ash crimson ash crimson video game character king fighters fighting game series developed appearance king fighters leader hero team ash teenager series fighting tournaments employs personal fighting style involves green flames despite series protagonist story arc ash behavior generally antagonistic tries steal powers recurring characters leaving powerless identity intentions explored recent title king fighters featured print adaptations drama based games staff created ash evil main character contrast previous main characters moves reworked game appeared gaining new techniques result actions modified balance character roster critical response ash largely negative appearance technique interviews press releases video game publisher entertainment noted unpopular western gamers design better suited japanese fans appearances introduced king fighters ash leads new hero team duo new king fighters tournament tournament host steals powers telling opponent king fighters character teams game end ash leaves teammates fight price joining finding drug obtain defeating enemy later finds defeats steals powers ash accuses abandoning original mission obsessed power leaves saying victim ash appears available fighter maximum impact update maximum impact regulation king fighters games storyline king fighters ash character team learned works past seen conflict organization leader end game ash final boss king fighters ash driven insane spiral blood known evil ash power stolen trying possess ultimately sacrifices destroy ash appearances king fighters media fourth chapter anime king fighters day sets fire city lure trap prominent adaptations king fighters wing yang king tournament ash team defeated final later helps defeat demon recurring tournament king fighters briefly confronts attempt steal powers ash appears drama mid summer struggle mock king fighters tournament outside king fighters character appears dating days memories series creation development ash designed attractive evil character contrast previous king fighters heroes supervising designer created character desired changes conception king fighters released ash introduced staff want disclose information instead telling fans look forward exploits canonical height weighs according staff member goal ash ambiguous protagonist players feel bad cheering design character added details illustrating ash late appearance king fighters staff joked teammate like series main character ash king fighters producer wanted gamers played previous titles ash consider character motivation relate reasons title maximum impact regulation ash introduction spin series called character wild role series personality artist charge said original king fighters characters liked ash looked forward development king fighters ash character staff worked reworking movements speech consistent rest cast king fighters producer jokingly called character players use version game makes multiple hits regular form style said fit character introduction ash acquired new moves accordance action series king fighters ash gained allowing steal opponents special moves defeating character acquired neo max strongest attack king fighters game development staff considered returning animation style earlier version tested reception ash crimson character mixed reception video game publications introduced gamespy christian called clone street fighter series similar ash team praised new characters new elements series lucas thomas ign wrote major fan complaint character strength games strongest opponents despite apparent lack effort according thomas ash strange writer lamented appearances compared popular characters playable characters arcade version king fighters introduced anime news network speculated ash lack teammates wondered likes ash networks ranked ash sixteenth list video game characters jokingly appearance desire japanese designers confuse western gamers sexuality called ash voice gaming deepest voices dan gamer referred female character writers game informer joked surprise discovery ash male character entertainment polled fans choose console versions king fighters company announced ash reduced number potential covers featuring interview entertainment director business development shane alex said north american fans ash complained inclusion king fighters storyline popular series characters overlooked defended character calling nuanced improved moves incredibly effective june stephen interviewed asked playing guess ash gender said character female called progressive introducing cross dressing character said fans apparently warming holmes praised ash character traditional gender roles kicking ass called perfect mascot series merchandising related ash appearance released


burn burn type injury skin tissues caused heat cold electricity chemicals friction radiation burns heat hot fire women areas world risk related use open cooking fires unsafe cook alcoholism smoking risk factors burns occur result self harm violence people burns affect superficial skin layers known superficial degree burns appear red pain typically lasts days injury extends underlying skin layer partial thickness second degree burn frequently present painful healing require weeks occur thickness degree burn injury extends layers skin pain burn area stiff healing typically occur fourth degree burn additionally involves injury deeper tissues muscle bone burn black frequently leads loss burned burns generally treatment depends severity burn superficial burns managed little simple pain medication major burns require prolonged treatment specialized burn centers cooling tap water help pain decrease damage prolonged cooling result low body temperature partial thickness burns require cleaning soap water followed clear manage probably reasonable leave intact small drain large thickness burns usually require surgical treatments skin extensive burns require large amounts fluid fluid tissue swelling common complications burns involve infection given date fire heat resulted million injuries resulted million dying deaths burns occur developing world particularly southeast_asia large burns fatal treatments developed improved outcomes especially children young adults united_states approximately admitted burn center survive injuries burns occur similar frequencies men women long term outcome related size burn age person affected signs symptoms characteristics burn depend depth superficial burns cause pain lasting days followed skin days individuals suffering severe burns indicate discomfort complain feeling pressure pain thickness burns entirely light touch superficial burns typically red color severe burns pink white black burns mouth hair inside nose indicate burns occurred findings definitive signs include breath common healing process occurring adults nearly children persist prolonged period time electrical injury burns produce emotional psychological distress cause burns caused variety external sources classified thermal heat related chemical electrical radiation united_states common causes burns fire flame hot objects electricity chemicals burn injuries occur home work accidental assault resulting suicide attempt sources cause injury lungs occurring burn injuries occur commonly poor smoking risk factor alcohol use fire related burns generally common colder climates specific risk factors developing world include cooking open fires floor developmental disabilities children chronic diseases adults thermal united_states fire hot common causes burns house fires result death smoking causes heating devices cause half injuries efforts fight fire caused hot gases commonly occurs exposure hot drinks high temperature tap water showers hot cooking oil steam injuries common children age united_states australia population makes thirds burns contact hot objects cause burns children generally second degree burns degree burns result especially prolonged contact fireworks common cause burns holiday seasons countries particular risk adolescent males chemical chemicals cause burns contribute burn related deaths chemical burns caused substances strong base strong acid chemical burn deaths secondary common agents include acid found toilet found found paint acid cause particularly deep burns time exposure acid cause breakdown significant numbers red blood cells electrical electrical burns injuries classified high voltage greater equal volts low voltage volts flash burns secondary electric arc common causes electrical burns children electrical followed electrical outlets lightning result electrical burns risk factors struck include involvement outdoor activities mountain climbing golf field sports working outside mortality lightning strike electrical injuries primarily result burns cause secondary blunt force trauma muscle high voltage injuries damage occur internally extent injury judged examination skin contact low voltage high voltage produce cardiac cardiac arrest radiation radiation burns caused protracted exposure light sun arc radiation radiation therapy rays radioactive fallout sun exposure common cause radiation burns common cause superficial burns overall significant variation easily people based skin type skin effects radiation depend exposure area hair loss seen seen wet skin occurs appear time exposure radiation burns treated burns microwave burns occur thermal heating caused short seconds cause injury overall uncommon occurrence non accidental hospitalized fire burns assault reasons include child abuse personal disputes abuse elder abuse business disputes injury indicate child abuse created lower body held surface hot water typically produces sharp upper border symmetrical high risk signs potential abuse include burns absence splash marks burn uniform depth association signs neglect abuse bride burning form domestic violence occurs cultures india women burned revenge husband family consider inadequate pakistan acid burns represent intentional burns frequently related domestic violence self setting oneself fire form protest parts world temperatures greater proteins begin losing dimensional shape start breaking results cell tissue damage direct health effects burn secondary disruption normal functioning skin include disruption skin sensation ability prevent water loss ability control body temperature disruption cell membranes causes cells lose potassium spaces outside cell water large burns total body surface area significant response results increased fluid subsequent tissue causes overall blood volume loss remaining blood suffering significant loss making blood concentrated poor blood flow organs tract result failure stomach increased levels cause state years associated increased cardiac output fast heart rate poor immune function diagnosis burns classified depth mechanism injury extent associated injuries commonly classification based depth injury depth burn usually determined examination difficult accurately determine depth burn single examination repeated examinations days necessary fire related burn carbon poisoning considered poisoning considered size size burn measured percentage total body surface area affected partial thickness thickness burns degree burns red color included burns involve number methods determine including wallace rule chart based person palm size rule easy remember accurate people years age accurate estimates charts account different proportions body parts adults children size person including palm fingers approximately severity determine need specialized burn unit american burn association devised classification system system burns classified major moderate minor assessed based number factors including total body surface area affected involvement specific zones age person associated injuries minor burns typically managed home moderate burns managed hospital major burns managed burn center prevention historically half burns deemed burn prevention programs significantly decreased rates burns measures include limiting hot water temperatures smoke systems proper construction buildings fire resistant clothing experts recommend setting water measures prevent include measure bath water temperatures splash guards effect regulation fireworks unclear tentative evidence benefit recommendations including limitation sale fireworks children management begins assessment person breathing circulation injury suspected early required followed care burn wound people extensive burns wrapped clean sheets arrive hospital burn wounds prone infection shot given individual years united_states burns present emergency department treated discharged require hospital admission major burns early feeding important useful addition traditional treatments poor tissue solution given children burns adults burns formal fluid monitoring follow begun pre hospital possible burns greater formula help determine volume required hours formula based affected individual weight half fluid administered hours remainder following hours time calculated burn occurred time fluid began children require additional maintenance fluid includes additionally injuries require fluid inadequate fluid cause problems detrimental guide tailored output adults children mean arterial pressure greater solution evidence superior normal appear good expensive recommended blood rarely required typically recommended level falls associated risk complications placed burned skin needed wound care early cooling minutes burn reduces burn depth pain care taken cooling result performed cool water ice water cause injury chemical burns require extensive irrigation cleaning soap water removal dead tissue application important aspects wound care intact present clear tentative evidence supports leaving intact second degree burns evaluated days management second degree burns little quality evidence exists determine dressing type use reasonable manage degree burns recommended little evidence support use silver type recommended potentially healing time insufficient evidence support use containing silver negative pressure wound therapy burns painful number different options pain management include simple addition help anxiety healing process nerve aid effective purpose people tentative evidence supporting use use reasonable improve requires study recommended pain recommended surgery extensive burns guidelines recommend general use concerns resistance increased risk fungal tentative evidence shows improve survival rates large severe burns found effective prevent treat burn cases burns caused acid calcium specific human growth burns involve body appears speed healing affecting risk death surgery wounds requiring surgical closure skin flaps typically small thickness burn dealt early possible burns limbs chest need urgent surgical release skin known treat prevent problems circulation ventilation uncertain useful neck digit burns required electrical burns alternative medicine honey ancient times aid wound healing beneficial second degree burns tentative evidence honey helps heal partial thickness burns evidence poor quality beneficial reducing pain review found tentative evidence improved healing times subsequent review find improved healing silver controlled trials use plants burns little evidence helps butter recommended low income countries burns treated time traditional medicine include applications eggs mud leaves cow surgical management limited cases insufficient financial resources availability number methods addition reduce procedural pain anxiety including virtual reality therapy approaches distraction techniques worse larger burns older females presence smoke injury significant injuries long bone heart disease diabetes psychiatric illness intent influence average admitted united_states burn centers die outcome individuals dependent extent burn injury example burn areas mortality rate mortality rate afghanistan people burns rarely survive score historically determine major burns improved care longer accurate score determined adding size burn age person taking equal risk death burns resulted million years lived disability million disability adjusted life years complications number complications occur common order frequency potential complications include pneumonia tract respiratory failure risk factors infection include burns thickness burns extremes age young old burns involving legs pneumonia occurs particularly commonly injuries secondary thickness burns greater common electrical burns lead compartment syndrome muscle breakdown blood veins legs estimated occur people state persist years major burn result decrease bone density loss muscle mass form subsequent burn particularly young dark skinned following burn children significant psychological trauma experience post traumatic stress disorder result disturbance body image developing world significant burns result social isolation extreme poverty child abandonment fire heat resulted million injuries resulted million dying deaths makes 4th leading cause injuries motor vehicle collisions falls violence burns occur developing world attributed partly unsafe cooking situation overall nearly fatal burns occur southeast_asia rate number fatal burns increased developed world adult males twice mortality females burns probably higher risk greater risk taking activities countries developing world females twice risk males related accidents kitchen domestic violence children deaths burns occur times rate developing developed world overall children leading causes death 1980s countries seen decrease rates fatal burns burns generally developed countries estimated burn injuries receive medical treatment yearly united_states resulted deaths burns deaths burns occur males highest fire burns occurs years old highest occurs children years old adults electrical burns result deaths year lightning results death people year europe intentional burns occur commonly middle aged men developing countries india people year sustain significant burns looked specialist burn units highest rates occur women years age high rate related unsafe loose fitting clothing typical india estimated burns india clothing catching fire open flames intentional burns common cause occur high rates young women secondary domestic violence self harm history cave paintings years ago document burns management earliest egyptian records treating burns describes prepared milk mothers baby boys bce smith describes treatments honey treatments ages including use tea leaves chinese documented bce pig fat documented bce wine documented french barber surgeon describe different degrees burns expanded degrees different hospital treat burns opened london england development modern burn care began late 1800s early 1900s world war henry developed standards cleaning burns wounds solutions significantly reduced mortality 1940s importance early skin acknowledged time fluid guide developed 1970s researchers demonstrated significance state follows large burns


injury injury damage tree structure involving result blunt penetrating trauma neck chest harmful smoke objects rare condition cause resulting life threatening respiratory injuries accompany half cases people die receiving emergency care injuries vital organs reach hospital mortality rate high frequently difficult treat early diagnosis important prevent complications include respiratory tract infection damage lung tissue diagnosis involves procedures ray tree signs symptoms vary based location severity injury commonly include difficulty breathing condition voice weak excessively abnormal breath sounds emergency setting ensure remains open severe cases surgery necessary repair anatomy form tree situated lower end center chest splits ridge called stabilized kept open rings surround sides structure rings closed surround membrane split smaller branches supply air tiny air filled lungs responsible absorbing oxygen arbitrary division inlet opening cavity structures surround protect tree include lungs large blood vessels rib cage spine children softer elastic trees adults helps protect structures injury compressed contribute lower children classification transverse occurring rings longitudinal spiral occur main complex occurring location type main transverse tears common longitudinal complex ones completely partial tears way allow completely detached tears allow separation occur classified complete incomplete incomplete layer tissue surrounding remains intact air preventing leaking areas surrounding incomplete require closer scrutiny detect diagnosed right away injuries divided accompanied disruption air leak hole form type associated minor signs small occurs function lost lung supplied injured unaffected parts lungs able compensate results blunt trauma occurs chest common injury tear near wall blunt chest trauma occurs time injury common right main left possibly near tissues mid chest surround left main protect possibility people left main injuries likely deadly injuries die reaching hospital making likely included studies determine rates injuries signs symptoms signs symptoms vary depending tree injured severely damaged direct signs certain signs suggest injury raise suspicion occurred signs symptoms present injuries similar injury mechanisms respiratory distress found people blood found isolated usually cause bleeding bleeding observed likely injury large blood vessel patient exhibit diminished breath sounds rapid breathing common present abnormal high pitched breath sound indicating upper occur damage cause air trapped tissue skin abdomen chest neck head present people particularly indicative injury neck air trapped chest cavity outside lungs especially strong evidence occurred failure resolve chest tube placed rid chest cavity air shows air continually leaking chest cavity site tear air trapped center chest cavity air escapes penetrating injury neck definite diagnosis sign sound occurs time accompany causes injuries tree chest occur penetrating forces gunshot wounds result blunt trauma blunt forces usually results high energy impacts falls height motor vehicle accidents injury rare low impact mechanisms injuries cause traffic related deaths potential causes falls high places injuries chest crushed explosions cause gunshot wounds form penetrating trauma cause commonly knife wounds motor vehicle accidents penetrate injuries occur neck chest deep protected quarter resulting penetrating trauma occurs chest injury usually affects anterior certain medical procedures include damaged resulting tube rare mechanism occurs unclear likely mechanism involves tube catching fold membrane tearing advanced downward tube tears typically posterior wall unlike results blunt trauma injuries involve longitudinal tears tears pull away excessive pressure tube reduce blood supply tissues leading potentially causing infected later narrowed lining injured hot gases harmful gas lead swelling death tissue formation ultimately foreign body medical procedures uncommon mechanism structures tree protected normally takes large force blunt trauma usually result violent compression chest rapid neck usually resulting vehicle crashes trauma neck crush crush injury occur head collisions neck strikes steering wheel called injury injured collisions seat belt mechanism understood blunt trauma widely thought caused combination possible mechanisms increase pressure pulling apart type injury called explosive occur chest violently compressed example driver strikes steering wheel vehicle accident chest crushed pressure especially larger quickly rises result compression closes pressure exceeds tissues burst commonly affected mechanism injury portions second mechanism occur chest suddenly occurs vehicle accidents producing force lungs mobile chest cavity movement restricted near areas near fixed respectively tear points mechanism occurs chest compressed causing widen lungs adhere chest wall negative pressure membranes lining inside chest cavity chest widens pulled apart creates tension tears force exceeds mechanism cause injury chest crushed probably combination mechanisms damaged air escape trapped surrounding tissues neck builds high pressures massive air leaks compromise circulation preventing blood returning heart head lower body causes potentially deadly reduction blood heart able pump blood build injury interfere interfere continuity completely tissues surrounding hold adequate air exchange occur diagnosis rapid diagnosis treatment important care injury diagnosed shortly injury risk complications higher effective method locate determine severity usually method allows definitive diagnosis diagnosis flexible allows injury directly fastest reliable technique people reveal torn blocked blood collapsed lower view chest ray initial imaging technique film signs patient indications seen include defect wall air tissues neck rays accompanying injuries signs occurs bone appears ray sitting unusually high throat indication severed suspected tube appears ray place appears normal tear torn way lung collapse outward chest wall inward usually loses attachment normally holds center person lying face lung collapses sign described called fallen lung sign occur conditions occurs rarely cases people blunt trauma signs injury chest ray scanning resulting blunt trauma ray replacement discovered number high cases specific signs chest detection complicated concurrent injuries tends occur high energy accidents weeks months injury diagnosed injury better known past prevention vehicle occupants wear seat belts lower motor vehicle accident situated neck instead chest increases risk injury design medical instruments modified prevent medical practitioners use techniques reduce risk injury procedures treatment treatment varies based location severity injury patient stable having trouble breathing ensuring patent patient breathe paramount importance ensuring open adequate ventilation difficult people method secure bypass disruption order send air lungs necessary tube placed single lung penetrating injury neck air escaping wound multiple unsuccessful attempts conventional direct threaten alternative techniques video employed facilitate upper injured membrane order ensure open useful site artificial cause complications impossible establish sufficient complicated surgery performed bypass blood pumped body machine pumped occurs chest tube inserted cavity remove air people provided supplemental oxygen need mechanical ventilation employment certain measures positive end pressure ventilation higher normal pressures helpful maintaining adequate measures increase air tear stress tear repaired lowest possible pressures maintain typically mechanical ventilation cause high pressure required lungs techniques toilet removal fluid management treatment pneumonia employed improve compliance lungs managed surgery surgical repair tear considered standard treatment required tear ventilation tissues mid chest occurs progresses rapidly air leak large persistent despite chest tube placement indications surgery tear tears loss tissue need positive pressure ventilation damaged tissue torn tissue removed order obtain clean edges repaired damaged tissue repair extensive tears include tissue taken membranes surrounding heart lungs respectively protect lung tissue destroyed result complications removal lung lobe respectively required avoided possible high rate death associated procedure surgery repair tear tree successful performed months trauma occur diagnosis delayed results delayed diagnosis surgery similar performed early diagnosis section removed cut repaired complications people die minutes injury complications insufficient injuries occurred time late deaths occur attributed multiple organ syndrome condition recognized treated early complications likely occur example pneumonia occur late complications years pass condition recognized small significant clinical noticed diagnosed heal intervention tissue grows injured site cause week month tissue delayed diagnosis increases risk infection hospital stay people narrowed suffer respiratory tract infection difficulty clearing completely occurs lung collapse lung tissue completely infected filled tissue remains functional removed affected portion lung commonly able function normally infection common lungs partially infected lung tissue damaged develop addition pneumonia cause develop restored normal resulting loss lung function permanent complications occur treatment example form site wound tear occurs excessive pressure ventilation people receive surgery soon injury repair outcome usually good long term outcome good people repaired early treatment surgery performed years injury outlook good low rates death disability good chances preserving lung function common type blunt injury difficult determine cases death occurs person reaches hospital people included studies hand small cause significant symptoms noticed addition injury associated symptoms complications develop later true autopsy studies revealed people died trauma neck chest including people died immediately estimated occur estimated patients treated trauma centers estimated blunt chest neck trauma penetrating chest trauma injuries occur patients penetrating injury neck occurs blunt chest trauma deaths people blunt trauma reach hospital alive reports found study blunt chest trauma revealed mortality rate possibly associated injuries caused medical procedures rising risk higher women elderly results times mouth performed high mortality rate people reach hospital alive estimated recent estimates place number number people reaching hospital alive increased improved care specialized treatment centers reach hospital alive die hours arrival sooner diagnosed higher mortality rate likely accompanying injuries prove fatal accompanying injuries play key role outcome injuries accompany include ribs spinal cord injury facial trauma traumatic injuries abdomen lung head present common accompanying injury known syndrome occurs penetrating injuries neck cause injury history history mortality rate thought healed noted duck killed hunter demonstrating injury survived general sense report record medical literature injury earliest reports medical literature year old woman chest crushed wagon wheel found autopsy right long term survival injury unknown humans report person survived report described successful removal lung year old girl injury repair probably attempted documented case successful prior mortality rate fallen improvement likely improvements treatments surgical techniques including injuries commonly associated


spelled structures anal canal normal state help control disease swollen term mean disease signs symptoms depend type present internal usually present bright red bleeding external result pain swelling area bleeding occurs usually darker symptoms frequently better days skin tag remain healing external exact cause remains unknown number factors increase pressure abdomen believed involved include sitting toilet long time common pregnancy diagnosis looking area people incorrectly refer occurring anal area causes symptoms ruled reasonable confirm diagnosis rule causes specific treatment needed initial measures consists increasing fiber intake drinking maintain help pain rest applied area poorly supported evidence number minor procedures performed symptoms severe improve conservative management surgery reserved fail improve following measures half thirds people problems point lives males females affected equally commonly affect people years age common wealthy outcomes usually good known mention disease egyptian signs symptoms people significant symptoms internal external present differently people combination bleeding cause rare life threatening bleeding uncommon people feel embarrassed facing problem seek medical care case advanced external external cause problems painful pain typically resolves days swelling weeks disappear skin tag remain healing large cause issues produce surrounding skin internal internal usually present bright red bleeding following movement blood typically covers condition known toilet paper toilet bowl usually normally coloured symptoms include discharge mass internal usually painful causes exact cause unknown number factors believed play role including irregular habits lack exercise factors low fiber increased abdominal pressure prolonged abdominal mass pregnancy absence veins aging factors believed increase risk include prolonged sitting chronic pelvic floor evidence associations poor pregnancy pressure abdomen changes cause vessels birth baby leads increased abdominal pressures pregnant women rarely need surgical treatment symptoms usually resolve delivery normal human anatomy disease experience abnormal changes main present normal anal canal located left lateral right anterior right posterior positions composed veins blood vessels called tissue smooth muscle muscle tissue walls veins set blood vessels known important contribute anal closure pressure rest protect internal external anal muscles passage person bears abdominal pressure grows increase size helping maintain anal closure symptoms believed result structures slide downwards pressure excessively increased increased internal external anal pressure involved symptoms types occur superior inferior line divides regions diagnosis typically diagnosed physical examination visual examination surrounding area external exam performed detect possible enlarged examination possible appropriate pain internal associated pain visual confirmation internal require hollow tube device light attached end types external internal differentiated position respect line persons concurrently versions pain present condition likely anal external internal internal internal originate line covered lacks pain classified grades based degree grade prominent blood vessels grade bearing spontaneous reduction grade iii bearing requiring manual reduction grade inability manually reduced external external occur line covered skin sensitive pain temperature differential problems including cancer similar symptoms incorrectly referred bleeding occur owing cancer including disease disease present potential causes considered conditions produce anal mass include skin anal enlarged anal increased portal blood pressure portal system present similar different condition portal increase risk prevention number measures recommended including avoiding attempting avoiding eating high fiber diet drinking plenty fluid taking fiber getting sufficient exercise spending time attempting avoiding reading toilet losing weight overweight persons avoiding heavy lifting recommended management conservative conservative treatment typically consists foods rich fiber intake oral maintain anti drugs rest increased fiber intake shown improve outcomes achieved alterations consumption fiber evidence benefits point treatment lacking limited minutes time agents available treatment little evidence supports use containing agents days cause skin agents include combination active ingredients include barrier cream petroleum agent contain peru certain people questionable benefit potential effects symptoms usually resolve following pregnancy active treatment delayed delivery procedures number office based procedures performed generally safe rare effects occur rubber band typically recommended line treatment grade disease procedure elastic bands applied internal line cut blood supply days falls band placed close line intense pain results immediately cure rate found rate involves injection agent causes vein walls collapse success rate years treatment number methods shown effective usually methods fail procedure infrared radiation laser surgery infrared option grade disease grade disease rates high surgery number surgical techniques conservative management simple procedures fail surgical treatments associated degree complications including bleeding infection anal retention close proximity nerves supply small risk occurs particularly liquid rates reported condition occur anal anal similar mild form surgical primarily severe cases associated significant pain usually requires weeks recovery long term benefit greater grade compared rubber band recommended treatment external carried hours procedure helps pain healing guided invasive treatment accurately locate arterial blood tied tissue normal position slightly higher rate fewer complications compared known involves removal enlarged tissue followed remaining tissue normal position generally painful associated faster healing compared complete removal chance returning greater conventional typically recommended grade disease difficult determine common people condition healthcare provider thought affect population time lives population affected given time sexes experience condition rates peaking years common higher status long term outcomes generally good people episodes small proportion persons end needing surgery history known mention disease egyptian advises thou recipe great protection leaves ground cooked strip fine place recovers immediately corpus discusses treatment similar modern rubber band like manner treat needle tying thick thread application drop leave patient recovers let course described bible earlier english translations obsolete spelling described procedures discussed possible complications advocated connection veins claiming reduced pain spread fourth fifth century similar words emphasizes wound 13th century european milan guy john great progress development surgical techniques medieval times known saint curse sixth century saint developed following soil use word english occurs derived old french latin turn greek liable discharge blood blood stream flow current flow stream notable cases hall fame baseball player george removed game world series pain undergoing minor surgery returned play game problems underwent surgery following spring conservative political commentator underwent surgery subsequently describing unpleasant experience widely viewed youtube video president jimmy carter surgery matthew richards condition


syndrome syndrome diagnosed chronic disorder characterized meals following consumption muscles abdomen abdominal pain associated typical disorder historically documented affecting young children people disabilities prevalence high patients mental disabilities today diagnosed increasing numbers healthy adults lack awareness condition doctors patients general public syndrome presents variety ways especially high contrast existing presentation typical adult mental disability presentation infant mentally impaired like related disorders adversely affect normal functioning social lives individuals linked depression little comprehensive data syndrome healthy individuals exists private illness number symptoms clinical similarities syndrome disorders stomach symptoms include acid induced erosion severe weight loss appetite individuals begin minute following cycle mimic diagnosis syndrome non invasive based history individual treatment promising upwards individuals responding positively treatment including mentally handicapped classification syndrome condition affects functioning stomach known functional disorder patients history eating disorders syndrome grouped alongside eating disorders grouped non mental disorder healthy adults mental disability syndrome considered disorder instead eating disorder patients tend control occurrence history eating disorders signs symptoms number severity symptoms varies individuals repetitive food known start meal present individuals small occurring long period time following short lasting expelled experience symptoms following meals experience episodes following single bite massive feast long term patients find select couple food drink items trigger response unlike typical typically described seldom preceding expulsion food lacks bitter taste stomach acid symptoms begin manifest point meal minutes common range seconds hour completion meal symptoms tend cease contents acidic abdominal pain lack production dental decay described common symptoms day day life symptoms necessarily prevalent episodes happen time weight loss observed average loss kilograms common cases disorder gone longer period time expected nutrition deficiencies accompany disorder consequence symptoms depression linked syndrome effects syndrome unknown acid erosion teeth feature bad breath causes cause syndrome unknown studies drawn causes history patients disorder impaired disease normally attributed parents causing individual seek self self lack abundance external disorder commonly attributed bout illness period stress individual recent past changes medication adults causes generally fall category habit induced trauma induced habit induced individuals generally history intentional professional example initially self induced forms habit continue manifest outside control affected individual trauma induced individuals describe emotional physical injury recent surgery psychological distress deaths family etc preceded onset months diagnosis syndrome diagnosed based complete history individual costly invasive studies testing unnecessary aid based typical observed features criteria suggested syndrome primary recently food consistent occurring weeks past months begin minutes completion meal patients matter expel symptoms stop minutes matter acidic symptoms result mechanical respond standard treatment disease adults diagnosis supported absence classical structural diseases system supportive criteria include taste sour acidic generally preceded sensation preceding act associated patients visit average physicians years correctly diagnosed syndrome differential diagnosis syndrome adults complicated disorder symptoms mimic disorders diseases especially prevalent adults especially far common patients hear experiences syndrome similarities symptoms outside observer following food intake long term patients include amounts offset lack willingness expose condition symptoms suggested connection unlike self inflicted adults syndrome generally aware gradually increasing unable control contrast intentionally induce seldom swallow food common like syndrome patients bring food following meal unlike causes contrast food stomach occurs hours meal preceded bitter sour taste typical syndrome poorly understood disorder number theories speculated mechanisms cause unique disorder theory gained consensus notable widely published widely documented mechanism food causes followed abdominal compression simultaneous lower les creates common cavity stomach allows partially material return mouth offered explanations sudden les explanations learned voluntary common having voluntary overall process generally abdominal pressure proposed explanation abdominal compression primary mechanism adaptation commonly described mechanism air immediately prior causes activation les patients describe feeling similar onset preceding treatment presently known cure pump little effect treatment different mentally handicapped adults normal intelligence adults techniques practice eating occurs proven effective mentally handicapped mild training shown cause improvement cases training involves behavior negative results rewarding good behavior eating placing sour bitter taste tongue individual begins movements breathing patterns typical behavior generally accepted method training older studies advocate use patients normal intelligence intentional behavior reversed breathing counter urge alongside explanation habit reversal patients shown breathe prior normal period similar breathing pattern prevent normal breathing method works physically preventing abdominal required expel stomach contents supportive therapy breathing shown cause improvement cases total cessation symptoms additional study adolescent patients followed months initial treatments patients successfully use technique notice immediate change health better individuals intentionally induced past reduced chance improvement reinforced behavior technique young children complex timing concentration required successful grow disorder year training disorder initially documented affecting children individuals mental functional disabilities handicapped recognized occur males females ages abilities described equal prevalence population adults typically occurs months age occurrence syndrome general population defined described rare described rare rarely recognized disorder female typical age adolescent onset years males affected sooner females males versus females little evidence concerning impact hereditary influence syndrome case reports involving entire families exist history term derived latin word means described ancient times mentioned writings aristotle syndrome documented italian wrote symptoms patient earliest cases physician nineteenth century charles brown acquired condition result experiments way evaluating testing acid response stomach foods doctor swallow tied string intentionally analyze contents result experiments doctor eventually meals numerous case reports exist twentieth century influenced greatly methods thinking time early twentieth century increasingly evident presented variety ways response variety conditions considered disorder infancy disability time difference presentation adults established studies healthy adults rare starting 1900s majority published reports analyzing syndrome mentally healthy patients appeared adult described treated condition described base patients examine gradually increased people come forward symptoms awareness condition medical community general public limited animals animals cows goats considered normal behavior animals known behavior termed related human syndrome ordinary similar seen humans described


facial syndrome facial syndrome called syndrome gypsy type facial syndrome rare syndrome characterized facial type bones tissues face including lip caudal human tail growth intellectual developmental disability system male heart skeletal present syndrome initially described associates thought genetically related syndrome syndrome considered spectrum genetic disorders associated similar facial skeletal termed syndrome proposed spectrum includes genes believed cause syndrome unknown pattern inheritance means gene associated syndrome located syndrome occurs copies gene inherited characteristics syndrome apparent birth characterized feature known facial observed noted initial description syndrome lip facial identified bones muscles tissues face including lips forms lip typically seen syndrome middle lip affecting sides mouth facial generally encompasses wide range severity ranging minor split lip major developmental structural defects facial bones soft tissues lip occurs additional facial dental described syndrome include unusually wide set eyes reported narrow separation upper lower frontal prominent ridge highly arched wide nasal root flattened nasal tip upper cheek bone lower jaw prominent include enlarged ear ridge hearing associated media ear middle ear hearing loss feature identified syndrome caudal caudal stemming present non human animal species typical tail feature seen infant described human tail observed individuals brazil rays variously appeared prominent physical examination resembles like animal tail deficiencies mental learning disability growth developmental delay common psychiatric reported syndrome include behavior obsessive disorder loss aggression fear physical contact actions like repeating words spoken person noted affecting reproductive systems common syndrome reported variously affected males split valve affected boy reported left enlarged displaced right kidney noted syndrome heart observed syndrome healthy japanese couple described sixth child features consistent disorder month old male infant affected cardiac including patent defect opening associated repaired infant days age number minor skeletal reported infant including bones classification syndrome shown physical similarities genetic disorders report year old boy exhibiting facial caudal consistent syndrome skeletal indicative syndrome suggests disorders caused different gene disorders similar overlapping features inheritance syndrome considered belong designation syndrome described year old female known syndrome review physical similarities particularly facial appearance including instances lip similarity abdominal believed represent spectrum genetic disorders individual disorders initially suggested spectrum named syndrome conclusion syndrome supported reported brother sister array symptoms overlapped assertion syndrome cause cause syndrome disorders syndrome consideration caused genes investigation families affected syndrome studied resulted identification genes proteins complement plays role complement system innate non specific immunity humans species gene located short arm humans protein type belongs family proteins role innate immunity protein thought involved development tissues including heart kidney function facial development study version contributed possibly associated errors crest cell migration binding gene located long arm human protein type called binding plays role innate immunity binding including hiv described turkish individuals families children relatives cousins said family characteristics syndrome including facial caudal evaluated investigation gene mapping revealed region location gene originate common ancestor families family location resulted replacement acid position gene sequence observed individuals second family dna showed nonsense resulted position gene occur form known process loss function associated causes availability like growth factor development period results indicate responsible array features found disorders including syndrome syndrome inherited manner means gene responsible disorder located copies gene inherited parent required order born disorder parents individual disorder carry copy gene usually experience signs symptoms disorder diagnosis suggested criteria syndrome include lip typical associated facial features following caudal growth developmental delay relatively high rate hearing found disorder considered diagnosis disorder wolf rogers syndrome shares features criteria lacking microscopic analysis individual employed distinguish short arm revealed wolf present favor syndrome diagnosis individual syndrome normal management found syndrome corrected include lip skeletal caudal primary area concern procedures applied disorders including syndrome regards logistics methods like management general hampered smaller mouth infant regional methods like spinal blocking difficult present report year old girl syndrome prepared unrelated undergoing needed identify placement tube troublesome presence attributed syndrome replacement adjusted size proceeded normally successful general followed rare follow male syndrome presented born term uneventful pregnancy delivery infant underwent surgical repair lip problems reported procedure heart defect apparent required intervention age years mental obsessive disorder diagnosed hearing diagnosed age managed use hearing aids course decade followed number psychiatric performed age exhibited fear physical contact age experienced severe episode characterized loss array symptoms treated maintained low level mental age moments history syndrome determined report suggested individuals worldwide affected disorder time syndrome reported colleagues observed children unspecified gender described gypsy family children included siblings cousin family known highly


self harm self harm defined intentional direct injuring body tissue intentions term self harm means self injury terms recent literature attempt reach neutral terminology older literature especially statistical manual mental disorders exclusively refers self common form self harm skin cutting self harm covers wide range behaviors including burning hitting body parts interfering wound healing hair pulling toxic substances objects associated substance abuse eating disorders usually considered self harm resulting tissue damage effect boundaries clearly defined cases usually fall outside boundaries self harm represent self harm performed explicit intent cause tissue damage suicide intention self harm relationship self harm suicide complex self behaviour potentially life threatening increased risk suicide individuals self harm extent self harm found self majority cases inaccurate desire self harm listed borderline personality disorder patients self harm including depression anxiety disorders substance abuse eating disorders post traumatic stress disorder personality disorders self harm apparent high functioning individuals underlying clinical diagnosis motivations self harm vary fulfill number different functions functions include self harm mechanism provides temporary relief intense feelings anxiety depression stress emotional sense failure self mental traits including low self esteem self harm associated history trauma abuse including emotional sexual abuse number different methods treat self harm concentrate treating underlying causes treating behaviour self harm associated depression drugs treatments effective approaches involve avoidance techniques focus keeping individual occupied activities replacing act self harm safer methods lead permanent damage million cases self harm occurred self harm common young adulthood usually appearing ages self harm childhood relatively rare rate increasing 1980s self harm behaviour occur age including elderly population risk injury suicide higher older people self harm self harm limited humans captive animals birds known participate self behaviour classification self harm referred self injury self inflicted violence self injury self behavior refers spectrum behaviors injury self inflicted behavior involves deliberate tissue damage usually performed intent common form self harm involves cutting skin sharp object knife razor blade term self phrase evokes find inaccurate offensive self inflicted wounds specific term associated soldiers describe non lethal injuries inflicted order obtain early dismissal combat differs common definition self harm damage inflicted specific secondary purpose broader definition self harm include inflict harm bodies means eating self injury added disorder distinguishes forms self harm disorder occurs person deliberately physical way intent committing suicide self harm intent seen spectrum like disorders substance abuse gambling addiction like disorders self behaviors cross certain threshold classified mental health disorder criteria include days self inflicted harm course year intent individual motivated seeking relief negative state resolving difficulty achieving positive state common belief self harm attention seeking behavior cases inaccurate self self conscious wounds feel guilty behavior leading great lengths conceal behavior offer alternative explanations injuries conceal clothing self harm individuals associated behavior people self harm usually seeking end life suggested instead self harm mechanism relieve emotional pain discomfort attempt communicate distress alternatively interpretations based supposed self harm clear indications intent life behaviour intent whilst seemingly superficial cuts suicide attempt studies individuals developmental disabilities intellectual disability shown self harm dependent environmental factors obtaining attention escape demands individuals desire feel real fit society rules signs symptoms eighty percent self harm involves stabbing cutting skin sharp object number self harm methods limited individual determination harm includes burning self poisoning alcohol abuse self objects hair pulling hitting self hurt self counter drugs forms self harm related locations self harm areas body easily hidden concealed detection defining self harm terms act damaging body accurate define self harm terms intent emotional distress person attempting deal provide criteria self harm seen underlying disorder people self harm like addressed cause mental disorder people self harm form recognised mental disorder people experiencing forms mental ill health higher risk self harm key areas disorder exhibit increased risk include spectrum disorders borderline personality disorder disorder depression conduct disorders contributing factor self harm diagnosed high risk suicide particularly greater younger patients insight effects disorder lives substance abuse considered risk factor personal characteristics poor problem solving skills parallels self harm syndrome psychiatric disorder individuals illness trauma common ground inner distress culminating self directed harm patient desire medical personnel order gain treatment attention important self harm psychological factors abuse childhood accepted primary social factor increasing self harm troubled parental partner relationships factors war poverty unemployment contribute self harm frequently described experience state individuals borderline personality disorder engage self harm estimated individuals spectrum disorders engage self harm point including eye skin picking hand biting head distinctive characteristic rare genetic condition syndrome self harm include biting head contribute risk developing psychological conditions anxiety depression turn lead self behaviour link self harm healthy patients largely inconclusive drugs alcohol substance dependence withdrawal associated self harm dependence withdrawal associated self behaviour young people alcohol major risk factor self harm study analysed self harm presentations emergency rooms northern_ireland found alcohol major contributing factor involved self harm presentations recent study relation use deliberate self harm norway england found general use specific risk factor young self harm typically behaviour possibility self inflicted injury result life threatening damage person recognise connection self harm response profound overwhelming emotional pain resolved functional way motivations self harm vary fulfill number different functions functions include self harm mechanism provides temporary relief intense feelings anxiety depression stress emotional sense failure self positive statistical self harm emotional abuse self harm means managing controlling pain contrast pain experienced earlier person life control abuse motives self harm fit models behaviour demonstrated quotation motivations self diverse included examining interior arms hydraulic lines sound strange assessment motives medical setting usually based incident circumstances information patient limited studies professional assessments tend suggest manipulative motives personal assessments study reported motives draw attention anger people means drawing attention need help ask assistance indirect way attempt affect manipulate way emotionally chronic repetitive self harm want attention hide carefully people self harm state allows away separating mind feelings causing achieved mind believing present suffering felt caused self harm instead issues facing previously physical pain acts distraction original emotional pain complement theory consider need stop feeling emotional pain mental person hyper sensitive overwhelmed great thoughts revolving mind triggered decision stop overwhelming feelings alternatively self harm means feeling sensation unpleasant painful self harm describe feelings physical pain relief feelings person detached detached life recognise need function desire feel real decision create sensation wake engage self harm face contradictory reality time obtaining relief act hard actually initiate cutting know relief follow self relief primarily psychological feeling relief comes beta released brain released response physical injury act natural induce pleasant feelings act reduce tension emotional distress self report feeling little pain self deliberate self harm means seeking pleasure mechanism self harm psychologically addictive self works enables deal intense stress current moment patterns created specific time intervals acts self harm create pattern result wanting fulfill thoughts self harm nervous system natural set point ability experience stress people high threshold people overwhelmed quickly emotional pain regions brain physical pain significantly state people environmental differences responding nervous system composed components sympathetic nervous system controls physical activation fight flight response nervous system controls physical processes automatic production sympathetic nervous system physically connected parts body involved stress responses studies shown self greater skin stress self stress response time staying constant increasing self injuring gradually decreases self treatment considerable uncertainty forms physical treatments people harm effective psychiatric personality disorders common individuals self harm result self harm indicator depression psychological problems people self harm moderate severe depression treatment tentative evidence medication greater study required recommended therapy established treatment self behavior children therapy assist axis depression disorder behaviour therapy successful individuals exhibiting personality disorder potentially mental disorders exhibit self behaviour diagnosis treatment causes self harm thought best approach treating self harm cases particularly people personality disorder effective starting approach order reduce behaviour people rely self harm hospitalised based stability ability especially willingness help therapy shows promise treatments family intervention therapy shown possibly effective treating self behavior children analysis found psychological therapy effective reducing self harm proportion self harmed follow period lower intervention groups controls psychological largest effect sizes behavior therapy therapy based therapy individuals developmental disabilities occurrence self harm demonstrated related effects environment obtaining attention desired materials escaping demands disabled individuals communication social self harm way obtaining things unable obtain socially appropriate way asking approach treating self harm teach alternative appropriate response result self harm avoidance techniques generating alternative person engage instead self harm successful method employed avoid self harm techniques aimed keeping busy include taking walk participating sports exercise friends person urge harm removal objects self harm easy reach helpful resisting self urges provision card allows person emergency contact services urge self harm arise help prevent act self harm alternative safer methods self harm lead permanent damage example snapping rubber band wrist help calm urge self harm help raise self awareness certain pre particular mental state mood bouts self behaviour help identify techniques avoid pre lead self harm avoidance strategy appropriate individual motivation reason difficult gain accurate picture prevalence self harm lack sufficient numbers dedicated research centres provide continuous monitoring system sufficient resources statistical estimates crude self harm undisclosed medical profession acts self harm frequently carried secret wounds superficial easily treated individual recorded figures based sources psychiatric samples hospital general population surveys world health organization estimates deaths occur result self harm medical result self harm majority drug studies based hospital hide larger group self need seek hospital treatment injuries instead treating present general hospitals deliberate self harm report previous episodes receive medical attention united_states adults self harm approximately population engaging chronic severe self harm current research suggests rates self harm higher young people average age onset earliest reported incidents self harm children years old rates self harm young people high addition appears increased risk self harm college students general population study undergraduate students students surveyed indicated cut burned occasion past definition self harm expanded include head oneself hitting oneself cutting burning sample said ireland study found instances hospital treated self harm higher city urban districts rural settings case child adolescent self harm europe study suggests life time risk self injury women men gender differences general latest research found difference prevalence self harm men women contrast past research indicated times females males direct experience self harm caution needed seeing self harm greater problem females males engage different forms self harm hitting easier hide explained result different circumstances remain widely opposing views gender real phenomenon merely artifact bias data collection euro study suicide established demonstrated age group female rate self harm exceeded males highest rate females age group highest rate males age group known vary significantly depending population criteria consistent wide ranging gathering interpreting data rates self harm general problems focus criticism context broader interpretation example feminist author barbara speculated reported gender differences rates self harm deliberate socially biased sampling errors directly blaming medical discourse female gender distorted specific populations rates self harm high implications significance interpretation factors gender study found extremely high prevalence self harm homeless runaway youths aged males females reporting history self harm study young people self harm saw gender gap close young females young males admitting self harm studies indicate males self harm greater risk completing suicide appear difference motivation self harm adolescent males females example increase deliberate self harm associated increase consumption cigarettes drugs alcohol triggering factors low self esteem having friends family members self harm common males females limited study found young individuals self harm equally likely use method skin cutting females self cut likely males explain self harm episode saying wanted punish new_zealand females hospitalised intentional self harm males females commonly choose methods self poisoning generally fatal require elderly study district general hospital hospital self harm cases aged male female ratio self harm rates males females local population identical conditions significant physical illness patients gave history earlier self harm repetition suicide rates low explained absence factors known associated repetition personality disorder alcohol abuse nice guidance self harm suggests older people self harm greater risk completing suicide older people self harm going end life study completed ireland showed older irish adults high rates deliberate self harm comparatively low rates suicide developing world recently attempts improve health developing world concentrated physical illness mental health deliberate self harm common developing world research self harm developing world limited important case study sri_lanka country exhibiting high suicide self poisoning agricultural natural people admitted deliberate self poisoning study young expressed desire die death relatively common young cases improvement medical management acute poisoning developing world poor improvements required order reduce mortality causes deliberate self poisoning included harsh discipline parents mechanisms spread local communities people surrounded previously deliberately harmed attempted suicide way reducing self harm limit access cases involve yellow seeds reduction access agents difficult great potential reduction self harm lies education prevention limited resources developing world methods challenging prison inmates deliberate self harm especially prevalent prison populations proposed explanation prisons violent places prisoners wish avoid physical confrontations resort self harm ruse convince prisoners dangerously insane pain obtain protection prison authorities history self harm known regular ritual practice cultures ancient maya civilization maya performed auto sacrifice cutting piercing bodies order draw blood reference priests cutting blades blood flowed found hebrew bible judaism self harm forbidden mosaic law self harm practised hindu catholic flesh ancient mourning rituals described annual ritual self chains swords takes place sect term self occurred study considered self cutting symbolic term reappeared article book refined conceptual definitions self study self differentiated self self non fatal expression death wish coined term partial suicide began classification system types nail extreme hair removal unnecessary surgery religious self rites removal alteration eye ear removal self extreme organic brain diseases allow repetitive head hand biting finger eye removal conventional nail hair differentiated delicate low coarse high self cut delicate young multiple episodic superficial cuts generally borderline personality disorder diagnosis coarse older generally ross categorized self groups cutting biting burning hitting 1970s focus self harm shifted sexual drives patients created categories numbered roman defining self rows iii reviewed hundreds studies divided self categories culturally sanctioned self self created sanctioned self rituals practices rituals repeated reflect traditions symbolism beliefs society practices historically piercing nose male non jews self equivalent self harm society culture awareness movements general self harm community self harm treatment better known mental health professionals general public example march designated self injury awareness day world day people choose open self harm awareness organizations special efforts raise awareness self harm people wear orange awareness ribbon encourage awareness self harm animals self harm non human mammals established widely known phenomenon study zoo laboratory conditions lead better understanding self harm human patients zoo laboratory isolation important factors leading increased self harm higher mammals lower mammals known laboratory conditions administration drugs example high toxic known self harm lab animals dogs obsessive disorder lead self inflicted injuries example captive birds known engage feather causing damage feathers range feather removal feathers bird reach skin muscle tissue breeders mice noticed similar behaviors known involves mouse facial fur cage mates behaviors include ears severely large sections lost


syndrome syndrome group symptoms indication number potentially life threatening drug interactions occur following drug use combination particular drugs recreational use certain drugs syndrome drug reaction predictable consequence excess peripheral nervous system reason experts strongly prefer terms accurately reflect form poisoning excessive levels produce spectrum specific symptoms including effects symptoms range barely fatal numerous drugs drug combinations reported produce syndrome exact mechanism understood instances diagnosis includes observing symptoms investigating patient history factors interacting drugs syndrome characteristic picture mistaken illnesses people particularly syndrome condition characterized excessive blockade usually result anti drugs leading movement disorders changes temperature problems laboratory tests currently confirm diagnosis diagnosed based symptoms disease course progression disease exclusion possible causes presenting symptoms treatment consists contribute moderate severe cases antagonist important treatment includes controlling high profile case generally accepted died syndrome resulted changes graduate medical education new_york state signs symptoms onset usually rapid occurring minutes elevated levels syndrome encompasses wide range clinical findings mild symptoms consist increased heart rate pupils intermittent symptoms effects drug drug interaction causing excessive levels effect elevated common effect action exposure moderate includes additional sounds high blood pressure temperature high moderate cases greater lower limbs upper limbs mental changes include severe symptoms include severe increases heart rate blood pressure lead shock temperature rise life threatening cases include failure effects usually arising consequence symptoms described clinical effects mental confusion coma effects effects muscle manifested cause large number high dose combination produce syndrome cases occur patients drug combinations increase occur single agent combination pose particularly acute risk life threatening syndrome case combination commonly known present similar dangers combination phenomenon described general terms cheese effect weeks replaced body instance incorrectly thought cause syndrome example case reports implicated syndrome appears based unlikely cause syndrome suggested significant effects dual action drug suggested cause syndrome evidence significant activity thought unlikely produce syndrome united_states food drug administration issued alert suggesting combined use potentially lead severe cases syndrome disputed researchers cases reported met hunter criteria syndrome condition occurred surprising clinical situations variations individuals associated unexpected drugs including relative risk severity effects individual drugs combinations complex syndrome reported patients ages including elderly children newborn exposure increases dose dose insufficient cause fatalities syndrome healthy adults elevations central nervous system typically reach potentially fatal levels drugs different mechanisms action mixed drugs significant associated severe cases syndrome involved multiple states including aggression pain sleep appetite anxiety depression humans effects excess noted patients receiving syndrome caused increased central nervous system originally suspected central grey responsible development syndrome study determined primarily appears contribute substantially condition contribute interaction increased concentrations additionally play role concentrations increased syndrome levels appear clinical outcome play role antagonists suggested affecting development syndrome pronounced following merge toxic effects spectrum concept spectrum concept role progressively increasing levels play clinical picture effects merge dose effect relationship effects progressive elevation raising dose drug combining drug produce large elevations levels diagnosis laboratory test syndrome diagnosis observation investigation patient history criteria proposed evaluated criteria introduced harvey professor ucla researchers australia later developed hunter criteria decision rules better sensitivity respectively compared gold standard diagnosis medical criteria commonly important symptoms syndrome extreme spontaneous physical examination patient include assessment deep muscle oral size pupils intensity sounds skin color presence absence patient history plays important role diagnosis investigations include use counter drugs illicit substances agents implicated development syndrome fulfill hunter criteria patient taken agent meet following conditions spontaneous plus plus plus plus temperature plus differential diagnosis characteristic picture generally hard confuse medical conditions situations mistaken viral illness anxiety disorder poisoning psychiatric condition condition confused syndrome syndrome clinical features syndrome syndrome share features difficult conditions altered mental status develop actually different conditions different underlying excess blockade time course clinical features differ significantly rapid onset administration drug responds blockade drugs like blockade slow onset typically days administration drug responds differential diagnosis difficult patients recently exposed drugs drugs features present useful lead pipe syndrome causes management management based primarily stopping usage drugs administration antagonists supportive care including control control instability control additionally large agents benefit activated administered hour intensity therapy depends severity symptoms symptoms mild treatment consist medication offering supportive measures giving waiting symptoms resolve moderate cases thermal corrected benefit antagonists antagonist recommended initial therapy controlled trials demonstrating syndrome despite absence controlled trials number case reports detailing apparent improvement people administered animal experiments suggest benefit antagonists available administered tube unlikely effective people administered activated limited use severe cases additional treatment severe case includes drugs antagonist activity critically ill people receive people instability low blood pressure require treatment direct acting conversely treated short acting drugs longer acting drugs avoided lead shock cause accumulation important factor determining course treatment presence oxygen care taken prevent unsafe spike body temperature assist excess principle applies alcohol cases syndrome caused help dispatch instances main concern specific treatment symptoms required important treatments control extreme possibility injury person administered sign physical restraints recommended contribute mortality enforcing muscle associated severe physical restraints necessary severe rapidly replaced cause large muscle breakdown breakdown cause severe damage condition called treatment includes reducing muscle severe cases require muscular artificial ventilation recommended muscular increase risk cardiac associated agents recommended increase body temperature muscular activity temperature set point drugs cases syndrome resolve hours cases persist number days symptoms typically persist longer time frame patients taking drugs long elimination half life active protracted duration action cases reported muscle pain weakness months contribute ongoing features following appropriate medical management syndrome generally associated favorable studies syndrome difficult physicians unaware diagnosis miss syndrome variable survey conducted england found general practitioners prescribed unaware syndrome increasing larger number pro drugs drugs increase levels clinical practice surveillance study identified cases patient months patients taking additionally percent persons thought develop syndrome notable cases widely recognized example syndrome death freshman college death march age died hours emergency admission new_york hospital medical center ongoing history depression came manhattan hospital evening march fever strange motions body times emergency room physicians unable condition definitively admitted observation death caused combination medical intern prescribed case impact graduate medical education residency work hours limits set working hours medical commonly referred residents hospital training programs require closer senior physician supervision


type respiratory infection usually caused virus infection leads swelling inside wind pipe normal breathing produces classic symptoms voice fever nose present symptoms mild moderate severe starts worse night normally lasts days caused number including virus rarely infection typically diagnosed based signs symptoms potentially severe causes foreign body ruled investigations blood tests rays cultures usually needed cases usually treated single dose mouth severe cases required percent cases relatively common condition affects children point commonly occurs months years age rarely seen children old slightly common males females occurs autumn frequently caused fatal cause rare western world success signs symptoms characterized difficulty breathing usually night described resembling seal sea lion worsened crying heard rest indicate critical decrease considerably symptoms include fever symptoms typical common cold chest wall sick appearance indicate medical conditions causes usually deemed viral infection use term broadly include acute conditions involve viral infection generally respect infection usually greater severity viral viral acute caused virus member family primarily types cases viral causes include respiratory virus caused group acute lacks usual signs infection fever sore throat increased white blood cell count treatment response treatment similar divided usually primary viral infection secondary growth common bacteria implicated viral infection causes leads swelling large white blood cells especially cells swelling produces significant leads dramatically increased work breathing characteristic turbulent noisy known diagnosis clinical diagnosis step exclude conditions upper especially foreign body frontal ray neck routinely performed characteristic called sign similar shape sign suggestive diagnosis absent half cases investigations blood tests viral culture discouraged cause unnecessary stress compromised viral cultures obtained confirm exact cause usually restricted research settings infection considered person improve standard treatment point investigations indicated severity commonly system classifying severity score primarily research purposes clinical practice sum points assigned factors level consciousness air entry points given factor listed table right final score ranges total score indicates mild characteristic present rest total score classified moderate presents easily heard signs total score severe presents obvious features marked chest wall total score indicates impending respiratory failure longer prominent stage children presenting emergency department mild disease severe rare prevention cases prevented time referred disease rare developed world treatment children generally kept calm possible given routinely severe cases children oxygen receive oxygen severe hospitalized observation oxygen needed blow administration holding oxygen source near child face recommended causes use mask treatment people require shown improve outcomes children significant relief obtained early hours administration effective given oral route preferred single dose usually required generally considered safe appear equally effective moderate severe improved temporarily typically produces reduction severity minutes benefits hours condition remains improved hours treatment complications arise child typically discharged hospital treatments studied sufficient evidence support use hot steam air traditional self care treatment clinical studies failed effectiveness currently rarely use usually contain discouraged breathing mixture oxygen decrease work breathing past little evidence support use usually viral disease secondary infection suspected cases possible secondary infection recommended severe cases associated administered viral usually self limited disease half cases going away day cases days rarely result death respiratory failure cardiac arrest symptoms usually improve days seven days uncommon complications include pneumonia affects children usually presents ages months years accounts hospital population rare cases occur children young months old years males affected frequently females increased prevalence autumn history word comes early modern english meaning cry applied disease scotland popularized 18th century known time homer ancient greece viral differentiated viral called faux french called false english true referred disease caused false known pseudo nearly unknown affluent countries modern times advent effective


syndrome syndrome called syndrome rare syndrome described colleagues syndrome characterized nose broad big toes hearing loss facial features unusually wide set eyes developmental delay believed inherited linked manner means genetic causing disorder located copies gene inherited female born disorder copy sufficient cause male born disorder syndrome likely caused gene located positions syndrome determined considered affect people united_states greater europe similar syndrome characteristics syndrome characterized number nasal facial features include broad high depressed nasal bridge nose eyes flattened nasal tip nose shortened arch like appearance unusually wide set eyes prominent frontal bones ridge ridge extra skin broad forehead overall enlarged head observed upper lip exaggerated bow shape upper jaw reported affecting fingers toes observed syndrome big toes reported brothers apparent fingers unaffected appeared bent fingers additional described big toes affected individuals rays year old boy disorder shown caused shortening joint ends big toes particular rounded like appearance acoustic observed syndrome include hearing loss affected turkish brothers mild form hearing loss voice reported examination brothers revealed swelling vocal associated hearing observed year old girl father number cases characteristics seen syndrome include developmental delay growth blood flow right heart associated breath failure develop period aggressive behavior noted syndrome thought caused gene study concluded based analysis markers small gene sequences found common individuals having ethnicity ancestry genetic disease family described gene likely located long arm positions definitive specific gene named syndrome strongly believed inherited linked manner female carries gene copies chance passing children like daughter carrier associated disease son disease males copy express disease form inheritance syndrome absolute girl reported disorder suggested analysis needed inheritance formally established diagnosis seen syndrome result distinct diagnosis criteria disorder broad big toes accompanied broad shortened nose hearing loss developmental delay predominant occurrence males classification syndrome similar share features common syndrome syndrome developmental delay hearing loss reported features syndrome include nasal big toes broad big toes primary characteristics syndrome management number features found syndrome managed treated hearing loss humans caused loss hair cells sensory inner ear associated hearing hereditary syndrome case syndrome attributed management hearing loss hearing aids treatments depending cause severity include approach use certain surgical intervention like valve present affected treatment cardiac require surgery non surgical procedures like balloon widening valve balloon history syndrome initially described james associates reported brothers broad hearing loss facial features consistent known syndrome specific rate determined syndrome considered rare disease office rare diseases national health suggests respectively syndrome affects people affects greater people europe publications hereditary hearing loss oxford_university press retrieved april


infectious disease caused virus affects liver cause acute chronic people symptoms initial infection develop rapid onset sickness yellowish skin dark abdominal pain symptoms weeks rarely initial infection result death days symptoms begin infected time birth develop chronic infected age chronic disease symptoms liver cancer eventually develop complications result death chronic disease virus transmitted exposure infectious blood body infection time birth contact people blood childhood frequent method acquired areas disease common areas disease rare drug use sexual intercourse frequent routes infection risk factors include working healthcare blood living infected person travel countries infection rate high living institution led significant number cases 1980s common improved spread holding hands sharing eating kissing infection diagnosed days exposure diagnosis typically testing blood parts virus virus known infection recommended world health organization day life possible required later time effect works time countries gave national programs recommended blood tested prevent infection initial infection care based symptoms person develop chronic disease medication useful drugs expensive liver world population infected point lives including million million chronic million new occurred people die year liver cancer disease common east asia sub africa adults infected rates europe north_america originally known research looking create foods contain disease affect great signs symptoms acute infection virus associated acute viral illness begins general ill health loss appetite body mild fever dark progresses development noted skin indication possible virus types illness lasts weeks gradually improves affected people people severe liver disease failure die result infection entirely chronic infection virus associated chronic liver chronic leading period years type infection dramatically increases liver cancer europe cause approximately chronic carriers encouraged avoid consuming alcohol increases risk liver cancer virus linked development symptoms outside liver present infected people include sickness like syndrome acute childhood syndrome sickness like syndrome occurs setting acute preceding onset clinical features fever skin symptoms shortly onset persist duration acute people acute carriers associated described adults common children common form immune disorders essential mixed cause transmission transmission virus results exposure infectious blood body containing blood times infectious hiv possible forms transmission include sexual contact blood human blood products use contaminated vertical transmission mother child intervention mother positive risk passing infection offspring time birth risk high mother positive transmitted family members households possibly contact skin membrane containing reported adults associated identifiable risk factor proper appear contribute mother child transmission virus detected days infection persist develop chronic period virus days average vary days structure virus member family virus particle consists outer envelope core composed protein diameter viral dna dna reverse activity outer envelope contains embedded proteins involved viral binding entry susceptible cells virus smallest animal capable liver cells known referred particles addition particles spherical bodies lacking core found infected individuals particles infectious composed protein forms surface called surface produced excess life cycle virus circular dna unusual dna fully double stranded end length strand linked viral dna long length strand long short length strand negative sense non viral viral dna found nucleus soon infection cell partially double stranded dna rendered fully double stranded completion sense strand removal protein sense strand short sequence sense strand non bases removed ends sense strand ends rejoined known genes called core protein coded gene start preceded upstream frame start pre core protein produced produced processing pre core protein rare strains virus known virus present dna gene gene gene codes surface gene long open reading frame contains frame start divide gene sections pre pre multiple start different sizes called large order surface inside pre pre middle pre small produced function protein coded gene fully understood associated development liver cancer genes promote cell growth growth regulating molecules life cycle virus complex known non use reverse process virus gains entry cell binding surface virus host viral dna transferred cell nucleus host proteins called partially double stranded viral dna fully double stranded viral transformed closed circular dna serves template viral host largest longer viral new copies core protein viral dna viral undergo additional processing form released cell returned nucleus produce copies long transported protein dna dna reverse activity virus divided major based presented envelope proteins according overall sequence variation distinct geographical distribution tracing evolution transmission virus differences affect disease severity course likelihood complications response treatment possibly differ sequence reported initially described types described divided distinct properties mechanisms virus primarily functions liver functional evidence closely related duck virus host cell domain viral surface subsequently specific expressed primarily viral dna proteins detected sites suggesting cellular exist cells infection host immune response causes damage viral clearance innate immune response play significant role processes immune response particular virus specific contributes liver injury associated infection eliminate infection killing infected cells producing purge viable liver damage initiated cells induced activated site infection facilitate accumulation liver diagnosis tests called detection virus infection involve blood tests detect viral proteins produced virus produced host interpretation complex surface frequently screen presence infection viral appear infection early infection present later infection cleared host infectious contains inner core particle viral core particle copies core protein alternatively known core window host remains infected successfully clearing virus specific core anti evidence disease panels contain total anti shortly appearance called appear traditionally presence host associated higher rates viral enhanced variants virus produce rule hold true natural course infection cleared anti arise immediately conversion usually associated dramatic decline viral host able clear infection eventually followed surface core anti anti time removal appearance anti called window period person negative positive anti cleared infection previously individuals remain positive months considered carriers carriers virus chronic reflected elevated levels liver immune clearance phase chronic infection carriers negative status particular acquired infection adults little viral little risk long term complications infection tests developed detect measure dna called viral load clinical specimens tests assess person infection status monitor treatment individuals high viral loads ground glass prevention prevention routinely recommended united_states given course months protective response defined anti concentration recipient effective children percent protective levels drops years age percent years protection afforded long lasting levels fall birth recommended infected mothers combination immune accelerated course prevents transmission time birth cases risk exposure body blood testing verify effective recommended given sufficiently assisted reproductive technology sperm washing necessary males prevent transmission female partner effectively females risk transmission mother child different risk spontaneous conception high risk infection tested effective treatment disease groups screening recommended include following people areas world occurs hiv drug users men sex men live duration year follow studies cases normal immune system rare chronic documented treatment acute infection usually require treatment adults clear infection spontaneously early treatment required fewer people infection takes aggressive course hand treatment chronic infection necessary reduce risk liver cancer infected individuals elevated marker liver damage dna levels candidates therapy treatment lasts months year depending medication available drugs clear infection stop virus liver damage seven licensed treatment infection united_states include drugs immune system world health organization recommended combination line agents current need treatment use requires daily weekly supplanted long acting injected weekly individuals likely respond virus person treatment reduces viral liver reducing viral load virus particles measured blood response treatment differs treatment produce rate type similar rates type type cases sustained loss treatment types types virus infection acute self limiting chronic long standing persons self limiting infection clear infection spontaneously weeks months children likely adults clear infection people infected adults older children stage recovery develop protective immunity virus drops younger children acquire infection mother birth clear infection population lifetime risk death infected age clear infection occur infection uses surface form infection increases risk liver liver cancer common people infection number different tests available determine degree present test choice expensive ratio index cost issue virus dna body infection people disease rare seen following alcohol drug use people impaired immunity goes cycles non approximately overt carriers experience acute males times likely develop people lower levels occur spontaneously people undergo higher risk drugs favor increased cell function liver risk varies depending profile blood greatest risk core risk presence surface considered marker immunity treatment drugs prevent associated disease estimated million individuals infected worldwide national regional prevalence ranges asia united_states northern europe routes infection include vertical transmission early life horizontal transmission bites habits adult horizontal transmission sexual contact drug use primary method transmission reflects prevalence chronic infection given area low prevalence areas continental united_states western_europe injection drug abuse unprotected sex primary methods factors important moderate prevalence areas include eastern_europe russia japan population infected disease predominantly spread children high prevalence areas china south east asia transmission common areas high africa transmission childhood significant factor prevalence chronic infection areas high prevalence africa far_east china million infected people followed india indonesia million million respectively according world health organization estimated people die year related infection united_states new cases occurred nearly history earliest record epidemic caused virus outbreak smallpox occurred bremen shipyard employees people weeks months later workers ill diagnosed suffering employees different remained healthy paper regarded classical example study proved contaminated source outbreak later numerous similar reported following introduction importantly reused treatment virus discovered working national health discovered australia later known surface blood australian people virus suspected research published discovered virus particle electron early 1980s virus tested society culture world day observed july aims raise global awareness encourage prevention diagnosis treatment led world alliance got global endorsement world health organization