Joseph Pollack
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Features

DeepCritical provides a comprehensive set of features for AI-assisted research:

Core Features

Multi-Source Search

  • PubMed: Search peer-reviewed biomedical literature via NCBI E-utilities
  • ClinicalTrials.gov: Search interventional clinical trials
  • Europe PMC: Search preprints and peer-reviewed articles (includes bioRxiv/medRxiv)
  • RAG: Semantic search within collected evidence using LlamaIndex

MCP Integration

  • Model Context Protocol: Expose search tools via MCP server
  • Claude Desktop: Use DeepCritical tools directly from Claude Desktop
  • MCP Clients: Compatible with any MCP-compatible client

Authentication

  • HuggingFace OAuth: Sign in with HuggingFace account for automatic API token usage
  • Manual API Keys: Support for OpenAI, Anthropic, and HuggingFace API keys
  • Free Tier Support: Automatic fallback to HuggingFace Inference API

Secure Code Execution

  • Modal Sandbox: Secure execution of AI-generated statistical code
  • Isolated Environment: Network isolation and package version pinning
  • Safe Execution: Prevents malicious code execution

Semantic Search & RAG

  • LlamaIndex Integration: Advanced RAG capabilities
  • Vector Storage: ChromaDB for embedding storage
  • Semantic Deduplication: Automatic detection of similar evidence
  • Embedding Service: Local sentence-transformers (no API key required)

Orchestration Patterns

  • Graph-Based Execution: Flexible graph orchestration with conditional routing
  • Parallel Research Loops: Run multiple research tasks concurrently
  • Iterative Research: Single-loop research with search-judge-synthesize cycles
  • Deep Research: Multi-section parallel research with planning and synthesis
  • Magentic Orchestration: Multi-agent coordination using Microsoft Agent Framework

Real-Time Streaming

  • Event Streaming: Real-time updates via AsyncGenerator[AgentEvent]
  • Progress Tracking: Monitor research progress with detailed event metadata
  • UI Integration: Seamless integration with Gradio chat interface

Budget Management

  • Token Budget: Track and limit LLM token usage
  • Time Budget: Enforce time limits per research loop
  • Iteration Budget: Limit maximum iterations
  • Per-Loop Budgets: Independent budgets for parallel research loops

State Management

  • Thread-Safe Isolation: ContextVar-based state management
  • Evidence Deduplication: Automatic URL-based deduplication
  • Conversation History: Track iteration history and agent interactions
  • State Synchronization: Share evidence across parallel loops

Advanced Features

Agent System

  • Pydantic AI Agents: Type-safe agent implementation
  • Structured Output: Pydantic models for agent responses
  • Agent Factory: Centralized agent creation with fallback support
  • Specialized Agents: Knowledge gap, tool selector, writer, proofreader, and more

Search Tools

  • Rate Limiting: Built-in rate limiting for external APIs
  • Retry Logic: Automatic retry with exponential backoff
  • Query Preprocessing: Automatic query enhancement and synonym expansion
  • Evidence Conversion: Automatic conversion to structured Evidence objects

Error Handling

  • Custom Exceptions: Hierarchical exception system
  • Error Chaining: Preserve exception context
  • Structured Logging: Comprehensive logging with structlog
  • Graceful Degradation: Fallback handlers for missing dependencies

Configuration

  • Pydantic Settings: Type-safe configuration management
  • Environment Variables: Support for .env files
  • Validation: Automatic configuration validation
  • Flexible Providers: Support for multiple LLM and embedding providers

Testing

  • Unit Tests: Comprehensive unit test coverage
  • Integration Tests: Real API integration tests
  • Mock Support: Extensive mocking utilities
  • Coverage Reports: Code coverage tracking

UI Features

Gradio Interface

  • Real-Time Chat: Interactive chat interface
  • Streaming Updates: Live progress updates
  • Accordion UI: Organized display of pending/done operations
  • OAuth Integration: Seamless HuggingFace authentication

MCP Server

  • RESTful API: HTTP-based MCP server
  • Tool Discovery: Automatic tool registration
  • Request Handling: Async request processing
  • Error Responses: Structured error responses

Development Features

Code Quality

  • Type Safety: Full type hints with mypy strict mode
  • Linting: Ruff for code quality
  • Formatting: Automatic code formatting
  • Pre-commit Hooks: Automated quality checks

Documentation

  • Comprehensive Docs: Detailed documentation for all components
  • Code Examples: Extensive code examples
  • Architecture Diagrams: Visual architecture documentation
  • API Reference: Complete API documentation