sexually transmitted infection caused subspecies signs symptoms vary depending stages presents primary secondary primary stage presents single firm non skin multiple secondary frequently involves hands feet occurs mouth little symptoms years soft non heart symptoms known great cause symptoms similar diseases commonly spread sexual activity transmitted mother baby pregnancy birth resulting human diseases caused related include subspecies subspecies subspecies diagnosis usually blood tests bacteria detected dark field center disease control recommends pregnant women tested risk decreased latex use having sex effectively treated preferred cases injected muscle severe potassium recommended treatment people develop fever muscle pains reaction known infected people caused deaths decreasing dramatically availability 1940s rates infection increased turn millennium countries combination human virus hiv believed partly increased prostitution decreasing use unsafe sexual practices men sex men cuba country world eliminate mother child transmission signs symptoms present different stages primary secondary occur referred great sir william varied presentations primary primary typically acquired direct sexual contact infectious person approximately days initial exposure average days skin called appears point contact time single firm non skin clean base sharp borders size form classic form finally erosion occasionally multiple present multiple common hiv painful tender occur outside common location women men relatively commonly men sex men frequently occurs area infection occurring seven days formation persist weeks treatment secondary secondary occurs approximately weeks primary infection secondary disease known different ways manifest symptoms commonly involve skin membranes symmetrical reddish pink non trunk including form flat broad whitish like known membranes harbor bacteria infectious symptoms include fever sore throat weight loss hair loss rare include liver kidney disease joint nerve acute symptoms usually resolve weeks people present secondary symptoms people present secondary women men report previously having classic primary defined having proof infection symptoms disease described early year secondary late year secondary united_states united_kingdom uses cut years early late early symptoms late early occur approximately years initial infection divided different forms late treatment infected people develop disease people infectious late usually occurs years initial infection average years stage characterized formation chronic soft like balls vary considerably size typically affect skin bone liver occur refers infection involving central nervous system occur early form late general associated poor balance lightning pains lower late typically occurs years initial infection typically presents seizure general pupils small pupils person focuses near objects exposed bright light usually occurs years initial infection common result formation transmitted pregnancy birth thirds born symptoms common symptoms develop couple years life include liver fever lung late occur including saddle nose sign joints cause subspecies spiral shaped negative highly mobile human diseases caused related including subspecies subspecies subspecies unlike cause disease humans known natural reservoir subspecies unable survive host days small failing pathways necessary slow doubling time greater hours transmission transmitted primarily sexual contact pregnancy mother able pass intact membranes compromised skin kissing near oral anal sex approximately exposed primary secondary disease exemplified fact individual organisms chance infected new cases united_states occur men sex men transmitted blood products tested countries risk low risk transmission sharing appears limited generally possible contract toilet seats daily activities hot sharing eating clothing mainly bacteria die quickly outside body making transmission objects extremely difficult diagnosis difficult early presentation confirmation blood tests direct visual inspection blood tests commonly easier perform tests unable distinguish stages disease blood tests blood tests divided tests tests initially include disease research laboratory rapid tests tests occasionally false confirmation required test particle absorption test false tests occur viral tuberculosis malaria tissue disease pregnancy tests usually positive weeks initial infection diagnosed finding high numbers high protein levels fluid setting known infection direct testing dark ground fluid immediate diagnosis hospitals equipment experienced staff members testing minutes acquiring sample sensitivity reported nearly confirm diagnosis rule tests carried sample direct testing acid tests direct testing uses tagged attach specific proteins acid uses techniques chain reaction detect presence specific genes tests time sensitive require living bacteria diagnosis prevention effective prevention based proteins reduce development animal model research ongoing sex intimate physical contact infected person effective reducing transmission proper use latex use completely eliminate risk centers disease control prevention recommends long term mutually relationship partner avoidance substances alcohol drugs increase risky sexual behavior disease newborn prevented screening mothers early pregnancy treating infected united_states services task force strongly recommends universal screening pregnant women world health organization recommends women tested visit positive recommend partners treated common developing world women receive care care receive include screening occasionally occurs developed world likely acquire drug use etc likely receive care pregnancy measures increase access testing appear effective reducing rates middle income countries point care testing detect appeared good research needed assess effectiveness improving outcomes mothers babies screening recommends sexually active men sex men tested yearly recommends screening high risk disease countries including canada european_union united_states means health care providers required public health authorities provide partner person partners physicians encourage patients send partners seek care strategies found improve follow testing including email text appointments treatment early choice treatment remains single dose alternative choices risk birth defects recommended pregnant women resistance present generation effective based treatment recommended treated person avoid sex healed late poor penetration central nervous system affected recommended given large minimum days person attempted late presentations treated weekly weeks case early disease albeit longer duration treatment stage limits progression slight effect damage occurred reaction potential effects treatment reaction frequently starts hour lasts hours symptoms fever muscle pains fast heart rate caused released immune system response released bacteria pregnancy effective treatment pregnancy agreement dose way giving effective research needed infected people believed infected million additional people greater cases developing world affects million year resulting spontaneous caused deaths sub africa contributes approximately deaths rates higher drug users infected hiv men sex men united_states rates times greater men women nearly equal african americans accounted half cases continue increase united_states common europe 18th 19th centuries found universal nineteenth century egyptian prostitutes developed world early 20th century declined rapidly widespread use 1980s 1990s rates increasing usa canada australia europe primarily men sex men rates american women remained stable time rates women increased rate men increased rates occurred china russia 1990s attributed unsafe sexual practices sexual prostitution decreasing use barrier protection mortality greater death rate males symptoms severe 19th 20th centuries widespread availability effective treatment partly decreasing early treatment complications result increases risk hiv transmission times common urban centers cuba country world mother child transmission history exact origin disputed present americas european contact dispute present world time primary proposes carried americas europe returning crewmen christopher columbus voyage americas hypothesis says existed europe previously went shortly columbus return referred pre respectively hypothesis best supported available evidence written records outbreak europe occurred naples italy french invasion italian war claimed spread french troops initially known french disease people naples pastoral character italian physician poet title latin poem describing disease italy known historically great organism identified effective treatment developed paul followed trials confirmation effectiveness discovery use mid twentieth century mercury isolation commonly treatments worse disease famous historical figures including arthur believed disease friedrich long believed gone mad result diagnosis recently come question arts literature earliest known depiction individual man believed represent northern european mercenary myth poison women 19th century believed partly derived devastation classic examples literature including john dame artist jan van der painted scene wealthy man receiving treatment tropical wood title work preparation use treating artist chose include image series works celebrating new world indicates important treatment ineffective european elite time richly colored detailed work depicts servants preparing physician looks hiding patient drinks guatemala studies infamous united_states cases questionable medical ethics 20th century study study took place alabama supported public health service partnership institute study began widespread problem safe effective treatment study designed measure progression shown effective cure early widely treat disease use later unclear study directors continued study offer participants treatment debated found given subjects 1960s peter sent letter controlled study expressing concern ethics letting hundreds black men die disease cured asserted needed continue study men died went mainstream press causing public outcry result program terminated lawsuit brought affected million dollars congress created commission empowered write regulations deter abuses occurring future thanks efforts study legacy committee formed survivors study invited white_house present president bill_clinton apologized behalf united_states government study experiments carried guatemala united_states sponsored human experiments conducted government juan cooperation health officials doctors infected soldiers prisoners mental patients sexually transmitted diseases informed consent subjects treated october formally apologized guatemala conducting experiments


nitrogen diving known nitrogen gas deep effect alteration consciousness occurs diving depth caused effect certain gases high pressure greek word derived temporary decline loss senses movement term homer produces state similar alcohol occur shallow usually noticeable depths meters probably neon gases effect widely varying degree effect consistently greater gases higher good evidence properties related depth increases mental hazardous divers learn cope effects impossible develop tolerance affects divers varies widely dive dive individuals completely reversed minutes ascending shallower depth long term effects diving open water rarely develops problem long divers aware symptoms able ascend manage diving generally considered outside scope recreational diving depths oxygen critical risk factors specialist training required use containing gas prevent replacing breathing gas non classification results breathing gases elevated pressure classified principal gas involved noble gases probably neon nitrogen oxygen hydrogen cause mental function effect function processes affecting coordination sensory processes motor activity varies widely effects carbon dioxide consistently result mental function noble gases nitrogen given pressure activity usable concentration normal atmospheric pressure historically expensive practice successfully surgical operations systems proposed designed signs symptoms perception altering effects onset hard recognize results relief anxiety feeling mastery environment effects essentially identical concentrations resemble closely effects alcohol marijuana familiar drugs effects harmful cause immediate danger stabilized effects generally remain given depth ventures deeper dangerous aspects judgement multi coordination loss decision making ability focus effects include visual disturbances syndrome cause extreme anxiety depression paranoia depending individual medical personal history feel normal safe diving practices relation depth informally known law idea results feeling depth professional divers use calculation rough guide new divers metaphor comparing situation familiar reported signs symptoms summarized typical depths meters feet sea water following table causes cause related increased gases body tissues result elevated pressures depth henry law modern theories suggested gases cell membranes cause recently researchers looking protein mechanisms possible cause breathing gas mix entering lungs pressure surrounding water known ambient pressure change depth pressure gases blood passing brain catches ambient pressure minute results delayed effect descending new depth rapid compression owing carbon dioxide retention divers affected shallow changes usually noticeable reliable method predict depth noticeable severity effect individual vary dive dive day significant increasing risk depths corresponding ambient pressure bar kpa sport training organizations recommend depths risk breathing air depths ambient pressure bar kpa divers leads loss memory number divers died attempts set air depth records incidents world records longer reports figure compared altitude sickness symptoms effects depend factors variations individuals thermal cold stress heavy work fatigue carbon dioxide retention increase risk severity carbon dioxide high potential causes increased blood flow brain increasing effects gases increased risk results increasing carbon dioxide retained heavy exercise shallow skip breathing poor gas exchange lungs known minimal alcohol effects drugs marijuana likely alcohol effects day use drugs add mechanism precise mechanism understood appears direct effect gas nerve membranes causing temporary disruption nerve effect observed air gases including hydrogen cause similar effects higher atmospheric pressure effects similar mechanism reproduction inactive gas makes unlikely strictly chemical bonding usual sense chemical bond indirect physical effect change membrane volume needed affect channels nerve cells suggested non chemical binding attractive van der force proteins gases similar mechanism effect increase gas dissolved nerve cell membranes cause altered properties cells partial pressure gas required cause measured degree gas greater partial pressure needed early theory hypothesis suggested happens gas brain nerve cells causing direct mechanical interference transmission signals nerve cell recently specific types nerve cells identified involved basic general underlying idea nerve transmission altered areas brain result gas molecules dissolved nerve cells membranes remains largely management diagnosis management simply ascend shallower depths effects disappear minutes event complications conditions present ascending correct initial response problems remain necessary dive schedule followed conditions require emergency assistance symptoms caused factors dive ear problems causing early signs oxygen causing visual disturbances causing rapid breathing presence symptoms imply effects ascending shallower depth confirm diagnosis given setting likely conditions produce effects rare event condition causing symptoms initial management ascending closer surface essential prevention straightforward way avoid nitrogen limit depth severe depth increases keeping shallower depths avoid recreational dive schools basic divers depths depths present significant risk training normally required certification air training include discussion effects cure training agencies offer specialized training prepare recreational divers depths consisting theory practice deep close supervision organizations train diving recreational depths diving gases cause depth average strongly encourage use breathing gas mixes containing place nitrogen air potential use gases forms technical diving requires training certification individual predict exactly depth onset occur given day symptoms given predictable personal example trouble eye focus close accommodation middle aged divers experience feelings feelings divers report hearing changes sound bubbles different specialist training help divers identify personal onset signs signal ascend avoid severe interfere judgement necessary action deep gradual training test individual sensitivity increasing depths careful supervision logging reactions diving organizations global underwater explorers emphasize sessions purpose gaining experience recognizing onset symptoms individual somewhat average group divers scientific evidence train overcome measure given depth tolerant equivalent depth end commonly way expressing effect different breathing gases national oceanic atmospheric administration diving manual states oxygen nitrogen considered equally standard tables based relative list conversion factors effect gases example hydrogen given pressure effect equivalent nitrogen times pressure principle usable twice depth times effect nitrogen poor choice breathing gas diving inflation gas owing low thermal gases dangerous effects pressure example high pressure oxygen lead oxygen breathing gases greater depths cause high pressure nervous syndrome mysterious apparently unrelated phenomenon gas factor influencing choice gas mixture risks sickness oxygen cost factors important similar effects divers avoid drugs marijuana alcohol dive combined reduced physical capacity goes makes nitrogen likely experts recommend total alcohol hours diving longer drugs time needed marijuana unknown owing longer half life active agent drug body likely longer alcohol potentially dangerous conditions affect occasional amnesia events depth effects entirely removed ascent pose problem repeated chronic acute exposure severity unpredictable fatal diving result behavior dangerous environment tests shown divers affected nitrogen experience lesser effects possible divers manage better learning cope underlying effects remain effects particularly dangerous feel experiencing affected history french researcher victor describe symptoms noting functions brain activated imagination lively thoughts peculiar charm persons symptoms present suggested resulted pressure causing increased blood flow nerve centers walter prominent victorian physician pressure forced blood inaccessible parts body blood resulted emotional changes report related published entitled der years later similar theory published independently charles known hypothesis illustrated comparing oil albert demonstrated gases nitrogen cause gas found proportional hydrogen nitrogen deep diving experiments conducted famously described des deep research possible mechanisms action led minimum concentration concept measures relative concentration different gases required prevent motor response subjects response shows similar results measurements diving manual revised recommend treating oxygen nitrogen following research christian


state blood increases risk blood blood vessels identified people episode deep vein leg provoked causes significant proportion population develop presence additional risk factor specific treatment episodes indication long term major form identified common including factor described 1990s signs symptoms common conditions associated deep vein referred collectively usually occurs legs characterized pain swelling limb lead long term swelling damage veins break migrate lungs depending size location lead sudden onset breath chest pain complicated collapse shock cardiac arrest occur unusual places veins brain liver portal vein vein vein kidney vein veins arms increases risk arterial underlying cause heart attacks strokes established linked possibly complications pregnancy growth restriction severe pre protein cause severe disorder newborn leads tissue death bleeding skin organs condition described adults protein protein associated increased risk skin commencing treatment related drugs causes acquired refers conditions usually hereditary case hereditary increase tendency develop hand acquired refers conditions arise later life common types arise result factors relatively mild classified type defects common ones factor gene position position region gene rare forms typically caused natural classified type severe cause main ones iii protein protein rare factor abnormal unclear disorders system destroys major contributors risk instance mainly causes eye symptoms problems organs link uncertain blood group determines risk significant extent blood groups type relative risk blood group associated reduced levels von factor increased clearance factor viii related risk acquired number acquired conditions augment risk prominent example syndrome caused constituents cell membrane particularly found people disease detected people disease anti anti regarded disease cases syndrome cause arterial strongly associated cause number symptoms skin induced hit immune system reaction drug derivatives named associated low counts hit strongly associated risk arterial nocturnal rare condition resulting acquired alterations gene plays role protection blood cells complement system increases risk associated resulting destruction red blood cells hit require particular treatment conditions associated sluggish blood flow increase risk example cell disease caused regarded mild state induced impaired flow similarly disorders bone produces blood cells particularly excess red blood cells essential excess conditions usually warrant specific treatment identified cancer particularly spread places body recognised risk factor number mechanisms proposed activation system cancer cells substances furthermore particular cancer treatments use central increase risk syndrome protein released kidney diseases particularly case severe cases indicated blood levels syndrome caused condition disease disease particularly disease active mechanisms proposed pregnancy associated increased risk probably results pregnancy protects female combined oral replacement therapy associated increased risk risk depends type dose presence risk factors mechanisms protein tissue factor said responsible long regarded risk factor doubles risk numerous studies particularly combination use oral period surgery described present higher levels people people larger numbers circulating fragments damaged cells bear tissue factor increased higher levels proteins von factor factor vii factor viii increases risk initial episode unclear number conditions linked possibly genetic possibly acquired include elevated levels factor viii factor factor decreased levels tissue factor activated protein resistance factor probably caused factors remains risk factor association blood levels reported consistently studies levels determined cbs genes levels acid depend diet mechanism problem multiple reasons person develop risk factors include combination blood vessel wall blood flow consistency blood caused blood consistency determined levels factors circulating blood proteins participate cascade normal initiated release tissue factor damaged tissue tissue factor circulating factor combination factor factor factor factor factor presence factor central process generates number factor factor factor factor viii enhance process step factor tissue factor factor protein factors presence protein protein factor balance activity disturbed severity determines likelihood develops small proteins reduction normal level increase risk contrast arises levels factors markedly decreased addition effects states accelerate development arterial disease forms disease diagnosis tests include complete blood count examination blood film time partial time test time time anti anti activated protein resistance tests factor basal levels testing extensive depending clinical judgement detected initial evaluation screening views episode investigated form necessarily risk likely previous unusual sites vein syndrome generally accepted indication screening likely cost effective people strong personal family history contrast combination risk factors provide indication treatment testing performed meet strict criteria tests searching normally undertaken patients obvious trigger example recent surgery regarded provoked surgery likely investigations yield important results occurs patient experiencing major risk factors prolonged surgery trauma testing appropriate outcome test change patient indicated treatment american society recommendations choosing campaign cautioned screening false positive results testing lead people labeled having treated clinical need united_kingdom professional guidelines specific indications testing recommended testing appropriate counseling investigations usually performed time diagnosed later time particular situations vein testing discouraged altogether regarded major risk factor rare conditions generally linked cerebral portal vein insufficient data state certain screening helpful decisions screening conditions regarded evidence based cost effectiveness quality adjusted life years return expenditure taken guide generally unclear investigations justify high cost testing restricted selected situations indication screening particularly anti factor activated protein resistance general assessment investigation known women planning use oral benefit routine screening absolute risk events low woman degree relative suffered risk developing increased screening selected group beneficial negative indicate risk professional guidelines suggest alternative forms relying screening screening people arterial generally regarded generally discouraged possibly unusually young patients especially precipitated smoking use containing arterial bypass fails rapid treatment specific treatment caused underlying medical illness syndrome treatment underlying disease needed high risk form important decision use long term basis reduce risk episodes risk needs weighed risk treatment cause significant bleeding reported risk major bleeding year major bleeding die result apart forms risk episode determined factors extent severity original provoked pregnancy number previous events male sex presence inferior filter presence cancer symptoms post syndrome factors tend important decision presence absence syndrome offered long term episode risk determined detected multiple detected detected repeatedly single occasion women contemplating pregnancy pregnant usually require alternatives pregnancy especially weeks produce child low molecular weight generally alternative safely women experience pregnancy loss secondary studies suggested low molecular weight reduces risk results studies analysed benefit demonstrated people cumulative risk developing age people experienced age people protein protein people activated protein resistance usually resulting factor contrast slightly raised absolute risk having event age general men likely women experience repeated episodes people factor relatively low risk develop presence additional risk factor people develop major type rare present general population people protein present population found people exact prevalence protein population unknown found people minor type common factor present population northern european descent asian african extraction people factor referred testing defect occurs rates general population people people referred testing like factor uncommon exact prevalence syndrome known different studies employ different definitions condition detected referred testing history german physician categorized consistency blood factor development exact nature remained elusive form recognized norwegian protein followed described researchers research institute centers disease control protein followed described researchers university oklahoma syndrome described 1980s previous reports specific people syndrome attributed british graham hughes referred hughes syndrome reason common genetic described 1990s studies previously indicated people showed resistance activated protein group netherlands identified common underlying defect factor resistant action activated protein defect called factor genetic typically named place discovered years later group described common gene caused elevation levels mild increase risk suspected genetic underlying future discovered studies entire genetic code looking small genes


hereditary hereditary known disease syndrome dominant genetic disorder leads abnormal blood vessel formation skin membranes organs lungs liver brain lead acute chronic digestive tract bleeding problems involvement organs treatment focuses reducing bleeding blood vessel surgery targeted remove organs chronic bleeding requires iron blood transmitted dominant fashion occurs people disease carries names sir william louis marie frederick described late 19th early 20th centuries signs symptoms small occur skin nose tract common problem happen frequently childhood affect people skin mouth bleed considered affect skin occur lips nose fingers skin face sun exposed areas appear suddenly number increasing time affected digestive tract higher percentage cause symptoms bleed intermittently rarely significant noticed form bloody black eventually lead iron body resulting iron larger occur larger organs predominantly lungs liver brain small proportion having spinal cord lungs cause number problems lungs normally filter bacteria blood bypass network lungs allow migrate brain bacteria cause brain blood lead stroke common cause lung people found lung bleeding lung relatively unusual cause blood blood accumulating chest cavity large lung allow oxygen depleted blood right bypass meaning blood opportunity absorb fresh oxygen lead large lead difficulty breathing marked sitting compared lying probably reflects changes blood flow associated positioning large cause marked inability absorb oxygen noted bluish lips skin encountered low oxygen levels noise affected lung symptoms produced liver depend type abnormal connection form blood vessels connection veins large blood bypasses body organs heart increasing cardiac output eventually cardiac failure develops high output cardiac failure leg swelling problems creates connection portal vein blood vessels liver result portal increased portal vein pressure blood vessels form bleed violently furthermore increased pressure rise fluid accumulation abdominal cavity flow direction portal blood flows directly veins running liver lead confusion portal waste products irritating brain rarely deprived blood leading severe liver people experience problems result brain occasionally exert pressure leading increase risk abnormal tissue brain finally lead bleeding brain causes symptoms stroke weakness body difficulty speaking bleeding occurs space usually severe sudden decreased level consciousness weakness body problems small proportion affected multiple large bleed transform cancer similarly small proportion experiences state pressure lung increased pressure right heart causing peripheral swelling legs attacks chest pain observed risk particularly form deep vein increased suspicion mild slightly increased risk genetic disorder definition inherited dominant manner means affected person carries abnormal gene chance passing gene offspring symptoms relatives disease new carrying abnormal copies gene compatible life described genetic types recognized linked particular genes remaining currently associated particular cases total different known likely type particular populations data conflicting cause addition comprise disease causing apart clear lead particular symptoms reports suggest likely cause lung problems cause liver problems particular problem people people exactly different nature severity symptoms suggesting additional genes risk factors determine rate develop identified thought arise changes development blood vessels existing ones development new blood vessel requires activation migration types cells chiefly smooth muscle exact mechanism influence process clear likely disrupt balance signals blood vessels wall unusually explains tendency bleed genes known far linked code proteins signaling group proteins signal transforming growth factor beta transforming growth factor beta bone protein growth factor classes specifically enter cell link cell membrane activate proteins eventually influencing cellular behavior number ways cellular survival increasing number specialized signal adequately combination proteins needed types specific type membrane bound type proteins transfer type proteins turn complex proteins chiefly migrate cell nucleus act factors participate particular genes addition membrane act additional actions behavior cells expressed predominantly explaining causing proteins lead predominantly blood vessel problems lead predominantly related proteins proteins diagnosis tests conducted reasons firstly tests needed confirm diagnosis secondly needed identify potential complications skin oral cavity visually identifiable physical examination similarly nose seen severity grid like number episodes duration recorded digestive tract identified stomach small procedure typically undertaken marked expected severity evidence severe bleeding blood black number seen unexpectedly low remainder small examined capsule patient capsule shaped device containing miniature camera images digestive tract portable digital recorder identification requires detailed medical imaging organs commonly affected cause symptoms risk degree variation specialists investigations performed decisions issue reached patient lung suspected abnormal appearance lungs chest ray low oxygen levels pulse arterial blood gas determination bubble contrast bubble echo screening tool identify abnormal connections lung veins involves injection agitated vein followed based imaging heart normally lungs remove small air bubbles circulation seen right right present bubbles appear left left usually cardiac cycles right slower heart defects direct connections right left heart larger number bubbles likely indicate presence bubble echo perfect screening tool miss smaller identify site contrast enhanced identify lung sensitivity possible contrast administration modern suspicion high output cardiac failure large liver followed cardiac measure pressures inside chambers heart liver suspected abnormal liver function tests blood symptoms heart failure develop symptoms liver reliable initial screening test liver high sensitivity identifying liver necessary contrast enhanced characterize extremely common find incidental liver commonly focal times common compared general population regarded harmless generally markers additional imaging differentiate liver liver discouraged people risk liver significant liver useful suspected meet criteria liver demonstrated brain detected magnetic resonance better showing vessels provides detail relationship surrounding brain tissue general recommended types encountered micro surgery treatment contemplated cerebral required sufficient detail vessels procedure carries small risk stroke limited specific circumstances recent professional guidelines recommend children suspected definite undergo brain early life identify cause major complications suggest screening cerebral probably unnecessary experiencing symptoms discovered screening require treatment creating undesirable genetic testing genetic tests available testing needed diagnosis symptoms sufficient distinguish disease situations testing particularly useful firstly children young adults parent definite limited symptoms risk complications mentioned known affected parent absence child prevent need screening tests furthermore genetic testing confirm diagnosis limited symptoms labeled possible genetic diagnosis difficult occur numerous different locations linked genes particular highly frequent opposed instance sequence analysis involved genes useful approach sensitivity followed additional testing detect large additional genes linked disease gene usually associated juvenile detection indicate need screen patient affected relatives large criteria diagnosis depending presence criteria known criteria met patient definite gives possible spontaneous multiple typical locations proven lung liver brain spine degree family member despite designation possible family history extremely likely uncommon general population time said sparse occur people absence status change course life young children exhibit symptoms age thirteen percent age vast majority definite classification children established patients labeled possible turn course life treatment treatment deals symptoms disease therapy stops development directly furthermore treatments applied prevent development common complications chronic digestive tract bleeding lead bleeding completely stopped requires treatment iron tolerate iron solutions require administration iron blood causing severe symptoms warrant rapid improvement blood count treatments described adults experience treating children limited women pregnant increased risk complications observed closely absolute risk low acute managed variety measures packing nasal cavity removal packs bleeding lead reopening fragile vessels packing recommended patients wish learn packing deal having resort medical help frequent prevented keeping nostrils moist applying solution containing acid effects small degree benefit number additional prevent bleeding simple measures unsuccessful medical include oral acid evidence relatively limited poorly tolerated men possibly carries risks cancer heart disease women past nasal reduce bleeding recommended surgery considered sessions needed possible requires passing large locating ray guidance followed injection vessel particles blood vessels benefit procedure tends short lived appropriate episodes severe bleeding failed operations reported provide benefit procedure skin nostrils young procedure nostrils sealed completely skin digestive tract skin respond treatment long laser skin bleed cause pain skin occasionally needed treat problem regards digestive tract mild bleeding mild resultant treated iron specific treatment administered limited data treatment acid reduce bleeding severe episodes severe bleeding treated laser treatment identified reduce need supportive treatment expected benefits repeated attempts treating advocated sudden severe bleeding unusual encountered alternative causes need considered instances lung lung identified usually treated prevent episodes bleeding importantly brain particularly feeding blood vessel larger likely cause long term complications treated effective current therapy metal procedure involves large vein usually general followed advancing right injected identified deployed blood flow allow experienced hands procedure tends effective limited effects attempts required repeated monitor surgical essentially abandoned success definite abnormal contrast clearly visible deemed risk brain avoid diving small air bubbles form migrate brain cause stroke similarly advised procedures bacteria enter dental work avoidance air bubbles therapy liver given liver generally cause high output cardiac failure emphasis treating reduce circulating blood volume restriction salt fluid intake agents case irregular heart beat sufficient treating symptoms swelling treatment effective leads effects complications remaining option liver reserved severe symptoms carries mortality leads good results successful exact point liver offered completely established treatment attempted leads severe complications proportion patients discouraged liver related complications portal treated use treatment discouraged lack documented benefit brain decision treat brain depends symptoms cause bleeding risk predicted previous episodes scan appears deep seated deep drainage size presence appears matter high flow tend cause problems treatment time intervention available depending location size surgery radiation based treatment multiple surgery open brain surgery offered based risks treatment determined martin scale grade score higher larger close important brain structures deep drainage high grade high risk surgery typically offered cases targeted radiation therapy gamma knife small close vital structures finally small single feeding vessel experimental treatments anti drugs approved conditions cancer investigated small clinical trials anti instance label studies largest study conducted far associated decrease cardiac output reduced duration number episodes treated patients anti drug reported beneficial effects patients treatment found induce vessel maturation experimental mouse model reduce severity frequency majority small group patients blood levels treated patients rose result reduced enhanced blood vessel population studies numerous areas world shown occurs roughly rate populations areas common instance french region rate twice common populations attributed founder effect population descending small number ancestors high rate particular genetic trait ancestors trait shown result particular named highest rate reported islands caribbean belonging netherlands antilles people normal lifespan skin tend develop childhood probably present birth don necessarily cause symptoms frequent common significantly affect quality life history 19th century english physicians starting henry followed benjamin guy john described common features particularly hereditary nature disease french physician louis marie observed skin distinguished condition canadian born sir william hospital later oxford_university contributions report described characteristic digestive tract english physician frederick reported condition series cases term hereditary american physician article condition diagnosis remained clinical genetic defects cause identified research group duke university medical center respectively international scientific advisory committee foundation international published widely criteria group international experts met canada formulated evidence based sponsored foundation international


known throat infection throat including caused group common symptoms include fever sore throat red enlarged neck occur develop like known scarlet fever symptoms typically begin days exposure seven days throat spread respiratory infected person spread directly touching touching mouth nose eyes people carry bacteria symptoms spread skin infected group diagnosis based results rapid detection test throat culture symptoms prevention washing hands sharing eating disease treatment recommended confirmed diagnosis infected stay away people hours starting treatment pain treated non drugs throat common infection children cause sore children adults cases common late winter early spring potential complications include fever signs symptoms typical symptoms sore throat fever greater large symptoms include abdominal pain muscle pain uncommon highly specific finding symptoms typically begin days exposure seven days throat unlikely symptoms red eyes nose mouth present unlikely fever cause throat caused group beta gas bacteria non group beta cause spread direct close contact infected person found military schools increases rate transmission dried bacteria dust infectious moist bacteria similar items persist days contaminated food result rare children signs symptoms carry gas treatment approximately remain positive true carriers diagnosis number scoring systems exist help diagnosis use controversial insufficient accuracy modified criteria set criteria total score indicates probability infection point given criteria absence swollen tender temperature swelling age point age score indicated treatment culture needed indicate need perform testing high risk factors exist family member having disease infectious disease society america recommends treatment considers appropriate given positive test testing needed children group fever rare child sibling disease laboratory testing throat culture gold standard diagnosis sensitivity rapid test called rapid detection testing rapid test quicker lower sensitivity equal throat culture areas world fever uncommon negative rapid test sufficient rule disease positive throat culture association symptoms establishes positive diagnosis diagnosis doubt adults negative sufficient rule diagnosis children throat culture recommended confirm result individuals routinely tested throat culture certain percentage population carries bacteria throat harmful results differential diagnosis symptoms overlap conditions difficult diagnosis nasal discharge red irritated eyes addition fever sore throat indicative viral sore throat throat presence marked sore throat fever occur infectious prevention reasonable measure frequent throat year benefits small episodes typically time regardless measures taken episodes test positive gas represent person chronic carrier gas getting viral treating people exposed symptoms recommended treating people carriers gas recommended risk spread complications low treatment usually resolves days treatment duration acute illness hours primary reason treatment reduce risk complications fever effective given days onset symptoms non anti drugs help significantly management pain associated throat useful help pain routinely recommended adults recommended children risk syndrome choice united_states safety cost effectiveness preferred europe india risk fever higher choice treatment appropriate decrease average day duration symptoms day reduce primarily prescribed reduce rare complications fever arguments favour treatment balanced consideration possible effects reasonable suggest treatment given healthy adults adverse reactions medication prescribed throat higher rate expected prevalence recommended people severe generation severe evidence supports superior lead acute effect reduced use symptoms throat usually improve days treatment treatment reduces risk complications transmission children return school hours administered risk complications adults low children acute fever rare developed world leading cause acquired heart disease india sub africa parts australia complications arising throat include economic cost disease united_states children approximately million annually broader category falls diagnosed million people annually united_states cause sore children adults cases usually occur late winter early spring


known reading disorder characterized trouble reading despite normal intelligence different people affected varying degrees problems include difficulties spelling words reading quickly writing words sounding words head words reading aloud understanding reads difficulties noticed school previously read loses ability known difficulties people disorder normal desire learn cause believed involve genetic environmental factors cases run families occurs people attention deficit disorder associated similar difficulties numbers begin adulthood result traumatic brain injury stroke underlying mechanisms problems brain language processing diagnosed series tests memory spelling vision reading skills separate reading difficulties caused insufficient teaching hearing vision problems treatment involves adjusting teaching methods meet person needs underlying problem decrease degree symptoms treatments targeting vision effective common learning disability affecting population degree symptoms diagnosed men suggested affects men women equally occurs areas world believe best considered different way learning benefits classification thought types cause related language processing visual processing considered disorder problem intelligence emotional problems arise published definitions purely descriptive propose causes usually cover variety reading skills difficulties distinct causes single condition national institute disorders stroke definition describes difficulty spelling processing manipulation sounds rapid visual verbal responding british association definition describes learning difficulty primarily affects skills involved accurate fluent word reading spelling characterized difficulties awareness verbal memory verbal processing speed acquired caused brain damage stroke forms include pure surface deep definition definition sources national health define specifically learning disorder sources define simply inability read context normal intelligence distinguish developmental learning disorder acquired loss ability read caused brain damage manual medical diagnosis world includes separate developmental manual psychiatric diagnosis united_states specifically define decision stating definitions meant terms useful disorder names criteria instead includes category called specific learning disorders signs symptoms early childhood symptoms later diagnosis include delayed onset speech difficulty distinguishing left right difficulty direction lack awareness easily distracted background noise reversal letters words mirror writing seen people considered defining characteristics disorder school age children exhibit signs difficulty identifying generating words counting number syllables words depend awareness difficulty words individual sounds blend sounds producing words indicating reduced awareness difficulties word naming things associated people commonly poor feature called depends problems persist adulthood accompany difficulties stories reading aloud learning foreign languages adults read good tend read slowly learning difficulty perform worse spelling tests reading nonsense words measure awareness common myth defining feature reading writing letters words backwards true children learn read write language complexity language directly impacts difficult learning read language english french comparatively deep latin alphabet writing system complex structures employing spelling patterns levels letter sound correspondence syllables languages spanish italian finnish primarily employ letter sound correspondence called shallow makes easier learn writing systems chinese characters extensive symbol use pose problems associated conditions accompanied learning disabilities unclear share underlying causes associated disabilities include disorder primarily expresses difficulties writing cases difficulties associated eye hand coordination direction sequence oriented processes tying knots carrying repetitive tasks impaired letter writing organizational difficulties impaired visual word forming makes difficult retrieve visual picture words required spelling attention deficit disorder disorder characterized problems paying attention excessive activity taking action commonly occur people people processing disorder listening disability affects ability process information lead problems memory people processing problems develop cues compensate type deficit research indicates processing skills primary developmental coordination disorder condition characterized marked difficulty carrying routine tasks involving balance fine motor control coordination difficulty use speech sounds problems short term memory organization causes researchers trying find basis condition identified example tried associate common problem able letters clearly abnormal development visual nerve cells modern techniques functional magnetic resonance imaging pet shown functional structural differences brains children reading difficulties electrical activation parts left hemisphere brain involved reading inferior frontal inferior middle ventral temporal past decade brain activation studies pet study language produced breakthrough understanding basis language bases visual verbal short term memory components proposed observed manifestation developmental task specific functional structural provided important data point interactive role cerebral brain structures theory proposes controlled muscle movement affects formation words tongue facial muscles resulting problems characteristic involved tasks reading fact children motor task balance evidence role reading difficulties theory supported controlled research studies research potential genetic causes roots post autopsy examination brains people observed differences language centers brains include microscopic known rarely micro previously cited studies suggest abnormal development presumed occur sixth month brain development cause abnormal cell formations reported non language cerebral brain structures genes associated including gene environment interaction contribution gene environment interaction reading disability intensely studied twin studies estimate proportion associated person environment proportion associated genes studies examining influence environmental factors parental education teacher quality determined greater influence supportive optimal environments optimal conditions allow genetic risk factors account outcome environmental risk factors environment plays large role learning memory likely modifications play important role reading ability animal experiments measures gene expression human periphery study processes types study limitations results application human brain mechanisms dual route theory reading aloud described early 1970s theory suggests separate mental mechanisms routes involved reading aloud mechanism route process skilled readers recognize known words sight dictionary procedure mechanism route process reader sound written word identifying word constituent parts letters applying knowledge parts associated example string neighboring letters sound dual route system explain different rates occurrence different languages spanish language dependence rules accounts fact spanish speaking children higher level performance non word reading compared english speakers disorder caused gene fact appears involve combined effects genes studying problems associated disorders helps better understand link imaging procedures characteristics identifying effects certain genes diagnosis tests indicate high probability person testing indicates person tests followed assessment determine extent nature disorder tests administered teacher computer test results indicate carry teaching strategies central central include surface deep reclassified previous distinction single classification terms applied developmental inherited developmental inherited considered synonymous surface surface words regular highly consistent spelling mint read accurately words irregular pronunciation colonel difficulty distinguishing forms surface disorder usually accompanied surface fluent acquired surface arises previously person experiences brain damage results pronunciation errors indicate route read familiar words difficulty unfamiliar words invented pseudo words associated parts brain supplied blood middle cerebral superior temporal lobe involved furthermore compensate brain region called area associated aspects language speech program lips treat system based way sensory feedback process visual oral skills learn recognize words word patterns case studies total patients found significant improvement spelling reading ability lips deep individuals deep experience causes person read word related meaning instead denoted meaning deep associated clear processing deep caused widespread damage brain includes left hemisphere hypothesis claims deep develops peripheral peripheral described affecting visual analysis letters result brain injury visual field loss left right vertical associated condition pure pure based known pure word difficulty recognizing written sequences letters words letters considered pure accompanied significant language related pure affect speech style language pure caused visual word form area composed left lateral activated reading stops transmission visual left angular caused involving left lobe usually accompanied right visual field multiple oral reading treatment pure considered processing technique affected individuals read texts number times reading speed accuracy improves commonly considered derive visual field loss damage primary visual complain slow reading able read individual words normally common form peripheral form best evidence effective treatments neglect neglect letters commonly beginning left word reading associated right use glasses shown substantially condition people complain letter migration blending elements words read better words presented isolation flanked words letters large glass help condition reducing effects flanking nearby words trials therapy left published management use compensation strategies therapy educational support individuals learn read write techniques technical aids help manage conceal symptoms disorder removing stress anxiety improve written intervention alphabet writing systems fundamental aim increase child awareness letters sounds relate reading spelling teaching sounds blend words found reinforced training focused reading spelling yields longer lasting gains oral training early intervention language areas brain developing successful reducing long term impacts evidence use specially tailored effects include created based idea letters latin alphabet visually similar confuse emphasis making letter distinctive order easily identified font design effect reading reading time perception readers studies conducted intervention studies analysis found functional activation result children require special instruction word analysis spelling early age help better understand writing generally speaking positive individuals identified childhood receive support friends family percentage people unknown estimated low high population diagnosed males believe affects males females equally different definitions world despite significant differences writing systems occurs different populations limited difficulty converting letters sounds chinese difficulty converting chinese characters meanings chinese vocabulary uses non alphabet writing character represent individual processing hypothesis attempts explain occurs wide variety languages furthermore relationship capacity reading appears influenced history identified term coined berlin term refer case young boy severe learning read write despite showing typical intelligence physical abilities respects morgan british physician east sussex published description reading specific learning disorder report british medical journal titled word distinction surface types descriptive assumption underlying brain mechanisms studies alluded potential differences variation performance research society majority currently available research relates writing systems especially european languages substantial research available speak arabic chinese hebrew languages case disorder society makes assessment based incomplete information 1980s thought consequence education basic disability result society disorder workplace stigma negative attitude instructors lack necessary training support child condition negative effect student learning participation evidence demonstrating use music education effective improving reading skills


carbon poisoning carbon poisoning occurs carbon carbon toxic gas initially non irritating difficult people detect carbon product incomplete organic matter insufficient oxygen supply enable complete carbon dioxide produced domestic industrial settings motor vehicles run gasoline diesel carbon based tools gas cooking equipment powered carbon based exposure greater dangerous human health symptoms mild acute poisoning include confusion flu like effects larger lead significant central nervous system heart death acute poisoning long term occur carbon severe effects pregnant woman chronic exposure low levels carbon lead depression confusion memory loss carbon mainly causes adverse effects humans combining form blood prevents carrying oxygen tissues effectively reducing oxygen carrying capacity blood leading additionally mitochondrial thought adversely affected revert recovery takes time complex fairly stable treatment poisoning largely consists oxygen providing oxygen therapy treatment remains controversial oxygen works increases removal carbon turn providing body normal levels oxygen prevention poisoning significant public health issue domestic carbon poisoning prevented early detection use household carbon carbon poisoning common type fatal poisoning countries historically commonly method commit suicide usually deliberately exhaust running car engine modern automobiles controlled produce levels carbon kill enclosed garage example snow exhaust gas escape normally carbon poisoning speculated possible cause apparent haunted houses symptoms led people suffering poisoning think seen ghosts believe house haunted signs symptoms carbon toxic forms life harmful effects binding danger organisms use compound doubtful effect plants easily absorbed lungs gas lead injury nervous system damage death different people populations different carbon tolerance levels average greater dangerous human health united_states limits long term workplace exposure levels averaged hour period addition employees removed confined space upper limit ceiling reached carbon exposure lead significantly shorter life span heart damage carbon tolerance level person altered factors including activity level rate ventilation pre existing cerebral disease cardiac output cell disease disorders barometric pressure rate acute effects produced carbon relation ambient concentration parts million listed acute poisoning main carbon poisoning develop organ systems dependent oxygen use central nervous system heart initial symptoms acute carbon poisoning include fatigue symptoms mistaken virus illnesses food poisoning common acute carbon poisoning described dull frontal continuous increasing exposure produces cardiac including fast heart rate low blood pressure cardiac central nervous system symptoms include confusion central nervous system depression respiratory arrest death common symptoms acute carbon poisoning include pneumonia high blood sugar muscle acute kidney failure skin visual problems major concerns following acute carbon poisoning severe delayed occur problems include difficulty higher intellectual functions short term memory loss amnesia strange speech disturbances disease like depressed mood depression occur pre existing depression delayed occur poisoned people days difficult predict develop delayed advanced age loss consciousness poisoned initial increase chance developing delayed symptoms classic sign carbon poisoning seen dead living people described looking red healthy cherry red appearance common deceased unusual living people considered useful sign clinical medicine autopsy examination appearance carbon poisoning notable dead persons normally bluish pale dead carbon poisoned persons simply appear unusually coloration effect carbon circumstances analogous use red commercial meat packing industry chronic poisoning chronic exposure relatively low levels carbon cause persistent depression confusion memory loss unknown low level chronic exposure cause permanent damage typically removal exposure carbon symptoms usually resolve episode severe acute poisoning case noted permanent memory loss learning problems year exposure relatively low levels carbon faulty chronic exposure symptoms people chronic carbon exposure increase risk developing long term carbon present greatest risk persons heart disease females pregnant causes carbon product organic matter conditions restricted oxygen supply prevents complete carbon dioxide sources carbon include cigarette smoke house fires faulty wood burning internal vehicle exhaust electrical generators fueled equipment portable gasoline powered tools leaf lawn high pressure concrete cutting power exposure typically occurs equipment buildings semi enclosed spaces riding trucks led poisoning children automobiles exhaust pipe blocked snow led poisoning car occupants exhaust result exhaust gases reaching cabin generators propulsion engines boats especially resulted fatal carbon poisoning occur following use self contained underwater breathing apparatus faulty diving air caves carbon build enclosed chambers presence organic matter coal mines incomplete occur explosions resulting production gas fatal single breath following explosion adjacent mines dangerous leaking incident followed explosion killed men source poisoning exposure organic found paint produces carbon precise mechanisms effects carbon induced systems complex fully understood known mechanisms include carbon binding mitochondrial restricting oxygen supply carbon causing brain carbon higher compared oxygen human body produces carbon located cells breaks normal conditions carbon levels approximately higher body easily gets rid principal oxygen carrying compound blood produces compound known traditional belief carbon arises formation decreases oxygen carrying capacity blood transport delivery oxygen body affinity carbon approximately times stronger affinity oxygen carbon preference oxygen oxygen binding sites binding carbon sites increases oxygen affinity remaining sites causes retain oxygen delivered tissue situation described carbon shifting oxygen curve left increased affinity oxygen carbon poisoning little oxygen actually released tissues causes tissue injury bright red color converted poisoned commercial treated carbon acquire unnatural reddish carbon high affinity times greater oxygen carbon bound ability utilize oxygen causes reduced cardiac output result brain delayed return symptoms reported results following increased levels effect late release carbon subsequently mechanism involves effects mitochondrial respiratory chain responsible effective tissue oxygen carbon affinity oxygen possible requires significant binding binding efficient synthesis cells respond switching causing eventual cell death rate carbon slow causing relatively prolonged central nervous system effects mechanism thought significant influence delayed effects involves formed blood cells chemical cause brain degradation carbon causes cell release formation oxygen free including brain causes mitochondrial result effects causes delayed white matter central nervous system known lead brain brain damage occurs mainly recovery period result defects especially affecting memory learning movement disorders disorders typically related damage cerebral white matter basal changes following poisoning white matter cerebral pregnancy carbon poisoning pregnant women cause severe adverse effects poisoning causes tissue decreasing release maternal oxygen carbon crosses combines causing direct tissue additionally higher affinity carbon adult causing severe poisoning adult elimination carbon slower leading accumulation toxic chemical level mortality acute carbon poisoning significant despite mild maternal poisoning following maternal recovery severe poisoning death occur diagnosis symptoms carbon poisoning occur types flu diagnosis difficult history potential carbon exposure exposed residential fire suggest poisoning diagnosis confirmed measuring levels carbon blood determined measuring compared blood people continue experience significant symptoms poisoning long blood concentration returned normal presenting examination normal level happen late states poisoning rule poisoning determine levels pulse estimate non invasive finger clip similar pulse devices function passing light measuring light absorption different types use regular pulse effective diagnosis carbon poisoning people suffering carbon poisoning normal oxygen level pulse breath monitoring offers viable alternative pulse levels shown strong breath concentration devices require user deeply hold breath allow blood escape lung measurement possible patient devices appropriate use scene emergency care detection poisoning detection biological specimens carbon blood methods techniques order confirm diagnosis poisoning person assist forensic investigation case fatal exposure blood range heavy persons extensively exposed automotive exhaust gases poisoned people range persons blood levels ratio molecules average person cigarette smoke packs day levels differential diagnosis conditions considered differential diagnosis carbon poisoning earliest symptoms especially low level non specific readily confused illnesses typically flu like viral depression chronic fatigue syndrome chest pain carbon called great presentation poisoning diverse conditions included differential diagnosis include acute respiratory distress syndrome altitude sickness toxic alcohol poisoning prevention prevention remains vital public health issue requiring public education safe operation internal engines increased emphasis installation carbon carbon detected smell united_states consumer product safety commission stated carbon important home safety smoke recommends home carbon level building devices relatively inexpensive widely available powered battery backup buildings carbon usually installed equipment relatively high level carbon detected device sounds alarm giving people chance evacuate building unlike smoke carbon need placed near ceiling level use carbon standardized areas usa carbon guidelines published national fire protection association placement carbon level residence including basement addition outside sleeping areas new homes powered battery backup ensure early warning occupants levels national carbon standard address devices non residential buildings guidelines schools healthcare centers nursing homes non residential buildings include main points secondary power supply battery backup operate carbon hours ceiling room permanently installed fuel burning located level zone building gas organizations recommend gas serviced year legal requirements standard necessarily enforced law april state massachusetts requires present residences potential sources regardless building age owner occupied rented enforced municipal inspired death year old snow blocking home heating vent jurisdictions requirement mandate new construction time sale despite similar deaths vehicles exhaust pipes example northeastern united_states february easter commercial availability equipment legal requirement automotive world health organization recommendations following values values rounded periods time weighted average determined way level exceeded normal subject engages light moderate exercise min min indoor air quality exceed chronic exposure treatment initial treatment carbon poisoning immediately remove person exposure people unconscious require site oxygen non mask half life carbon minutes minutes normal air oxygen carbon turning possible severe effects pregnant women treated oxygen longer periods time non pregnant people oxygen oxygen treatment carbon poisoning greater extent normal oxygen oxygen times atmospheric pressure reduces half life carbon minutes minutes compared minutes regular oxygen enhance oxygen transport tissues partially bypassing normal transfer controversial oxygen actually offers extra benefits normal high flow oxygen terms increased survival improved long term outcomes controlled trials treatment options compared performed found oxygen improved outcome found benefit oxygen trials criticized apparent flaws implementation review literature carbon poisoning treatment concluded role oxygen unclear available evidence confirms denies medically meaningful benefit authors suggested large designed externally trial compare normal oxygen oxygen treatment complications seizure cardiac required increased muscle activity treated given appropriate respiratory support requires treatment required treat depression cardiac treated standard advanced cardiac life support severe treated treatment controversial increase tissue oxygen availability treatment need consist oxygen therapy delayed development complications carbon poisoning brain damage confirmed following cat extensive follow supportive treatment required delayed damage outcomes difficult predict following poisoning especially people symptoms cardiac arrest coma high levels study reported approximately people severe carbon poisoning fatal outcome reported therapy increase likelihood delayed carbon poisoning true number incidents carbon poisoning unknown non lethal available data carbon poisoning common cause injury death poisoning worldwide poisoning typically common winter months increased domestic use gas gas space kitchen winter months faulty adequate ventilation produce excessive carbon carbon detection poisoning increases power outages estimated people year seek medical attention carbon poisoning united_states carbon poisoning deaths united_states gas space countries carbon cause fatal united_states approximately people die year carbon poisoning associated home fuel burning heating equipment carbon poisoning contributes approximately smoke deaths year united_states reports year americans die carbon poisoning commit suicide intentionally poisoning year period deaths carbon poisoning occurred united_states leaving deaths report new_zealand showed people died carbon poisoning years total carbon poisoning responsible deaths poisoning country south_korea people poisoned carbon deaths report jerusalem showed people poisoned annually china deaths poisoning reported year period carbon exposure society culture holocaust world war german nazis gas camp kill estimated prisoners carbon poisoning method gas chambers death camps carbon started action programme developed nazis germany murder mentally ill disabled people war started earnest key personnel recruited murder larger numbers people gas special gas chambers death camps exhaust tank engines example supply gas chambers research carbon produced naturally body converting carbon combines toxic levels small amounts beneficial exist produce times stress drugs developed introduce small amounts certain kinds surgery drugs called carbon releasing molecules


termed recurring oral greek mouth common condition characterized repeated formation non mouth healthy individuals informal term mainly north_america refer mouth cause completely understood involves cell immune response triggered variety factors different individuals different include deficiencies local trauma stress influences genetic factors occur periodically heal completely attacks majority cases individual days episodes occur times year appear non surfaces mouth attached hard tongue severe forms common involve surfaces symptoms range minor interfering eating drinking severe forms causing weight loss condition common affecting general population degree onset childhood condition usually lasts years gradually disappearing cure treatments aim manage pain reduce healing time reduce frequency episodes signs symptoms persons symptoms signs outside mouth generally symptoms include burning appearance hours pain proportion extent worsened physical contact especially certain foods drinks acidic pain worst days immediately following initial formation healing progresses tongue speaking uncomfortable soft cause painful signs limited episodes usually occur times year severe disease characterized virtually constant new developing old ones healed cause chronic pain interfere comfortable eating severe cases prevents adequate nutrient intake leading weight loss typically begin flat area develop covered yellow grey membrane away halo surrounds size number location healing time episodes formation dependent causes cause entirely clear thought suggested single entity group conditions different causes multiple research studies attempted identify organism appears non non infectious sexually destruction thought result cell immune response involves generation factor alpha mast cells involved cells early appearance shows dense infiltrate cells persons circulating react heat shock protein ratio cells cells peripheral blood individuals decreased despite preferred theory held researchers diseases regards association diseases accompany common detected condition tends resolve spontaneously advancing age usually normal levels evidence cell mechanism destruction strong exact process unknown thought multiple varied person suggests number possible capable producing disease different words different appear different causes condition considered general groups primary decrease barrier states heightened sensitivity factors considered host related environmental immunity people positive family history suggesting people genetically suffering oral examples human types associated types associated condition vary according ethnicity people positive family history tend develop severe form condition earlier age typical stress effects immune system explain cases directly stress stated exacerbated examination periods periods vacation alternatively suggested oral activities lip cheek pronounced periods stress subjected minor trauma like occurs conditions involving human virus infection severe oral occurs periods severe resolution underlying prevents cycle relative increase percentage cells caused reduction numbers cells implicated type hiv infection barrier thickness important factor usually form thinner non surfaces mouth factors decrease thickness increase frequency occurrence factors increase thickness decreased deficiencies associated iron cause decrease thickness oral local trauma associated known trauma decrease barrier trauma occur local mouth dental treatments trauma sharp surface mouth broken tooth tooth factors capable altering barrier study small group females fewer occurrences phase cycle use phase associated fall levels experiences pregnancy studies report period pregnancy uncommon people smoke habit duration severity condition tobacco use associated increase oral extreme forms manifest increased reinforce reduce tendency form minor trauma present substantial barrier unclear known stimulate production reduce production tobacco products protect cessation smoking known onset people previously unaffected condition experiencing despite starting smoking usually condition sensitivity condition represents state heightened sensitivity cross resulting cell immune response cells caused expression class normally found class cells results recognized immune system foreign cells self implicated trigger including forms virus virus argue available evidence demonstrates organisms capable causing people virus productive infection persons attacks occur time viral elevated viral medication effect instances mouth manifestation reaction possible include certain foods chocolate coffee eggs nuts tomatoes cheese citrus fruits highly acidic foods responsible mouth usually develop hours exposure present brands oral healthcare products produce oral individuals shown common people containing reduction occurs free argued oral products unlikely true caused disease like occur association disorders table identical type oral considered true sources conditions cause surfaces addition mouth membranes resolution condition leads decreased frequency severity oral disease mouth anterior main feature disease like usually severe seen cause typically resembles major like sign disease cases common individuals ethnic origin regions silk road mediterranean far_east tends rare countries united_states united_kingdom magic syndrome possible variant disease associated like stands mouth syndrome rare condition tends occur children stands periodic fever sore throat neck occur periodically weeks condition appears improve suggesting cause reduction level circulating blood occurs days commonly occur like worst time deficiencies acid iron occurring singly combination underlying disease twice common people iron improve relationship subject studies studies found suffer association rare absence helpful unclear mechanisms deficiencies cause associated like disorders associated like commonly disease disease disease link disorders probably related deficiencies caused people disease usually presents severe abdominal pain tongue like sign disease despite association free diet usually improve oral examples conditions associated like include syndrome diagnosis diagnosis based clinical appearance medical history important feature history self healing fairly regular intervals causes oral oral relatively causes commonly rarely disease associated disease oral infection cause likely adults suddenly develop oral prior history special investigations indicated rule causes oral include blood tests exclude deficiencies iron disease deficiencies peripheral blood picture appear relatively normal suggest screening disease form routine work individuals complaining oral diseases cause symptoms apart oral contrast isolated oral patch testing indicated suspected strong relationship certain foods episodes drugs cause oral trial alternative drug highlight relationship tissue usually required rule suspected conditions oral cell appearance microscopic appearance specific condition early central zone covered membrane tissue deep increased mixed infiltrate composed margins shows cells basal tissue surrounding deeper blood vessels near described classification classified type non infectious mouth classification distinguishes common simple accounting cases attacks year rapid healing minimal pain restriction mouth complex accounting cases present addition mouth healing slower pain severe common method classifying variants distinguished size number location healing time individual left healing minor common type accounting cases termed minor minor referred minor minor generally diameter usually affect non surfaces lateral borders tongue floor mouth usually appear time single possible healing usually takes seven days leaves episodes usually free period variable length major makes cases termed major major major major similar minor diameter deeper larger healing takes longer thirty days leave episode usually produces greater number time attacks seen minor major usually affects non surfaces commonly involved surface tongue soft throat involved oral cavity compared minor major tend irregular outline termed like named resemble primary infection virus primary caused types unlike true preceded small fluid filled diameter occur sized crops time adjacent merge form larger continuous areas healing occurs days affect surfaces addition non extremely painful frequently minor major frequent virtually continuous generally occurs slightly older age group females affected slightly frequently males type oral associated conditions termed type like like occurs individuals associated disease persons certain diseases prone oral secondary underlying medical condition disease section kind considered separate true definition strictly applied example sources refer oral caused deficiencies consider disease variant treatment vast majority people minor symptoms require specific therapy pain simple modification episode avoiding acidic foods different proposed table showing little evidence formally investigated results truth represent effect therapy treatment aiming relieve pain promote healing reduce frequency episodes line therapy agents medication treatment treatment usually reserved severe disease risk adverse effects associated agents application shown effective treating systematic review found single intervention found effective good oral important prevent secondary infection occasionally females cycle oral change oral beneficial use replacement therapy people developed oral stopping smoking reported starting smoking usually condition trauma reduced avoiding rough sharp teeth care suspected cause avoidance products containing chemical useful prevent individuals similarly patch testing indicate food responsible diet modified accordingly investigations reveal states correction result resolution example evidence prevent individuals surgical described ineffective inappropriate treatment silver chemical apart mainstream approaches detailed numerous treatments effectiveness ranging alternative treatments including virus definition underlying medical condition importantly represent oral cancer infectious capable causing significant discomfort spectrum severity symptoms ranging minor pain eating weight loss develop result eating severe cases usually condition lasts years spontaneously disappearing later life reported prevalence ranges populations individuals affected degree making common disease oral occurs worldwide common developed countries nations slightly higher prevalence higher groups males females affected equal ratio peak age onset years people developed condition age reports ethnic variation example united_states times common white skinned people black skinned people history society culture mouth mentioned times treatise corpus 4th century likely oral manifestation infectious disease described occurring epidemic like patterns concurrent symptoms fever thought form virus infection refer condition despite having informal term sore mainly north_america describe condition generally refer individual condition mouth cause unrelated condition origin word thought influenced latin old english middle english old north french latin cancer translates literally crab related limbs crab closely related word middle english old north french usually applied thought involved despite etymology form cancer entirely non specific term refers mouth word derived greek word meaning eruption oral conditions described including infected traumatic hard oral foot mouth disease qualification commonly refers word taken synonymous suggested term redundant remains common use non specific term referring process mouth oral describe different conditions apart angular current widely medical term simply historically different terms refer sub types use synonym minor named jan synonyms major include named richard disease syndrome synonyms include oral oral traditional chinese medicine treatments focus clearing heat gentle white contain specifically marketed benefit sore manufacturer johnson johnson discontinued product caused backlash anger long term customers began sell times original price auction website


simon parliament simon parliament english parliament held january mid march year instigated simon rebel leader simon seized power england following victory henry iii battle second barons war grip country threat attempt gather support summoned representatives barons knights occurred previous major towns resulting parliament london discussed radical reforms temporarily political situation killed battle later year idea inviting knights popular reign henry son edward 14th century norm gathering known house_of_commons parliament referred english parliament termed founder background king henry iii england faced revolt english barons anger grown way king officials raising funds influence relatives court unpopular policy english church grievances treatment king henry court strong feeling king unable lead country problems april hugh marched westminster middle king parliament backed conspirators including simon earl leicester carried coup état henry fearful arrested imprisoned agreed abandon policy personal rule instead govern council barons half chosen king half barons pressure reform continued grow parliament met june term parliament appeared describe large gatherings royal court parliamentary gatherings held periodically henry reign agree raising taxes 13th century single typically property intended support king normal revenues particular projects henry reign counties begun send regular came represent broader cross section community simply major barons new parliament passed set measures known provisions oxford henry swore uphold provisions created smaller council members elected solely barons power appoint england chancellor treasurer monitored pressure lesser barons gentry present oxford helped push wider reform intended limit abuse power king officials major barons radical measures passed new council year form provisions westminster disagreements leading barons involved revolt soon evident championed radical reforms place limitations authority power major barons crown promoted moderate change conservative barons expressed concerns existing limitations king powers years henry barons able restore stability england power swung forth different factions early remained henry authority country slipped open civil war convened council rebel barons oxford pursue radical agenda october england faced likely civil war marched east army london rose revolt took henry queen eleanor prisoner maintained fiction ruling henry rebels completely replaced royal government household trusted men coalition began quickly fragment henry regained freedom movement renewed chaos spread england henry appealed brother law louis france arbitration dispute initially hostile idea war likely decided agree french arbitration initially legal arguments held sway january louis announced condemning rebels king rights provisions oxford second barons war finally broke april henry led army territories desperate marched pursuit henry armies met battle despite numerical superiority henry forces overwhelmed captured henry forced pardon rebel barons provisions oxford leaving historian adrian describes little parliament simon claimed ruling king council officials effective political control government monarch time happened english history successfully held parliament london june confirm new constitutional arrangements england knights summoned county chosen county court allowed comment general matters state time occurred unable consolidate victory widespread disorder persisted country france eleanor plans invasion england support louis response hoping win wider support government summoned new parliament january continued mid march year held short notice summons issued december leaving little time attendees respond summoned barons senior knights county major towns york lincoln sandwich ports time lack support barons summoned parliament comparison summons issued largely supported new government unknown called event overseen king henry held palace westminster london largest city england continuing loyalty essential cause parliament populist tactical attempt gather support regions historian hamilton partisan assembly sort democratic representative body representatives allowed comment wider political matters usual issues taxation business parliament focused enforcing provisions westminster particular restrictions major nobles promising judicial help felt suffering unfair feudal parliament bought temporary calm opposition grew particularly immediate family began huge personal fortune prince edward escaped captors formed new army resulting fresh outbreak civil war edward pursued forces welsh marches striking east attack fortress turning rebel leader accompanied captive henry unable retreat battle ensued edward triumphant corpse mutilated places rebellion dragged rebels gathering henry edward took long siege remaining pockets resistance final rebels isle surrendered july marking end war legacy henry iii ruled england death continuing summon including county knights occasion including towns edward reign norm early 14th century normal include knights grouping known england ultimately form house_of_commons simon parliament referred english parliament inclusion knights regarded founder house_of_commons 19th century historian william model parliament edward genuine parliament modern scholarship questions analysis historian david carpenter describes parliament landmark development parliament institution medieval period modern recognition parliament united_kingdom presented loyal address queen elizabeth_ii mark anniversary parliament queen addressed houses parliament house_of_lords record office known parliamentary archives organised exhibition houses parliament important acts parliament documents displayed exhibition parliament planned year long programme events called parliament making coordinated parliament week including events mark anniversary parliament bbc broadcast democracy day january coincide anniversary consisting live discussions debate parliament democracy presented partnership speaker office house_of_commons including broadcasts inside palace westminster westminster abbey held special january commemorating anniversary parliament development rights representation


political pamphlet written napoleon french revolution fourth year civil war spread france rival political factions napoleon involved military action government rebellious cities southern france events spoke merchants heard views loyal soldier republic responded turn set fears merchants beliefs later wrote conversation form pamphlet calling end civil war background french revolution national convention executive power france following execution king louis powerful members club french political party established birth revolution managed secure control government pursue revolution ends culminating reign terror policies resulted insurrection france including largest cities paris toulon south france citizens south opposed government rule resulted rebellion prior revolution france divided provinces local governments government national constituent assembly reorganised france administrative departments order uneven distribution french wealth subject rebellion southern france july captain napoleon artillery officer placed command jean deal rebels situated army munitions required french army italy stored july troops attacked rebellious national killing citizens siege capturing town army supplies napoleon travelled nearby find wagons transport visited river holding annual fair napoleon arrived july day fair went tavern shared supper conversation merchants evening napoleon merchants discussed revolution subsequent rebellions consequences speaking pro republican napoleon supported cause explained benefits revolution whilst defending actions merchants expressed moderate views revolution reasons supporting civil war central government merchant stressed fight royalist cause opposed nature convention condemning deeming execution citizens unlawful napoleon concluded people reject counter revolutionary ideals adopt constitution french republic order end civil war allow regular army restore france following conversation group drank champagne morning paid merchant publication recognition shortly events possibly july whilst napoleon wrote political pamphlet titled supper soldier speaks merchants sympathetic opinions attempts dissipate counter revolutionary sentiments pamphlet read brother impressed revolutionary context pamphlet little effect rebellious forces served advance napoleon career soon recognised political ambitions born politician family friend arranged published distributed influence fellow convention deputy advanced napoleon position senior gunner toulon memoirs napoleon biography napoleon private secretary louis notes reprinted book edition issued cost public treasury august second edition following napoleon death states absence france rank chef major performed campaign contributed recapture toulon period life personal knowledge shall speak eye witness shall merely relate facts fill interval collected papers delivered papers little production entitled copies bought considerable expense destroyed attaining