UniProt ID stringlengths 6 10 | Protein Sequence stringlengths 5 15.6k | Functional Description stringlengths 6 12.4k |
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Q5JIR1 | MAELLNVKPTRMELLNLKRRITLAKKGHKLLKDKQDALVMEFFTIYDEALRLREELNEKMMEAFKALQRAEIDVGTLRMKEISLSVKPNREVEVKTRNVMGVPVPLIEAESFKRSAGERGYAFVSSSARVDLAAEKFEEVLDLAVRLAEVEETLKRLAKEIEVTKRRVNALEYIIIPRMEATVKFIKQRLDEMERENFFRLKRVKALIEARSGS | Produces ATP from ADP in the presence of a proton gradient across the membrane. Belongs to the V-ATPase D subunit family. |
Q8T8U2 | MWYSTVRNPSIALIKQGYHILAEYNLVKEELKNIYAIPSYACGLHWFGVIFVHSGIYAGSVFRFSILLPENFPADISLPTVVFSTEVLHPHICPQNKTLDLAHFLNEWRKDEHHIWHVLRYIQAIFADPEGSICTGQSSSGDLVIMDEVRNMNALNMLAKSRPEYIKRVQEQAILSRNLIYDRPPTEDPHYIIVEPYCAERHLKFMDQLKSPCWKEATSMDCSQPSEYLGHIDSSRQLDEEEANQVEKLHRGRIPEHQREESEVSL | Belongs to the ubiquitin-conjugating enzyme family. FTS subfamily. Lacks the conserved Cys residue necessary for ubiquitin-conjugating enzyme E2 activity. |
B2FR21 | MTQKTLLNDTHRALGAKMVDFGGWDMPIHYGSQLDEHHLVRRESGVFDVSHMTVVDLRGDQVRPFLRRLLANSVDKLKVPGKALYSCMLNPRGGVIDDLIVYYLGDDFFRMVVNASTREKDLAWLREQAAPFGVSVEQRPDLAILAVQGPQARAIVIGLARESEREALTKLGRFAALQVQSDDGVELFVARTGYTGEDGFEILLPQDAVVAFWNRLLAAGVKPAGLGARDTLRLEAGMNLYGQDMDEEISPYEAALAWTVSLDEGRDFIGRDALEAQKAAGTARQMIGLVMDEKGVLRHGQAVTTAGGQGEILSGTFSPT... | The glycine cleavage system catalyzes the degradation of glycine. (6S)-5,6,7,8-tetrahydrofolate + (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[protein] = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NH4(+) The glycine cleavage system is composed of four proteins: P, T, ... |
Q5RC95 | MAGVLKKTTGLVGLAVCNTPHERLRILYTKILDVLEEIPKNAAYRKYTEQITNEKLAMVKAEPDVKKLEDQLQGGQLEEVILQAEHELNLARKMKEWKLWEPLVEEPPADQWKWPI | Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Complex I ... |
A7ZC01 | MPKASLISIASYVPEKILTNFDFEKMVDTSDEWIVKRTGIEQRHIATTEITSDLGTKAAELAIKRSGLEKSQIDAVICATISPDHLCMPSTACKIAANLGLNFGITAFDISAACTGFIYLLELANSLIVSGAKKNVLIIGAEKLSSIIDYTDRSTCILFGDGAGAAVISASEENEIIDIHTASDGRQAELLITPGCGSAFPASDETLKNRLNFIHMSGNEVFKIAVQTLSKSVIEILHANKMQSEDIDFFIPHQANIRIIDAVKNRLNFTDEQCVLTVAKYGNTSSASIPMAINDAYEDGRIKNGSVLLLDAFGGGFTWG... | Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-A... |
Q04YC8 | MPKHSALERAWPAKEIVEDLLELRKRSPLTHIMTNIVVTNWTANVLLAVGASPAMVIAEEEAGEFVKIANGLLINVGTITSNDAKAMKIAATVAHQTNTPWVLDPVAVGALGFRTETTKKLLDLKPTVIRGNASEILTLAGIAGKGKGVDSTVNSKDALPYAQELSGKTGAVVAVSGEVDYVTNGKETIEIYGGDPIMTKVTGVGCSLGALIASFLGIQKDPLRASASASAVFAIAGSRSAKKSNGPGSFAINFIDQLSQLSIE | Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ). 5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphooxyethyl)-thiazole + ADP + H(+) Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-met... |
A1AN84 | MSRRETTQENLTCSFCGKSQEEVKKLIAGPAVYICDECIELCNDIIAEELKMEETLGPDLKKLPKPREIKDVLDEYVIGQEKAKKVLSVAVYNHYKRIETSNKPGDVEMQKSNILLLGPTGSGKTLLAQTLARILKVPFAMADATNLTEAGYVGEDVENIILSLLQAADYDVERAQKGIIYIDEIDKIARKSESPSLTRDVSGEGVQQALLKIIEGTVASIPPKGGRKHPQQEFMKVDTTNILFICGGAFAGLDSVIQQRIGMKSLGFGADVKKRAEKKLGELLLNVTPDDLLKYGYIPEFIGRLPMLATLTELDEDAMV... | ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure w... |
A5UDB2 | MIIPWQELEAETLDNIVESVILREGTDYGIEELSLNQKKQLLLTQIRNGIALIVWSELHESIDIKNKTEFLKQECKEQECQMN | Belongs to the UPF0270 family. |
C1DC39 | MPSVRVKENEPFEVAMRRFKRSIEKTGLLTELRAREFYEKPTTERKRKKAAAVKRHYKRLRSQMLPPKLY | Belongs to the bacterial ribosomal protein bS21 family. |
Q0CIL3 | MEEQVVNAIQIASNPSADQALKAQAFDYVNQLRSDPSGWQICLALFTKTPQHSEVVRHVALEVVNSAAQAGLIDPQALGYVRDGLMAYLRQVYAQETATPDSPGIQNKIAQTITFLFSALYGNGWESFFDDLLSLTYKSPSSTGRDNAPGIVFYLRVINSIHDEIGDVLVSRSRAEQDKANSLKDLIRMRDMQKIAGSWQEILSDWRDGNDIIVEMALKAVGSWVSWIDIGLVVNQTMLDLLFQQLARAQKADLRAGEDKVRDAAVDVFTEIVGKKMKAEDKVDMIIFLNLDTIVSQLSNSPPLHENRFTFKYDTDLAET... | tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease (By similarity). Shuttles between the nucleus and the cytoplasm. Belongs to the exportin family. |
B9J1K4 | MKFAVIVFPGSNCDVDMFHAIKDELGEEVDYVWHDTENLDEYDAILLPGGFSYGDYLRCGAISRFANAMKAVQKAAEQGKPILGVCNGFQILVESGLLPGALMRNENLKFMCRTVQLRVENNETMFTSQYEKDEVINIPIAHGEGNYYCDEETLKKLEENNQIAFRYVENPNGSVSDIAGIVNEKGNVLGMMPHPERAVDELLGGAEGLKVFQSILKQWRETYVVNA | Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three su... |
C6XJX0 | MDILNDISIAAPEALLIGVALIGVLLGATFKQSFNGLSRLLGALALAGAAFLAASQSAVDASTAFNGLYKVTPFIAIAKAVSYGVGAIALLVAGGYLHRENMNKFEYTLLVMFGSAGMGVMLSANNLMTLYMGIETLSLSSYVLAAFNRDSRRSAEAGLKYFVLGALASGLLLFGCSLVYGYTGFASFEQIAAADQSIGLTFGLVLILMALSFKASAAPFHVWTPDVYEGAPTPVVTFFSTAPKLATVAVLANIMFTVFGVYEESWMLIIAIVSAISMLVGAFGGLAQNNIKRLLAYSSIANVGYALMGVAAGEVNGAAS... | NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are t... |
P94536 | MFLQPLLAKKIIAEVKKMYEREVIIVNTDGLIMAGTNDERVGQFHEGALICAKERRSVIITKEDETRLKGVKAGINLPVFFDHDVIAVFGLTGEPAEIQPFGELLRKMTELFIKESRHLEQSQWRERMLESFMIDWLQLKEWSPSFLEKAQLLGVDLSSRRQMILIQGYEWSPHDIEQMARSWKSSYPADLFIRWGNERILINHEVPQHEQRDRLLRKILHICSFANTASSQYTAAGAGRAVASSSLTDSYEQAEKALAVSLKRKTPIFEEDLKLDMCLTEISPGTRNEFPQRVLGKALEHQELMNTIRTFFHHDLSLKQ... | Belongs to the CdaR family. |
Q9GIY8 | MVDGTLLLLLSEALALTQTWAGSHSLKYFHTSVSRPGRGEPRFISVGYVDDTQFVRFDNDAASPRMVPRAPWMEQEGSEYWDRETRSARDTAQIFRVNLRTLRGYYNQSEAGSHTLQWMHGCELGPDGRFLRGYEQFAYDGKDYLTLNEDLRSWTAVDTAAQISEQKSNDASEAEHQRAYLEDTCVEWLHKYLEKGKETLLHLEPPKTHVTHHPISDHEATLRCWALGFYPAEITLTWQQDGEGHTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPVTLRWKPASQPTIPIVGIIAGLVLLGSVVS... | Non-classical major histocompatibility class Ib molecule involved in immune self-nonself discrimination. In complex with B2M/beta-2-microglobulin binds nonamer self-peptides derived from the signal sequence of classical MHC class Ia molecules (VL9 peptides) (PubMed:9754572, PubMed:18083576, PubMed:18339401). Peptide-bo... |
Q0KF31 | MTFEPSETLRDPFVLYGESFGSRLLLGTARYPSPATLEAAVQASRPAMITVALRRQGAVGAGEGGQAFWQMLKALDVPVLPNTAGCFTAQEVITTAMMAREVFETPWIKLELIGDDYTLQPDTLNLPAVAETLIKEGFKVLPYCTEDLVLCRRLLDVGCQALMPWAAPIGTGRGAVNPHAMRVLRERLPDTPLIVDAGLGLPSHAAQVLEWGYDGVLLNTAVAQAAYPVNMARAFAQAVEAGRTAYLAGPMPEREVAQASTPVVGMPFWHADSTEQRA | Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. 1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + [sulfur-carrier protein Thi... |
Q4K399 | MDFPSRFEVIVIGGGHAGTEAALASARMGAKTLLLTHNVETLGAMSCNPAIGGIGKSHLVKEIDALGGAMAMATDKGGIQFRVLNSRKGPAVRATRAQADRILYKAAVREILENQPNLWIFQQAADDLIVEQDQVRGVVTQMGLRFFAESVVLTTGTFLGGLIHIGMQNYSGGRAGDPPSIALAQRLRELPLRVGRLKTGTPPRIDGRSVDFSVMTEQPGDTPIPVMSFLGSKEQHPPQVSCWITHTNARTHEIIASNLDRSPMYSGVIEGIGPRYCPSIEDKIHRFADKESHQVFIEPEGLTTHELYPNGISTSLPFDV... | NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34. Homodimer. Heterotetramer of two MnmE and two MnmG subunits. Belongs to the MnmG family. |
Q2G9P8 | MSAPILEMDIDPVWGDAIDWEDIASRAAEAAAKVAPELAHENLLVSVVLADDDEVHALNKQWRAKDKPTNVLSFPMLSREEVLHAAADEGAPGMLGDMILAHGVCTREAAEKGVSVETHATHLVVHGLLHLAGYDHELGEAEAEEMENLERKALALMGIADPYAVED | Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. Binds 1 zinc ion. Belongs to the endoribonuclease YbeY family. |
B2I0I4 | MNKEQFDVNLVPTWRQGYRFQFEPAQNGFVILYPEGMIKLNESAGAIGQYIDGTNNVSAIIAQLKQQFGDIPEIDNDVIDYMLVAQQQHWIDLV | Functions as a PqqA binding protein and presents PqqA to PqqE, in the pyrroloquinoline quinone (PQQ) biosynthetic pathway. Cofactor biosynthesis; pyrroloquinoline quinone biosynthesis. Monomer. Interacts with PqqE. Belongs to the PqqD family. |
B9JVN4 | MAREYKIEDYRNFGIMAHIDAGKTTTTERILYYTGKSHKIGEVHDGAATMDWMEQEQERGITITSAATTTYWKGRDGKMRRFNIIDTPGHVDFTIEVERSLRVLDGAIALLDANAGVEPQTETVWRQAEKYNVPRMIFCNKMDKTGADFYRSVEMIKTRLGATAVVMQLPIGAETEFKGVVDLIEMNALVWRDESLGAAWDVTEIPDDLKEKAVEYREKLIETVVEIDEQAMEDYLNGIMPDNDKIRALVRQGTIEVKFHPMFCGTAFKNKGVQPLLDAVCEYLPSPLDIPAIKGIDVKTDGEIERHPDDAEPLSMLAFK... | Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respective... |
Q5LJ70 | MNELTGADFKSATADDNKKLFIETYGCQMNVADSEVIASVMQMAGYSVAETLEEADAVFMNTCSIRDNAEQKILNRLEFFHSMKKKKKHLIVGVLGCMAERVKDDLIEHHHVDLVVGPDAYLTLPELIASVEAGEKAMNVELSTTETYRDVIPSRICGNHISGFVSIMRGCNNFCTYCIVPYTRGRERSRDVESILNEVADLVSKGYKEITLLGQNVNSYRFEKEGGEVVTFPMLLRLVAEAAPGIRVRFTTSHPKDMSDETLEVIAQVPNVCKHIHLPVQSGSSRILKLMNRKYTREWYLDRVAAIKRIVPDCGLTTDI... | Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine. [sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine = 2-me... |
B2V6T1 | MTLKEFIIPAIDIKGGKVVRLYKGEFDKVKVYNENPIDMAKYFEDAGAEHIHVVDLDGALEGLPKNIKILESIVRSVNIPIEFGGGLRSFEAVKAVLDLGVERVVIGSLAYQNPEEFYKIVESFPNKVIVGIDAKDGKVAIKGWTEKTEVSPLEFAKKYDDLDIFGFLFTDVSRDGSMIGANVEATVELAKNLKHPVIASGGVGSLEDVIKLYEKREFGIFGVVVGKAIYEGKIDLKEI | 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate:... |
A3Q7A7 | MFEGPVQDLIDELGKLPGIGPKSAQRIAFHLLSVEPPDIDRLTAVLNRIRDGVKFCEVCGNVSDADRCRICSDPRRDASLVCVVEEPKDVQAVERTREFRGRYHVLGGALDPLSGVGPDQLRIRELLNRIGERVDGVDVAEVIIATDPNTEGEATATYLVRMLRDIPGLTVTRIASGLPMGGDLEFADELTLGRALAGRRAMA | May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. Belongs to the RecR family. |
Q5V5M3 | MPVYVDFDVPADLEDDALEALEVARDTGAVKKGTNETTKSIERGSAELVFVAEDVQPEEIVMHIPELADEKGVPFIFVEQQDDLGHAAGLEVGSAAAAVTDAGEADADVEDIADKVEELR | Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs. Part of the 50S ribosomal subunit. Interacts with protein L15e. Probably part of the RNase P complex. Belongs to the eukaryotic ribosomal protein eL8 family. Was o... |
A9BIU9 | MSNKDLLPIALGKEKADLVFKNGKIIDVFNEKVIEEDLAISNGVIIGFGKYEGKEEVDLEGKFISPGFIDAHLHLESAMVTIEEFAKTVIPLGTLTLVADPHEIANVAGKVGIKYFLTIGNNIPWNFNLMVPSCVPVTTFDKSGSVLNAEKIKELITEENFFGLGEVMDYEGVITGQDYIWDKIELMKDYFIDGHAPKLQGKILNAYLLAGIMADHETTSPNEALEKISKGMYIMVREGSVTRDLQSLLPAINDKNNCNFLFATDDKHPEDLISEGHINFMIKKAIKLGMEPFRAIKLATLNAARSLGLHRLGGIAPGYK... | adenine + H(+) + H2O = hypoxanthine + NH4(+) Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family. |
P0DPT3 | EHGYLLDKYTGCKVWCVINNESCNGECNKRRGGYYGYCYFWKLACYCQGARKSELWNYKTNKCKS | Has a toxic effect on insects and mammals. On German cockroach larvae, it provokes contraction, paralysis and lethality (PubMed:26109302). Intracerebroventricular injection into mice causes severe neurotoxic symptoms (PubMed:26109302). It fully competes with the binding of the iodinated Css4 (AC P60266) on rat brain sy... |
A5PJX4 | MAEASSLERQSPGAASCLPHSLCPGEPNLQTTAVVSMGSADHQFHLAEILSQNYGVREEHEGAAPGPEKPEEELEKDFVSQSSDMPLDELLALYGYETSDPISERESEGSDTAAHLPDMTLDKDQIAKDLLSGEEEEETQSSADDLTPSVTSHEASDLFPSQSGSCFLADADKEPGSSSSSDAEEDPLPANKCKKEIMVGPQFQADLSNLHSNRHGEKIYENEDQLLWDPNILPEREVEEFLYRAVKRRWHEMAGSQLPEGEAVKDSEQALYELVKCNFNAEEALRRLRFNVKVIRDGLCAWSEEERRNFEHGFRVHGKN... | Transcriptional repressor. Part of a complex containing at least CDYL, MIER1, MIER2, HDAC1 and HDAC2. |
M1W848 | MASITTTTNFFESIPRPTKTYRSASYDRISTRHGFNGTGKTVLITGGSSGIGLSIAKAFAGAGVARIAILSRSRATQLTAKAEIEAAYPSTSILLFEASVTDADRFASVLEELAGVHVLVLCAAAVHARVPLAELSGKDVQHVFDTNSVSTVNLARLYTATPGKDKTILHVSSAVAQMYAPLRSVYGASKAAAVQAMQHLAREHQGTGDRVRVFSFHPGAITTPASGAIYTPGAVQWDDADLPAHFSLWLAGPESDFLNGRYVWANWDVDELVALKERLACDGRFLTIGLVL | Short chain dehydrogenase/reductase; part of the ergochrome gene cluster responsible for the typical purple-black color of the ergot sclerotia (Probable). The ergochrome gene cluster produces several ergot pigments including the yellow ergochrome secalonic acid and its derivatives, as well as the red anthraquinones end... |
A2BYK1 | MTKESIPKELLKLITGEEIMMFQELRIRIQELNYKTNLTRLIEGDDYWISQVYDSLWTFKENSKKIFDNKKFIDIGSGCGFPGFAYAITHPNSEIYLVDSSKKKTDSLKEIIKRMNFKNNIFVINDRIENVGRQSSFKKSFNIATARAVSNPSTVAEYILPMLEQNGLGILYCGKWRNEDNKNLENTLNVLEGKIMEIKSKSLPKEKGIRNVIFIKPKASCPDIFPRSIGKAEKYPLKG | Specifically methylates the N7 position of a guanine in 16S rRNA. Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family. |
Q9CAS4 | MSQPPWRCFSLLIFVLTIFSTKPSSASTSCSSSFHCPPFNSSPPYPFSASPGCGHPNFQIQCSSSRATITIKNLTFSILHYSSISSSLTLSPITNTNRNTNNCSSLRFSSSPNRFIDLTGSPFRVSDSSCSRLSLLRPCSPFTLPNCSRCPWDCKLLKNPGRILHGCESTHGSLSEQGCQGDLLGFLQDFFTRFGFEVEWDESQDPYFIKCRDCQIKNGVCGFNSTHPNQDFICFHKSRSELVTQRDNNKRVNHIAVLSLIFALTCLLLVFSVAVAIFRSRRASFLSSINEEDPAALFLRHHRSAALLPPVFTFEELESA... | ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein] ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein] Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. |
A0LUC3 | MSRDLTAVQAKAATLVEALPWLATFHGRTVVIKYGGHAMIDPGLAASFAADVVFLRYAGLRPVVVHGGGPQIDAMLRRLGIEPVFAAGLRVTTPETMDVVRMVLVGQVQREVVGLLNAHGPFAVGVSGEDGRLFTAVRRSAVVDGHDVDLGLVGEITEVNPTVIQSLLDDGHVPVVSSIAGGVDSDGRRCVYNVNADTAAAALAVALGAEKLVVLTDVEGLFADWPNTDEVISRLTADELEKLLPGLAAGMIPKMEACLRAVRGGVAAAHVLDGRVPHAILLEIFTDEGVGTMVVP | Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate. ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamyl 5-phosphate Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4. Belongs to the acetylglutamate kinase family. ArgB subfamily. |
A3N2G1 | MSLQKSNKITPFLTFDRQKWAELRKSVPLKLTEQDLKPLLGFNEDLSLDEVSTIYLPLARLINYYIEENLKRQTVLHRFLDVASPKVPYIISIAGSVSVGKSTSARILQALLSQWPSERKVDLITTDGFLYPLTTLQEKDLLKRKGFPESYDIHRLIQFVSDIKSGKRHIQAPIYSHLTYDIIPDQYNVVDQPDIVILEGLNVLQSGMNYPSSPHNVFVSDFVDFSIYVDADEDLLKEWYVARFLKFRRSAFSDPNAYFHHYSKLSEQEAIRTASSIWDEINGLNLKQNILPSRERANLILIKGEDHAIQTVKLRK | (R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+) Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5. Belongs to the prokaryotic pantothenate kinase family. |
Q88E79 | MMIAENAPFWRRKTLEELSQQEWESLCDGCGLCCLQKLEDEDDNSVYYTRIACKLLDLNTCQCSDYPNRFAQVPDCIQLTPGKADQFKWLPSTCGYRLVSEGKDLPAWHHLVCGDRQQVHEQRISQSGRMLSEHDVHEDDWEDHLIFRAS | Belongs to the UPF0260 family. |
P58187 | MIKLLYPEFWQKRNIIAYLLLPISLIYQFLGYLRASLARPIMLPAKVICVGNCSVGGTGKTQIVMYLAKLLKARNVSFVIVTKAYGSNLKSATTIHQGHTALEVGDEGVILAKYGAVIATKNIKEIVPLINELKPDIIIVDDFLQNPYFHKDFTIVSVDSQRLFGNGFLIPAGPLRQYPNKALDAADLIFLVSSHQDKIPQILTPYVNKLINAQIVPSNNIDKTKNYFAFSGIGNPERFFATLKNYGLNITGYKIFPDHYNYLQADLENLYSLAKEHNAILVTTRKDHVKFNDLNNNIVCLDVELSINHPDLLNEKIFKK... | Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). ATP + {2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-beta-D-glucosaminyl}-(1->6)-{2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosam... |
Q9BDN3 | MIETYNQPVPRSAATGPPVSMKIFMYLLTVFLITQMIGSALFAVYLHRRLDKIEDERNLHEDFVFMKTIQRCNTGERSLSLLNCEEIKSQFEGFVKDIMLNKEEKKKENSFEMQKGDQNPQIAAHVISEASSKTTSVLQWAEKGYYTMSNNLVTLENGKQLTVKRQGLYYIYAQVTFCSNREASSQAPFIASLCLKPPNRFERILLRAANTHSSAKPCGQQSIHLGGIFELQPGASVFVNVTDPSQVSHGTGFTSFGLLKL | Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By simil... |
P77560 | MAVKISGVLKDGTGKPVQNCTIQLKAKRNSTTVVVNTLASENPDEAGRYSMDVEYGQYSVILLVEGFPPSHAGTITVYEDSQPGTLNDFLGAMTEDDARPEALRRFELMVEEVARNASAVAQNTAAAKKSASDASTSAREAATHAADAADSARAASTSAGQAASSAQSASSSAGTASTKATEASKSAAAAESSKSAAATSAGAAKTSETNASASLQSAATSASTATTKASEAATSARDAAASKEAAKSSETNASSSASSAASSATAAGNSAKAAKTSETNARSSETAAGQSASAAAGSKTAAASSASAASTSAGQASASA... | Belongs to the tail fiber family. |
P58616 | MTLLLAGDIGGTKTILRLVEISNSSELHNIYEESYQSGDFPDLVPMVQQFLVKANIPSHPEKACFAIAGPVVNNTAKLTNLVWFLDTERLAQELSIPFISLINDFAAVGYGIFGLNKQDLLTLQAGKHQPEAPIAIIGAGTGLGQGFLIKQGNQYQVFPSEGGHADFAPRNELEFQLLKYLLDKHDIQRVSVERVVSGQGIVAIYQFLRDRKLATESPEIAQVVRTWEQQAGQAEKTVDPGAAIGKAAVQGSDRLSEQALQLFIDAYGAEAGNLALKLLPYGGLYIAGGIAPKILPLIENSNFLLNFSQKGRMRPLLAEI... | ATP + D-glucose = ADP + D-glucose 6-phosphate + H(+) Belongs to the bacterial glucokinase family. |
B3QZW0 | MSRYTGSIWKVSRRLNYSLSETGKELIKRPYAPGMHGKKRIKAKDYGLQLQEKQKVRFTYGISEKQFKKIFKDAGKLKGIHGEMFLFLLESRLDNVVYRLGFAKTRQQARQLVNHGHILVDGKKVDIPSYSLRVGQIITLKEKSKDLIIVKEALANKLNRVDYISLNKELVGKYVRIPHRDELLPNIKEQLIVEFYNRK | One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. With S5 and S12 plays an important role in translational accuracy. Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control ... |
Q8LAV4 | MANPWWTNQSGLAGMVDHSVSSGHHQNHHHQSLLTKGDLGIAMNQSQDNDQDEEDDPREGAVEVVNRRPRGRPPGSKNKPKAPIFVTRDSPNALRSHVLEISDGSDVADTIAHFSRRRQRGVCVLSGTGSVANVTLRQAAAPGGVVSLQGRFEILSLTGAFLPGPSPPGSTGLTVYLAGVQGQVVGGSVVGPLLAIGSVMVIAATFSNATYERLPMEEEEDGGGSRQIHGGGDSPPRIGSNLPDLSGMAGPGYNMPPHLIPNGAGQLGHEPYTWVHARPPY | Transcription factor that specifically binds AT-rich DNA sequences related to the nuclear matrix attachment regions (MARs) (By similarity). Negatively regulates plant innate immunity (PTI) to pathogens through the down-regulation of the PAMP-triggered NHO1 and FRK1 expression (PubMed:20738724). The PPC domain mediates ... |
Q3YSB1 | MAGHSQFANIKHRKGAQDAKRAQRFTKLIREIIVSAKQGLPDPEFNSRLRSAIIAAKKENLPKDRIDAAIKSATGNTQSDNYEEVVYEGYGPGNIALMIQTLTNNRNRTAAELRHALSKYNGKLGESGSVSFLFNHVGVIAYKAASIDNFDSLFNIAIELQALDVEETTQDESQEKMYYVTCNVQDFGNVRDQLFNKFSDAEFSRLFWKPSDILKIEDEEIQKKISSLMDLLENNDDVQYIDSNFTFC | Belongs to the TACO1 family. |
Q1GFB3 | MKLIWLGHGGFRLETGETTLLIDPWLTGNPMLEDSQHDAATQGATHILLTHAHFDHVADVLELAKHLSVPIVGQYDLMGYWGETEGVQTVGFNKGGTVTVGDTRVSMVPASHSNTFSTRDGLRTAGSEVGYMIRAEGKTLYVSGDTDIMADMDWMGDYYKPEIGILSAGGHFTMDMKAAAYAAQRYFAFKTVIPCHYRTFPLLEQSAQDLIDGLPGVNVIEPQIMKDIEL | Belongs to the UPF0173 family. |
D6VTP0 | MSGETFEFNIRHSGKVYPITLSTDATSADLKSKAEELTQVPSARQKYMVKGGLSGEESIKIYPLIKPGSTVMLLGTPDANLISKPAKKNNFIEDLAPEQQVQQFAQLPVGFKNMGNTCYLNATLQALYRVNDLRDMILNYNPSQGVSNSGAQDEEIHKQIVIEMKRCFENLQNKSFKSVLPIVLLNTLRKCYPQFAERDSQGGFYKQQDAEELFTQLFHSMSIVFGDKFSEDFRIQFKTTIKDTANDNDITVKENESDSKLQCHISGTTNFMRNGLLEGLNEKIEKRSDLTGANSIYSVEKKISRLPKFLTVQYVRFFWK... | Predominant proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Has proteasome-inhibitory activity and delays the degradation of ubiquitinated proteins to provide a time window allowing gradual deubiq... |
P15297 | MPAKPQVDGHTLVDAFCCANIFTETGALKPRSDKVWMDISNQLKGAISAKTLNFYARINRNNMITVVKERCGIQQLDTSANLTLNSTFPDDDPEFQITEASKNGPLPILYFNLELDLELWRSIAPKKDQKTEKLQPNWTDTMAKLIYKKVPLPCAFNFRKAKLSDKVDNIWLRIEGYCNDCSSILKGHCLVKPDEQCGIMISVSVPDTRGIPHNKKRRCTGSRRLEIGNELILKKAALWRKEATDNMNDDDPEPSYIPNLPTLRKLREEATNRHLGITKDRDPVSSLYLKKYEGELAGCILDIGLDEFFCIYCTGTQVKT... | May be involved in the transposition of NOF-FB and other FB elements. |
Q99UR3 | MAKEIAKSLLDIEAVTLSPNDLYTWSSGIKSPIYCDNRVTLGYPLVRGAIRDGLINLIKEHFPEVEVISGTATAGIPHAAFIAEKLKLPMNYVRSSNKSHGKQNQIEGAKSEGKKVVVIEDLISTGGSSVTAVEALKQAGAEVLGVVAIFTYGLKKADDTFSNIQLPFYTLSDYNELIEVAENEGKISSEDIQTLVEWRDNLA | Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). diphosphate + orotidine 5'-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + orotate Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orot... |
Q3AB79 | MPSPKYKRVVLKLSGEALAGEKGYGIDPEVVNSIAGQIAEIIKEFGIQVAVVVGGGNIWRGLSGSAKGMDRATADYMGMLATVINSLALQDALEKLGIDTRVQTAIEMRQIAEPYIRRRAIRHLEKGRVVIFAAGTGNPYFSTDTTAALRAAEIEAEVILMAKRVDGVYDSDPLKNPNAQKFDELEYIEVLNRGLGVMDSTATSLCMDNNIPLIVFNLEVPGNIKRVILGENIGTIVGGERK | Catalyzes the reversible phosphorylation of UMP to UDP. ATP + UMP = ADP + UDP Allosterically activated by GTP. Inhibited by UTP. Pyrimidine metabolism; CTP biosynthesis via de novo pathway; UDP from UMP (UMPK route): step 1/1. Homohexamer. Belongs to the UMP kinase family. |
P28555 | MSIVTKSIVNADAEARYLSPGELDRIKSFVLSGQRRLNIAQILTDNRENIVKQGGQQLFQKRTDIVSPGGNAYGEEMTATCLRDLDYYLRLVTYGIVAGDVTPIEEIGLVGVKEMYNSLGTPISGVAEGVRCMKAIACSLLSGEDSAEAGFYFDYTLGAMQ | Light-harvesting photosynthetic bile pigment-protein from the phycobiliprotein complex. Allophycocyanin has a maximum absorption at approximately 650 nanometers. Heterodimer of an alpha and a beta chain. Forms the core of the phycobilisome. Contains one covalently linked phycocyanobilin chromophore. Belongs to the phyc... |
Q6F1W6 | MSYIQKQGKNTAWRVALMRNLTSELIVSERLEITETRAKELRKHLDKMVTLAKRGDLHARRQAASWLRNIEASSKEDVLQKLFTTIAKKYKDRDGGYTRILKLDNRKGDNAPMVIIELV | Part of the 50S ribosomal subunit. Contacts protein L32. Belongs to the bacterial ribosomal protein bL17 family. |
P33900 | MATIHVDGKEYEVNGADNLLQACLSLGLDIPYFCWHPALGSVGACRQCAVKQYQNAEDTRGRLVMSCMTPATDGTFISIDDEEAKQFRESVVEWLMTNHPHDCPVCEEGGNCHLQDMTVMTGHSFRRYRFTKRTHRNQDLGPFISHEMNRCIACYRCVRYYKDYADGTDLGVYGAHDNVYFGRPEDGTLESEFSGNLVEICPTGVFTDKTHSERYNRKWDMQFAPSICQQCSIGCNISPGERYGELRRIENRYNGTVNHYFLCDRGRFGYGYVNLKDRPRQPVQRRGDDFITLNAEQAMQGAADILRQSKKVIGIGSPRA... | NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are t... |
A1WVN6 | MKIVLATGNAGKLAEMTRMLQGYDAEVVRQGHLGIDSPAETGLTFVENALIKARHCAERSGLPAVADDSGLAVPALGGEPGIYSARYAGSDAGDAANIERLLAELSERGQGDRRGTFHCVMVYLRHAADPAPVIAHGSWTGRIVETPRGHHGFGYDPVFEDPELGQTAAELDAPAKDARSHRGQALRALIQGIAAEVAG | Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical p... |
A0A0A0MT89 | WTFGQGTKVEIK | J region of the variable domain of immunoglobulin kappa light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunog... |
Q6F199 | MKTNKNKTNIKMIGFYHFFYFVKPYYLLINENVIIFKAKGDFMIQKPRGTQDLFLNNSKEWNAVEEKFRKVLNLFNYGEIITPMFESKELFVRGVGDSSDIVSKEMYEFTDRKGREYVLRPEGTAPTVRALIENKLYIQENLPYKTFYIGPIFRYERPQAGRYRQFNQLGVETFGIDSISHDVELISLGQSFLKELKINKDVIVEMNYLISGNERKEYELELKKYLNLFDDLCSDCEIRINKNVLRVLDCKIDGNKFAEAPKMTLFASQENKERLNKTFDQLKQLGIEAKINFNLVRGLDYYTGLVFEFKNIKTDQAIIA... | ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-histidyl-tRNA(His) Homodimer. Belongs to the class-II aminoacyl-tRNA synthetase family. |
A9M6S7 | MSKWKDVKKVVLAYSGGLDTSIILKWLQTELGAEVVTFTADLGQGEELEPARKKAEMLGIKEIFIEDVREEFVRDFVFPMFRANAVYEGVYLLGTSIARPLISKHLIDIAKKTGADAIAHGATGKGNDQVRFELSAYALNPDIKIIAPWRDWSFKSRTQLLEFAEQHQIPVAKDKKGEAPFSVDANLLHSSSEGKVLEDPSQEAPEYVHMRTISPETAPDKATIIKIGFEKGDAVSINGERLSPATLLAKLNDYGRDNGIGRLDLVENRFVGMKSRGVYETPGGTILLAAHRAIESITLDRGAAHLKDELMPRYAELIYY... | ATP + L-aspartate + L-citrulline = 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+) Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3. Homotetramer. Belongs to the argininosuccinate synthase family. Type 1 subfamily. |
Q9UTE7 | MRILNRVFLNTFQACFRRFVHQIPTIYALSTPPGTSAVAIVRISGPNACKVAKTLAGSVPKPRIASLRTIKHPVRSEVIDKALMLYFKKPSSFTGEDVVELQLHGGTAVVDVTLEAIKQSGIPNIRYAKPGEFSERAFYNGRADLTQLEGLIDVINAQTAEQLYSANKEAHGSIYDICFRWRKKLIEYRAFLEASIDFSEEHELDDIETIKLFEELNEMKDEIDAHIEGGKCKEVLRKGINVAILGPSNAGKSSLINLLANRRISIVSPQSGTTRDAIEVLVDINGFPVLLSDTAGLRKGEDVQEIEKIGIEIAKARAEE... | GTPase involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs. Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. |
A4IW96 | MAKVSKRMKEISAKINAEKKYPVSEAFDLLREVSSVKFVESVDVSVALGVDPRKSDQVVRGASVLPNGTGKTVRVAVFAKGPAADAAKEAGAEVVGMEDLADEVKKGNMDFDVVIASPDSMRVVGQLGQILGPKGLMPNPKVGTVTMDVAKAVRDAKAGQVRYRVDKAGIIHTTIGKVNFTSDALKQNLERLLTDLKKAKPAVSKGIYLKKVSVSSTMGPGINVDFSDLNI | Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA. Part of the 50S ribosomal subunit. Belongs to the universal ribosomal protein uL1 ... |
P02020 | MRFSQDDEVLIKEAWGLLHQIPNAGGEALARMFSCYPGTKSYFPHFGHDFSANNEKVKHHGKKVVDAIGQGVQHLHDLSSCLHTLSEKHARELMVDPCNFQYLIEAIMTTIAAHYGEKFTPEINCAAEKCLGQIVHVLISLYR | Involved in oxygen transport from the lung to the various peripheral tissues. Heterotetramer of two alpha chains and two beta chains. Red blood cells. Belongs to the globin family. |
Q31FG2 | MFDRHTLSLYKRLLKYISGYKSAIFITLITIAIIAATEPLSAIILGNLVDESLIEKDPNSFLLLPLQLAAVFIVKGVAEYFSKVMSTWIAQKAIFNIRSELYDKMLCLPQAEHNQTSTGTLMSKVTYDVTQTGNALSEAWIVIARDSLTILALLATLIYYSWQLTLVMLIIGPIVAFFIDRAGKLMRTSSTDMQDNMGEMTHRLEEGLKGYQDIKIYGSEKYELDRFKASAESLRQNTMKVIKVSALNVPLVQVIAAIALSIVVYIAVQMVNAETMTAGNLITYVTAMGLIFEPIRRITNINATVQRGMAAAKSIFAILD... | Involved in lipopolysaccharide (LPS) biosynthesis. Translocates lipid A-core from the inner to the outer leaflet of the inner membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation. ATP + H2O + lipid A-core oligosaccharideSide 1 = AD... |
A1JHR9 | MITKAIYPGTFDPITNGHLDLVTRASEMFSHVILAIADSSSKKPMFTLAERVILAKQVTAPLKNVEVLGFSELMAEFAKKHNANILVRGLRSVSDFEYEWQLANMNRHLMPKLESVFLMPSEKWSFISSSLVKEVARHGGDITPFLPAPVTKALMTKLA | Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. (R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA + diphosphate Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5. Homohexamer. Belongs to the bacterial C... |
Q896K7 | MSRLENLTSKIIKDSEEKAKIILDEAKREEEKIMLGQKQEGESIKSKIIEKAYLESKNRKERIISNSHLFVRNRKLEAKQEVIDKVYKEALNKLAKLNKEEYLNFIKDSILALEIYGDEEIILSQDEKYINKETIEEINKELKSKGKKGEIKISDKKRDFRGGFILNKDGIEINNTFEALILSLKDDLEPVIIDTLFS | Produces ATP from ADP in the presence of a proton gradient across the membrane. Belongs to the V-ATPase E subunit family. |
Q8ESS0 | MIAIIDYGAGNIKSLQFALDKLNKHSIVTTEAAEIKQADSIILPGVGAFKDAMEAIRQLQLDSVIQEEAQKGKPILGICLGMQLFYEQSLENGDWEGLGLLKGSIKRISGEVKVPHMGWNTLDIQQASPLFDSKLENPYVYFVHSYAVSSFEENTLLASSQYGQLIPAIVQKGNITGMQFHPEKSGEFGIELLKRYEEMIR | IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)m... |
Q9LIS1 | MGLVQEEGSGPVHGFRLSTVSASLPSETGTTHEPTGLDLAMKLHYLKAVYIYSAGTARDLTVMDVKAPLFSVFYQIPCIIGRFRRHESGRPYLKCNDCGTRFVESHCDLTVEEWLRVPDRSVDESLVYHQPVGPDLAFSPLLYIQMTRFSCGGLALGLSWAHIMGDPFSLSHFFNLWAQAFAGGKIYCPKTSVTERDFQNPTSTFKKPDSVKQVDLVGDLWVAPNNSKMTTFSFNLTVNDLKTHFPVNGDGEFEILTGIIWKCVATVRGESAPVTITVIRSDPKKLKPRAVRNGQMISSIHVDFSVAEASLEEIVKSIGE... | Involved in biosynthesis of the epicuticular wax. Plays a role in very-long-chain fatty acid (VLCFA) biosynthesis and is required for VLCFA elongation in leaf. Despite its classification as a BAHD acyltransferase based on sequence homology, CER26L does not seem to share the catalytic mechanism of the members of the BAH... |
P84865 | SPCTCSTCNCAGACNSCSCTSCSH | Metallothioneins have a high content of cysteine residues that bind various heavy metals. By cadmium. Contains 4 disulfide bonds. The measured mass is that of apo-metallothionein with intact disulfide bonds. The measured mass is that of apo-metallothionein treated with acid to cleave disulfide bonds. The measured mass ... |
Q62RZ5 | MVKVYYNGDIKENVLAGKKVAVIGYGSQGHAHALNLKESGVDVIVGVRKGKSFAKAEEDGHQVFTVREAAEQADIVMVLLPDEQQQKVYEAEIKDGLQAGNSLVFAHGFNVHFHQIVPPADVDVFLVAPKGPGHLVRRTFEQGAGVPALFAIYQDVTGEAKDKALAYAKAIGGARAGVLETTFKEETETDLFGEQAVLCGGLTSLVKAGFETLTEAGYQPELAYFECLHELKLIVDLMYEEGLAGMRYSISDTAQWGDFVSGPRVVDEKVKESMKEVLKDIQNGTFAKEWIVENQVNRPRFNAINASENEHQIEVVGRKL... | Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobu... |
Q8J0D7 | MGCIKVISVFLAAVAAVDARAFFHNRGGNDVIPNSYIVVMKDGVTAEDFDSHISSVATTHSINKAKRGSETVGHKDSFNINGWRAYNGHFDEATIESILNDDKVDYVEHDRVVKLAALTTQPNAPTWGLGRVSHKAPGNKDFVYDSSAGQGVTIYGVDTGIDINHPEFRGRIRWGTNTVDNDNTDGNGHGTHTAGTFAGTTYGVAKKANIVAVKVLSAGGSGSTAGVIKGIDWCVTDAKAKGALGKAALNLSLGGAFSQANNDAVTRAQNAGIFVAVAAGNDNKDAKNSSPASAPAVCTAASSTIDDQKSSFSNWGTIVD... | Secreted subtilisin-like serine protease with keratinolytic activity that contributes to pathogenicity. Belongs to the peptidase S8 family. |
A0LZH6 | MATEGNNLSQYDKNTIPNAKDFRFGIVVSEWNEEITEGLFQGAFDAWIENGVQKENIVRWNVPGSFELIYGCKKMQQSFEMLDAIVAVGNVIQGETKHFDFVCDGVTQGIKDLNVQTDIPVIFCVLTDNNIEQSRARSGGKHGNKGTEAAIAAIKMAQLRKDAKFYKG | Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lu... |
A4TEB9 | MTTAIQYPSASAKARFVRVSPTKARRVIDLVRGKSVEDALDILRWAPQAASEPVAKVIASAAANAQNNEGLDPSTLVVATVFADEGPTAKRIRPRAQGRAFRIRKRTSHITVIVESRPAKKQGASASAARARRAQASKAASQKEGSE | This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity). The globular do... |
P04325 | MAGRSGDSDEELLKAVRLIKFLYQSNPPPNPEGTRQARRNRRRRWRERQRQIHSISERILSTYLGRSAEPVPLQLPPLERLTLDCNEDCGTSGTQGVGSPQILVESPTILESGAKE | Escorts unspliced or incompletely spliced viral pre-mRNAs (late transcripts) out of the nucleus of infected cells. These pre-mRNAs carry a recognition sequence called Rev responsive element (RRE) located in the env gene, that is not present in fully spliced viral mRNAs (early transcripts). This function is essential si... |
Q6TC36 | MFGVLNSNDHRAAVQQRNIPAFGRTSFEPWTDNPTSNYRCEPGGNGRDSGQNRVRRPMNAFMVWSRDQRRKVALENPQMQNSEISKQLGYQWKMLTEAEKWPFFEEAQRLQAMHREKYPDYKYRPRRKALPQKSDKLLPAASSSMLCRQVLVDEKWYPFTYRDSCSRAAHSRMEDQLSSSQPVNIANSLLQQEHHYRSTSLRDSPETLATHLSADPPFYPK | Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. Involved in different aspects of gene regulation inclu... |
Q6ACL1 | MSKVLSSLPVGERVGIAFSGGLDTSCAVAWMREKGAVPCAYTADIGQYDEPNIEEVPGRATEYGAEIARLVDAKRALVEEGLIALQCGAFHIRSGGKTYFNTTPLGRAVTGVMLVRAMRDDDVEIWGDGSTYKGNDIERFYRYGLIANPRLRIYKPWLDTAFVEELGGRTEISEWLVARGFPYRDATEKAYSTDANIWGATHEAKRLEELDAGLDIVEPIMGVAAWREDIEVAPETVSVSFEYGRPVALNGIEFADPVALVPEANAIGGRHGLGASDQIENRIIEAKSRGIYEAPGMALLHIAYERLLNAIHNEDTVANY... | ATP + L-aspartate + L-citrulline = 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+) Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3. Homotetramer. Belongs to the argininosuccinate synthase family. Type 2 subfamily. |
B2FRV1 | MPVTPTSLADHLLVALPSLLDATFARSVALICQHDENGAMGVLVNQPSEYTLGEVLAQMDITTGDGDLQARMVLNGGPVHPERGFVIHDDARAWDSSLTVGDGLYLTTSRDILEAMARGEGPANAVVTLGCAGWGAGQLESELSENSWLTVPADAELVFQLPLEQRWQGAASRIGVDLFRLTDYSGHV | Belongs to the UPF0301 (AlgH) family. |
B2UTQ8 | MLKIKLEKTTFENAKAECGLVFIINKDFDHAWVKNKKLLETFKYEGEGVFLDQENKILYAGVKEDDVHLLRESACLAVRTLKKLAFKSVKVGVYTCDTHSKDNALLENLKALFLGLKLGLYEYDTFKSNKKESVLKEAIVALELHKPCEKTCANSLEKSAKEALKYAEIMTESLNIVRDLVNTPPMIATPVYMAEVAQKVAKENHLEIHVHDEKFLEEKKMNAFLAVNKASLGVNPPRLIHLVYKPKKAKKKIALVGKGLTYDCGGLSLKPADYMVTMKADKGGGSAVIGLLNALAKLGVEAEVHGIIGATENMIGPAAY... | Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides. Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, ... |
Q2YJG3 | MAANSKTAIRLSLRAGERIFINGAVLRADRKVSLELLNDATFLLENHVLQPEDTTTPLRQLYFAAQMMLIEPAMREQAGATFAQMLKGMFAMFKDAEILNALKLVDELVHNGRVFEALKTIRAQYPREAELMGAQPVVWPVTKSGKSAGANP | Has a post-transcriptional repressor function in flagellum biogenesis. Associates with the 5'-UTR of fljK mRNA and promotes its degradation. Belongs to the FlbT family. |
Q831A3 | MAIKAEEISALIKEQIENYQQQLAVEEVGTVTYVGDGIARAHGLENAMSGELVEFSNGSYGMAQNLETNDVGIIILGDFETIREGDKVQRTGKIMEVPVGEALIGRVVNPLGQPLDGLGEIKTDKTRPVEATAPGVMQRQSVAEPMQTGLKAIDALVPIGRGQRELVIGDRKTGKTSIAIDTIINQKGQDVICIYVAIGQKESTVRNQVETLRKFGALDYTIVVTAGASQPAPLLYIAPYAGTAMGEEFMYNGKHVLIIFDDLSKQAVAYRELSLLLRRPPGREAYPGDVFYLHSRLLERAAKLSDELGGGSMTALPFVE... | Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(... |
Q8Q0G3 | MQYHIKDQTLIIKGDFEAVSTGLNGGRARVEYIFNKQVPRTFNPPSPEEFIREEARKDGIETASLGLLTAVNMEYLQVIEDDYMTAFITAGVSNCSEFRAKAGTINIILVSKARLSETALFGAIITATEAKGLALLEKGYNFLGTNTDAVIVAYETCSDSGPKSKTNQEIPYAGSSTEFGKKITEAVIKGIKAGLELRGE | Converts adenosylcobinamide (AdoCbi) to adenosylcobyric acid (AdoCby), an intermediate of the de novo coenzyme B12 biosynthetic route. adenosylcob(III)inamide + H2O = (R)-1-aminopropan-2-ol + adenosylcob(III)yrate Cofactor biosynthesis; dicyanocobinamide salvage pathway. Belongs to the CbiZ family. |
Q0HXA2 | MPEQALLEEVVDKVRPLLGQGKVANYIPALANVDAGKLGIAVTTIDGETIGAGDYLEPFSIQSISKVFSLTLALTLYEETEIWSRVGKEPSGHSFNSLVQVELERGKPRNPFINAGALVIADLLQSRLGAPKHRMLELVRALSQNDKVCFDKQVADSEYQHSARNAAIAYLMKSFGNFQGDVDTVLRTYFHYCALKMNCADLSRAMLYLANRGKTLDGTELISQVQTRQLNALLATSGLYDGAGEFAYRVGMPGKSGVGGGIIAVIPGELSVCVWSPELDNQGNSLAGTAMLEHLSQRLGRSIF | H2O + L-glutamine = L-glutamate + NH4(+) Homotetramer. Belongs to the glutaminase family. |
Q8EJM1 | MTVANHARPIRRALLSVSDKTGILEFAKALHAQGVELLSTGGTARLLADNGVPVIEVSDYTGHPEIMDGRVKTLHPKVHGGILARRGLDENVMAANNINAIDLVAVNLYPFADTVAKAGCTLEDAIENIDIGGPTMVRAAAKNHKDVTIVVNAADYNRVLAEMAVNNGSTTHATRFDLAIAAFEHTAGYDGMIANYFGTMVPMHRVPAHSTDECFQDSLSVEGSKFPRTFNTQLVKKQDLRYGENSHQAAAFYVDTKIDEASVATAVQLQGKALSYNNIADTDAALECVKEFSEPACVIVKHANPCGVALGKDLLDAYNR... | (6S)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = (6S)-5,6,7,8-tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide H2O + IMP = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide Purine metabolism; IMP biosynthesis via de novo pathway; 5-form... |
A0A2Z4HPY4 | MPSYHNTDKTLLGDARQSLQQAVDYSLGCQQPDGHWVAPVMADATFTAQYVFFKHQIPELSLDEDGPEIQRWLLGEQTADGSWTLAPDLPGNLSTTVEAYLALRILGVPKSDQAMLRARDFVVRNGGVEGVRFFTRFFLATFGLVPWTAIPQMPAELILLPTFMFLNIYVLSSWARSTLIPILLVRHHEPVYALPNGQSANNNFLDELWCNPGEKNIPFALPLWDLLRRYQWIEFAFTLLDHILALFGGLRRWPCRHMALKRCTAWLLEHQEESGDWAGFFPPIHGSIWALLLDGFSFQSEVIRLGMEALERLVVIDPKG... | Terpene cyclase-glycosyl transferase fusion protein; part of the gene cluster that mediates the biosynthesis of enfumafungin, a glycosylated fernene-type triterpenoid with potent antifungal activity, mediated by its interaction with beta-1,3-glucan synthase and the fungal cell wall (PubMed:30051576). The pathway begins... |
Q5NE16 | MKMIEQHNQEYREGKHSFTMAMNAFGEMTSEEFRQVVNGFQNQKHRKGKVLQEPLLHDIRKSVDWREKGYVTPVKDQCNWGSVRTDVRKTEKLVSLSVQTWWTALGFKAMLAAFLENHYFASSMLPTMEAWTLRKPFHMKKSSGDWKVQGHRGASGESLLASGESQQSPEVAQYSGKHQVQCHLIEEALQMLSGGDEDHDEDKWPHDMRNHLAGEAQV | Belongs to the peptidase C1 family. Could be the product of a pseudogene. Lacks the region corresponding to the signal sequence and the propeptide. Has mutations in all 3 active site positions. |
Q9VZM4 | MAASMRALLKVRDGFVAGVRCNSQYNKTRGNLKLNGDSRVICQGFTGKQGTFHSQQALEYGTKLVGGISPKKGGTQHLGLPVFASVAEAKKATDPHATVIYVPPPGAAAAIIEALEAEIPLIVCITEGVPQHDMVKVKHALISQSKSRLVGPNCPGIIAPEQCKIGIMPGHIHKRGKIGVVSRSGTLTYEAVHQTTEVGLGQTLCVGIGGDPFNGTDFIDCLEVFLKDPETKGIILIGEIGGVAEEKAADYLTEYNSGIKAKPVVSFIAGVSAPPGRRMGHAGAIISGGKGGANDKIAALEKAGVIVTRSPAKMGHELFK... | Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate ... |
B2S6L0 | MPAKLSVNLNAIAMLRNRRDLPWPSVTGLGRAALAAGAAGLTVHPRPDQRHIRFSDLGDIRALIDDEYPQAEFNIEGFPSEAFLDLVEKHEPEQVTLVPDDPMQATSDHGWDFMSKADFLAPIVARLKGRGMRVSLFADPDSLGYERAKAIGADRVELYTGPYGATHDDPAAAARELDRLEKAARAATALGLAVNAGHDLTVDNLPALVKRIPQLAEVSIGHGLTADALMYGIPVTVSRYITALAG | Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. 1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate = H(... |
B0XUL1 | MSTTSLQHFPHSYSPFSSSRSLNRMAQSQTSGLDTLAEGSQYALEQLQMSREAAGSGEATDSVGKPKDQFQVDNDNHHNNHSLSNFKNPSQRDPLVEARSTIRKNSASAPVRRRISRACDQCNQLRTKCDGQNPCAHCIEFGLTCEYARERKKRGKASKKDLAAAAAAAAAAATNSGQPNGSSGKEDAALVGGHTSPDRRPTINGRYDPAFEVPRNLNGSAQHSEASGMVGMQNSQHLPPHSQSSMGGGLEGLPLNGYNGLNDSGRPSMPVPELQSLHMLHNSHTNPRSPSSILTHHRYNGGYNDSAYSLMNPQEPNSTS... | Transcriptional activator of the xylanolytic system. Involved in the regulation of extracellular cellulolytic and xylanolytic genes and in the regulation of the intracellular activities of D-xylose catabolic genes in the pentose catabolic pathway (PCP) in response to the presence of D-xylose (By similarity). Belongs to... |
Q8DYI1 | MTFKSGFVAILGRPNVGKSTFLNHVMGQKIAIMSDKAQTTRNKIMGIYTTETEQIVFIDTPGIHKPKTALGDFMVESAYSTLREVETVLFMVPADEKRGKGDDMIIERLKAAKIPVILVINKIDKVHPDQLLEQIDDFRSQMDFKEVVPISALQGNNVPTLIKLLTDNLEEGFQYFPEDQITDHPERFLVSEMVREKVLHLTQQEVPHSVAVVVESMKRDEETDKVHIRATIMVERDSQKGIIIGKQGAMLKKIGKMARRDIELMLGDKVYLETWVKVKKNWRDKKLDLADFGYNEKEY | An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism. Monomer. Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase f... |
A8LRR5 | MSEHGPLRIGIGGPVGAGKTTLTERLCAALRDDYSVAVITNDIYTSEDAEYLMRAQALPLERIRGVETGGCPHTAIREDASINLAAVADLRASFADLDVILIESGGDNLAATFSPELADLTIYVIDTAAGQDIPRKKGPGLARSDLLVINKTDLAPHVDVDLALLESDARTARGARPFVMAALKSGQGVAQIVAFLEREGGL | Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG. Homodimer. UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel c... |
Q28HN9 | MQSPTNGVSTPKDFSSARRSIQFQNTGFPQIGLASARRHTPFHHAPSKRRIPQTSPLSETVDPLKIALLLSKQWTLYSVTPMHKFSYTNLKEYARLLSAHICAEKQKGLAVEVGTELNVKATFSPLPGLKGREQDPGSILIQVLAKPQFSAAGAQDRIVWSGCFCCTFADEDTLDLLTSETLLCLPLFLVNGAEALTAMVGTWFQKAFDCSFSNLPISSRDLAWMAAMWTGYEAHEHITATEFIFSVPIEPHMDISYAIHPEDIKALWSNIHKGQDEVLAEEVDLLFQCLYTHFFRHFKIHLSATHLVKVSTSVASAHCD... | Probable component of a centromeric complex involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. Localizes exclusively in the centromeres. Belongs to the CENP-L/IML3 family. |
Q96069 | MNIFPSLMLTSLFTLTLPIIASTLNIHKNSNTPHHMKNIISFAFIISLIPTMMFIYSGQEMIISNWHWMTTQTLKLSLSFKLDYFSMIFVPVALFVTWSIMEFSIWYMHSDPHITQFFKYLLMFLITMMILVTANNLFQLFIGWEGVGIMSFLLIGWWYGRTDANTAALQAILYNRIGDIGFIMSMAWFLSNMNSWDLQQIFTLDPNHTNLPLMGLLLAATGKSAQFGLHPWLPSAMEGPTPVSALLHSSTMVVAGVFLLIRFHPLMENNKTAQTLTLCLGAITTLFTAICALTQNDIKKIIAFSTSSQLGLMIVTIGIN... | Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I. a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol ... |
A6QIT5 | MFNQSYLNVYFICGTSDVPSHRTIHEVLEAALKAGITLFQFREKGESALKGNDKLVLAKELQHLCHQYDVPFIVNDDVSLAKEINADGIHVGQDDAKVKEIAQYFTDKIIGLSISDLDEYAKSDLTHVDYIGVGPIYPTPSKHDAHIPVGPEMIATFKEMNPQLPIVAIGGINTNNVAPIVEAGANGISVISAISKSENIEKTVNRFKDFFNN | Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diph... |
A4IVV7 | MISNFILFALFIVTIALITKPLGSYIFRVFNNERTYLDWLAKPFQRVYLLVLGESSKKEQTAKAYFFSLVSFSVMAFIFVLVILLLQGILPLNPQEIKGMSFPQALNTAVSFITNTNWQSYSGETGVSYFAQMLALAVQNFVSAAVGLCVAIALIRSVARHETATIGNFWNDLGKGVFWILLPISIVIAIVYIFQGVPQNVMAYLHVHTLAGTEQIIPQGPIASQEAIKSLGTNGGGFFNANSAHPYENPTVITNYIQMVSIFAIAAALTYTFGKWVGNTKQGWLIFGVMLVLFIISLVVMTISELHGLDFLHSKDIQDI... | Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds the periplasmic potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.... |
A0LTD9 | MTAVTPDGRKLLRIEARNAQVPIERKPAWIRTRARMGPQYHALKELVRREGLHTVCEEAGCPNIFECWEDREATFLIGGDTCSRNCSFCQISSGRPQPLDRDEPRRVAESVARMGLRYATVTGVTRDDLDDEGAWLYAQTVREIHHAVPGCGVELLTPDFHGRPELLDEVFSARPEVFAHNIETVPRIFKSIRPGFRYERSLDVLRAAHDAGLVTKSNLILGLGETRQEIRAALADLRSAGCDLVTITQYLRPSIRHHPVVRWVEPAEFEELAAEARELGFAGVMSGPLVRSSYRAGRLYRAAIASRTDRRTDGATTQAP... | Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. [[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] +... |
Q06GU1 | MIIDTTEVQAINSFSRSESLKEGYGLIGMLVPIFTPVSGITIGVLVIVWLEREISAGIQQRIGPEYAGPLGILQALADGTKLLFKEDLLPSRGDIRLFSIGPSIAVISILLSYSVIPFGYRLVLADLSIGVFLWIAISSIAPIGLLMSGYGSNNKYSFSGGLRAAAQSISYEIPLTPCVLSISLLSNSSSTIDIVEAQSKYGFWGWNLWRQPIGFIVFIISSLAECERLPFDLPEAEEELVAGYQTEYSGIKFGLFYVASYLNLLVSSLFVTVLYLGGWNLSIPYIFIPELFGINKTGGVFGTTIGILITLAKAYLFLFI... | NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translo... |
O13669 | MDEFQTLKQNASWDISEDANDTPSLLVVILDANPASWYSLSKKVPVSKVLADITVFLNAHLAFHHDNRVAVLASHSDKVEYLYPSIAPEQKVAEVDPTKEANTYRKFREVDDLVLSGMKRLMSSTDKVSRKTMISGALSRALAYINQVQNKNTLRSRILIFSLTGDVALQYIPTMNCIFCAQKKNIPINVCNIEGGTLFLEQAADATGGIYLKVDNPKGLLQYLMMSLFPDQNLRKHLNTPNQANVDFRATCFCHKKVLDIGFVCSVCLSIFCEPRVHCSTCHTKFTVEPMSKKLHT | Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to al... |
Q9SZ52 | MVALLCSASLCGDISVGDACLVSNIKAKCRDNLVTGGLKFHALKIGSRKKHWRRKSMRCSVVSMKSSDFSGSMIRKSSKPDLSSSEEVTRGLKSFPDTDSSFSYFKSVAGNLNLVHTTETCNYMLEALRVDGKLEEMAYVFDLMQKRIIKRDTNTYLTIFKSLSVKGGLKQAPYALRKMREFGFVLNAYSYNGLIHLLLKSRFCTEAMEVYRRMILEGFRPSLQTYSSLMVGLGKRRDIDSVMGLLKEMETLGLKPNVYTFTICIRVLGRAGKINEAYEILKRMDDEGCGPDVVTYTVLIDALCTARKLDCAKEVFEKMK... | Plays a role in the stabilization of the primary polycistronic transcript of the petL operon encoding subunits of the cytochrome b6-f complex. Belongs to the PPR family. P subfamily. |
A9WTR8 | MSNFWLAVVSAQHVRQGVEFGIVQTNHGKPQGIRRMSPGDGLVYYSPKTSYPDGEPLKAFTAVGRIADGEPWQSDVENFKPWRRKVHYDLSTDVSLAELQPQLEFTQEANWGYQLRRGVVPITEHDFALIRQAITSTTA | Belongs to the UPF0310 family. |
Q5NVQ3 | MAEGEITTFTALTEKFNLPPGNYKKPKLLYCSNGGHFLRILPDGTVDGTRDRSDQHIQLQLSAESVGEVYIKSTETGQYLAMDTDGLLYGSQTPNEECLFLERLEENHYNTYISKKHAEKNWFVGLKKNGSCKRGPRTHYGQKAILFLPLPVSSD | Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophos... |
P91758 | MLLKLIVALSLTLTLASATSDPKGWFCSFECNDWNQLEMACQKEKDCFEKTNNQFTNETVACMQPCWDLGIPCRTQCYKVYDQCTSDCPYTVPNPYECFTTCFKEAFAEVKPQIPKANLDE | Interacts with the p75 low-affinity neurotrophin receptor. Evokes neurite outgrowth and modulated calcium currents in pedal motor neurons. May be involved in target-derived trophic support for motor neurons. |
A3A083 | MEHIARFFFGVSGNVIALFLFLSPVVTFWRIIKKRSTEDFSGVPYNMTLLNCLLSAWYGLPFVSPNNILVTTINGTGSVIEAIYVVIFLIFAERKARLKMMGLLGLVTSIFTMVVLVSLLALHGQGRKLFCGLAATIFSICMYASPLSIMRLVIKTKSVEFMPFLLSLSVFLCGTSWFIYGLLGRDPFIAIPNGCGSFLGLMQLILYAIYRNHKGATPAAAAGKGDAADEVEDAKKAAAAVEMADAKTNKVVADDADADADGKSADDKVASQV | Mediates both low-affinity uptake and efflux of sugar across the plasma membrane. Forms homooligomers and/or heterooligomers. Belongs to the SWEET sugar transporter family. |
B1KD01 | MTDRYAVFGNPISHSKSPLIHGIFANETQQVLDYEAILAPKDGFESCLKLFWSQNGKGANVTAPFKEQAFNLCDELSEEAKLAGAVNTLTLLTNGKVRGDNTDGLGLVADLIRNISSLEGKRVLLLGAGGAARGSVLPLLKAGLKVYIHNRTQEKAEKLVEIFTPFGDVKALSIAELIAPFDIIINSTSSSLSGDVPAIPSCVIGVESLCYDMMYSKEMTSFNSWALELGAVKAIDGLGMLVGQAAKSFELWRGVTPEVDTTIKLLREKIKSE | Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). NADP(+) + shikimate = 3-dehydroshikimate + H(+) + NADPH Metabolic intermediate biosynthesis; chorismate biosynthe... |
Q9A8T7 | MALSPRESAAKRAQRVRTRLKSLANGRPRLSVFRSSKNIYAQVIDDERGVTLASASTLEAEGKGADKDAAAAVGKLVAERAIEKGVKDVVFDRGSYIFHGRVKALADAAREAGLNF | This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs. Belongs to the universal ribosomal pro... |
B3PQ90 | MNIHEYQAKALLKGYGAPVAEGVAILKAEEAEAAAKSLPGPLYVVKSQIHAGGRGKGKFKELSPEAKGGVRLAKSVEDVVANVKEMLGNTLVTAQTGEAGKQVNRLYIEDGADIERELYCSLLVDRSVGKVAFVVSTEGGMDIEAVAHDTPEKIQTIAIDPETGVTAADVAKISSALKLDGAAGEDAKSLFPLLYKAFNEKDMSLLEINPLIVMKNGHLRVLDAKMSFDGNALFRHDDVRALRDETEEDAKEIEASKWDLAYVALDGNIGCMVNGAGLAMATMDIIKLYGKEPANFCDVGGGAGKEKVAAAFKIITADPK... | Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinat... |
A1B969 | MRSISVLGATGSVGESAFDLLMGAGGPERFRTVALTGGANVARLAQMARALRAELAVTAWPERLADLRAALAGSGIEAAAGPQAVAEAAARPADWTLSAIVGAAGLPPGLEVLNRGGTLALANKETLVAAGPLVMARARETGARILPVDSEHSAIFQALHGENLDSVEHVTITASGGAFRDWPLERLARATVAEASRHPNWDMGQRITIDSASMFNKALEVIEAHEFFGLGVDRLRVLVHPQSIIHAMVTHRDGGSIAHLGAPDMRHAIGYALNWPARAALPVPALDLAALGSLTFAQPDEVRWPALRLAREAIGAGGAA... | Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP). 2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isop... |
Q62VF0 | MASIAVCPGSFDPVTFGHLDIIRRGAKVFDKVYVCVLNNSSKKPLFTVEERCGLLREVTQDIPNVQVESFQGLLIDYAKSKQANVILRGLRAVSDFEYEMQGTSMNKVLDENIETFFMMTNNQYSFLSSSIVKEVAKYKGSVAELVPEAVEAALEKKFAKNERP | Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. (R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA + diphosphate Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5. Homohexamer. Belongs to the bacterial C... |
B7VAQ9 | MSWLTPALVTIILTVVKAIVVLLAVVICGALLSWVERRLLGLWQDRYGPNRVGPFGAFQLGADMVKMFFKEDWTPPFADKMIFTLAPVIAMGALLVAFAIVPITPTWGVADLNIGILFFFAMAGLTVYAVLFAGWSSNNKFALLGSLRASAQTISYEVFLALSLMGIVAQVGSFNMRDIVQYQIDNVWFIIPQFFGFCTFIIAGVAVTHRHPFDQPEAEQELADGYHIEYAGMKWGMFFVGEYIGIVLVSALLATLFFGGWHGPFLDTLPWLSFFYFAAKTGFFIMLFILIRASLPRPRYDQVMAFSWKVCLPLTLINLL... | NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are t... |
A5CW96 | MIEEDLLIDEKDHNNEDLVITSIRPNSLENYIGQNDVKSQMMLFIKAAKKRKDTLDHCLIYGPPGLGKTTLANVIANQMSTGFKKTSGPVLERAGDLAAILTKLDPYDILFIDEIHRLNYVVEETLYPALEDFKLDIIVGEGLASHSVQLELPPFTLIGATTRVGMLTSPLRDRFGIIQRLQFYNVEDLKMIVERSADILDIQIESKGALEIAKRSRGTPRIANRLLRRVRDFADVKANSMIHQDIAKEALIILKVDEAGLEQLDRDYLSIIMNKFSGGPVGLDTLATSIGEERGTLEDMVEPYLIQQGFIMRTPRGRSI... | The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. ATP ... |
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