and gastric secretory tests.
Secretory studies available for 14 (10 healthy volunteers and four with non-ulcer dyspepsia) of the 24 subjects (mean age 45 years; range 24–60; five women, nine men) were analysed. At the time of the study all had normal endoscopy and normal gastric mucosa on histological examination. None was receiving antisecretory drugs and other drug treatments were stopped 48 hours before the secretion tests.
Biopsies were performed during endoscopic examination. At least four samples were collected from antral and fundic sites. Samples were fixed in Bouin's solution or buffered formalin for 24 hours, dehydrated, and embedded in paraffin. Sections (4 μm) were stained with haematoxylin-eosin-Safran to assess if the normal gastric mucosa was well oriented, and immunohistochemical staining was performed using the avidin biotin complex, diluted 1:100 (Kit ABC Vectastain; Vector Laboratories Burlington, California, USA), and diaminobenzidine to detect peroxidase activity. The antibodies used were: (a) a polyclonal antibody raised in rabbits against the carboxyl terminal fragment (137–156) of mouse leptin (A-20) and (b) a polyclonal antibody raised in goats against the C terminal fragment (1146–1165) of human leptin receptor (C-20) (Santa Cruz Biotechnology, California, USA). For leptin immunostaining, antileptin antibody was diluted 1:50 and sections were incubated for one hour at 37°C using a microwave method. For leptin receptor, antireceptor antibody was used at a dilution of 1:25 or 1:50 on tissue previously digested with 0.1% pepsin in 0.01 N HCl, pH 2.25, for eight minutes at room temperature to retrieve antigen. Then, incubation was performed overnight at 4°C. For controls, no immunostaining was observed in gastric tissues under the following conditions: (a) omission of the primary antibody, (b) for leptin receptor only, normal goat serum used in place of immune goat serum; (c) overnight prior incubation of the antileptin antibody with 40 μg of the homologous peptide per ml of diluted antiserum at 4°C; and (d) prior incubation of antireceptor antibody with 40 μg of homologous peptide per ml of diluted antiserum for 3–4 hours at room temperature.
Sections of fatty tissues were fixed in the same way and were used as positive controls for leptin immunostaining.
GASTRIC JUICE COLLECTION AND SECRETION TESTS
After an overnight fast, gastric juices were collected using a nasogastric tube as previously described.16 ,17 The stomach was first emptied for 15 minutes and then basal gastric juice was collected by gentle manual suction every 15 minutes for one hour. Pentagastrin (6 μg/kg/h) or secretin (3 IU/kg/h) was infused for one hour. Gastric juices and blood samples were collected every 15 minutes for determination of leptin. The volume of gastric juice was measured and the acid concentration was determined by titration. Mean integrated basal acid output and stimulated acid output in millimoles of [H+] per hour were calculated as the sum of the four 15 minute samples. The 15 minute samples were stored at −20°C until leptin assay by radioimmunoassay (RIA).
125I labelled human leptin (∼6×104cpm; Linco Research Inc, St Charles, Missouri, USA) was incubated with or without stimulated gastric juice (pH 1.8) for 30 minutes at 37°C and eluted at room temperature from a Sephadex G-100 gel filtration column with 25 mM phosphate buffered saline, pH 7.4, containing 0.01% sodium azide. Fractions (1 ml) were collected and the radioactivity of each sample was determined. The total amount of radioactivity eluted in the peak was calculated and per cent recovery determined.
Leptin was measured on fundic biopsy samples from five of the 14 individuals who underwent the secretion tests. Biopsy samples were weighed and homogenised in Krebs-Ringer-HEPES (1 mg wet weight per millilitre) with a glass Teflon homogeniser. The homogenates were centrifuged at 10 000 g for 10 minutes. The supernatants were used for leptin assays. Fundic, plasma, and gastric juice leptin contents were estimated using a human leptin RIA kit from Linco Research Inc.
PCR PRIMERS AND RT-PCR CONDITIONS
Reverse transcription-polymerase chain reaction (RT-PCR) was performed with total RNA extracted using Trizol reagent (Gibco BRL, France) from human fundic biopsy samples. Firstly, strand cDNA was prepared from 4 μg of total RNA according to the manufacturer's procedure (Pharmacia Biotech, Saclay, Orsay, France) using murine reverse transcriptase. It was amplified by PCR using primers based on the human oband Ob-RL genes. The cDNA primers for the ob gene were1: f5′-CCTGACCTTATCCAAG ATGG-3′ and r5′-GAGTAGCCTGAAGC TTCCAG-3′, and for the Ob-Rb gene18 (huB219.1), f5′-GCCAACAACTGTGGTC TCTC-3′ and r5′-AGAGAAGCACTTGG TGACTG-3′. The sample was denatured at 95°C for three minutes. PCR was carried out for 40 cycles of one minute denaturation at 95°C, 30 seconds annealing at 62°C, and two minutes of extension at 72°C. Amplification was terminated by a final 10 minute extension step at 72°C. In controls, RT was omitted to demonstrate that PCR amplification was not due to contamination with genomic DNA. Electrophoresis in a 1% agarose gel and ethidium bromide staining were used to verify the PCR products. The expected 224 bp and 246 bp were detected for the ob gene and for Ob-Rb, respectively.
WESTERN BLOT ANALYSIS OF LEPTIN RECEPTORS
Samples from fundic and antral biopsies, and from the entire rat brain (positive control) were weighed and immediately frozen in liquid nitrogen and stored at −80°C. They were homogenised at 4°C in RIPA buffer containing 0.1 mg/ml PMSF, 100 μM benzamidine, and 100 mM Na3VO4 as protease inhibitors. They were resolved on 7.5% SDS-PAGE gel electrophoresis after loading 20–40 μg of total protein. Protein bands were transferred to nitrocellulose sheets and probed with polyclonal antileptin receptor antibody C-20 or K-20 (Santa Cruz Biotechnology). The specificity of the immunoreactive bands was verified by preincubating the antibodies overnight with 40 μg of their homologous peptide. The immune complex was revealed by an enhanced chemiluminescence detection system (Amersham, France).
RADIOIMMUNOASSAY FOR GASTRIN
A gastrin RIA (Gammadab, New York, USA) with a polyclonal antibody directed against the COOH terminal fragment of G-17 and G-34 was used. Serum gastrin levels were determined before and one hour after the pentagastrin or secretin infusion tests.
Results are expressed as mean (SEM) or median (range) for individuals, or the mean value in each test period was used for statistical comparisons. Acid and leptin secretions under basal conditions were compared with those during pentagastrin and secretin stimulation using the Mann-Whitney U test with significance at p<0.05.
LEPTIN EXPRESSION IN NORMAL GASTRIC MUCOSA
In all specimens of normal human gastric mucosa, leptin immunoreactive cells were detected in the fundic epithelium. They were concentrated in the lower half of the glands at a site similar to that of chief cells, as shown in rats (fig 1A). Leptin immunostaining was also strong in the canaliculi of the parietal cells (fig 1B). The staining was leptin specific as it disappeared if the antibody was adsorbed onto the antigen fragment before use (fig 1C). No leptin immunoreactive cells were detected in the antrum (not shown). RIA determinations for fundic biopsies showed a mean of 10.4 (3.7) ng leptin/g mucosa for five subjects (table 1).
LEPTIN SECRETION INTO THE BLOOD AND GASTRIC JUICE OF NORMAL SUBJECTS
Leptin was detected in gastric juice at basal concentrations of 0.2–0.6 ng/ml (mean 0.3 (0.04) ng/ml). Basal leptin output was 25.2 (5.2) ng/h (table 1). Secretin infusion increased circulating plasma leptin levels by 28%, which paralleled the increase in leptin output in gastric juice, reaching a mean value of 1165.8 (130.1) ng/h. Intravenous infusion of pentagastrin also significantly increased leptin output in gastric juice to a mean of 91.7 (14.3) ng/h (fig 2A). This was accompanied by a 25% increase in circulating plasma leptin (1.8 (0.5) v 2.4 (0.3) ng/ml; p<0.05). The secretin induced increase in leptin output in gastric juice was markedly higher than that induced by pentagastrin infusion (1165.8 (130.1) v 91.7 (14.3) ng/h; p<0.001) (fig 2B). Secretin inhibited acid secretion but circulating gastrin levels were unaffected (data not shown).
STABILITY OF LEPTIN IN GASTRIC JUICE
Figure 3 shows a representative elution profile for Sephadex G-100 gel filtration of 125I leptin incubated for 30 minutes with or without stimulated gastric juice (pH 1.8). 125I labelled human leptin eluted in one peak and showed no apparent dissociation because 80% was recovered from gel filtration. Leptin was incubated with gastric juice and subjected to gel filtration. One peak was eluted in the bed volume suggesting that leptin was not associated with macromolecules or proteolytically degraded.
LEPTIN RECEPTOR EXPRESSION IN GASTRIC MUCOSA
Leptin receptors were detected in fundic and antral epithelial cells (fig 4). Staining was more intense in superficial and pit cells than in glandular cells. It was restricted to the basolateral membrane and, in the fundic mucosa, to parietal cells, with a stronger signal on sections of the microcanaliculi in some but not all parietal cells. Prior immunoadsorption of the antibody with the corresponding antigen resulted in a reduction in or total abolition of immunostaining of the membrane and parietal cells, except for the microcanaliculi where it was only slightly decreased. However, there was no staining if the primary antibody was omitted, and very weak diffuse background staining throughout the tissue with no particular staining of the microcanaliculi if the corresponding normal serum was used rather than primary antiserum.
RT-PCR AND WESTERN BLOT ANALYSIS
Finally, mRNA encoding ob protein was detected only in the corpus while mRNA encoding Ob-RL was detected both in the corpus and antrum of the human stomach (fig 5A). Western blot analysis of total protein with two independent antibodies for leptin receptor showed an immunoreactive band with a predicted size of ∼120 kDa in the corpus and antrum (fig 5B).
We have shown that leptin and its receptor are present in the human gastric mucosa and provide the first evidence that leptin is a stomach derived protein in humans. In addition, leptin mRNA was found and leptin containing cells were restricted to the lower half of the fundic glands at a site similar to that of the pepsinogen secreting chief cells, as previously found in rats.15 In contrast with the results obtained in rat gastric mucosa, we detected additional immunoreactivity on the parietal cell canaliculi that was abolished by immunoadsorption. This suggests simple accumulation of luminally secreted leptin in the acidic compartment of the parietal cell or alternatively, binding of leptin to receptors on parietal cell microcanaliculi.
The amount of gastric leptin determined by RIA was twice that reported for rats. Gastric leptin is simultaneously released into the blood and gastric juice by pentagastrin and secretin. These data are consistent with results in rats showing that cholecystokinin (CCK) causes a significant decrease in fundic leptin content. Secretin stimulation of gastric leptin output is not dependent on gastric acid secretion. Indeed, secretin inhibited acid secretion consistently in previous reports in rats,19 dogs,20 and humans21 but had no effect on circulating gastrin levels. Thus this effect is probably a direct effect of secretin on gastric chief cells, consistent with the presence of secretin receptors on these cells and the efficacy of secretin for stimulating pepsinogen secretion.22 ,23
The leptin receptor was detected on the basolateral membranes of epithelial fundic and antral cells. However, an additional signal was detected on sections of the parietal cell canaliculi in the fundic mucosa. The reason for this is unclear. Prior immunoadsorption of the antibody with the corresponding antigen abolished basolateral staining thereby supporting its specificity. Staining of parietal cell canaliculi was not completely abolished by antigen adsorption, even if other controls were negative. Therefore, whether the leptin receptor is really present on the apical membrane invagination of the parietal cells requires further investigation.
Several isoforms of the leptin receptor generated by alternative mRNA splicing have been previously reported.5 ,6 One short form was detected in almost all tissues whereas the longest form, Ob-Rb, was found to be highly expressed in the hypothalamus6 and also in some peripheral tissues.18 ,24 ,25 ,26 In this study, a protein of approximately 120 kDa was detected by immunoblotting in both the normal corpus and antral gastric mucosa of humans. This protein is the same size as the ∼120 kDa protein detected in pancreatic islets transfected with Ob-Rb cDNA to overproduce wild-type Ob-Rb.27 It is also consistent with previous studies showing that there are multiple mRNA splicing variants for the leptin receptor in the stomach.28 In total, our findings clearly support the conclusion that human stomach expresses the longest form of the leptin receptor (Ob-Rb).
It is thought that only the Ob-Rb receptor, which contains the box1 and box3 motifs, activates the JAK/STAT cascade, mediating the biological effects of leptin.29-32 Therefore, our findings suggest that human gastric epithelial cells are direct targets for gastric leptin. It is not known if activation of these putative targets involves luminal, endocrine, or paracrine pathways. However, the presence of the receptors on the basolateral side suggests an endocrine and/or paracrine pathway but further investigations are required to resolve this issue.
In terms of physiological function, gastric leptin may be involved in the short term control of satiety, acting in synergy with CCK via vagal afferent fibres in rat.33 Demonstration in this study that leptin receptors are present on gastric epithelial cells in humans suggests that leptin may have an additional action on these cells which are responsible for control of their secretory function. Alternatively, leptin secreted into the gastric juice, if not degraded, may reach the intestine, having biological effects on food digestion and absorption, as recently suggested by the effects of leptin on intestinal cells.34
In summary, we have demonstrated that in the human stomach, leptin is produced by the pepsinogen secreting chief cells of the fundic mucosa. We have also provided evidence that gastric epithelial cells bear the functional leptin receptor. Thus gastric epithelial cells may be physiological targets for gastric leptin. Our findings may open a new field of investigations into the actions of leptin.
We thank Michel Saadoun and Isabelle Prevost for technical support.
Abbreviations used in this paper
- reverse transcription-polymerase chain reaction

domain: biology


text:
Location: Sugarbeet and Bean ResearchTitle: Peach maturity/quality assessment using hyperspectral imaging-based spatially-resolved technique Author
Submitted to: Proceedings of SPIE
Publication Type: Proceedings
Publication Acceptance Date: 4/30/2011
Publication Date: 6/25/2011
Citation: Cen, H., Lu, R., Mendoza, F., Ariana, D. 2011. Peach maturity/quality assessment using hyperspectral imaging-based spatially-resolved technique. Proceedings of SPIE. April 25-29, 2011. Orlando, Florida. Paper No. 8027-0L, 15 p. Interpretive Summary: Maturity is an important indicator for determining harvest time and postharvest handling and marketing procedures for horticultural products. Peach maturity is commonly assessed using multiple destructive techniques, including Magness-Taylor penetrometry for firmness, refractometry for soluble solids content, and colorimetry for the color of fruit skin and flesh. This research was aimed at nondestructively assessing multiple maturity parameters of peaches using a newly in-house developed optical property measuring instrument. Five hundred ‘Redstar’ peaches were harvested in 2010 and their optical absorption and scattering properties for the wavelengths of 515-1,000 nm were measured using the optical property measuring instrument. The firmness, soluble solids content, and fruit skin and flesh color of the peaches were measured using standard destructive methods. In addition, the firmness of the peaches was also measured nondestructively using a commercial acoustic and impact firmness sensor. Mathematical models were developed to predict the maturity parameters of peaches using the optical property data. The absorption and scattering properties of peaches changed, in different patterns, with the ripening and development of pigments in the fruit. The measured optical properties were able to predict the firmness, soluble solids content, and skin and flesh color of peaches with values of the correlation coefficient being 0.749, 0.504, 0.898 and 0.741, respectively. The optical firmness prediction compared favorably to acoustic and impact firmness measurement. This research demonstrated that the optical property measuring technique is useful for assessing the maturity or quality of peaches and can also be suitable for other horticultural and food products.
Technical Abstract: The objective of this research was to measure the absorption and reduced scattering coefficients of peaches, using a hyperspectral imaging-based spatially-resolved method, for their maturity/quality assessment. A newly developed optical property measuring instrument was used for acquiring hyperspectral reflectance images of 500 ‘Redstar’ peaches. Absorption and reduced scattering coefficient spectra for 515-1,000 nm were extracted from the spatially-resolved reflectance profiles using a diffusion model coupled with an inverse algorithm. The absorption spectra of peach fruit were featured by several absorption peaks around 525 nm for anthocyanin, 620 nm for chlorophyll-b, 675 nm for chlorophyll-a, and 970 nm for water, while µs' decreased consistently with the increase of wavelength for most of the tested samples. Both µa and µs' were correlated with peach firmness, soluble solids content (SSC), and skin and flesh color parameters. Better prediction results for partial least squares models were obtained using the combined values of absorption and scattering spectra than using them separately. The results were further improved using least squares support vector machine models with values of the best correlation coefficient for firmness, SSC, skin lightness and flesh lightness being 0.749 (standard error of prediction or SEP = 17.39 N), 0.504 (SEP = 0.92 Brix), 0.898 (SEP = 3.45), and 0.741 (SEP = 3.27), respectively. These results compared favorably to acoustic and impact firmness measurements with the correlation coefficient of 0.639 and 0.631, respectively. Hyperspectral imaging-based spatially-resolved technique is useful for measuring the optical properties of peach fruit, and it also has good potential for assessing fruit maturity/quality attributes.

domain: agronomy


text:
Posted by FYI on March 31, 2010 at 11:13:21:
The Trinity Broadcasting Network has turned off several of its analog low-power TV stations and sold several others. The stations in Duluth (K58CM) and Rochester, MN (K56HW) left the air this month, and the Dickinson, ND station (K28EP) left the air several months ago. Meanwhile, TBN has reached an agreement to sell 17 LPTV stations, including three in Wisconsin, to Word of God Fellowship, which operates the Daystar network. The allocated values for the stations are $18,153 for Green Bay (W49CB), $5,201 for Janesville (W65EE), and $14,127 for Madison (W38CT).
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domain: geography


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text:
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domain: game


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Solar - Page 2 - Blowout Sale! Save up to 55%
Blowout Sale! Up to 55% off on Solar at Game Drive Save, Page 2. Top brands include vanpower, OWI, DDI, Sundance Solar, PicoTurbine, Pica Toys, 4M, Thames & Kosmos, Greenbrier, Elenco, Bee Line Industries, S.T.E.A.M. Line Toys, Engino, & S&S Worldwide. Hurry! Limited time offers. Offers valid only while supplies last.
Desktop Model Solar Powered Windmills Wind Turbine Education Learning Toys Model
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The Solar Space Fleet Kit MSK641 is an innovative solar powered science kit that can transform into seven different lunar modules and energized via direct sunlight or micro rechargeable battery. Some solar powered toys, particularly those children ca...
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OWI 7-in-1 Rechargeable Solar Transformers An innovative solar science kit that encourages children to exercise their sense of creativity and imagination. It features all snap together plastic parts (no screws, tools required), solar panel and access...
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The solar powered robot can be transformed into 14 different robot modes that include a multitude of comical and functional movements. Easily change from a wagging-tail dog - running beetle - walking crab - surfer - speedster - zombie chaser and more...
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The newest release of our popular SolarLab 1.0 is now available! One of the most advanced solar energy educational kits on the market, it is being used at middle schools, high schools and universities around the US and internationally. Designed to te...
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"8" Tall Wind Turbine 1-4V at 150mA *12 Electricity Labs Solar Lab: 6V at 150mA- .90 Watt Solar Panel and DC Motor.Powerful mini or small scale Wind Turbine. Generates Alternating Current and power through Magnetic Induction. Hands on and easy to ass...
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Assorted Solar Dancing Flowers. Cute decorative pieces for car deck and other places with sunshine available. As soon as the sunlight falls on the flower, it moves and dances. Comes in assorted styles. Flower is about 2"""" high and total height is a...
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The Fuel Cell 10 Car & Experiment Kit provides a hands-on introduction to one of the most significant technologies of the early 21st century. With this kit, you can build a model car that actually runs on water! First, use solar energy to separate wa...
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We supply schools, learning stores, and home-school coops. Our focus are toys with an educational component. Our mission is to show that learning is fun and that expanding the mind is the greatest gift one can share.The solar powered robot can be tra...
Engino S.T.E.M. Solar Power Building Model Kit
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Convert sunlight to electricity! this set includes one 3V solar panel that powers an electrical motor.Build 16 different solar powered models such as a car, fan, winch crane. Includes instruction booklet with 12 pages of theories and facts. For ages ...
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domain: physics


Hacker Re-Engineers Google Glass With Unofficial Facial Recognition Ability
Stephen Balaban built an alternative operating system that runs on Google Glass but isn’t authorized by Google.
San Francisco-based developer Stephen Balaban has re-engineered his Google Glass with an alternative operating system that isn't authorized by Google. This makes it possible for the wearer to use Glass for facial recognition.
Balaban's hack highlights the ability to take over Glass with ideas that Google didn't originally intend, as it could enable all kinds of apps. NPR reports that he is building an OS that “runs on Glass but is not controlled by Google.”
Hacks like this put Google in an awkward position and Glass has raised lots of questions and fears about privacy. The company has said that it won't support any programs on Glass that enable facial recognition, changing its terms of service to ban them.


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WW2 Red Army Uniform Guide
The soviet pilot is wearing a pre-war leather flight coat and genuine leather flight helmet. Pay attention to the signs on the buttonholes. Junior officers wore red enamel squares (lieutenant – two squares) and an emblem – a propeller with wings.
By the time the Germans invaded the territory of the USSR, the Red Army Air Forces were undergoing a painful reorganization; the commanders tried to find ways to improve their combat effectiveness compared to the miserable state they had shown during the “winter war” against Finland. Aviation was unprepared for combat, and therefore the Germans on the very first day of the invasion managed to destroy 1489 Soviet aircraft on the ground and 322 in the air while losing only 35 of their aircraft. Unfortunately, these losses were only the beginning of the route.
During the war, the Germans continued to inflict heavy losses on Soviet aviation. Even in air battles, the Red Army Air Force could not be compared with the Luftwaffe. By the end of November 1941, the Germans claimed to have destroyed 16,000 Soviet aircraft, losing 3,453 of their aircraft killed or damaged.
The winter of 1941/42 gave the Russian Air Force a break, as a result of which they turned out to be better than the revolution, trained their pilots to fly on new forms, such as the Il-2 attack aircraft and the Yakovlev and Lavochkin fighters. In addition, the aviation industry was relocated to the East, mainly to the Urals, out of the reach of quality bombers.
The new rules for wearing uniforms, adopted on January 6, 1943, made many changes to the uniforms of the officers of the air force. In particular, new tunics and tunics were introduced, on which there were more obvious signs of difference: all employees received chase signals for full dress and everyday uniforms and cloth ones for field uniforms.
Field epaulets had blue edging and one or two dark red gaps. Junior officers, such as this lieutenant, had one lumen and one to four silver stars with a diameter of 13 mm. The ceremonial tunic had buttonholes and a double edging on the cuffs.
The buttonholes were blue with one or two embroidered stripes, according to belonging to the senior or middle command staff, which was also shown by the double edging of the cuffs.
On the right side of the chest, this officer has a Guards badge and stripes for wounds introduced in July 1942. On the left side of the chest, there is the Order of the Red Star.
WW2 Red Army Uniform of Officers
The Soviet Air Force was not an independent branch of the armed forces but was part of the Red Army as a branch of service. In August 1924, the aviators received blue uniforms, and in December 1935 they were declared to be every day, full dress and full dress uniforms. The basic uniform in the Air Force was the same as in the ground forces, differing only in blue buttonholes and piping. Later, this color was transferred to the shoulder straps of aviators.
In 1935, the Soviet Air Force received new buttonholes with a blue field and gold piping for officers and black for political workers, soldiers, and junior commanders. On the buttonholes were placed the emblem of aviation – a propeller with wings – and insignia in the form of red enamel rhombuses, rectangles, squares, and triangles, introduced in 1924.
The gold and red chevrons shown in the illustration were introduced for the Soviet Air Force in 1935 and changed in 1940. Initially, only generals wore gold chevrons, and other officers wore red chevrons, but in 1940 generals were given one wide gold chevron with a narrow red stripe at the bottom and a golden star at the top. The chevrons assigned to officers consisted of a combination of gold and red stripes.
This shirt of the WW2 red army uniform you can purchase here: WW2 Red Army Uniform
This is example video : Soviet Uniforms 1939-1945


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Katie Holmes, Julianna Margulies, Emma Roberts and more stepped out to celebrate the new Narciso Rodriguez for Kohl's DesignNation fashion collection Monday in New York City. DesignNation is the store's new limited-edition collection concept and Rodriguez is the first designer to participate. His collection is scheduled to hit Kohl's stores and Kohls.com on Nov. 7.
Margulies, star of "The Good Wife," walked the party in the Narciso Rodriguez for Kohl's long-sleeve, slim, two-tone ponte dress ($64) and Roberts donned the V-neck ponte dress ($60).
The collection consists of bodycon dresses with clean, sharp asymmetrical lines across the front, pajama-style silk pants in black and white and colored paisley, cigarette leg pants, sleek tweed jackets and silky tops and knee-length skirts. There is outerwear, dresses for the office, looks for a night out and some flirty styles for date night.
The color palette includes classic black and white with bold pieces in fuchsia, orange and blue. Prices range from $30 to $150.

domain: design


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Home » Opinion » Editorials
Reform the tax code: The need is obvious
"In this report, we identify tax complexity as the #1 most serious problem facing taxpayers, and we recommend (as we have in prior reports) that Congress vastly simplify the tax code to make tax compliance easier," wrote National Taxpayer Advocate Nina Olson.
"An analysis of IRS data by the Office of the Taxpayer Advocate shows it takes U.S. taxpayers (both individuals and businesses) more than 6.1 billion hours to complete filings required by a tax code that contains almost four million words and that, on average, has more than one new provision added to it daily," she wrote. "Indeed, few taxpayers complete their returns without assistance. Nearly 60 percent of taxpayers hire paid preparers and another 30 percent rely on commercial software to prepare their returns. To inspire confidence and trust, the tax laws should be comprehensible and the computations of tax should be transparent and relatively simple, yet few taxpayers today can confidently say they understand the tax code or even that they have correctly computed their tax liabilities."
Simplifying the tax code is not some right-wing code for cutting taxes. It is a necessary step for relieving what has become an onerous burden on the American public. And yet both parties have spent decades making the code more complex because both believe in using the code as a tool for achieving political ends, not simply for raising revenue.
Both President Obama and Republican leaders in the U.S. House say they believe the code should be simplified. Olson's report gives them ample reasons for doing so sooner rather than later. But the odds are that we shall pass yet another Tax Day with no real reform, only excuses and blame.
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Manchester pub crawl leads to arrest of four
School's out for voters

domain: politics


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domain: gamble


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Seen on December 18th, 2010
The son of a virtual world designer goes looking for his father and ends up inside the digital world that his father designed. [imdb]
Nominated for 1 Oscar:
Best Sound Editing
If there was a 2010 film other than Inception that required a big screen experience, this was it. To fully appreciate its fabulous moments, you need to see it on the big screen, with crazy sound all around you. Because when it's good, TRON: Legacy is fantastic; when the screenplay drops the ball, it's still interesting.
Arguably, the first 30 minutes of the film are the best I've seen all year. There's a fabulous cool mystical easiness to the beginning that makes the experience really special. The visual effects (minus Clu), the art direction, the costume design, the cinematography - all are fabulous and would've deserved Oscar nominations. And the original score, oh the original score: I still get excited about Son of Flynn - Daft Punk did an AMAZING job, so stupid that they were snubbed.
My rating for the film: 7.5/10. The film loses its focus in the second half, and I admit some might think I was too generous. But the visuals and the potential of the film - hard not to consider. Of course it deserves the Sound win, which will not happen.

domain: movie


Now that we’re in peak growth season for lawns, you can identify the areas that need some TLC.
🔬 Zoom in: In areas of your yard where the soil has gotten compacted, aerating the lawn is an easy remedy.
- NOTE: You can de-thatch and aerate the whole lawn earlier in the season for maximum growth.
- For now, use an aerating tool in areas next to grass that’s growing well to help the grass spread.
⚙ How it works: Poking holes in the dirt creates a path.
- For oxygen
- For water
- For fertilizer
✅ For your Smart Homeowner list
- I have a heavy duty rolling aerator
- Or make your neighbor’s jealous with a sweet pair of aerating shoes!


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On 14th March 2019Fortis Hospital and Kidney Institute (FHKI), Kolkata organized a 1.5 Kms long walkathon to raise awareness on maintaining a healthy Kidney to mark World Kidney Day. As many 200 people, counting specially-abled children from Manovikas Kendra, participated in the walkathon which was kick-started at FHKI. Leading personalities of Kolkata like Actor Abir Chatterjee, Dr. Shivaji Basu, and Consultant Urologist at FHKI, Dr. R.K. Gopalakrishna, Consultant Urology at FHKI and Dr. Upal Sengupta, Consultant Nephrologist, FHKI flagged off the walkathon.
The walk started from FHKI and moved towards Deshapriya Park, Rashbehari Avenue, Rashbehari Gurudwara and finally back to FHKI.A health checkup camp was also prearranged outside of FHKI for people. The basic health screening was done like weight and blood pressure check, Urea, Creatinine, Uric Acid, and Random Blood Sugar check followed by Diet Consultation. The core idea behind this walk is to raise cognizance about the growing incidence of Chronic Kidney Disease (CKD) with severe consequences and concerns if goes untreated. On completion of the walkathon, FHKI presented 10 cycles to Kolkata Police as a goodwill gesture.
Are you aware of the facts of CKD? Let us talk about it more. You are sure to find this term in the prescription of all the kidney patients. CKD is a worldwide public health problem with hostile outcomes of kidney failure and premature death. 850 million people worldwide are now assessed to have kidney diseases from various causes.
Chronic kidney diseases (CKD) cause at least 2.4 million deaths per year and are now the 6th fastest growing cause of death.
Speaking on the need to remain vigil and alert for healthy kidneys, Dr. Partha Karmakar, Consultant Nephrologist at Fortis Hospitaland Kidney Institute said, "It is important to be aware of the health of your kidneys. Timely diagnosis and proper care under professional supervision can cure the most challenging diseases. The concern with renal disease is that it does not show any symptoms at the onset. However, at the later stage, it can result in major concerns like swelling of body, weakness, vomiting, breathing problems etc."
Dr. Upal Sengupta laid down the following guidelines for kidney care:
The main cause behind Chronic Kidney Disease (CKD) is high blood pressure and high blood sugar levels. Thus, early detection and control of blood pressure and blood sugar levels are important to avoid the incidence of CKD.
Avoid drugs that are harmful to kidney mainly painkillers.
Avoid non-proprietary medicines.
Avoid dehydration during summer. Consume adequate water.
Regular kidney checkup after the age of 40years is advised especially if one suffers from diabetes, high blood pressure and has a family history of CKD.
There are some women-specific diseases like SLE, pregnancy-related kidney disease which can lead to CKD. These conditions need early visit nephrologist to avoid long-term complications.